FAM86B2-DT

Summary

FAM86B2-DT (FAM86B2 divergent transcript, HGNC:48726) is a long non-coding RNA gene on chromosome 8p23.1.

At a glance

• Clinical variants (ClinVar): 7 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48726
Approved symbol	FAM86B2-DT
Name	FAM86B2 divergent transcript
Location	8p23.1
Locus type	RNA, long non-coding
Status	Approved
Entrez	100506990
RNAcentral	URS000075BA24 — lncRNA, 3213 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

7 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000038870 (8:12490044 T>C), RS1000062350 (8:12486613 T>C), RS1000434949 (8:12483388 C>A,G,T), RS1000499483 (8:12441633 A>G), RS1000571658 (8:12443014 T>C), RS1001040304 (8:12506405 C>A,G,T), RS1001468083 (8:12515307 C>A,T), RS1001501116 (8:12453553 T>C), RS1001561632 (8:12455050 A>T), RS1002072544 (8:12534682 A>G), RS1002233412 (8:12478484 C>A,G), RS1002443057 (8:12529494 G>T), RS1002531970 (8:12467723 C>A,T), RS1002904428 (8:12551644 G>A,T), RS1003535468 (8:12480842 C>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.