FAM66E

Summary

FAM66E (family with sequence similarity 66 member E, HGNC:18735) is a long non-coding RNA gene on chromosome 8p23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18735
Approved symbol	FAM66E
Name	family with sequence similarity 66 member E
Location	8p23.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225725
Ensembl biotype	lncRNA
Entrez	100132103
RNAcentral	URS000075DA44 — lncRNA, 1434 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000529252, ENST00000533615, ENST00000840786

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000529252 — 7 exons

Exon	Start	End
ENSE00001626978	7955014	7955558
ENSE00001754190	7961233	7961296
ENSE00002168200	7986537	7986601
ENSE00002174970	7985481	7985548
ENSE00002194590	7986006	7986073
ENSE00002225187	7985172	7985233
ENSE00003414123	8008195	8008755

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 61.08.

Top tissues by expression

85 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	61.08	gold quality
calcaneal tendon	UBERON:0003701	60.65	gold quality
ganglionic eminence	UBERON:0004023	60.07	gold quality
stromal cell of endometrium	CL:0002255	55.95	gold quality
superior frontal gyrus	UBERON:0002661	53.73	gold quality
prefrontal cortex	UBERON:0000451	52.75	gold quality
mucosa of stomach	UBERON:0001199	50.90	gold quality
islet of Langerhans	UBERON:0000006	49.10	gold quality
primary visual cortex	UBERON:0002436	48.76	gold quality
corpus callosum	UBERON:0002336	48.16	silver quality
blood	UBERON:0000178	47.63	gold quality
frontal cortex	UBERON:0001870	46.81	gold quality
cerebellum	UBERON:0002037	46.24	silver quality
substantia nigra	UBERON:0002038	45.65	gold quality
cerebellar cortex	UBERON:0002129	45.58	silver quality
right hemisphere of cerebellum	UBERON:0014890	45.51	silver quality
right ovary	UBERON:0002118	45.31	gold quality
adenohypophysis	UBERON:0002196	45.29	gold quality
endometrium	UBERON:0001295	45.12	silver quality
gastrocnemius	UBERON:0001388	45.05	silver quality
cerebral cortex	UBERON:0000956	44.97	gold quality
tibial artery	UBERON:0007610	44.88	gold quality
lymph node	UBERON:0000029	44.87	silver quality
cerebellar hemisphere	UBERON:0002245	44.87	silver quality
myometrium	UBERON:0001296	44.50	gold quality
heart left ventricle	UBERON:0002084	44.46	silver quality
ovary	UBERON:0000992	44.37	gold quality
brain	UBERON:0000955	44.21	gold quality
adrenal gland	UBERON:0002369	44.09	silver quality
left ovary	UBERON:0002119	44.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.96

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.