FBN1-DT

Summary

FBN1-DT (FBN1 divergent transcript, HGNC:55413) is a long non-coding RNA gene on chromosome 15q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55413
Approved symbol	FBN1-DT
Name	FBN1 divergent transcript
Location	15q21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259705
Ensembl biotype	lncRNA
Entrez	105370809
RNAcentral	URS00026A1E33 — lncRNA, 2579 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000558061, ENST00000752571, ENST00000752572, ENST00000752573, ENST00000752574

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558061 — 2 exons

Exon	Start	End
ENSE00004098842	48650954	48652016
ENSE00004098844	48645906	48646830

Expression profiles

Bgee: expression breadth ubiquitous, 116 present calls, max score 95.09.

Top tissues by expression

220 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	95.09	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.24	silver quality
buccal mucosa cell	CL:0002336	67.51	silver quality
stromal cell of endometrium	CL:0002255	64.51	gold quality
pancreatic ductal cell	CL:0002079	60.41	silver quality
ventricular zone	UBERON:0003053	59.77	gold quality
ganglionic eminence	UBERON:0004023	57.93	silver quality
pigmented layer of retina	UBERON:0001782	57.31	silver quality
calcaneal tendon	UBERON:0003701	55.98	silver quality
right adrenal gland cortex	UBERON:0035827	55.66	gold quality
right adrenal gland	UBERON:0001233	55.07	gold quality
left adrenal gland	UBERON:0001234	54.84	gold quality
epithelial cell of pancreas	CL:0000083	54.70	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
left adrenal gland cortex	UBERON:0035825	53.90	gold quality
adrenal gland	UBERON:0002369	53.71	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
adrenal cortex	UBERON:0001235	53.25	gold quality
ileal mucosa	UBERON:0000331	52.70	silver quality
prefrontal cortex	UBERON:0000451	52.12	gold quality
descending thoracic aorta	UBERON:0002345	51.48	gold quality
tibialis anterior	UBERON:0001385	51.29	silver quality
tendon	UBERON:0000043	51.15	silver quality
nucleus accumbens	UBERON:0001882	50.75	gold quality
deltoid	UBERON:0001476	50.46	gold quality
right hemisphere of cerebellum	UBERON:0014890	50.26	gold quality
myocardium	UBERON:0002349	50.25	gold quality
gall bladder	UBERON:0002110	50.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.27

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.