FAM85B

Summary

FAM85B (family with sequence similarity 85 member B, HGNC:32160) is a long non-coding RNA gene on chromosome 8p23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32160
Approved symbol	FAM85B
Name	family with sequence similarity 85 member B
Location	8p23.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncRNA-HEIM
Ensembl gene	ENSG00000253893
Ensembl biotype	lncRNA
Entrez	105379219
RNAcentral	URS0000BC465B — lncRNA, 869 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 56 — 56 lncRNA

ENST00000518201, ENST00000519726, ENST00000522393, ENST00000523017, ENST00000688025, ENST00000689104, ENST00000692661, ENST00000701202, ENST00000701529, ENST00000834293, ENST00000834294, ENST00000834295, ENST00000834296, ENST00000834297, ENST00000834298, ENST00000834299, ENST00000834300, ENST00000834301, ENST00000834302, ENST00000834303, ENST00000834304, ENST00000834305, ENST00000834306, ENST00000834307, ENST00000834308, ENST00000834309, ENST00000834310, ENST00000834311, ENST00000834312, ENST00000834313, ENST00000834314, ENST00000834315, ENST00000834316, ENST00000834317, ENST00000834318, ENST00000834319, ENST00000834320, ENST00000834321, ENST00000834322, ENST00000834323, ENST00000834324, ENST00000834325, ENST00000834326, ENST00000834327, ENST00000834328, ENST00000834329, ENST00000834330, ENST00000834331, ENST00000834332, ENST00000834333, ENST00000834334, ENST00000834335, ENST00000834336, ENST00000834337, ENST00000834338, ENST00000834339

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000518201 — 2 exons

Exon	Start	End
ENSE00004251758	8238191	8238358
ENSE00004251810	8235474	8236363

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 83.43.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.43	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.70	silver quality
colonic epithelium	UBERON:0000397	71.86	gold quality
sural nerve	UBERON:0015488	66.44	silver quality
ventricular zone	UBERON:0003053	66.34	gold quality
cortical plate	UBERON:0005343	66.05	gold quality
urinary bladder	UBERON:0001255	64.75	gold quality
bone marrow cell	CL:0002092	63.84	silver quality
skeletal muscle tissue	UBERON:0001134	63.77	gold quality
ganglionic eminence	UBERON:0004023	63.70	gold quality
hindlimb stylopod muscle	UBERON:0004252	62.55	gold quality
cerebellum	UBERON:0002037	61.57	gold quality
cerebellar cortex	UBERON:0002129	61.51	gold quality
cerebellar hemisphere	UBERON:0002245	61.32	gold quality
primary visual cortex	UBERON:0002436	60.40	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.20	gold quality
lower esophagus mucosa	UBERON:0035834	59.51	gold quality
superior frontal gyrus	UBERON:0002661	59.02	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	58.89	gold quality
tonsil	UBERON:0002372	58.56	gold quality
pituitary gland	UBERON:0000007	58.54	gold quality
hypothalamus	UBERON:0001898	58.52	gold quality
brain	UBERON:0000955	58.44	gold quality
frontal cortex	UBERON:0001870	58.38	gold quality
prefrontal cortex	UBERON:0000451	58.35	gold quality
cerebral cortex	UBERON:0000956	58.24	gold quality
right frontal lobe	UBERON:0002810	58.21	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	58.18	gold quality
Brodmann (1909) area 9	UBERON:0013540	58.01	gold quality
anterior cingulate cortex	UBERON:0009835	57.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.84

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• lncRNA-HEIM Facilitated Liver Fibrosis by Up-Regulating TGF-beta Expression in Long-Term Outcome of Chronic Hepatitis B. (PMID:34168644)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.