FAM66B

Summary

FAM66B (family with sequence similarity 66 member B, HGNC:28890) is a long non-coding RNA gene on chromosome 8p23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28890
Approved symbol	FAM66B
Name	family with sequence similarity 66 member B
Location	8p23.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000215374
Ensembl biotype	lncRNA
Entrez	100128890
RNAcentral	URS0000BC4533 — lncRNA, 4308 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 43 — 41 lncRNA, 2 retained_intron

ENST00000529456, ENST00000606573, ENST00000653873, ENST00000656213, ENST00000656567, ENST00000663272, ENST00000664195, ENST00000665607, ENST00000670717, ENST00000820789, ENST00000820790, ENST00000820791, ENST00000820792, ENST00000820793, ENST00000820794, ENST00000820795, ENST00000820796, ENST00000820797, ENST00000820798, ENST00000820799, ENST00000820800, ENST00000820801, ENST00000820802, ENST00000820803, ENST00000820804, ENST00000820805, ENST00000820806, ENST00000820807, ENST00000820808, ENST00000820809, ENST00000820810, ENST00000820811, ENST00000820812, ENST00000820813, ENST00000820814, ENST00000820815, ENST00000820816, ENST00000820817, ENST00000820818, ENST00000820819, ENST00000820820, ENST00000820821, ENST00000820822

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000529456 — 7 exons

Exon	Start	End
ENSE00002157146	7349083	7349146
ENSE00002159332	7325137	7325198
ENSE00002159780	7324822	7324889
ENSE00002165372	7301611	7302171
ENSE00002177785	7324297	7324364
ENSE00004227055	7323769	7323833
ENSE00004227062	7354811	7355355

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 87.04.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	87.04	gold quality
sural nerve	UBERON:0015488	77.77	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.62	gold quality
cortical plate	UBERON:0005343	73.45	gold quality
superior frontal gyrus	UBERON:0002661	72.32	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.20	gold quality
calcaneal tendon	UBERON:0003701	71.04	gold quality
substantia nigra	UBERON:0002038	70.71	gold quality
amygdala	UBERON:0001876	70.49	gold quality
temporal lobe	UBERON:0001871	70.45	gold quality
ventricular zone	UBERON:0003053	70.40	gold quality
primary visual cortex	UBERON:0002436	69.77	gold quality
right frontal lobe	UBERON:0002810	69.68	gold quality
putamen	UBERON:0001874	69.53	gold quality
Ammon’s horn	UBERON:0001954	69.44	gold quality
ganglionic eminence	UBERON:0004023	69.29	gold quality
anterior cingulate cortex	UBERON:0009835	69.19	gold quality
hypothalamus	UBERON:0001898	68.86	gold quality
brain	UBERON:0000955	68.78	gold quality
left ovary	UBERON:0002119	68.66	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.64	gold quality
cerebellum	UBERON:0002037	68.63	gold quality
cerebellar cortex	UBERON:0002129	68.62	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.58	gold quality
cerebellar hemisphere	UBERON:0002245	68.54	gold quality
cerebral cortex	UBERON:0000956	68.47	gold quality
nucleus accumbens	UBERON:0001882	68.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.02	gold quality
stromal cell of endometrium	CL:0002255	68.01	gold quality
ovary	UBERON:0000992	68.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.56

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.