FBXL15

Summary

FBXL15 (F-box and leucine rich repeat protein 15, HGNC:28155) is a protein-coding gene on chromosome 10q24.32, encoding F-box/LRR-repeat protein 15 (Q9H469). Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway.

Involved in several processes, including G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of BMP signaling pathway. Located in cytoplasm. Part of SCF ubiquitin ligase complex.

Source: NCBI Gene 79176 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 40 total
• MANE Select transcript: NM_024326

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28155
Approved symbol	FBXL15
Name	F-box and leucine rich repeat protein 15
Location	10q24.32
Locus type	gene with protein product
Status	Approved
Aliases	MGC11279, Fbl15
Ensembl gene	ENSG00000107872
Ensembl biotype	protein_coding
OMIM	610287
Entrez	79176

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 14 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000369956, ENST00000425536, ENST00000432590, ENST00000440407, ENST00000457067, ENST00000481808, ENST00000864349, ENST00000864350, ENST00000933208, ENST00000933209, ENST00000948416, ENST00000948417, ENST00000948418, ENST00000948419, ENST00000948420

RefSeq mRNA: 2 — MANE Select: NM_024326 NM_001387294, NM_024326

CCDS: CCDS31273

Canonical transcript exons

ENST00000369956 — 4 exons

Exon	Start	End
ENSE00000811530	102422804	102423136
ENSE00001290000	102420836	102421182
ENSE00001782501	102421787	102422292
ENSE00002229252	102421354	102421507

Expression profiles

Bgee: expression breadth ubiquitous, 202 present calls, max score 91.73.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.9818 / max 50.9335, expressed in 1509 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
106714	3.7758	1504
106713	0.2060	86

Top tissues by expression

265 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adenohypophysis	UBERON:0002196	91.73	gold quality
mucosa of transverse colon	UBERON:0004991	91.63	gold quality
right frontal lobe	UBERON:0002810	91.31	gold quality
anterior cingulate cortex	UBERON:0009835	91.10	gold quality
pituitary gland	UBERON:0000007	91.08	gold quality
cingulate cortex	UBERON:0003027	90.95	gold quality
Brodmann (1909) area 9	UBERON:0013540	90.25	gold quality
right hemisphere of cerebellum	UBERON:0014890	89.52	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	89.46	gold quality
prefrontal cortex	UBERON:0000451	88.65	gold quality
nucleus accumbens	UBERON:0001882	88.43	gold quality
muscle layer of sigmoid colon	UBERON:0035805	87.90	gold quality
neocortex	UBERON:0001950	87.86	gold quality
left adrenal gland	UBERON:0001234	87.82	gold quality
granulocyte	CL:0000094	87.81	gold quality
apex of heart	UBERON:0002098	87.81	gold quality
left adrenal gland cortex	UBERON:0035825	87.71	gold quality
right adrenal gland	UBERON:0001233	87.63	gold quality
caudate nucleus	UBERON:0001873	87.60	gold quality
frontal cortex	UBERON:0001870	87.59	gold quality
cerebellar hemisphere	UBERON:0002245	87.56	gold quality
cerebellar cortex	UBERON:0002129	87.40	gold quality
primary visual cortex	UBERON:0002436	87.26	gold quality
middle temporal gyrus	UBERON:0002771	87.26	gold quality
body of stomach	UBERON:0001161	87.17	gold quality
transverse colon	UBERON:0001157	87.13	gold quality
putamen	UBERON:0001874	87.10	gold quality
right adrenal gland cortex	UBERON:0035827	87.07	gold quality
cerebral cortex	UBERON:0000956	86.74	gold quality
cerebellum	UBERON:0002037	86.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

9 targeting FBXL15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-4446-5P	99.72	69.19	2544
HSA-MIR-6837-5P	99.25	65.47	1632
HSA-MIR-455-3P	98.94	67.68	878
HSA-MIR-6796-3P	98.68	65.49	689
HSA-MIR-3928-5P	98.50	67.48	980
HSA-MIR-6806-3P	98.50	67.31	980
HSA-MIR-6883-3P	97.97	67.35	643
HSA-MIR-127-5P	97.78	67.64	869

Literature-anchored findings (GeneRIF, showing 1)

• We identified the known APC/C regulator Cdh1 and the F-box protein Fbxl15 as specific modulators of N-cyclin B1-luciferase steady-state levels and turnover. Collectively, our studies suggest that analyzing the steady-state levels of luciferase fusion proteins in parallel facilitates identification of specific regulators of protein turnover. (PMID:28296622)

Cross-species orthologs

30 orthologs

Organism	Symbol	Gene ID
danio_rerio	fbxl15	ENSDARG00000005284
mus_musculus	Fbxl15	ENSMUSG00000025226
rattus_norvegicus	Fbxl15	ENSRNOG00000019509
drosophila_melanogaster	CG15056	FBGN0030918
drosophila_melanogaster	CG8272	FBGN0033337
drosophila_melanogaster	CG9003	FBGN0033639
drosophila_melanogaster	Skp2	FBGN0037236
drosophila_melanogaster	CG14891	FBGN0038445
drosophila_melanogaster	CG5003	FBGN0039554
drosophila_melanogaster	FipoQ	FBGN0039667
caenorhabditis_elegans		WBGENE00007206
caenorhabditis_elegans		WBGENE00007208
caenorhabditis_elegans		WBGENE00007887
caenorhabditis_elegans		WBGENE00008177
caenorhabditis_elegans		WBGENE00009689
caenorhabditis_elegans	gadr-6	WBGENE00009823
caenorhabditis_elegans		WBGENE00010365
caenorhabditis_elegans	K05C4.9	WBGENE00010585
caenorhabditis_elegans		WBGENE00012655
caenorhabditis_elegans		WBGENE00015350
caenorhabditis_elegans		WBGENE00018561
caenorhabditis_elegans		WBGENE00018613
caenorhabditis_elegans		WBGENE00018766
caenorhabditis_elegans		WBGENE00019239
caenorhabditis_elegans		WBGENE00020884
caenorhabditis_elegans		WBGENE00021053
caenorhabditis_elegans		WBGENE00021180
caenorhabditis_elegans	zeel-1	WBGENE00021463
caenorhabditis_elegans		WBGENE00044459
caenorhabditis_elegans	gadr-5	WBGENE00045058

Paralogs (15): FBXL3 (ENSG00000005812), FBXL19 (ENSG00000099364), FBXL20 (ENSG00000108306), FBXL4 (ENSG00000112234), FBXL5 (ENSG00000118564), FBXL16 (ENSG00000127585), SKP2 (ENSG00000145604), FBXL17 (ENSG00000145743), FBXL2 (ENSG00000153558), FBXL18 (ENSG00000155034), FBXL13 (ENSG00000161040), FBXL14 (ENSG00000171823), FBXL6 (ENSG00000182325), FBXL7 (ENSG00000183580), FBXL22 (ENSG00000197361)

Protein

Protein identifiers

F-box/LRR-repeat protein 15 — Q9H469 (reviewed: Q9H469)

Alternative names: F-box only protein 37

All UniProt accessions (6): Q9H469, A0A0C4DFV0, X6RCZ8, X6RGT4, X6RHD7, X6RJB2

UniProt curated annotations — full annotation on UniProt →

Function. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.

Subunit / interactions. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15.

Subcellular location. Cytoplasm.

Pathway. Protein modification; protein ubiquitination.

Similarity. Belongs to the FBXL15 family.

RefSeq proteins (2): NP_001374223, NP_077302* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001810	F-box_dom	Domain
IPR006553	Leu-rich_rpt_Cys-con_subtyp	Repeat
IPR032675	LRR_dom_sf	Homologous_superfamily
IPR036047	F-box-like_dom_sf	Homologous_superfamily
IPR057207	FBXL15_LRR	Domain

Pfam: PF00646, PF25372

UniProt features (10 total): repeat 5, chain 1, domain 1, region of interest 1, modified residue 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H469-F1	90.12	0.84

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 1

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-8951664	Neddylation
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation

MSigDB gene sets: 96 (showing top): GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION, REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION, GOBP_CELL_CYCLE_PHASE_TRANSITION, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_DORSAL_VENTRAL_PATTERN_FORMATION, FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_DN, GOBP_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_DN, GOBP_BONE_MINERALIZATION, GOBP_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBP_MITOTIC_CELL_CYCLE, GOBP_CELL_CYCLE_G2_M_PHASE_TRANSITION

GO Biological Process (6): G2/M transition of mitotic cell cycle (GO:0000086), dorsal/ventral pattern formation (GO:0009953), protein ubiquitination (GO:0016567), bone mineralization (GO:0030282), positive regulation of BMP signaling pathway (GO:0030513), SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): cytoplasm (GO:0005737), cytosol (GO:0005829), SCF ubiquitin ligase complex (GO:0019005)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Post-translational protein modification	1
Class I MHC mediated antigen processing & presentation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
mitotic cell cycle	1
mitotic cell cycle phase transition	1
cell cycle G2/M phase transition	1
regionalization	1
protein modification by small protein conjugation	1
ossification	1
biomineral tissue development	1
BMP signaling pathway	1
regulation of BMP signaling pathway	1
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	1
proteasome-mediated ubiquitin-dependent protein catabolic process	1
binding	1
intracellular anatomical structure	1
cytoplasm	1
cullin-RING ubiquitin ligase complex	1

Protein interactions and networks

STRING

904 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FBXL15	TIPIN	Q9BVW5	810
FBXL15	TIMELESS	Q9UNS1	755
FBXL15	FBXO3	Q9UK99	596
FBXL15	CUEDC2	Q9H467	550
FBXL15	SKP1	P34991	543
FBXL15	CLOCK	O15516	528
FBXL15	CUL1	Q13616	528
FBXL15	PER3	P56645	522
FBXL15	FBXO33	Q7Z6M2	507
FBXL15	FBXO45	P0C2W1	504
FBXL15	BMAL1	O00327	497
FBXL15	TMEM150A	Q86TG1	497
FBXL15	SLC68A1	Q14CX5	490
FBXL15	CEP97	Q8IW35	489
FBXL15	FBXW2	Q9UKT8	488

IntAct

41 interactions, top by confidence:

A	B	Type	Score
FBXL15	SKP1	psi-mi:“MI:0914”(association)	0.840
FBXL15	CUL1	psi-mi:“MI:0914”(association)	0.840
COPS6	RHOBTB1	psi-mi:“MI:0914”(association)	0.730
SKP1	MYCBP2	psi-mi:“MI:0914”(association)	0.640
SMURF1	FBXL15	psi-mi:“MI:0915”(physical association)	0.640
FBXL15	SMURF1	psi-mi:“MI:0407”(direct interaction)	0.640
FBXL15	SMURF1	psi-mi:“MI:0915”(physical association)	0.640
FBXL15	SMURF1	psi-mi:“MI:0403”(colocalization)	0.640
CUL1	FBXO21	psi-mi:“MI:0914”(association)	0.600
FBXL15	SMURF2	psi-mi:“MI:0407”(direct interaction)	0.600
FBXL15	SMURF2	psi-mi:“MI:0915”(physical association)	0.600
FBXL15	RBX1	psi-mi:“MI:0914”(association)	0.530
HSP90AB1	FBXL15	psi-mi:“MI:0915”(physical association)	0.400
FBXL15	NEDD4	psi-mi:“MI:0915”(physical association)	0.400
NEDD4L	FBXL15	psi-mi:“MI:0915”(physical association)	0.400
HECW1	FBXL15	psi-mi:“MI:0915”(physical association)	0.400
FBXL15	HECW2	psi-mi:“MI:0915”(physical association)	0.400
FBXL15	ITCH	psi-mi:“MI:0915”(physical association)	0.400
WWP1	FBXL15	psi-mi:“MI:0915”(physical association)	0.400
WWP2	FBXL15	psi-mi:“MI:0915”(physical association)	0.400
Skp1	XPO1	psi-mi:“MI:0914”(association)	0.350
CUL1	LGALS8	psi-mi:“MI:0914”(association)	0.350
COPS6	DDX3X	psi-mi:“MI:0914”(association)	0.350
SKP1	BHLHE40	psi-mi:“MI:0914”(association)	0.350

BioGRID (55): FBXL15 (Two-hybrid), FBXL15 (Two-hybrid), RORC (Two-hybrid), SKP1 (Affinity Capture-MS), CUL1 (Affinity Capture-MS), ARIH1 (Affinity Capture-MS), SKP1 (Affinity Capture-Western), FBXL15 (Affinity Capture-MS), CUL1 (Affinity Capture-MS), SKP1 (Affinity Capture-MS), ARIH1 (Affinity Capture-MS), FBXL15 (Reconstituted Complex), FBXL15 (Affinity Capture-MS), FBXL15 (Affinity Capture-MS), FBXL15 (Affinity Capture-MS)

ESM2 similar proteins: A6NED2, D2HEW7, D3ZZC3, D4A2K4, E1BNS0, E2RKN7, O35709, O60294, O94819, Q08BL9, Q08DS0, Q0D2K2, Q2TBA0, Q2WGJ6, Q3B7M1, Q3U410, Q4R828, Q53GT1, Q53HC5, Q5BK60, Q5U575, Q5ZJ37, Q66HD2, Q6DEL7, Q6E804, Q6INL2, Q6NYM1, Q6PF15, Q6TDP4, Q8BFQ9, Q8BGY4, Q8BNW9, Q8BSF5, Q8BYR1, Q8C3F7, Q8N239, Q8N4N3, Q8NEP7, Q8R2P1, Q8TD43

Diamond homologs: B5X441, D4ABB4, E1BNS0, E2RKN7, E6ZHJ8, Q5XGC0, Q6NW95, Q7SZ73, Q91W61, Q9H469

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
FBXL15	“down-regulates quantity by destabilization”	SMURF1	binding
FBXL15	“up-regulates activity”	“Cullin 1-RBX1-Skp1”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 32 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Downregulation of TGF-beta receptor signaling	5	72.8×	7e-07
Degradation of GLI1 by the proteasome	5	40.0×	7e-06
Regulation of RUNX2 expression and activity	6	38.8×	7e-07
Hedgehog ‘on’ state	5	28.3×	4e-05
Antigen processing: Ubiquitination & Proteasome degradation	12	15.9×	9e-10
Class I MHC mediated antigen processing & presentation	6	15.0×	8e-05
Neddylation	7	11.8×	5e-05
Adaptive Immune System	6	6.4×	3e-03

GO biological processes:

GO term	Partners	Fold	FDR
protein monoubiquitination	6	68.8×	3e-08
protein K48-linked ubiquitination	6	33.7×	1e-06
ubiquitin-dependent protein catabolic process	9	22.3×	3e-08
protein ubiquitination	13	17.9×	2e-11
proteasome-mediated ubiquitin-dependent protein catabolic process	9	15.7×	3e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

40 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	32
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

717 predictions. Top by Δscore:

Variant	Effect	Δscore
10:102419877:A:C	donor_gain	1.0000
10:102421210:G:T	donor_gain	1.0000
10:102421349:CGCAG:C	acceptor_loss	1.0000
10:102421351:CAGGT:C	acceptor_loss	1.0000
10:102421352:A:AC	acceptor_loss	1.0000
10:102421352:A:AG	acceptor_gain	1.0000
10:102421353:G:GG	acceptor_gain	1.0000
10:102421353:G:GT	acceptor_loss	1.0000
10:102421508:GTGAG:G	donor_loss	1.0000
10:102422274:TCGG:T	donor_gain	1.0000
10:102422277:G:GT	donor_gain	1.0000
10:102419873:CCTAA:C	donor_gain	0.9900
10:102419880:TG:T	donor_gain	0.9900
10:102421179:TCAGG:T	donor_loss	0.9900
10:102421180:CAGG:C	donor_loss	0.9900
10:102421181:AGGTA:A	donor_loss	0.9900
10:102421183:G:GC	donor_loss	0.9900
10:102421184:T:G	donor_loss	0.9900
10:102421210:G:GT	donor_gain	0.9900
10:102421225:G:GT	donor_gain	0.9900
10:102421226:G:T	donor_gain	0.9900
10:102421346:A:AG	acceptor_gain	0.9900
10:102421352:AG:A	acceptor_gain	0.9900
10:102421353:GG:G	acceptor_gain	0.9900
10:102421353:GGTT:G	acceptor_gain	0.9900
10:102421353:GGTTC:G	acceptor_gain	0.9900
10:102421504:GCAG:G	donor_gain	0.9900
10:102421508:G:GG	donor_gain	0.9900
10:102422288:GTCAG:G	donor_loss	0.9900
10:102422289:TCAGG:T	donor_loss	0.9900

AlphaMissense

1859 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:102422256:T:A	L226H	0.998
10:102422211:T:A	V211D	0.997
10:102422250:T:A	L224H	0.997
10:102422250:T:C	L224P	0.997
10:102422097:T:A	L173H	0.996
10:102422188:C:A	N203K	0.996
10:102422188:C:G	N203K	0.996
10:102422256:T:C	L226P	0.996
10:102422241:T:A	L221H	0.995
10:102422264:T:C	C229R	0.995
10:102422266:C:G	C229W	0.995
10:102422854:G:A	C255Y	0.995
10:102422019:T:A	L147H	0.994
10:102422223:C:A	A215D	0.994
10:102422855:C:G	C255W	0.994
10:102422265:G:A	C229Y	0.993
10:102422274:T:A	V232D	0.993
10:102422839:T:C	L250P	0.993
10:102422097:T:C	L173P	0.992
10:102422172:T:A	L198H	0.992
10:102422289:T:A	V237D	0.992
10:102422174:T:C	S199P	0.991
10:102421442:A:C	S48R	0.990
10:102421444:C:A	S48R	0.990
10:102421444:C:G	S48R	0.990
10:102422035:G:C	W152C	0.990
10:102422035:G:T	W152C	0.990
10:102422100:C:T	T174I	0.990
10:102422130:T:A	I184N	0.990
10:102422256:T:G	L226R	0.990

dbSNP variants (sampled 300 via entrez): RS1000872443 (10:102422498 T>C,G), RS1001330523 (10:102423001 G>A), RS1002159288 (10:102421576 G>A,T), RS1002206188 (10:102421920 C>T), RS1002877708 (10:102419565 C>A), RS1005086808 (10:102418937 C>G,T), RS1005117859 (10:102419155 C>T), RS1005175856 (10:102420657 T>C,G), RS1005682557 (10:102421244 G>A,C,T), RS1005785325 (10:102421907 C>T), RS1006029737 (10:102418907 C>A,G,T), RS1006175809 (10:102419346 G>A), RS1007008490 (10:102422474 C>CT), RS1007311214 (10:102420716 T>C), RS1007342241 (10:102420996 T>G)

Disease associations

OMIM: gene MIM:610287 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST001942_1	Prostate cancer	5.000000e-10
GCST005956_50	Waist-to-hip ratio adjusted for BMI	8.000000e-06
GCST005958_15	Waist-to-hip ratio adjusted for BMI (age >50)	4.000000e-06
GCST005962_36	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	6.000000e-07

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects expression, increases abundance, decreases expression	2
Hydrogen Peroxide	affects expression	2
Valproic Acid	affects expression, increases expression	2
bisphenol A	decreases expression	1
sodium arsenite	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
abrine	increases expression	1
bisphenol S	affects cotreatment, decreases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Ketoconazole	decreases expression	1
Lead	affects expression	1
Ozone	increases abundance, affects expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1
Aflatoxin B1	decreases expression	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	decreases expression	1
Acrylamide	decreases expression	1
Vitamin K 3	affects expression	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.