FAM53B-AS1

Summary

FAM53B-AS1 (FAM53B antisense RNA 1, HGNC:49499) is a long non-coding RNA gene on chromosome 10q26.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49499
Approved symbol	FAM53B-AS1
Name	FAM53B antisense RNA 1
Location	10q26.13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233334
Ensembl biotype	lncRNA
Entrez	101927944
RNAcentral	URS0002A2492D — lncRNA, 2050 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000432699, ENST00000448422, ENST00000611797, ENST00000780545

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000432699 — 3 exons

Exon	Start	End
ENSE00001694171	124707851	124707990
ENSE00004151902	124704022	124704331
ENSE00004151904	124713434	124713705

Expression profiles

Bgee: expression breadth ubiquitous, 153 present calls, max score 84.18.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1422 / max 14.3536, expressed in 72 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
107547	0.1422	72

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.18	silver quality
bone marrow cell	CL:0002092	74.73	gold quality
apex of heart	UBERON:0002098	73.20	gold quality
medial globus pallidus	UBERON:0002477	70.03	gold quality
left adrenal gland cortex	UBERON:0035825	69.29	gold quality
hindlimb stylopod muscle	UBERON:0004252	69.20	gold quality
sural nerve	UBERON:0015488	69.14	gold quality
left adrenal gland	UBERON:0001234	68.97	gold quality
tendon of biceps brachii	UBERON:0008188	68.37	silver quality
right adrenal gland	UBERON:0001233	67.96	gold quality
right adrenal gland cortex	UBERON:0035827	67.48	gold quality
globus pallidus	UBERON:0001875	67.36	gold quality
adrenal cortex	UBERON:0001235	66.91	gold quality
gastrocnemius	UBERON:0001388	66.87	gold quality
heart left ventricle	UBERON:0002084	66.86	gold quality
muscle of leg	UBERON:0001383	66.62	gold quality
adrenal gland	UBERON:0002369	66.37	gold quality
cardiac ventricle	UBERON:0002082	66.00	gold quality
colonic epithelium	UBERON:0000397	65.78	silver quality
tendon	UBERON:0000043	64.22	gold quality
corpus callosum	UBERON:0002336	64.15	gold quality
ventricular zone	UBERON:0003053	63.33	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.26	gold quality
prefrontal cortex	UBERON:0000451	61.43	gold quality
spinal cord	UBERON:0002240	61.12	gold quality
heart	UBERON:0000948	60.75	gold quality
putamen	UBERON:0001874	60.73	gold quality
left ovary	UBERON:0002119	60.03	gold quality
adrenal tissue	UBERON:0018303	59.73	gold quality
monocyte	CL:0000576	59.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.04

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.