FBXL14

Summary

FBXL14 (F-box and leucine rich repeat protein 14, HGNC:28624) is a protein-coding gene on chromosome 12p13.33, encoding F-box/LRR-repeat protein 14 (Q8N1E6). Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes.

Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).

Source: NCBI Gene 144699 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 40 total
• MANE Select transcript: NM_152441

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28624
Approved symbol	FBXL14
Name	F-box and leucine rich repeat protein 14
Location	12p13.33
Locus type	gene with protein product
Status	Approved
Aliases	MGC40195, Fbl14
Ensembl gene	ENSG00000171823
Ensembl biotype	protein_coding
OMIM	609081
Entrez	144699

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000339235, ENST00000543278, ENST00000923181

RefSeq mRNA: 3 — MANE Select: NM_152441 NM_001405291, NM_001405292, NM_152441

CCDS: CCDS8509

Canonical transcript exons

ENST00000339235 — 2 exons

Exon	Start	End
ENSE00001250508	1565993	1566810
ENSE00001374491	1592873	1594581

Expression profiles

Bgee: expression breadth ubiquitous, 179 present calls, max score 92.12.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.6259 / max 399.7117, expressed in 1658 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
128926	2.4842	845
128929	0.8632	446
128927	0.8563	470
128928	0.8200	413
128931	0.8010	465
128930	0.7844	425
128925	0.5468	336
128923	0.2609	96
128932	0.1383	34
128924	0.0708	28

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	92.12	gold quality
right testis	UBERON:0004534	91.88	gold quality
testis	UBERON:0000473	87.83	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.09	gold quality
granulocyte	CL:0000094	81.75	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.56	gold quality
prefrontal cortex	UBERON:0000451	81.33	gold quality
ventricular zone	UBERON:0003053	80.92	gold quality
ganglionic eminence	UBERON:0004023	80.89	gold quality
cortical plate	UBERON:0005343	80.73	gold quality
mucosa of transverse colon	UBERON:0004991	80.52	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	80.20	gold quality
anterior cingulate cortex	UBERON:0009835	79.74	gold quality
leukocyte	CL:0000738	79.53	gold quality
transverse colon	UBERON:0001157	79.38	gold quality
monocyte	CL:0000576	79.09	gold quality
gall bladder	UBERON:0002110	78.78	gold quality
body of stomach	UBERON:0001161	78.49	gold quality
stromal cell of endometrium	CL:0002255	78.48	gold quality
right frontal lobe	UBERON:0002810	78.13	gold quality
adenohypophysis	UBERON:0002196	78.12	gold quality
Brodmann (1909) area 9	UBERON:0013540	78.04	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.90	gold quality
right uterine tube	UBERON:0001302	77.53	gold quality
calcaneal tendon	UBERON:0003701	77.18	gold quality
spinal cord	UBERON:0002240	77.13	gold quality
caudate nucleus	UBERON:0001873	77.04	gold quality
nucleus accumbens	UBERON:0001882	76.95	gold quality
neocortex	UBERON:0001950	76.75	gold quality
body of pancreas	UBERON:0001150	76.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.50

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

40 targeting FBXL14, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-4697-3P	99.89	67.09	1123
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-7-5P	99.67	70.53	1809
HSA-MIR-545-5P	99.66	70.18	2308
HSA-MIR-6716-5P	99.56	68.62	1244
HSA-MIR-4643	99.49	67.63	1791
HSA-MIR-940	99.37	66.14	2064
HSA-MIR-6808-5P	99.31	66.23	2150
HSA-MIR-6893-5P	99.31	66.25	2119
HSA-MIR-580-5P	99.28	70.94	1776
HSA-MIR-4528	99.18	69.77	1936
HSA-MIR-3145-3P	98.85	69.07	2031

Literature-anchored findings (GeneRIF, showing 5)

• Data show that Twist1 small interfering RNA prevents hypoxia-induced Fbxl14 down-regulation and SNAIL1 stabilization. (PMID:19955572)
• USP13 and FBXL14 play opposing roles in the regulation of glioma stem cells (GSCs) through reversible ubiquitination of c-Myc. (PMID:27923907)
• induced FBXL13 expression downregulates centrosomal gamma-tubulin and disrupts centrosomal microtubule arrays. In addition, depletion of FBXL13 induces high levels of CEP192 and gamma-tubulin at the centrosomes with the consequence of defects in cell motility. (PMID:29348145)
• FBXL14 acts as an novel interaction partner of CDCP1, and facilitates its ubiquitination and proteasomal degradation with an enhanced capacity to suppress CDCP1 protein stability that eventually prevents CDCP1 target genes involved in breast cancer metastasis. (PMID:29973690)
• Loss of FBXL14 promotes mesenchymal shift and radioresistance of non-small cell lung cancer by TWIST1 stabilization. (PMID:34285182)

Cross-species orthologs

20 orthologs

Organism	Symbol	Gene ID
danio_rerio	fbxl14a	ENSDARG00000034497
danio_rerio	fbxl14b	ENSDARG00000045801
mus_musculus	Fbxl14	ENSMUSG00000030019
rattus_norvegicus	Fbxl14	ENSRNOG00000070828
drosophila_melanogaster	Ppa	FBGN0020257
caenorhabditis_elegans		WBGENE00008177
caenorhabditis_elegans		WBGENE00009689
caenorhabditis_elegans	gadr-6	WBGENE00009823
caenorhabditis_elegans		WBGENE00010365
caenorhabditis_elegans	K05C4.9	WBGENE00010585
caenorhabditis_elegans		WBGENE00012655
caenorhabditis_elegans		WBGENE00018561
caenorhabditis_elegans		WBGENE00018613
caenorhabditis_elegans		WBGENE00018766
caenorhabditis_elegans		WBGENE00019239
caenorhabditis_elegans		WBGENE00021053
caenorhabditis_elegans		WBGENE00021180
caenorhabditis_elegans	zeel-1	WBGENE00021463
caenorhabditis_elegans		WBGENE00044459
caenorhabditis_elegans	gadr-5	WBGENE00045058

Paralogs (15): FBXL3 (ENSG00000005812), FBXL19 (ENSG00000099364), FBXL15 (ENSG00000107872), FBXL20 (ENSG00000108306), FBXL4 (ENSG00000112234), FBXL5 (ENSG00000118564), FBXL16 (ENSG00000127585), SKP2 (ENSG00000145604), FBXL17 (ENSG00000145743), FBXL2 (ENSG00000153558), FBXL18 (ENSG00000155034), FBXL13 (ENSG00000161040), FBXL6 (ENSG00000182325), FBXL7 (ENSG00000183580), FBXL22 (ENSG00000197361)

Protein

Protein identifiers

F-box/LRR-repeat protein 14 — Q8N1E6 (reviewed: Q8N1E6)

Alternative names: F-box and leucine-rich repeat protein 14

All UniProt accessions (1): Q8N1E6

UniProt curated annotations — full annotation on UniProt →

Function. Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.

Subunit / interactions. Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase complex. Interacts with SKP1 and CUL1. Interacts with SNAI1; the interaction requires the phosphorylation of the two serine residues in the substrate destruction motif D-S-G-X(2,3,4)-S.

Subcellular location. Cytoplasm.

Induction. Down-regulated by hypoxia.

RefSeq proteins (3): NP_001392220, NP_001392221, NP_689654* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001810	F-box_dom	Domain
IPR006553	Leu-rich_rpt_Cys-con_subtyp	Repeat
IPR032675	LRR_dom_sf	Homologous_superfamily
IPR036047	F-box-like_dom_sf	Homologous_superfamily
IPR047932	FBXL14_F-box	Domain
IPR057207	FBXL15_LRR	Domain

Pfam: PF12937, PF25372

UniProt features (9 total): repeat 5, chain 1, domain 1, region of interest 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N1E6-F1	91.59	0.84

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-8951664	Neddylation
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation

MSigDB gene sets: 132 (showing top): BENPORATH_ES_WITH_H3K27ME3, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION, REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, AP2_Q3, CEBPB_01, WTGAAAT_UNKNOWN, GOBP_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS, RYTTCCTG_ETS2_B, HAND1E47_01, GOBP_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS, GOBP_PROTEIN_CATABOLIC_PROCESS, TGGAAA_NFAT_Q4_01, GOCC_SCF_UBIQUITIN_LIGASE_COMPLEX

GO Biological Process (2): ubiquitin-dependent protein catabolic process (GO:0006511), SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)

GO Molecular Function (2): ubiquitin-protein transferase activity (GO:0004842), protein binding (GO:0005515)

GO Cellular Component (3): cytoplasm (GO:0005737), cytosol (GO:0005829), SCF ubiquitin ligase complex (GO:0019005)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Post-translational protein modification	1
Class I MHC mediated antigen processing & presentation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
protein ubiquitination	1
modification-dependent protein catabolic process	1
proteasome-mediated ubiquitin-dependent protein catabolic process	1
ubiquitin-like protein transferase activity	1
binding	1
intracellular anatomical structure	1
cytoplasm	1
cullin-RING ubiquitin ligase complex	1

Protein interactions and networks

STRING

1127 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FBXL14	FBXO11	Q86XK2	773
FBXL14	SKP1	P34991	753
FBXL14	CUL1	Q13616	749
FBXL14	FBXL5	Q9UKA1	727
FBXL14	SNAI1	O95863	711
FBXL14	BTRC	Q9Y297	637
FBXL14	FBXO45	P0C2W1	627
FBXL14	USP17L2	Q6R6M4	546
FBXL14	LRTM2	Q8N967	511
FBXL14	FBXL12	Q9NXK8	505
FBXL14	DUSP6	Q16828	495
FBXL14	FBXO25	Q8TCJ0	492
FBXL14	SPSB3	Q6PJ21	490
FBXL14	FBXO28	Q9NVF7	477
FBXL14	FBXO33	Q7Z6M2	470

IntAct

32 interactions, top by confidence:

A	B	Type	Score
SKP1	FBXL14	psi-mi:“MI:0915”(physical association)	0.840
COPS6	RHOBTB1	psi-mi:“MI:0914”(association)	0.730
CUL1	FBXO21	psi-mi:“MI:0914”(association)	0.600
MTA3	KDM1A	psi-mi:“MI:0914”(association)	0.530
FBXL14	CRYZL1	psi-mi:“MI:0914”(association)	0.530
FBXL14	SEC11A	psi-mi:“MI:0914”(association)	0.530
FBXL14	DAPK1	psi-mi:“MI:0407”(direct interaction)	0.440
SNAI1	FBXL14	psi-mi:“MI:0915”(physical association)	0.400
HSP90AB1	FBXL14	psi-mi:“MI:0915”(physical association)	0.400
FKBP5	FBXL14	psi-mi:“MI:0915”(physical association)	0.400
FBXL14	Hacd3	psi-mi:“MI:0915”(physical association)	0.400
FBXL14	HSP90AB1	psi-mi:“MI:0915”(physical association)	0.400
FBXL14		psi-mi:“MI:0915”(physical association)	0.400
FBXL14	AARSD1	psi-mi:“MI:0915”(physical association)	0.400
FBXL14	SNAI1	psi-mi:“MI:0915”(physical association)	0.400
CUL1	LGALS8	psi-mi:“MI:0914”(association)	0.350
COPS5	FBLL1	psi-mi:“MI:0914”(association)	0.350
COPS6	DDX3X	psi-mi:“MI:0914”(association)	0.350
STYX	PAK4	psi-mi:“MI:0914”(association)	0.350
FEM1A	RNF113A	psi-mi:“MI:0914”(association)	0.350
TLE1	TBX1	psi-mi:“MI:0914”(association)	0.350
TLE1	PCBP3	psi-mi:“MI:0914”(association)	0.350
FEM1A	DHRS3	psi-mi:“MI:0914”(association)	0.350
FBXL14	MYH7B	psi-mi:“MI:0914”(association)	0.350
SKP1	NDUFAB1	psi-mi:“MI:0914”(association)	0.350
TLE1	CKB	psi-mi:“MI:0914”(association)	0.350
SKP1	NDC80	psi-mi:“MI:0914”(association)	0.350
SKP1	FBXL14	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (83): FBXL14 (Affinity Capture-MS), PPP1R21 (Affinity Capture-MS), TTC9C (Affinity Capture-MS), CRYZL1 (Affinity Capture-MS), CUL1 (Affinity Capture-MS), SEC11C (Affinity Capture-MS), SUGT1 (Affinity Capture-MS), AAGAB (Affinity Capture-MS), ITPR1 (Affinity Capture-MS), COPS2 (Affinity Capture-MS), SPCS2 (Affinity Capture-MS), COPS6 (Affinity Capture-MS), GPS1 (Affinity Capture-MS), DAAM1 (Affinity Capture-MS), FSTL1 (Affinity Capture-MS)

ESM2 similar proteins: A1A5X2, A2RT62, A6H639, A8Y3R9, B3FL73, D3Z902, D3ZXS4, G5EDB9, O49286, P34284, P87053, Q09299, Q0P4D1, Q0VD31, Q17R01, Q19857, Q32PG9, Q4R642, Q570C0, Q5BJ29, Q5JU00, Q5MJ12, Q65XV2, Q8BFZ4, Q8BH70, Q8BID8, Q8BVU0, Q8C4V4, Q8CDU4, Q8CFJ9, Q8J2J3, Q8LB33, Q8N1E6, Q8N461, Q8W104, Q96S15, Q9EPX5, Q9LPL4, Q9LW29, Q9NXK8

Diamond homologs: Q17R01, Q8BID8, Q8N1E6

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
FBXL14	“down-regulates quantity by destabilization”	MYC	ubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 31 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Neddylation	6	12.4×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

40 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	34
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1117 predictions. Top by Δscore:

Variant	Effect	Δscore
12:1574842:G:GG	donor_gain	1.0000
12:1574837:GTCAT:G	donor_gain	0.9900
12:1574840:ATG:A	donor_loss	0.9900
12:1574841:TGT:T	donor_loss	0.9900
12:1574842:G:GC	donor_loss	0.9900
12:1574843:TG:T	donor_loss	0.9900
12:1574844:GA:G	donor_loss	0.9900
12:1574845:AGT:A	donor_loss	0.9900
12:1574846:G:C	donor_loss	0.9800
12:1587440:CTTT:C	donor_gain	0.9800
12:1587443:T:A	donor_gain	0.9800
12:1566807:CCTC:C	acceptor_gain	0.9700
12:1566808:CTCC:C	acceptor_gain	0.9700
12:1566808:CTCCT:C	acceptor_loss	0.9700
12:1566809:TCCT:T	acceptor_gain	0.9700
12:1566809:TCCTG:T	acceptor_loss	0.9700
12:1566810:CCTG:C	acceptor_loss	0.9700
12:1566812:T:A	acceptor_loss	0.9700
12:1574838:TCAT:T	donor_gain	0.9700
12:1579164:T:TG	donor_gain	0.9700
12:1587439:A:AC	donor_gain	0.9700
12:1587440:C:CC	donor_gain	0.9700
12:1590294:A:AG	donor_gain	0.9700
12:1590393:A:T	donor_gain	0.9700
12:1592895:CAGAG:C	acceptor_gain	0.9700
12:1574692:G:GT	donor_gain	0.9600
12:1566811:C:CC	acceptor_gain	0.9500
12:1566815:A:T	acceptor_gain	0.9500
12:1579164:T:G	donor_gain	0.9500
12:1587446:TTTGC:T	donor_gain	0.9500

AlphaMissense

2710 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:1592950:C:G	G373R	1.000
12:1592969:G:C	C366W	1.000
12:1592971:A:G	C366R	1.000
12:1592979:A:G	L363P	1.000
12:1592979:A:T	L363Q	1.000
12:1592985:A:T	I361K	1.000
12:1593028:C:G	G347R	1.000
12:1593033:T:A	D345V	1.000
12:1593047:A:C	C340W	1.000
12:1593049:A:G	C340R	1.000
12:1593054:C:A	G338V	1.000
12:1593054:C:T	G338E	1.000
12:1593063:A:G	L335P	1.000
12:1593063:A:T	L335H	1.000
12:1593106:C:G	G321R	1.000
12:1593112:C:G	D319H	1.000
12:1593136:A:G	S311P	1.000
12:1593179:A:C	S296R	1.000
12:1593179:A:T	S296R	1.000
12:1593181:T:G	S296R	1.000
12:1593200:A:C	C289W	1.000
12:1593201:C:T	C289Y	1.000
12:1593202:A:G	C289R	1.000
12:1593203:G:C	F288L	1.000
12:1593203:G:T	F288L	1.000
12:1593205:A:G	F288L	1.000
12:1593205:A:T	F288I	1.000
12:1593258:C:T	G270D	1.000
12:1593259:C:G	G270R	1.000
12:1593279:C:T	C263Y	1.000

dbSNP variants (sampled 300 via entrez): RS1000089218 (12:1573825 A>T), RS1000112145 (12:1579413 C>G), RS1000150728 (12:1595150 C>T), RS1000163375 (12:1590958 T>C), RS1000276173 (12:1568686 AC>A,ACC), RS1000281556 (12:1591380 A>G), RS1000564663 (12:1577589 C>CA), RS1000581305 (12:1583473 C>G,T), RS1000658273 (12:1589823 C>T), RS1000881397 (12:1567487 T>C), RS1000918317 (12:1569285 C>A,G), RS1000951258 (12:1572523 G>T), RS1001096153 (12:1589738 G>A), RS1001227890 (12:1584510 T>C), RS1001245331 (12:1567277 A>G)

Disease associations

OMIM: gene MIM:609081 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006106_4	Forehead morphology	3.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, decreases methylation, increases expression, affects cotreatment	6
trichostatin A	affects cotreatment, decreases expression	3
entinostat	decreases expression, affects cotreatment	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Silicon Dioxide	decreases expression	2
Aflatoxin B1	decreases methylation, decreases expression	2
Cadmium Chloride	decreases expression, increases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, decreases expression	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, increases expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
ferrous chloride	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
PCI 5002	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Vorinostat	decreases expression, affects cotreatment	1
Benzo(a)pyrene	decreases methylation, increases methylation	1
Cisplatin	decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Diazinon	increases methylation	1
Indomethacin	affects cotreatment, increases expression	1
Rotenone	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression	1
Zinc	affects cotreatment, increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E1X1	HAP1 FBXL14 (-) 1	Cancer cell line	Male
CVCL_E1X2	HAP1 FBXL14 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.