FAM98A

Summary

FAM98A (family with sequence similarity 98 member A, HGNC:24520) is a protein-coding gene on chromosome 2p22.3, encoding Protein FAM98A (Q8NCA5). Positively stimulates PRMT1-induced protein arginine methylation.

Enables protein methyltransferase activity. Involved in positive regulation of cell population proliferation; positive regulation of gene expression; and protein methylation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of tRNA-splicing ligase complex.

Source: NCBI Gene 25940 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 87 total
• MANE Select transcript: NM_015475

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24520
Approved symbol	FAM98A
Name	family with sequence similarity 98 member A
Location	2p22.3
Locus type	gene with protein product
Status	Approved
Aliases	DKFZP564F0522
Ensembl gene	ENSG00000119812
Ensembl biotype	protein_coding
OMIM	620904
Entrez	25940

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 8 retained_intron, 5 nonsense_mediated_decay, 4 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000238823, ENST00000403368, ENST00000437680, ENST00000464415, ENST00000474985, ENST00000475122, ENST00000492649, ENST00000685835, ENST00000687030, ENST00000689312, ENST00000689698, ENST00000689713, ENST00000690423, ENST00000690429, ENST00000692348, ENST00000692917, ENST00000693631, ENST00000693737

RefSeq mRNA: 2 — MANE Select: NM_015475 NM_001304538, NM_015475

CCDS: CCDS33179, CCDS92735

Canonical transcript exons

ENST00000238823 — 8 exons

Exon	Start	End
ENSE00001698792	33588335	33588519
ENSE00001899085	33599169	33599299
ENSE00001928155	33583660	33585444
ENSE00003463957	33585530	33585697
ENSE00003547734	33595489	33595637
ENSE00003590748	33586562	33586678
ENSE00003608806	33587240	33587320
ENSE00003669055	33592080	33592214

Expression profiles

Bgee: expression breadth ubiquitous, 297 present calls, max score 97.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 29.7496 / max 797.7526, expressed in 1802 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
27719	26.7603	1799
27718	2.7308	1373
27720	0.2585	103

Top tissues by expression

298 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibia	UBERON:0000979	97.25	gold quality
male germ cell	CL:0000015	96.02	gold quality
sperm	CL:0000019	95.83	gold quality
esophagus squamous epithelium	UBERON:0006920	95.81	gold quality
smooth muscle tissue	UBERON:0001135	95.39	gold quality
pons	UBERON:0000988	95.35	gold quality
inferior vagus X ganglion	UBERON:0005363	95.33	gold quality
heart right ventricle	UBERON:0002080	95.07	gold quality
biceps brachii	UBERON:0001507	95.00	gold quality
epithelium of esophagus	UBERON:0001976	94.96	gold quality
endothelial cell	CL:0000115	94.92	silver quality
choroid plexus epithelium	UBERON:0003911	94.92	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	94.90	gold quality
lateral nuclear group of thalamus	UBERON:0002736	94.74	gold quality
Brodmann (1909) area 46	UBERON:0006483	94.69	gold quality
stromal cell of endometrium	CL:0002255	94.66	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	94.52	gold quality
dorsal plus ventral thalamus	UBERON:0001897	94.31	gold quality
dorsal root ganglion	UBERON:0000044	94.29	gold quality
subthalamic nucleus	UBERON:0001906	94.24	gold quality
substantia nigra pars compacta	UBERON:0001965	94.17	gold quality
body of tongue	UBERON:0011876	94.15	gold quality
substantia nigra pars reticulata	UBERON:0001966	94.12	gold quality
gingival epithelium	UBERON:0001949	93.98	gold quality
superior vestibular nucleus	UBERON:0007227	93.98	gold quality
decidua	UBERON:0002450	93.87	gold quality
gingiva	UBERON:0001828	93.77	gold quality
CA1 field of hippocampus	UBERON:0003881	93.75	gold quality
orbitofrontal cortex	UBERON:0004167	93.75	gold quality
islet of Langerhans	UBERON:0000006	93.67	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.14
E-MTAB-6379	no	51.75

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

115 targeting FAM98A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-380-3P	99.89	70.18	1978
HSA-MIR-3140-3P	99.88	68.47	2069
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917

Literature-anchored findings (GeneRIF, showing 4)

• FAM98A is expressed in numerous ovarian cancer cell lines and is important for the malignant characteristics of ovarian cancer cells. (PMID:26503212)
• the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 and C14orf166 are required for PRMT1 expression in colorectal cancer cell lines (PMID:28040436)
• Mechanistically, it was demonstrated that miR-142-3p directly targeted FAM98A, and modulated its expression. (PMID:31114934)
• Circular RNA intraflagellar transport 80 facilitates endometrial cancer progression through modulating miR-545-3p/FAM98A signaling. (PMID:34783205)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	fam98a	ENSDARG00000078391
mus_musculus	Fam98a	ENSMUSG00000002017
rattus_norvegicus	Fam98a	ENSRNOG00000030328
drosophila_melanogaster	CG5913	FBGN0039385
caenorhabditis_elegans		WBGENE00044326

Paralogs (2): FAM98C (ENSG00000130244), FAM98B (ENSG00000171262)

Protein

Protein identifiers

Protein FAM98A — Q8NCA5 (reviewed: Q8NCA5)

All UniProt accessions (9): A0A8I5KR56, A0A8I5KX90, A0A8I5KXK5, A0A8I5KZA5, Q8NCA5, A0A8I5QKV4, A0A8I5QKV5, B4DT23, E9PH82

UniProt curated annotations — full annotation on UniProt →

Function. Positively stimulates PRMT1-induced protein arginine methylation. Involved in skeletal homeostasis. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts.

Subunit / interactions. Interacts (via N- and C-terminus) with DDX1. Interacts (via N- and C-terminus) with C14orf166. Interacts with FAM98B. Interacts with PLEKHM1 (via N- and C-terminus).

Tissue specificity. Expressed strongly in colorectal cancer cells. Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples.

Similarity. Belongs to the FAM98 family.

RefSeq proteins (2): NP_001291467, NP_056290* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR018797	FAM98	Family

Pfam: PF10239

UniProt features (13 total): compositionally biased region 8, region of interest 2, sequence conflict 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NCA5-F1	68.95	0.41

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 213 (showing top): MYOGENIN_Q6, TGCGCANK_UNKNOWN, BASSO_B_LYMPHOCYTE_NETWORK, GOBP_TRNA_METABOLIC_PROCESS, GOBP_REGULATION_OF_RUFFLE_ASSEMBLY, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, CAGCTG_AP4_Q5, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN, MYOD_01, GOBP_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION, GOBP_RNA_SPLICING, OCT1_07

GO Biological Process (6): tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388), protein methylation (GO:0006479), positive regulation of cell population proliferation (GO:0008284), positive regulation of gene expression (GO:0010628), lysosome localization (GO:0032418), positive regulation of ruffle assembly (GO:1900029)

GO Molecular Function (3): RNA binding (GO:0003723), protein methyltransferase activity (GO:0008276), protein binding (GO:0005515)

GO Cellular Component (3): nucleus (GO:0005634), cytoplasm (GO:0005737), tRNA-splicing ligase complex (GO:0072669)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA splicing, via endonucleolytic cleavage and ligation	1
tRNA processing	1
protein alkylation	1
macromolecule methylation	1
cell population proliferation	1
regulation of cell population proliferation	1
positive regulation of cellular process	1
gene expression	1
regulation of gene expression	1
positive regulation of macromolecule biosynthetic process	1
vacuolar localization	1
ruffle assembly	1
positive regulation of plasma membrane bounded cell projection assembly	1
regulation of ruffle assembly	1
nucleic acid binding	1
methyltransferase activity	1
catalytic activity, acting on a protein	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1
intracellular protein-containing complex	1
catalytic complex	1

Protein interactions and networks

STRING

1052 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FAM98A	DDX1	Q92499	893
FAM98A	RTCB	Q9Y3I0	729
FAM98A	RTRAF	Q9Y224	727
FAM98A	ATXN2	Q99700	691
FAM98A	HNRNPUL2	Q1KMD3	666
FAM98A	DHX36	Q9H2U1	657
FAM98A	NUFIP2	Q7Z417	647
FAM98A	DHX15	O43143	640
FAM98A	ELAVL1	Q15717	621
FAM98A	C2orf49	Q9BVC5	620
FAM98A	PRPF3	O43395	612
FAM98A	NDEL1	Q9GZM8	592
FAM98A	ATXN2L	Q8WWM7	580
FAM98A	ELAVL4	P26378	569
FAM98A	ELAVL3	Q14576	569

IntAct

122 interactions, top by confidence:

A	B	Type	Score
GDI1	RAB4A	psi-mi:“MI:0914”(association)	0.820
FAM98A	RTRAF	psi-mi:“MI:0915”(physical association)	0.810
RTRAF	FAM98A	psi-mi:“MI:0915”(physical association)	0.810
FAM98A	DDX1	psi-mi:“MI:0915”(physical association)	0.780
DDX1	FAM98A	psi-mi:“MI:0915”(physical association)	0.780
NS	PIK3R2	psi-mi:“MI:0914”(association)	0.750
FAM98A	HERC2	psi-mi:“MI:0914”(association)	0.640
FAM98A	NUFIP2	psi-mi:“MI:0914”(association)	0.640
YWHAG	BLTP3B	psi-mi:“MI:0914”(association)	0.640
YWHAH	BLTP3B	psi-mi:“MI:0914”(association)	0.570
tat	PPM1G	psi-mi:“MI:0914”(association)	0.560
RACGAP1	CHEK1	psi-mi:“MI:0914”(association)	0.530
N	RRP9	psi-mi:“MI:0914”(association)	0.530
N	NOP56	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
FUS	DDX3X	psi-mi:“MI:0914”(association)	0.430
FAM98A	FAM98B	psi-mi:“MI:0915”(physical association)	0.400
FAM98A	FAM98A	psi-mi:“MI:0915”(physical association)	0.400
	TK2	psi-mi:“MI:0915”(physical association)	0.400
SDC1	ILVBL	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (312): FAM98A (Affinity Capture-MS), C14orf166 (Two-hybrid), FAM98A (Affinity Capture-RNA), FAM98A (Affinity Capture-MS), FAM98A (Affinity Capture-MS), FAM98A (Affinity Capture-MS), FAM98A (Affinity Capture-MS), C14orf166 (Co-fractionation), FAM98A (Co-fractionation), FAM98A (Co-fractionation), PFKM (Co-fractionation), FAM98A (Affinity Capture-MS), FAM98A (Affinity Capture-MS), FAM98A (Affinity Capture-MS), FAM98A (Affinity Capture-MS)

ESM2 similar proteins: A4IFB1, A6H7H1, A9ULY7, B1H1X4, B5DDX6, B5DF93, B5X165, D3Z8X7, O60308, P70501, Q05AW9, Q28HX4, Q3TC46, Q3TJZ6, Q52LJ0, Q5EA95, Q5FWT1, Q5R4R4, Q5R539, Q5R679, Q5R8Q4, Q5RHQ8, Q60520, Q62418, Q66I22, Q6A0A9, Q6DEZ2, Q6IVW0, Q80V31, Q80VD1, Q86TB9, Q8BH43, Q8BXG3, Q8CBY3, Q8CDG3, Q8CF97, Q8K2L8, Q8NCA5, Q8ND56, Q8R3P2

Diamond homologs: Q17RN3, Q3TJZ6, Q52LJ0, Q5FWT1, Q5R679, Q80VD1, Q8NCA5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 122 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SARS-CoV-1-host interactions	7	14.8×	2e-04
Nonsense-Mediated Decay (NMD)	5	14.0×	3e-03
Formation of the ternary complex, and subsequently, the 43S complex	5	13.0×	3e-03
Translation initiation complex formation	5	11.5×	3e-03
Ribosomal scanning and start codon recognition	5	11.5×	3e-03
SARS-CoV-1 Infection	6	10.3×	3e-03
rRNA processing in the nucleus and cytosol	5	9.7×	5e-03
Signaling by ALK fusions and activated point mutants	5	9.1×	5e-03

GO biological processes:

GO term	Partners	Fold	FDR
intrinsic apoptotic signaling pathway	5	17.4×	1e-03
negative regulation of translation	7	13.3×	4e-04
ribosomal small subunit biogenesis	6	13.3×	1e-03
cytoplasmic translation	7	12.6×	4e-04
positive regulation of translation	5	11.1×	6e-03
rRNA processing	6	8.2×	6e-03
translation	7	7.0×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

87 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	81
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2270 predictions. Top by Δscore:

Variant	Effect	Δscore
2:33543508:GCA:G	acceptor_loss	1.0000
2:33543509:CAGT:C	acceptor_loss	1.0000
2:33543510:A:AG	acceptor_gain	1.0000
2:33543510:AGTC:A	acceptor_loss	1.0000
2:33543510:AGTCT:A	acceptor_gain	1.0000
2:33543511:G:GG	acceptor_gain	1.0000
2:33543511:GT:G	acceptor_gain	1.0000
2:33543511:GTCT:G	acceptor_gain	1.0000
2:33543511:GTCTG:G	acceptor_gain	1.0000
2:33543623:GATCA:G	donor_gain	1.0000
2:33543624:A:G	donor_gain	1.0000
2:33543624:ATCA:A	donor_gain	1.0000
2:33543625:TCA:T	donor_gain	1.0000
2:33543628:G:GG	donor_gain	1.0000
2:33549747:GATTT:G	donor_gain	1.0000
2:33549748:ATTT:A	donor_gain	1.0000
2:33549752:G:GG	donor_gain	1.0000
2:33585693:TGGCT:T	acceptor_gain	1.0000
2:33585694:GGCT:G	acceptor_gain	1.0000
2:33585696:CT:C	acceptor_gain	1.0000
2:33585698:C:CC	acceptor_gain	1.0000
2:33585701:T:TC	acceptor_gain	1.0000
2:33586557:TGTA:T	donor_loss	1.0000
2:33586558:GTACC:G	donor_loss	1.0000
2:33586559:TAC:T	donor_loss	1.0000
2:33586561:C:A	donor_loss	1.0000
2:33586566:G:C	donor_gain	1.0000
2:33586677:TC:T	acceptor_gain	1.0000
2:33586678:CC:C	acceptor_gain	1.0000
2:33586679:C:CC	acceptor_gain	1.0000

AlphaMissense

3328 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:33585367:C:A	W322C	1.000
2:33585367:C:G	W322C	1.000
2:33585369:A:G	W322R	1.000
2:33585369:A:T	W322R	1.000
2:33585377:A:C	M319R	1.000
2:33585377:A:G	M319T	1.000
2:33585409:T:A	R308S	1.000
2:33585409:T:G	R308S	1.000
2:33585410:C:G	R308T	1.000
2:33585414:C:G	G307R	1.000
2:33585416:C:A	G306V	1.000
2:33585416:C:T	G306D	1.000
2:33585417:C:A	G306C	1.000
2:33585417:C:G	G306R	1.000
2:33585418:T:A	R305S	1.000
2:33585418:T:G	R305S	1.000
2:33585419:C:A	R305I	1.000
2:33585419:C:G	R305T	1.000
2:33585422:T:A	D304V	1.000
2:33585422:T:C	D304G	1.000
2:33585422:T:G	D304A	1.000
2:33585423:C:G	D304H	1.000
2:33585437:A:G	M299T	1.000
2:33586577:C:A	W235C	1.000
2:33586577:C:G	W235C	1.000
2:33586579:A:G	W235R	1.000
2:33586579:A:T	W235R	1.000
2:33586588:A:G	S232P	1.000
2:33586617:A:G	L222P	1.000
2:33585358:C:A	R325S	0.999

dbSNP variants (sampled 300 via entrez): RS1000251531 (2:33599649 C>T), RS1000498688 (2:33590242 A>C,G), RS1000700693 (2:33596150 CT>C,CTT), RS1000827508 (2:33597640 C>T), RS1001155098 (2:33597320 C>T), RS1001224851 (2:33587455 A>G), RS1001254744 (2:33594221 T>C), RS1001287152 (2:33594479 C>A,T), RS1001313528 (2:33593581 C>T), RS1001491796 (2:33599707 C>G), RS1001525949 (2:33598784 A>G), RS1001817969 (2:33599565 G>C), RS1002225387 (2:33588668 C>A,T), RS1002274978 (2:33592970 C>A,T), RS1002292909 (2:33593143 C>G,T)

Disease associations

OMIM: gene MIM:620904 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST000390_1	Hypertension (young onset)	3.000000e-10
GCST003461_2	IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7)	8.000000e-06
GCST003803_1	Response to antidepressants in depression	2.000000e-07
GCST003812_5	Non-response to antidepressants and depression	2.000000e-06
GCST003876_3	Gut microbiota (beta diversity)	5.000000e-08
GCST004068_49	Venous thromboembolism adjusted for sickle cell variant rs77121243-T	9.000000e-07
GCST006304_3	Irritable bowel syndrome	2.000000e-06
GCST008765_2	Perceived intensity of aspartame	4.000000e-06
GCST009391_1298	Metabolite levels	5.000000e-06

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007812	Plasmodium falciparum antigen IgG measurement
EFO:0007874	gut microbiome measurement
EFO:0010549	xanthosine measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

57 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	7
bisphenol A	decreases expression	2
sodium arsenite	increases activity, affects cotreatment, increases abundance, increases expression, decreases expression	2
FR900359	decreases phosphorylation	1
tremortin	increases expression	1
2,4,6-tribromophenol	decreases expression	1
triphenyl phosphate	affects expression	1
sodium arsenate	decreases expression	1
trichostatin A	increases expression	1
beta-lapachone	increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
isobutyl alcohol	increases abundance, increases expression, affects cotreatment	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
pentabromodiphenyl ether	increases expression	1
chloropicrin	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
nutlin 3	affects cotreatment, increases secretion	1
ICG 001	decreases expression	1
bisphenol B	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	decreases expression, increases response to substance	1
bisphenol AF	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Arsenic	increases abundance, increases expression, affects cotreatment	1
Benzene	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1RW	Abcam HeLa FAM98A KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.