FAM90A24

Summary

FAM90A24 (family with sequence similarity 90 member A24, HGNC:32272) is a protein-coding gene on chromosome 8p23.1, encoding Protein FAM90A24 (P0C7X0).

At a glance

• Clinical variants (ClinVar): 2 total
• MANE Select transcript: NM_001423530

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32272
Approved symbol	FAM90A24
Name	family with sequence similarity 90 member A24
Location	8p23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000215354
Ensembl biotype	protein_coding
Entrez	441332

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 retained_intron

ENST00000520792, ENST00000521100

RefSeq mRNA: 1 — MANE Select: NM_001423530 NM_001423530

Canonical transcript exons

ENST00000520792 — 4 exons

Exon	Start	End
ENSE00002114375	8022876	8022998
ENSE00002186785	8019988	8020950
ENSE00003517382	8021615	8021723
ENSE00003689943	8022182	8022381

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 79.62.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.62	gold quality
right uterine tube	UBERON:0001302	64.05	gold quality
right coronary artery	UBERON:0001625	61.25	gold quality
right ovary	UBERON:0002118	56.90	gold quality
left ovary	UBERON:0002119	56.06	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	55.37	gold quality
body of uterus	UBERON:0009853	54.99	gold quality
endocervix	UBERON:0000458	54.91	gold quality
ovary	UBERON:0000992	54.81	gold quality
right hemisphere of cerebellum	UBERON:0014890	54.69	gold quality
right frontal lobe	UBERON:0002810	54.06	gold quality
mucosa of stomach	UBERON:0001199	54.00	gold quality
ectocervix	UBERON:0012249	53.88	gold quality
left coronary artery	UBERON:0001626	53.81	gold quality
pituitary gland	UBERON:0000007	53.76	gold quality
prostate gland	UBERON:0002367	53.48	gold quality
cerebellar hemisphere	UBERON:0002245	53.26	gold quality
cerebellar cortex	UBERON:0002129	53.25	gold quality
cerebellum	UBERON:0002037	53.11	gold quality
uterine cervix	UBERON:0000002	52.93	gold quality
monocyte	CL:0000576	52.83	gold quality
smooth muscle tissue	UBERON:0001135	52.46	gold quality
substantia nigra	UBERON:0002038	52.40	gold quality
ascending aorta	UBERON:0001496	52.35	gold quality
ventricular zone	UBERON:0003053	52.08	gold quality
thoracic aorta	UBERON:0001515	51.72	gold quality
Brodmann (1909) area 9	UBERON:0013540	51.66	gold quality
right adrenal gland	UBERON:0001233	51.55	gold quality
right adrenal gland cortex	UBERON:0035827	51.54	gold quality
leukocyte	CL:0000738	51.50	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-36552	yes	354.18
E-GEOD-99795	no	3.12
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Fam90a1b	ENSMUSG00000043549
mus_musculus	Fam90a1a	ENSMUSG00000079112
rattus_norvegicus	Fam90a1l1	ENSRNOG00000064072

Paralogs (21): FAM90A1 (ENSG00000171847), FAM90A27P (ENSG00000189348), FAM90A5 (ENSG00000215373), FAM90A13 (ENSG00000223885), FAM90A26 (ENSG00000229924), FAM90A15 (ENSG00000230045), FAM90A11 (ENSG00000233115), FAM90A3 (ENSG00000233132), FAM90A20 (ENSG00000233295), FAM90A12 (ENSG00000254229), FAM90A9 (ENSG00000285607), FAM90A16 (ENSG00000285620), FAM90A19 (ENSG00000285657), FAM90A22 (ENSG00000285687), FAM90A17 (ENSG00000285720), FAM90A23 (ENSG00000285765), FAM90A14 (ENSG00000285814), FAM90A18 (ENSG00000285913), FAM90A8 (ENSG00000285937), FAM90A10 (ENSG00000285950), FAM90A7 (ENSG00000285975)

Protein

Protein identifiers

Protein FAM90A24 — P0C7X0 (reviewed: P0C7X0)

All UniProt accessions (1): P0C7X0

UniProt curated annotations — full annotation on UniProt →

Miscellaneous. Primate-specific FAM90A gene family, thought to have arisen during multiple duplication and rearrangement events.

Similarity. Belongs to the FAM90 family.

RefSeq proteins (1): NP_001410459* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR039213	FAM90	Family
IPR041670	Znf-CCHC_6	Domain

Pfam: PF15288

UniProt features (7 total): region of interest 3, compositionally biased region 3, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0C7X0-F1	49.79	0.04

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr8p23

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LP49, A0A8V8TNH8, A0A8V8TPE2, A2VE02, A5D7I0, A6NDY2, A6NGG8, A6NIJ5, A6NNJ1, A8MXJ8, A8MYA2, B1ASB6, B2RW88, D6RGX4, O60269, P0C7V4, P0C7W8, P0C7W9, P0C7X0, P0DV75, P0DV76, Q2KIS6, Q2NL68, Q3SY00, Q4R736, Q4V8B5, Q5RCQ2, Q5SZB4, Q5VZ46, Q5XIK6, Q658T7, Q66JV7, Q6NS69, Q6PAC4, Q6ZMY3, Q76N32, Q7TSA6, Q7Z591, Q80VW7, Q80X53

Diamond homologs: A0A8V8TNH8, A0A8V8TPE2, A6NDY2, A6NIJ5, A6NJQ4, A6NKC0, A6NNH2, A6NNJ1, A8MWA6, A8MX19, A8MXJ8, A8MXZ1, D6RGX4, P0C7V4, P0C7W8, P0C7W9, P0C7X0, P0DV73, P0DV74, P0DV75, P0DV76, Q658T7, Q86YD7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Copper	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.