FAM66C

Summary

FAM66C (family with sequence similarity 66 member C, HGNC:21644) is a long non-coding RNA gene on chromosome 12p13.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21644
Approved symbol	FAM66C
Name	family with sequence similarity 66 member C
Location	12p13.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226711
Ensembl biotype	lncRNA
Entrez	440078
RNAcentral	URS000075D2E7 — lncRNA, 3266 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 21 lncRNA

ENST00000372173, ENST00000420514, ENST00000438689, ENST00000454799, ENST00000456135, ENST00000535567, ENST00000540566, ENST00000541558, ENST00000544214, ENST00000653230, ENST00000685711, ENST00000687015, ENST00000736407, ENST00000736408, ENST00000736409, ENST00000736410, ENST00000736411, ENST00000736412, ENST00000736413, ENST00000736414, ENST00000736415

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000372173 — 4 exons

Exon	Start	End
ENSE00002203274	8215806	8216035
ENSE00002242113	8204058	8204175
ENSE00002285651	8188485	8188535
ENSE00002316234	8194203	8194481

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 84.68.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2676 / max 11.6531, expressed in 120 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
206571	0.2676	120

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	84.68	gold quality
ganglionic eminence	UBERON:0004023	81.29	gold quality
sural nerve	UBERON:0015488	80.69	gold quality
ventricular zone	UBERON:0003053	80.53	gold quality
right hemisphere of cerebellum	UBERON:0014890	79.41	gold quality
cerebellar hemisphere	UBERON:0002245	79.24	gold quality
left ovary	UBERON:0002119	79.19	gold quality
cerebellar cortex	UBERON:0002129	79.19	gold quality
adenohypophysis	UBERON:0002196	78.77	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	78.58	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.50	gold quality
right ovary	UBERON:0002118	77.99	gold quality
anterior cingulate cortex	UBERON:0009835	77.68	gold quality
body of uterus	UBERON:0009853	77.59	gold quality
cerebellum	UBERON:0002037	77.57	gold quality
popliteal artery	UBERON:0002250	77.51	gold quality
tibial artery	UBERON:0007610	77.51	gold quality
nucleus accumbens	UBERON:0001882	77.16	gold quality
stromal cell of endometrium	CL:0002255	77.04	gold quality
right frontal lobe	UBERON:0002810	76.70	gold quality
calcaneal tendon	UBERON:0003701	76.47	gold quality
aorta	UBERON:0000947	76.44	gold quality
tibial nerve	UBERON:0001323	76.43	gold quality
pituitary gland	UBERON:0000007	76.19	gold quality
endocervix	UBERON:0000458	76.09	gold quality
putamen	UBERON:0001874	75.97	gold quality
hypothalamus	UBERON:0001898	75.92	gold quality
ascending aorta	UBERON:0001496	75.62	gold quality
amygdala	UBERON:0001876	75.54	gold quality
spinal cord	UBERON:0002240	75.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• FAM66C expression is significantly downregulated in human masticatory mucosa during wound healing (PMID:28005267)
• Long non-coding RNA FAM66C is associated with clinical progression and promotes cell proliferation by inhibiting proteasome pathway in prostate cancer. (PMID:32430927)
• LncRNA-FAM66C Was Identified as a Key Regulator for Modulating Tumor Microenvironment and Hypoxia-Related Pathways in Glioblastoma. (PMID:35874989)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.