FAM90A11

Summary

FAM90A11 (family with sequence similarity 90 member A11, HGNC:32259) is a protein-coding gene on chromosome 8p23.1, encoding Protein FAM90A11 (A0A8V8TNH8).

At a glance

• MANE Select transcript: NM_001423539

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32259
Approved symbol	FAM90A11
Name	family with sequence similarity 90 member A11
Location	8p23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000233115
Ensembl biotype	protein_coding
Entrez	441331

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000518378

RefSeq mRNA: 1 — MANE Select: NM_001423539 NM_001423539

Canonical transcript exons

ENST00000518378 — 4 exons

Exon	Start	End
ENSE00002094175	8015230	8015352
ENSE00002100548	8012342	8013304
ENSE00002192415	8014536	8014735
ENSE00002197681	8013969	8014077

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 78.34.

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.34	gold quality
stromal cell of endometrium	CL:0002255	54.14	gold quality
superior frontal gyrus	UBERON:0002661	52.05	gold quality
mucosa of stomach	UBERON:0001199	49.89	gold quality
primary visual cortex	UBERON:0002436	49.81	gold quality
right uterine tube	UBERON:0001302	49.66	gold quality
cortical plate	UBERON:0005343	49.10	gold quality
ventricular zone	UBERON:0003053	48.82	gold quality
right coronary artery	UBERON:0001625	47.32	gold quality
left ovary	UBERON:0002119	46.10	gold quality
right hemisphere of cerebellum	UBERON:0014890	45.64	silver quality
ovary	UBERON:0000992	45.39	gold quality
cerebellar cortex	UBERON:0002129	45.05	silver quality
cerebellum	UBERON:0002037	44.98	silver quality
right frontal lobe	UBERON:0002810	44.96	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	44.88	gold quality
cerebellar hemisphere	UBERON:0002245	44.77	silver quality
substantia nigra	UBERON:0002038	44.34	gold quality
descending thoracic aorta	UBERON:0002345	44.30	silver quality
body of uterus	UBERON:0009853	44.21	gold quality
myometrium	UBERON:0001296	43.99	silver quality
Ammon’s horn	UBERON:0001954	43.64	gold quality
right ovary	UBERON:0002118	43.31	silver quality
Brodmann (1909) area 9	UBERON:0013540	43.12	gold quality
skeletal muscle tissue	UBERON:0001134	43.11	silver quality
frontal cortex	UBERON:0001870	43.03	gold quality
cortex of kidney	UBERON:0001225	43.00	silver quality
hindlimb stylopod muscle	UBERON:0004252	42.71	gold quality
cerebral cortex	UBERON:0000956	42.62	gold quality
pituitary gland	UBERON:0000007	42.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.24

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Fam90a1b	ENSMUSG00000043549
mus_musculus	Fam90a1a	ENSMUSG00000079112
rattus_norvegicus	Fam90a1l1	ENSRNOG00000064072

Paralogs (21): FAM90A1 (ENSG00000171847), FAM90A27P (ENSG00000189348), FAM90A24 (ENSG00000215354), FAM90A5 (ENSG00000215373), FAM90A13 (ENSG00000223885), FAM90A26 (ENSG00000229924), FAM90A15 (ENSG00000230045), FAM90A3 (ENSG00000233132), FAM90A20 (ENSG00000233295), FAM90A12 (ENSG00000254229), FAM90A9 (ENSG00000285607), FAM90A16 (ENSG00000285620), FAM90A19 (ENSG00000285657), FAM90A22 (ENSG00000285687), FAM90A17 (ENSG00000285720), FAM90A23 (ENSG00000285765), FAM90A14 (ENSG00000285814), FAM90A18 (ENSG00000285913), FAM90A8 (ENSG00000285937), FAM90A10 (ENSG00000285950), FAM90A7 (ENSG00000285975)

Protein

Protein identifiers

Protein FAM90A11 — A0A8V8TNH8 (reviewed: A0A8V8TNH8)

All UniProt accessions (1): A0A8V8TNH8

UniProt curated annotations — full annotation on UniProt →

Miscellaneous. Primate-specific FAM90A gene family, thought to have arisen during multiple duplication and rearrangement events.

Similarity. Belongs to the FAM90 family.

RefSeq proteins (1): NP_001410468* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR039213	FAM90	Family
IPR041670	Znf-CCHC_6	Domain

Pfam: PF15288

UniProt features (8 total): compositionally biased region 4, region of interest 3, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A8V8TNH8-F1	50.82	0.05

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr8p23

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LP49, A0A8V8TNH8, A0A8V8TPE2, A2VE02, A5D7I0, A6NDY2, A6NGG8, A6NIJ5, A6NNJ1, A8MXJ8, A8MYA2, B1ASB6, B2RW88, D6RGX4, O60269, P0C7V4, P0C7W8, P0C7W9, P0C7X0, P0DV75, P0DV76, Q2KIS6, Q2NL68, Q3SY00, Q4R736, Q4V8B5, Q5RCQ2, Q5SZB4, Q5VZ46, Q5XIK6, Q658T7, Q66JV7, Q6NS69, Q6PAC4, Q6ZMY3, Q76N32, Q7TSA6, Q7Z591, Q80VW7, Q80X53

Diamond homologs: A0A8V8TNH8, A0A8V8TPE2, A6NDY2, A6NIJ5, A6NJQ4, A6NKC0, A6NNH2, A6NNJ1, A8MWA6, A8MX19, A8MXJ8, A8MXZ1, D6RGX4, P0C7V4, P0C7W8, P0C7W9, P0C7X0, P0DV73, P0DV74, P0DV75, P0DV76, Q658T7, Q86YD7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.