FAM88C

Summary

FAM88C (family with sequence similarity 88 member C, HGNC:56159) is a long non-coding RNA gene on chromosome 9q13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56159
Approved symbol	FAM88C
Name	family with sequence similarity 88 member C
Location	9q13
Locus type	RNA, long non-coding
Status	Approved
Aliases	Lnc-PPRL
Ensembl gene	ENSG00000204802
Ensembl biotype	lncRNA
Entrez	102724238
RNAcentral	URS0000BC45C9 — lncRNA, 2275 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 28 lncRNA, 1 retained_intron

ENST00000377518, ENST00000412631, ENST00000429818, ENST00000430302, ENST00000438072, ENST00000448491, ENST00000717363, ENST00000717364, ENST00000717365, ENST00000717366, ENST00000717367, ENST00000717368, ENST00000717369, ENST00000717370, ENST00000717371, ENST00000717372, ENST00000717373, ENST00000717374, ENST00000717375, ENST00000717376, ENST00000717377, ENST00000717378, ENST00000717379, ENST00000755025, ENST00000755026, ENST00000755027, ENST00000755028, ENST00000755029, ENST00000755030

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000377518 — 2 exons

Exon	Start	End
ENSE00004103578	62373992	62376382
ENSE00004103583	62376498	62376890

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 85.73.

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	85.73	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.79	gold quality
colonic epithelium	UBERON:0000397	82.17	gold quality
ventricular zone	UBERON:0003053	82.09	gold quality
ganglionic eminence	UBERON:0004023	77.34	gold quality
bone marrow cell	CL:0002092	74.79	gold quality
lower esophagus mucosa	UBERON:0035834	72.58	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.74	gold quality
tonsil	UBERON:0002372	70.07	gold quality
cortical plate	UBERON:0005343	69.42	gold quality
esophagus mucosa	UBERON:0002469	69.38	gold quality
skin of leg	UBERON:0001511	68.17	gold quality
zone of skin	UBERON:0000014	67.88	gold quality
left adrenal gland cortex	UBERON:0035825	67.87	gold quality
right adrenal gland	UBERON:0001233	67.49	gold quality
left adrenal gland	UBERON:0001234	67.35	gold quality
bone marrow	UBERON:0002371	67.32	gold quality
skin of abdomen	UBERON:0001416	67.10	gold quality
right adrenal gland cortex	UBERON:0035827	67.05	gold quality
adrenal gland	UBERON:0002369	67.04	gold quality
adult mammalian kidney	UBERON:0000082	66.17	gold quality
kidney	UBERON:0002113	65.90	gold quality
duodenum	UBERON:0002114	65.79	gold quality
islet of Langerhans	UBERON:0000006	65.53	gold quality
adenohypophysis	UBERON:0002196	65.51	gold quality
tibial nerve	UBERON:0001323	65.47	gold quality
pancreas	UBERON:0001264	65.44	gold quality
body of pancreas	UBERON:0001150	65.03	gold quality
calcaneal tendon	UBERON:0003701	64.92	gold quality
muscle tissue	UBERON:0002385	64.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.05

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A novel lncRNA lnc-PPRL promotes pterygium development by activating PI3K/PDK1 signaling pathway. (PMID:35304111)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.