FAM3D-AS1

Summary

FAM3D-AS1 (FAM3D antisense RNA 1, HGNC:41276) is a long non-coding RNA gene on chromosome 3p14.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41276
Approved symbol	FAM3D-AS1
Name	FAM3D antisense RNA 1
Location	3p14.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-KCTD6-3
Ensembl gene	ENSG00000244383
Ensembl biotype	lncRNA
Entrez	105377108
RNAcentral	URS00004E44CC — lncRNA, 821 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000464125, ENST00000649469

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000464125 — 4 exons

Exon	Start	End
ENSE00001840551	58607682	58607945
ENSE00001846324	58634056	58634440
ENSE00001870918	58607080	58607129
ENSE00002324622	58632539	58632660

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 85.83.

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	85.83	gold quality
mucosa of transverse colon	UBERON:0004991	78.38	gold quality
rectum	UBERON:0001052	68.71	gold quality
saliva-secreting gland	UBERON:0001044	66.67	gold quality
minor salivary gland	UBERON:0001830	66.66	gold quality
adult mammalian kidney	UBERON:0000082	65.94	gold quality
esophagus mucosa	UBERON:0002469	65.70	gold quality
transverse colon	UBERON:0001157	65.19	gold quality
kidney	UBERON:0002113	64.18	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	63.08	gold quality
ganglionic eminence	UBERON:0004023	63.06	gold quality
ventricular zone	UBERON:0003053	63.01	gold quality
cortical plate	UBERON:0005343	62.02	gold quality
tonsil	UBERON:0002372	61.18	gold quality
liver	UBERON:0002107	59.15	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.86	gold quality
colon	UBERON:0001155	58.64	gold quality
esophagus	UBERON:0001043	57.59	gold quality
right lobe of liver	UBERON:0001114	57.51	gold quality
intestine	UBERON:0000160	57.28	gold quality
cortex of kidney	UBERON:0001225	57.02	gold quality
duodenum	UBERON:0002114	56.71	gold quality
gall bladder	UBERON:0002110	56.55	gold quality
metanephros cortex	UBERON:0010533	55.84	gold quality
vagina	UBERON:0000996	55.71	gold quality
pituitary gland	UBERON:0000007	54.84	gold quality
adenohypophysis	UBERON:0002196	54.71	gold quality
prefrontal cortex	UBERON:0000451	54.22	gold quality
monocyte	CL:0000576	53.31	silver quality
small intestine	UBERON:0002108	53.14	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	32.05
E-ANND-3	yes	10.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long noncoding RNA FAM3D-AS1 inhibits development of colorectal cancer through NF-kappaB signaling pathway. (PMID:31147452)
• Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer. (PMID:35351056)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.