FAM99A

Summary

FAM99A (family with sequence similarity 99 member A, HGNC:32368) is a long non-coding RNA gene on chromosome 11p15.5.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32368
Approved symbol	FAM99A
Name	family with sequence similarity 99 member A
Location	11p15.5
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ42833
Ensembl gene	ENSG00000205866
Ensembl biotype	lncRNA
Entrez	387742
RNAcentral	URS000075DAD5 — lncRNA, 1430 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000382167, ENST00000538190, ENST00000660644, ENST00000825151, ENST00000825152, ENST00000825153, ENST00000825154

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000382167 — 3 exons

Exon	Start	End
ENSE00001491091	1666702	1667856
ENSE00001491093	1665597	1665764
ENSE00001641141	1666435	1666543

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 98.53.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0390 / max 31.4757, expressed in 7 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
112473	0.0390	7

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	98.53	gold quality
liver	UBERON:0002107	96.92	gold quality
placenta	UBERON:0001987	72.57	gold quality
left testis	UBERON:0004533	64.65	gold quality
right testis	UBERON:0004534	64.02	gold quality
testis	UBERON:0000473	63.42	gold quality
spleen	UBERON:0002106	58.24	gold quality
blood	UBERON:0000178	57.60	gold quality
multicellular organism	UBERON:0000468	54.45	gold quality
pancreas	UBERON:0001264	53.51	gold quality
left adrenal gland cortex	UBERON:0035825	53.23	gold quality
body of pancreas	UBERON:0001150	53.18	gold quality
kidney	UBERON:0002113	52.46	gold quality
duodenum	UBERON:0002114	50.75	gold quality
vagina	UBERON:0000996	50.43	gold quality
left adrenal gland	UBERON:0001234	50.38	gold quality
adult mammalian kidney	UBERON:0000082	49.48	gold quality
adrenal gland	UBERON:0002369	49.41	gold quality
Ammon’s horn	UBERON:0001954	48.79	gold quality
monocyte	CL:0000576	48.36	silver quality
cortex of kidney	UBERON:0001225	47.36	gold quality
upper lobe of left lung	UBERON:0008952	46.75	gold quality
gastrocnemius	UBERON:0001388	46.69	gold quality
urinary bladder	UBERON:0001255	46.31	gold quality
heart left ventricle	UBERON:0002084	45.65	gold quality
heart	UBERON:0000948	45.62	gold quality
hypothalamus	UBERON:0001898	45.45	gold quality
right atrium auricular region	UBERON:0006631	45.38	gold quality
metanephros cortex	UBERON:0010533	45.19	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	45.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis. (PMID:31173227)
• Long non-coding RNA FAM99A modulated YAP1 to affect trophoblast cell behaviors in preeclampsia by sponging miR-134-5p. (PMID:33111745)
• Expression of serum long noncoding RNA FAM99A in patients with hypertensive disorder complicating and its clinical significance. (PMID:35258024)
• Liver-specific lncRNA FAM99A may be a tumor suppressor and promising prognostic biomarker in hepatocellular carcinoma. (PMID:36289466)
• In silico analysis of the association between long non-coding RNA family with sequence similarity 99 member A (FAM99A) and hepatic cancer. (PMID:36854891)
• The comprehensive roles of lncRNA FAM99A/FAM99B in hepatocellular carcinoma: Expressions, regulatory mechanisms and functional pathway analysis. (PMID:38740325)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.