FAM90A15

Summary

FAM90A15 (family with sequence similarity 90 member A15, HGNC:32263) is a protein-coding gene on chromosome 8p23.1, encoding Protein FAM90A15 (P0C7V4).

FAM90A15 belongs to subfamily II of the primate-specific FAM90A gene family, which originated from multiple duplications and rearrangements (Bosch et al., 2007 [PubMed 17684299]). For background information on the FAM90A gene family, as well as information on the evolution of FAM90A genes, see FAM90A1 (MIM 613041).

Source: NCBI Gene 389630 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001423538

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32263
Approved symbol	FAM90A15
Name	family with sequence similarity 90 member A15
Location	8p23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000230045
Ensembl biotype	protein_coding
OMIM	613051
Entrez	389630

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000514465

RefSeq mRNA: 1 — MANE Select: NM_001423538 NM_001423538

Canonical transcript exons

ENST00000514465 — 4 exons

Exon	Start	End
ENSE00002062527	7258179	7258287
ENSE00003460982	7256904	7257026
ENSE00003519386	7258952	7259914
ENSE00003639856	7257521	7257720

Expression profiles

Bgee: expression breadth broad, 43 present calls, max score 48.62.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	48.62	silver quality
descending thoracic aorta	UBERON:0002345	42.07	silver quality
ganglionic eminence	UBERON:0004023	38.04	gold quality
monocyte	CL:0000576	37.63	gold quality
sural nerve	UBERON:0015488	37.54	gold quality
skeletal muscle tissue	UBERON:0001134	37.49	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
leukocyte	CL:0000738	36.73	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
muscle tissue	UBERON:0002385	36.23	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.34	gold quality
endocervix	UBERON:0000458	34.88	gold quality
myometrium	UBERON:0001296	34.29	gold quality
left ovary	UBERON:0002119	34.09	gold quality
urinary bladder	UBERON:0001255	33.94	gold quality
mucosa of transverse colon	UBERON:0004991	33.59	gold quality
body of uterus	UBERON:0009853	33.49	gold quality
ovary	UBERON:0000992	32.93	silver quality
bone marrow	UBERON:0002371	32.79	gold quality
Brodmann (1909) area 9	UBERON:0013540	32.76	silver quality
left uterine tube	UBERON:0001303	32.52	gold quality
smooth muscle tissue	UBERON:0001135	32.42	gold quality
duodenum	UBERON:0002114	32.33	gold quality
prefrontal cortex	UBERON:0000451	32.30	gold quality
calcaneal tendon	UBERON:0003701	31.83	gold quality
islet of Langerhans	UBERON:0000006	31.82	gold quality
prostate gland	UBERON:0002367	31.70	gold quality
mucosa of stomach	UBERON:0001199	31.47	gold quality
lower esophagus	UBERON:0013473	31.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Fam90a1b	ENSMUSG00000043549
mus_musculus	Fam90a1a	ENSMUSG00000079112
rattus_norvegicus	Fam90a1l1	ENSRNOG00000064072

Paralogs (21): FAM90A1 (ENSG00000171847), FAM90A27P (ENSG00000189348), FAM90A24 (ENSG00000215354), FAM90A5 (ENSG00000215373), FAM90A13 (ENSG00000223885), FAM90A26 (ENSG00000229924), FAM90A11 (ENSG00000233115), FAM90A3 (ENSG00000233132), FAM90A20 (ENSG00000233295), FAM90A12 (ENSG00000254229), FAM90A9 (ENSG00000285607), FAM90A16 (ENSG00000285620), FAM90A19 (ENSG00000285657), FAM90A22 (ENSG00000285687), FAM90A17 (ENSG00000285720), FAM90A23 (ENSG00000285765), FAM90A14 (ENSG00000285814), FAM90A18 (ENSG00000285913), FAM90A8 (ENSG00000285937), FAM90A10 (ENSG00000285950), FAM90A7 (ENSG00000285975)

Protein

Protein identifiers

Protein FAM90A15 — P0C7V4 (reviewed: P0C7V4)

All UniProt accessions (1): P0C7V4

UniProt curated annotations — full annotation on UniProt →

Miscellaneous. Primate-specific FAM90A gene family, thought to have arisen during multiple duplication and rearrangement events.

Similarity. Belongs to the FAM90 family.

RefSeq proteins (1): NP_001410467* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR039213	FAM90	Family
IPR041670	Znf-CCHC_6	Domain

Pfam: PF15288

UniProt features (7 total): region of interest 3, compositionally biased region 3, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0C7V4-F1	50.37	0.04

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr8p23

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LP49, A0A8V8TNH8, A0A8V8TPE2, A2VE02, A5D7I0, A6NDY2, A6NGG8, A6NIJ5, A6NNJ1, A8MXJ8, A8MYA2, B1ASB6, B2RW88, D6RGX4, O60269, P0C7V4, P0C7W8, P0C7W9, P0C7X0, P0DV75, P0DV76, Q2KIS6, Q2NL68, Q3SY00, Q4R736, Q4V8B5, Q5RCQ2, Q5SZB4, Q5VZ46, Q5XIK6, Q658T7, Q66JV7, Q6NS69, Q6PAC4, Q6ZMY3, Q76N32, Q7TSA6, Q7Z591, Q80VW7, Q80X53

Diamond homologs: A0A8V8TNH8, A0A8V8TPE2, A6NDY2, A6NIJ5, A6NJQ4, A6NKC0, A6NNH2, A6NNJ1, A8MWA6, A8MX19, A8MXJ8, A8MXZ1, D6RGX4, P0C7V4, P0C7W8, P0C7W9, P0C7X0, P0DV73, P0DV74, P0DV75, P0DV76, Q658T7, Q86YD7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

Disease associations

OMIM: gene MIM:613051 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.