FBXL18

Summary

FBXL18 (F-box and leucine rich repeat protein 18, HGNC:21874) is a protein-coding gene on chromosome 7p22.1, encoding F-box/LRR-repeat protein 18 (Q96ME1). Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.

Source: NCBI Gene 80028 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 113 total
• MANE Select transcript: NM_024963

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21874
Approved symbol	FBXL18
Name	F-box and leucine rich repeat protein 18
Location	7p22.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ11467, Fbl18
Ensembl gene	ENSG00000155034
Ensembl biotype	protein_coding
OMIM	609084
Entrez	80028

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 nonsense_mediated_decay

ENST00000382368, ENST00000415009, ENST00000458142, ENST00000948868

RefSeq mRNA: 6 — MANE Select: NM_024963 NM_001321213, NM_001363441, NM_001363442, NM_001367780, NM_001367781, NM_024963

CCDS: CCDS43546

Canonical transcript exons

ENST00000382368 — 5 exons

Exon	Start	End
ENSE00001018855	5505412	5505630
ENSE00001126796	5513657	5513809
ENSE00001491867	5475797	5481931
ENSE00001713688	5491231	5491449
ENSE00002150451	5500488	5502031

Expression profiles

Bgee: expression breadth ubiquitous, 208 present calls, max score 90.14.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.5221 / max 116.5308, expressed in 1795 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
82581	15.5221	1795

Top tissues by expression

266 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vena cava	UBERON:0004087	90.14	gold quality
lateral globus pallidus	UBERON:0002476	89.68	silver quality
buccal mucosa cell	CL:0002336	88.96	silver quality
lateral nuclear group of thalamus	UBERON:0002736	87.45	silver quality
entorhinal cortex	UBERON:0002728	86.19	gold quality
cardia of stomach	UBERON:0001162	85.79	silver quality
postcentral gyrus	UBERON:0002581	85.67	gold quality
substantia nigra pars compacta	UBERON:0001965	85.66	silver quality
parietal lobe	UBERON:0001872	85.35	gold quality
superior frontal gyrus	UBERON:0002661	84.94	gold quality
ventral tegmental area	UBERON:0002691	84.58	silver quality
pons	UBERON:0000988	84.41	silver quality
oocyte	CL:0000023	84.08	gold quality
inferior vagus X ganglion	UBERON:0005363	83.76	silver quality
tendon of biceps brachii	UBERON:0008188	83.06	gold quality
Brodmann (1909) area 46	UBERON:0006483	82.65	silver quality
globus pallidus	UBERON:0001875	82.61	gold quality
superior vestibular nucleus	UBERON:0007227	82.23	silver quality
pharyngeal mucosa	UBERON:0000355	82.04	gold quality
superior surface of tongue	UBERON:0007371	81.85	gold quality
saphenous vein	UBERON:0007318	81.82	silver quality
middle temporal gyrus	UBERON:0002771	81.71	gold quality
epithelium of nasopharynx	UBERON:0001951	81.54	gold quality
medial globus pallidus	UBERON:0002477	81.42	gold quality
CA1 field of hippocampus	UBERON:0003881	81.31	silver quality
nipple	UBERON:0002030	81.19	silver quality
Brodmann (1909) area 23	UBERON:0013554	80.99	gold quality
renal medulla	UBERON:0000362	80.49	silver quality
cerebellar vermis	UBERON:0004720	80.29	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	80.05	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6379	no	6.68
E-ANND-3	no	4.65

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

183 targeting FBXL18, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-23B-5P	99.98	66.07	587
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-6793-5P	99.97	65.95	758
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-23A-5P	99.94	65.39	468
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-498-3P	99.91	71.27	1114
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-130A-3P	99.90	73.31	1861
HSA-MIR-130B-3P	99.90	73.27	1850
HSA-MIR-301A-3P	99.90	73.15	1839
HSA-MIR-301B-3P	99.90	73.19	1836

Literature-anchored findings (GeneRIF, showing 3)

• Fbxl18 regulates apoptosis by mediating ubiquitin-dependent proteasomal degradation of the pro-apoptotic protein Fbxl7 that may impact cellular processes involved in cell cycle progression. (PMID:25654763)
• Study showed that LRRK2 phosphorylation is required for LRRK2 to bind to Fbxl18, and that this interaction is important for regulating the amount of LRRK2 via ubiquitination of LRRK2 by the SCFFbxl18 ubiquitin ligase and subsequent proteasomal degradation of LRRK2. We also show that LRRK2 can induce caspase 8 mediated cell death and that the degradation of LRRK2 mediated by Fbxl18 can prevent LRRK2-mediated toxicity. (PMID:27890708)
• FBXL18 plays an oncogenic role through promoting lysine 63-linked ubiquitination of Akt in glioma. (PMID:27926990)

Cross-species orthologs

31 orthologs

Organism	Symbol	Gene ID
danio_rerio	fbxl18	ENSDARG00000007443
mus_musculus	Fbxl18	ENSMUSG00000066640
rattus_norvegicus	Fbxl18	ENSRNOG00000001117
rattus_norvegicus	Fbxl18l1	ENSRNOG00000062659
drosophila_melanogaster	CG15056	FBGN0030918
drosophila_melanogaster	CG8272	FBGN0033337
drosophila_melanogaster	CG9003	FBGN0033639
drosophila_melanogaster	Skp2	FBGN0037236
drosophila_melanogaster	CG14891	FBGN0038445
drosophila_melanogaster	CG5003	FBGN0039554
drosophila_melanogaster	FipoQ	FBGN0039667
caenorhabditis_elegans		WBGENE00007206
caenorhabditis_elegans		WBGENE00007208
caenorhabditis_elegans		WBGENE00007887
caenorhabditis_elegans		WBGENE00008177
caenorhabditis_elegans		WBGENE00009689
caenorhabditis_elegans	gadr-6	WBGENE00009823
caenorhabditis_elegans		WBGENE00010365
caenorhabditis_elegans	K05C4.9	WBGENE00010585
caenorhabditis_elegans		WBGENE00012655
caenorhabditis_elegans		WBGENE00015350
caenorhabditis_elegans		WBGENE00018561
caenorhabditis_elegans		WBGENE00018613
caenorhabditis_elegans		WBGENE00018766
caenorhabditis_elegans		WBGENE00019239
caenorhabditis_elegans		WBGENE00020884
caenorhabditis_elegans		WBGENE00021053
caenorhabditis_elegans		WBGENE00021180
caenorhabditis_elegans	zeel-1	WBGENE00021463
caenorhabditis_elegans		WBGENE00044459
caenorhabditis_elegans	gadr-5	WBGENE00045058

Paralogs (15): FBXL3 (ENSG00000005812), FBXL19 (ENSG00000099364), FBXL15 (ENSG00000107872), FBXL20 (ENSG00000108306), FBXL4 (ENSG00000112234), FBXL5 (ENSG00000118564), FBXL16 (ENSG00000127585), SKP2 (ENSG00000145604), FBXL17 (ENSG00000145743), FBXL2 (ENSG00000153558), FBXL13 (ENSG00000161040), FBXL14 (ENSG00000171823), FBXL6 (ENSG00000182325), FBXL7 (ENSG00000183580), FBXL22 (ENSG00000197361)

Protein

Protein identifiers

F-box/LRR-repeat protein 18 — Q96ME1 (reviewed: Q96ME1)

Alternative names: F-box and leucine-rich repeat protein 18

All UniProt accessions (2): Q96ME1, A0A994ENR3

UniProt curated annotations — full annotation on UniProt →

Function. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Subunit / interactions. Directly interacts with SKP1 and CUL1.

Isoforms (5)

UniProt ID	Names	Canonical?
Q96ME1-4	4	yes
Q96ME1-1	1
Q96ME1-2	2
Q96ME1-3	3
Q96ME1-5	5

RefSeq proteins (6): NP_001308142, NP_001350370, NP_001350371, NP_001354709, NP_001354710, NP_079239* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001810	F-box_dom	Domain
IPR032675	LRR_dom_sf	Homologous_superfamily
IPR036047	F-box-like_dom_sf	Homologous_superfamily
IPR045627	FBXL18_LRR	Domain
IPR047948	FBXL18_F-box	Domain

Pfam: PF12937, PF19729

UniProt features (27 total): repeat 12, splice variant 6, sequence conflict 4, sequence variant 3, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96ME1-F1	87.44	0.72

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8951664	Neddylation
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation

MSigDB gene sets: 111 (showing top): RNGTGGGC_UNKNOWN, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION, REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, chr7p22, GATA1_04, GATA1_03, MAF_Q6, GOBP_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS, GOBP_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS, NIKOLSKY_BREAST_CANCER_7P22_AMPLICON, GOBP_PROTEIN_CATABOLIC_PROCESS, GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN

GO Biological Process (1): SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
G2/M Transition	1
Post-translational protein modification	1
Class I MHC mediated antigen processing & presentation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
proteasome-mediated ubiquitin-dependent protein catabolic process	1
binding	1
cytoplasm	1
cellular anatomical structure	1

Protein interactions and networks

STRING

578 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FBXL18	SKP1	P34991	834
FBXL18	CUL1	Q13616	729
FBXL18	RBX1	P62877	614
FBXL18	FBXL7	Q9UJT9	495
FBXL18	FBXL14	Q8N1E6	456
FBXL18	RNF216	Q9NWF9	420
FBXL18	FBXO21	O94952	385
FBXL18	FBXL2	Q9UKC9	383
FBXL18	FBXL6	Q8N531	374
FBXL18	FBXL22	Q6P050	374
FBXL18	FBXO9	Q9UK97	345
FBXL18	FBXL20	Q96IG2	337
FBXL18	FBXO45	P0C2W1	326
FBXL18	FBXL12	Q9NXK8	313
FBXL18	FBXO7	Q9Y3I1	310

IntAct

33 interactions, top by confidence:

A	B	Type	Score
SKP1	MYCBP2	psi-mi:“MI:0914”(association)	0.640
CUL1	FBXO21	psi-mi:“MI:0914”(association)	0.600
FBXL18	WWP2	psi-mi:“MI:0915”(physical association)	0.550
SKP2	DPYSL4	psi-mi:“MI:0914”(association)	0.530
MAGEA1	MAGEB3	psi-mi:“MI:0914”(association)	0.530
FBXL16	UBB	psi-mi:“MI:0914”(association)	0.530
IRGC	RAP1GDS1	psi-mi:“MI:0914”(association)	0.530
FBXL18	DHRS2	psi-mi:“MI:0915”(physical association)	0.400
FBXL18	HSP90AB1	psi-mi:“MI:0915”(physical association)	0.400
FBXL18	E7	psi-mi:“MI:0915”(physical association)	0.370
FBXL18	WWP2	psi-mi:“MI:0915”(physical association)	0.370
CUL1	LGALS8	psi-mi:“MI:0914”(association)	0.350
COPS5	FBLL1	psi-mi:“MI:0914”(association)	0.350
COPS6	DDX3X	psi-mi:“MI:0914”(association)	0.350
DUSP16	MEIOC	psi-mi:“MI:0914”(association)	0.350
LYPD4	PIK3C2A	psi-mi:“MI:0914”(association)	0.350
SKP1	BHLHE40	psi-mi:“MI:0914”(association)	0.350
TTC9C	PLD2	psi-mi:“MI:0914”(association)	0.350
TBL1Y	HDAC3	psi-mi:“MI:0914”(association)	0.350
RBX1	OBSL1	psi-mi:“MI:0914”(association)	0.350
MOCS3	HSPA8	psi-mi:“MI:0914”(association)	0.350
ATG7	IFT56	psi-mi:“MI:0914”(association)	0.350
SKP1	RNASET2	psi-mi:“MI:0914”(association)	0.350
MAGEA1	ANKRD17	psi-mi:“MI:0914”(association)	0.350
SKP2	ZNF195	psi-mi:“MI:0914”(association)	0.350

BioGRID (86): FBXL18 (Two-hybrid), FBXL18 (Two-hybrid), FBXL18 (Two-hybrid), FBXL18 (Two-hybrid), FBXL18 (Two-hybrid), FBXL18 (Two-hybrid), FBXL18 (Two-hybrid), FBXL18 (Two-hybrid), FBXL18 (Two-hybrid), FBXL18 (Two-hybrid), FBXL18 (Two-hybrid), FBXL18 (Two-hybrid), FBXL18 (Two-hybrid), FBXL18 (Two-hybrid), FBXL18 (Two-hybrid)

ESM2 similar proteins: A1A5X2, A2RT62, A3KMV1, A4IIK1, B3FL73, F4HX15, P0C192, P0C5J9, P0CC10, Q09299, Q17R01, Q2T9W8, Q32KX5, Q32PG9, Q38SD2, Q3TX51, Q3UHC2, Q3V1N1, Q3ZBA7, Q4G017, Q570C0, Q5BJ29, Q5MJ12, Q65XV2, Q6GLE8, Q6P7W2, Q80TM9, Q86V97, Q86X40, Q8BFZ4, Q8BID8, Q8C4V4, Q8N1E6, Q8N461, Q8TBC3, Q8W104, Q8WVZ9, Q96ME1, Q9EPX5, Q9LW29

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
FBXL18	“down-regulates quantity by destabilization”	ERCC3	binding
FBXL18	“down-regulates quantity by destabilization”	FBXL7	binding
FBXL18	“up-regulates activity”	“Cullin 1-RBX1-Skp1”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 42 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
NOTCH1 Intracellular Domain Regulates Transcription	5	42.5×	9e-06
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	5	42.5×	9e-06
Constitutive Signaling by NOTCH1 PEST Domain Mutants	5	35.2×	1e-05
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	5	35.2×	1e-05
Regulation of RUNX2 expression and activity	5	32.4×	2e-05
Orc1 removal from chromatin	5	31.9×	2e-05
Neddylation	10	16.9×	3e-08
Antigen processing: Ubiquitination & Proteasome degradation	8	10.6×	2e-05

GO biological processes:

GO term	Partners	Fold	FDR
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	5	48.0×	2e-05
protein K48-linked ubiquitination	5	21.6×	5e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

113 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	92
Likely benign	5
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1528 predictions. Top by Δscore:

Variant	Effect	Δscore
7:5481930:AG:A	acceptor_gain	1.0000
7:5481932:C:CC	acceptor_gain	1.0000
7:5481938:C:CT	acceptor_gain	1.0000
7:5491226:CTCA:C	donor_loss	1.0000
7:5491227:TCAC:T	donor_loss	1.0000
7:5491228:CACCT:C	donor_loss	1.0000
7:5491229:A:AC	donor_gain	1.0000
7:5491230:C:CC	donor_gain	1.0000
7:5491230:C:CT	donor_loss	1.0000
7:5491230:CCTG:C	donor_gain	1.0000
7:5491445:CCAGC:C	acceptor_gain	1.0000
7:5491446:CAGC:C	acceptor_gain	1.0000
7:5491446:CAGCC:C	acceptor_gain	1.0000
7:5491447:AGC:A	acceptor_gain	1.0000
7:5491447:AGCC:A	acceptor_loss	1.0000
7:5491448:GC:G	acceptor_gain	1.0000
7:5491448:GCCT:G	acceptor_loss	1.0000
7:5491449:CC:C	acceptor_gain	1.0000
7:5491450:C:CC	acceptor_gain	1.0000
7:5491451:T:G	acceptor_loss	1.0000
7:5502027:CTCGC:C	acceptor_gain	1.0000
7:5502028:TCGC:T	acceptor_gain	1.0000
7:5502029:CGCC:C	acceptor_gain	1.0000
7:5502032:CTGC:C	acceptor_loss	1.0000
7:5502046:CAGGG:C	acceptor_gain	1.0000
7:5505407:CTCA:C	donor_loss	1.0000
7:5505408:TCACC:T	donor_loss	1.0000
7:5505409:CACCT:C	donor_loss	1.0000
7:5505410:A:AC	donor_gain	1.0000
7:5505410:A:T	donor_loss	1.0000

AlphaMissense

4668 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000003585 (7:5493205 C>T), RS1000004388 (7:5464128 G>A), RS1000013631 (7:5472624 G>A), RS1000060219 (7:5483994 G>A), RS1000098776 (7:5463972 C>T), RS1000168022 (7:5468174 G>A), RS1000178261 (7:5497452 T>C), RS1000209760 (7:5455713 T>A), RS1000348757 (7:5471974 C>T), RS1000374751 (7:5507690 G>A), RS1000414862 (7:5476811 C>G,T), RS1000428663 (7:5507883 C>T), RS1000442709 (7:5513765 C>A), RS1000458279 (7:5493421 G>A,C,T), RS1000473064 (7:5502958 C>T)

Disease associations

OMIM: gene MIM:609084 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST002183_6	Relative hand skill in reading disability	4.000000e-06
GCST003139_17	Glomerular filtration rate in chronic kidney disease	4.000000e-06
GCST006284_14	Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease	2.000000e-06
GCST006284_5	Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease	7.000000e-09
GCST90002380_41	Basophil percentage of white cells	1.000000e-11
GCST90002385_177	High light scatter reticulocyte count	8.000000e-12
GCST90002394_183	Monocyte percentage of white cells	4.000000e-13
GCST90002395_680	Mean platelet volume	1.000000e-09

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0009902	handedness
EFO:0006899	PCSK9 protein measurement
EFO:0007992	basophil percentage of leukocytes
EFO:0007986	reticulocyte count
EFO:0007989	monocyte percentage of leukocytes

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, increases expression, increases methylation	3
sodium arsenite	increases expression	2
Benzo(a)pyrene	affects methylation	2
aristolochic acid I	increases expression	1
dicrotophos	increases expression	1
2,4,6-tribromophenol	decreases expression	1
bisphenol A	affects cotreatment, decreases methylation	1
titanium dioxide	decreases methylation	1
decabromobiphenyl ether	decreases expression	1
trichostatin A	affects expression	1
afimoxifene	decreases expression, decreases reaction	1
tetrabromobisphenol A	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Air Pollutants	affects expression, increases abundance	1
Arsenic	affects methylation	1
Cisplatin	decreases expression	1
Estrogens	decreases expression, decreases reaction	1
Methyl Methanesulfonate	increases expression	1
Ozone	affects expression, increases abundance	1
Phthalic Acids	decreases methylation	1
Plant Extracts	decreases expression, affects cotreatment	1
Rotenone	decreases expression	1
Thiram	increases expression	1
Urethane	increases expression	1
Cyclosporine	decreases expression	1
Cadmium Chloride	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.