FBXL16

Summary

FBXL16 (F-box and leucine rich repeat protein 16, HGNC:14150) is a protein-coding gene on chromosome 16p13.3, encoding F-box/LRR-repeat protein 16 (Q8N461). Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).

Source: NCBI Gene 146330 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 53 total
• MANE Select transcript: NM_153350

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14150
Approved symbol	FBXL16
Name	F-box and leucine rich repeat protein 16
Location	16p13.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC33974, Fbl16
Ensembl gene	ENSG00000127585
Ensembl biotype	protein_coding
OMIM	609082
Entrez	146330

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 4 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000397621, ENST00000562563, ENST00000562585, ENST00000562648, ENST00000926353, ENST00000926354

RefSeq mRNA: 1 — MANE Select: NM_153350 NM_153350

CCDS: CCDS10421

Canonical transcript exons

ENST00000397621 — 6 exons

Exon	Start	End
ENSE00000873939	695415	695923
ENSE00001227237	696773	697419
ENSE00001529427	705512	705801
ENSE00003530942	692500	694423
ENSE00003541344	694992	695076
ENSE00003678142	694634	694697

Expression profiles

Bgee: expression breadth ubiquitous, 227 present calls, max score 99.79.

FANTOM5 (CAGE): breadth broad, TPM avg 13.5949 / max 984.9750, expressed in 652 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155769	11.7487	347
155766	0.5431	230
155767	0.4083	137
155762	0.3474	194
155763	0.2876	103
155764	0.1673	77
155765	0.0714	38
155768	0.0211	10

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
Brodmann (1909) area 46	UBERON:0006483	99.79	gold quality
postcentral gyrus	UBERON:0002581	99.73	gold quality
parietal lobe	UBERON:0001872	99.71	gold quality
entorhinal cortex	UBERON:0002728	99.71	gold quality
endothelial cell	CL:0000115	99.66	gold quality
superior frontal gyrus	UBERON:0002661	99.65	gold quality
lateral globus pallidus	UBERON:0002476	99.55	gold quality
temporal lobe	UBERON:0001871	99.42	gold quality
putamen	UBERON:0001874	99.42	gold quality
cerebellar vermis	UBERON:0004720	99.42	gold quality
caudate nucleus	UBERON:0001873	99.32	gold quality
right frontal lobe	UBERON:0002810	99.32	gold quality
amygdala	UBERON:0001876	99.27	gold quality
occipital lobe	UBERON:0002021	99.27	gold quality
lateral nuclear group of thalamus	UBERON:0002736	99.27	gold quality
nucleus accumbens	UBERON:0001882	99.25	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	99.19	gold quality
frontal cortex	UBERON:0001870	99.18	gold quality
primary visual cortex	UBERON:0002436	99.18	gold quality
Ammon’s horn	UBERON:0001954	99.14	gold quality
middle temporal gyrus	UBERON:0002771	99.13	gold quality
Brodmann (1909) area 23	UBERON:0013554	99.00	gold quality
anterior cingulate cortex	UBERON:0009835	98.99	gold quality
prefrontal cortex	UBERON:0000451	98.93	gold quality
cerebral cortex	UBERON:0000956	98.81	gold quality
Brodmann (1909) area 9	UBERON:0013540	98.75	gold quality
neocortex	UBERON:0001950	98.68	gold quality
pons	UBERON:0000988	98.62	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.86	gold quality
forebrain	UBERON:0001890	97.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.34

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F1

miRNA regulators (miRDB)

123 targeting FBXL16, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-3662	99.99	73.82	5684
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-185-3P	99.95	67.01	1743
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-3151-5P	99.86	63.83	1069

Literature-anchored findings (GeneRIF, showing 6)

• the expression of FBXL16 reproducibly upregulated in p16INK4A and p14ARF knockdown HeLa cells (PMID:20043084)
• The F-box protein FBXL16 up-regulates the stability of C-MYC oncoprotein by antagonizing the activity of the F-box protein FBW7. (PMID:32345600)
• FBXL16 modulates the proliferation and autophagy in breast cancer cells via activating SRC-3-AKT signaling pathway. (PMID:34333223)
• Suppression of breast cancer progression by FBXL16 via oxygen-independent regulation of HIF1alpha stability. (PMID:34818544)
• FBXL16 Promotes Endometrial Progesterone Resistance via PP2A(B55alpha) /Cyclin D1 Axis in Ishikawa. (PMID:36106050)
• MiR-1307-5p enhances fibroblast transdifferentiation to exacerbate chronic obstructive pulmonary disease through regulating FBXL16/HIF1alpha axis. (PMID:39420370)

Cross-species orthologs

19 orthologs

Organism	Symbol	Gene ID
danio_rerio	fbxl16	ENSDARG00000060915
mus_musculus	Fbxl16	ENSMUSG00000025738
rattus_norvegicus	Fbxl16	ENSRNOG00000022248
drosophila_melanogaster	CG32085	FBGN0052085
caenorhabditis_elegans		WBGENE00008177
caenorhabditis_elegans		WBGENE00009689
caenorhabditis_elegans	gadr-6	WBGENE00009823
caenorhabditis_elegans		WBGENE00010365
caenorhabditis_elegans	K05C4.9	WBGENE00010585
caenorhabditis_elegans		WBGENE00012655
caenorhabditis_elegans		WBGENE00018561
caenorhabditis_elegans		WBGENE00018613
caenorhabditis_elegans		WBGENE00018766
caenorhabditis_elegans		WBGENE00019239
caenorhabditis_elegans		WBGENE00021053
caenorhabditis_elegans		WBGENE00021180
caenorhabditis_elegans	zeel-1	WBGENE00021463
caenorhabditis_elegans		WBGENE00044459
caenorhabditis_elegans	gadr-5	WBGENE00045058

Paralogs (15): FBXL3 (ENSG00000005812), FBXL19 (ENSG00000099364), FBXL15 (ENSG00000107872), FBXL20 (ENSG00000108306), FBXL4 (ENSG00000112234), FBXL5 (ENSG00000118564), SKP2 (ENSG00000145604), FBXL17 (ENSG00000145743), FBXL2 (ENSG00000153558), FBXL18 (ENSG00000155034), FBXL13 (ENSG00000161040), FBXL14 (ENSG00000171823), FBXL6 (ENSG00000182325), FBXL7 (ENSG00000183580), FBXL22 (ENSG00000197361)

Protein

Protein identifiers

F-box/LRR-repeat protein 16 — Q8N461 (reviewed: Q8N461)

Alternative names: F-box and leucine-rich repeat protein 16

All UniProt accessions (1): Q8N461

UniProt curated annotations — full annotation on UniProt →

Function. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Subunit / interactions. Interacts with SKP1 and CUL1.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8N461-1	1	yes
Q8N461-2	2

RefSeq proteins (1): NP_699181* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006553	Leu-rich_rpt_Cys-con_subtyp	Repeat
IPR032675	LRR_dom_sf	Homologous_superfamily
IPR036047	F-box-like_dom_sf	Homologous_superfamily
IPR050648	F-box_LRR-repeat	Family
IPR057207	FBXL15_LRR	Domain

Pfam: PF25372

UniProt features (14 total): repeat 7, chain 1, domain 1, compositionally biased region 1, modified residue 1, splice variant 1, sequence variant 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N461-F1	84.53	0.78

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 92

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-8951664	Neddylation
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation

MSigDB gene sets: 118 (showing top): REACTOME_ADAPTIVE_IMMUNE_SYSTEM, REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION, REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION, KOINUMA_COLON_CANCER_MSI_UP, AAGCCAT_MIR135A_MIR135B, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GGGTGGRR_PAX4_03, GOBP_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS, ATAACCT_MIR154, GOBP_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS, GOBP_PROTEIN_CATABOLIC_PROCESS, SENESE_HDAC3_TARGETS_DN, GOCC_SCF_UBIQUITIN_LIGASE_COMPLEX, GOCC_TRANSFERASE_COMPLEX, GOBP_PROTEOLYSIS

GO Biological Process (1): SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): cytosol (GO:0005829), SCF ubiquitin ligase complex (GO:0019005), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Post-translational protein modification	1
Class I MHC mediated antigen processing & presentation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
proteasome-mediated ubiquitin-dependent protein catabolic process	1
binding	1
cytoplasm	1
cullin-RING ubiquitin ligase complex	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1404 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FBXL16	SKP1	P34991	813
FBXL16	CUL1	Q13616	703
FBXL16	FBXO16	Q8IX29	593
FBXL16	FBXL6	Q8N531	532
FBXL16	CEP97	Q8IW35	471
FBXL16	CETN2	P41208	453
FBXL16	FBXL8	Q96CD0	448
FBXL16	CEP164	Q9UPV0	445
FBXL16	NEU4	Q8WWR8	433
FBXL16	AP2A2	O94973	421
FBXL16	RUNDC3A	Q59EK9	416
FBXL16	NGEF	Q8N5V2	410
FBXL16	PROSER2	Q86WR7	407
FBXL16	KDM4B	O94953	396
FBXL16	FAM199X	Q6PEV8	396

IntAct

31 interactions, top by confidence:

A	B	Type	Score
PPP2R2B	MYO9A	psi-mi:“MI:0914”(association)	0.640
FBXL16	HIF1A	psi-mi:“MI:0915”(physical association)	0.620
FBXL16	HIF1A	psi-mi:“MI:2364”(proximity)	0.620
FBXL16	UBB	psi-mi:“MI:0914”(association)	0.530
Lats2	MPDZ	psi-mi:“MI:0914”(association)	0.420
FBXL16	MAPK6	psi-mi:“MI:0915”(physical association)	0.370
Ppp2r1a	CCHCR1	psi-mi:“MI:0914”(association)	0.350
MARK2	WDR46	psi-mi:“MI:0914”(association)	0.350
Skp1	XPO1	psi-mi:“MI:0914”(association)	0.350
PPP2R1A	INTS2	psi-mi:“MI:0914”(association)	0.350
PPP2R2A	RBM7	psi-mi:“MI:0914”(association)	0.350
Ppp2r2d	KLF4	psi-mi:“MI:0914”(association)	0.350
PPP2CA	ENSA	psi-mi:“MI:0914”(association)	0.350
PPP2CB	ENSA	psi-mi:“MI:0914”(association)	0.350
SKP1	BHLHE40	psi-mi:“MI:0914”(association)	0.350
COMTD1	TARS3	psi-mi:“MI:0914”(association)	0.350
FBXL16	POTEF	psi-mi:“MI:0914”(association)	0.350
SKP1	RNASET2	psi-mi:“MI:0914”(association)	0.350
IGFBP5	RPP40	psi-mi:“MI:0914”(association)	0.350
FBXL16	HSPA8	psi-mi:“MI:0914”(association)	0.350
FBXL16	STK25	psi-mi:“MI:0914”(association)	0.350
SKP1	NDUFAB1	psi-mi:“MI:0914”(association)	0.350
	PPP2R1A	psi-mi:“MI:0914”(association)	0.350
DSCR9	FBXL16	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (42): FBXL16 (Affinity Capture-MS), FBXL16 (Affinity Capture-MS), FBXL16 (Affinity Capture-MS), FBXL16 (Affinity Capture-MS), FBXL16 (Affinity Capture-MS), FBXL16 (Affinity Capture-MS), FBXL16 (Affinity Capture-MS), FBXL16 (Affinity Capture-MS), DAAM1 (Affinity Capture-MS), UBB (Affinity Capture-MS), FBXL18 (Affinity Capture-MS), SKP1 (Affinity Capture-Western), SKP1 (Affinity Capture-Western), MYC (Affinity Capture-Western), HSPA8 (Affinity Capture-MS)

ESM2 similar proteins: A1A5X2, A2RT62, A6H639, A8Y3R9, B3FL73, D3Z902, D3ZXS4, G5EDB9, O49286, P34284, P87053, Q09299, Q0P4D1, Q0VD31, Q17R01, Q19857, Q32PG9, Q4R642, Q570C0, Q5BJ29, Q5JU00, Q5MJ12, Q65XV2, Q8BFZ4, Q8BH70, Q8BID8, Q8BVU0, Q8C4V4, Q8CDU4, Q8CFJ9, Q8J2J3, Q8LB33, Q8N1E6, Q8N461, Q8W104, Q96S15, Q9EPX5, Q9LPL4, Q9LW29, Q9NXK8

Diamond homologs: A2RT62, Q5MJ12, Q8N461

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 34 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Cyclin A/B1/B2 associated events during G2/M transition	5	70.2×	1e-06
Cyclin D associated events in G1	6	63.6×	1e-07
Degradation of beta-catenin by the destruction complex	5	39.3×	1e-05
Separation of Sister Chromatids	5	13.8×	4e-04

GO biological processes:

GO term	Partners	Fold	FDR
intracellular signal transduction	7	9.2×	9e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	40
Likely benign	3
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

869 predictions. Top by Δscore:

Variant	Effect	Δscore
16:694628:TCTCA:T	donor_loss	1.0000
16:694629:CTCA:C	donor_loss	1.0000
16:694630:TCA:T	donor_loss	1.0000
16:694631:CAC:C	donor_loss	1.0000
16:694696:ACC:A	acceptor_loss	1.0000
16:694697:CCTGT:C	acceptor_loss	1.0000
16:694698:C:A	acceptor_loss	1.0000
16:694699:T:A	acceptor_loss	1.0000
16:695410:CGCA:C	donor_loss	1.0000
16:695411:GCAC:G	donor_loss	1.0000
16:695412:CACC:C	donor_loss	1.0000
16:695413:ACCT:A	donor_loss	1.0000
16:695414:C:CG	donor_loss	1.0000
16:694420:CAGC:C	acceptor_gain	0.9900
16:694424:C:CC	acceptor_gain	0.9900
16:694424:CTGCG:C	acceptor_loss	0.9900
16:694695:CAC:C	acceptor_gain	0.9900
16:694698:C:CC	acceptor_gain	0.9900
16:694703:G:T	acceptor_gain	0.9900
16:695409:GCGCA:G	donor_loss	0.9900
16:695413:A:AC	donor_gain	0.9900
16:695414:C:CC	donor_gain	0.9900
16:695414:CCTGT:C	donor_gain	0.9900
16:696768:CACA:C	donor_loss	0.9900
16:696769:ACACC:A	donor_loss	0.9900
16:696771:ACCT:A	donor_loss	0.9900
16:696772:CCTCG:C	donor_loss	0.9900
16:696786:T:TA	donor_gain	0.9900
16:697416:CGCT:C	acceptor_gain	0.9900
16:697418:CT:C	acceptor_gain	0.9900

AlphaMissense

3063 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:694354:A:G	L454P	1.000
16:694360:A:G	L452P	1.000
16:694423:C:T	G431D	1.000
16:695001:C:A	W406C	1.000
16:695001:C:G	W406C	1.000
16:695003:A:G	W406R	1.000
16:695003:A:T	W406R	1.000
16:695053:C:T	G389D	1.000
16:695054:C:G	G389R	1.000
16:695059:T:A	D387V	1.000
16:695073:A:C	C382W	1.000
16:695074:C:T	C382Y	1.000
16:695075:A:G	C382R	1.000
16:695415:C:A	R381M	1.000
16:695415:C:G	R381T	1.000
16:695418:T:A	D380V	1.000
16:695421:A:T	L379H	1.000
16:695427:A:G	L377P	1.000
16:695427:A:T	L377H	1.000
16:695475:T:A	D361V	1.000
16:695476:C:A	D361Y	1.000
16:695476:C:G	D361H	1.000
16:695478:G:A	T360I	1.000
16:695489:G:C	C356W	1.000
16:695491:A:G	C356R	1.000
16:695494:A:G	W355R	1.000
16:695494:A:T	W355R	1.000
16:695499:A:C	L353R	1.000
16:695499:A:G	L353P	1.000
16:695499:A:T	L353H	1.000

dbSNP variants (sampled 300 via entrez): RS1000003040 (16:693954 G>A), RS1000175819 (16:702879 G>A), RS1000480062 (16:697918 T>A,G), RS1000607163 (16:692806 C>A,T), RS1000610108 (16:702682 G>A,C), RS1000827165 (16:695354 G>A,C,T), RS1001041321 (16:692495 A>G), RS1001061565 (16:700701 C>A), RS1001358685 (16:692934 A>T), RS1001405810 (16:700449 C>A,T), RS1001483948 (16:697691 GT>G,GTT), RS1001720914 (16:702812 G>A,C), RS1001821864 (16:702358 T>C), RS1002010215 (16:701601 C>G,T), RS1002097573 (16:692159 G>A)

Disease associations

OMIM: gene MIM:609082 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST007327_175	Smoking status (ever vs never smokers)	7.000000e-13
GCST012226_124	Waist circumference adjusted for body mass index	3.000000e-08
GCST012226_126	Waist circumference adjusted for body mass index	4.000000e-08
GCST012597_2	Attention deficit hyperactivity disorder	2.000000e-07

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004318	smoking behavior
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, increases methylation	8
trichostatin A	increases expression	2
entinostat	increases expression, affects cotreatment	2
Benzo(a)pyrene	increases methylation, affects methylation, increases expression	2
Tobacco Smoke Pollution	decreases expression	2
bisphenol A	decreases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
manganese chloride	increases abundance, increases expression	1
beta-methylcholine	affects expression	1
pentanal	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
2,2’,4,4’,5-brominated diphenyl ether	increases expression	1
abrine	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
(+)-JQ1 compound	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Calcitriol	increases expression	1
Catechin	affects cotreatment, increases expression	1
Cisplatin	decreases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
Hydrogen Peroxide	affects expression	1
Manganese	increases abundance, increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Polychlorinated Biphenyls	affects expression	1
Silicon Dioxide	increases expression	1
Dihydrotestosterone	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.