FAM99B

Summary

FAM99B (family with sequence similarity 99 member B, HGNC:32369) is a long non-coding RNA gene on chromosome 11p15.5.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32369
Approved symbol	FAM99B
Name	family with sequence similarity 99 member B
Location	11p15.5
Locus type	RNA, long non-coding
Status	Approved
Aliases	DKFZp781M09150
Ensembl gene	ENSG00000205865
Ensembl biotype	lncRNA
Entrez	100132464
RNAcentral	URS000075C1A3 — lncRNA, 1066 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000382166

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000382166 — 3 exons

Exon	Start	End
ENSE00001491089	1683269	1684034
ENSE00001634235	1684194	1684302
ENSE00001707634	1685438	1685629

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 86.76.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0390 / max 31.4757, expressed in 7 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
117985	0.1041	7
112473	0.0390	7
117984	0.0237	7
206153	0.0078	5

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	86.76	gold quality
liver	UBERON:0002107	85.14	gold quality
placenta	UBERON:0001987	67.94	gold quality
heart left ventricle	UBERON:0002084	60.02	gold quality
right atrium auricular region	UBERON:0006631	54.29	gold quality
right adrenal gland	UBERON:0001233	51.39	gold quality
blood	UBERON:0000178	50.55	gold quality
multicellular organism	UBERON:0000468	50.07	gold quality
spleen	UBERON:0002106	48.98	gold quality
body of pancreas	UBERON:0001150	48.01	gold quality
duodenum	UBERON:0002114	48.00	silver quality
urinary bladder	UBERON:0001255	46.04	gold quality
kidney	UBERON:0002113	45.00	gold quality
left adrenal gland	UBERON:0001234	44.38	gold quality
intestine	UBERON:0000160	44.35	gold quality
gastrocnemius	UBERON:0001388	44.32	silver quality
left adrenal gland cortex	UBERON:0035825	43.58	silver quality
subcutaneous adipose tissue	UBERON:0002190	43.57	gold quality
adult mammalian kidney	UBERON:0000082	43.47	gold quality
transverse colon	UBERON:0001157	42.95	silver quality
small intestine	UBERON:0002108	42.72	silver quality
omental fat pad	UBERON:0010414	41.69	silver quality
body of stomach	UBERON:0001161	41.40	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	41.31	silver quality
small intestine Peyer’s patch	UBERON:0003454	41.23	silver quality
left ovary	UBERON:0002119	41.08	silver quality
right testis	UBERON:0004534	40.79	gold quality
esophagus mucosa	UBERON:0002469	40.64	silver quality
putamen	UBERON:0001874	40.43	silver quality
left testis	UBERON:0004533	40.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• FAM99B may serve as a tumor suppressor in hepatocellular carcinoma (HCC) and may provide a promising therapy target for patients with HCC. (PMID:31243545)
• The comprehensive roles of lncRNA FAM99A/FAM99B in hepatocellular carcinoma: Expressions, regulatory mechanisms and functional pathway analysis. (PMID:38740325)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.