FAM85A

Summary

FAM85A (family with sequence similarity 85 member A, HGNC:17606) is a long non-coding RNA gene on chromosome 8p23.1.

At a glance

• Clinical variants (ClinVar): 71 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17606
Approved symbol	FAM85A
Name	family with sequence similarity 85 member A
Location	8p23.1
Locus type	RNA, long non-coding
Status	Approved
Entrez	619423
RNAcentral	URS0000BC43AD — lncRNA, 1848 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

71 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	63
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1002446503 (8:12185082 C>G,T), RS1003063594 (8:12193444 G>GT), RS1003422476 (8:12191778 C>G,T), RS1004016892 (8:12201591 G>A), RS1006664094 (8:12187922 G>A,C), RS1006960338 (8:12189755 C>A), RS1007527214 (8:12199583 C>T), RS1008079147 (8:12197590 A>C,G,T), RS1010739092 (8:12186445 C>A,G,T), RS1010853887 (8:12185327 C>A,T), RS1011590412 (8:12191988 G>A,T), RS1011743327 (8:12196623 A>G), RS1011859674 (8:12193624 G>A), RS1016691050 (8:12189929 C>T), RS1017684460 (8:12197594 T>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
methylmercuric chloride	decreases expression	1
bisphenol A	increases expression	1
Methyl Methanesulfonate	decreases expression	1
Smoke	decreases expression	1
Thimerosal	decreases expression	1
1-Methyl-4-phenylpyridinium	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.