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FBXO24

gene
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Also known as FBX24

Summary

FBXO24 (F-box protein 24, HGNC:13595) is a protein-coding gene on chromosome 7q22.1, encoding F-box only protein 24 (O75426). Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 26261 — RefSeq curated summary.

At a glance

  • GWAS associations: 3
  • Clinical variants (ClinVar): 103 total
  • MANE Select transcript: NM_033506

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:13595
Approved symbolFBXO24
NameF-box protein 24
Location7q22.1
Locus typegene with protein product
StatusApproved
AliasesFBX24
Ensembl geneENSG00000106336
Ensembl biotypeprotein_coding
OMIM609097
Entrez26261

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 8 protein_coding, 1 retained_intron, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000241071, ENST00000427939, ENST00000461079, ENST00000465843, ENST00000466053, ENST00000468962, ENST00000474649, ENST00000488079, ENST00000498195, ENST00000883034, ENST00000883035

RefSeq mRNA: 3 — MANE Select: NM_033506 NM_001163499, NM_012172, NM_033506

CCDS: CCDS55138, CCDS5698, CCDS5699

Canonical transcript exons

ENST00000241071 — 10 exons

ExonStartEnd
ENSE00000710697100592783100593017
ENSE00001955396100586328100586664
ENSE00003545551100594383100594541
ENSE00003553701100600534100601117
ENSE00003567423100595575100595706
ENSE00003597619100589977100590075
ENSE00003634472100591667100591902
ENSE00003634512100600031100600201
ENSE00003690037100595102100595223
ENSE00003790196100590174100590357

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 95.63.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1244 / max 64.9562, expressed in 21 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
800090.081318
800100.04315

Top tissues by expression

266 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
left testisUBERON:000453395.63gold quality
right testisUBERON:000453495.44gold quality
testisUBERON:000047392.64gold quality
spermCL:000001989.53gold quality
male germ cellCL:000001587.57gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099184.57gold quality
adult organismUBERON:000702384.46gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047378.15gold quality
sural nerveUBERON:001548870.74gold quality
buccal mucosa cellCL:000233669.63gold quality
granulocyteCL:000009467.56gold quality
skeletal muscle tissue of rectus abdominisUBERON:000451167.12gold quality
heart right ventricleUBERON:000208067.05gold quality
stromal cell of endometriumCL:000225567.03gold quality
tendon of biceps brachiiUBERON:000818866.89gold quality
metanephros cortexUBERON:001053366.67gold quality
right uterine tubeUBERON:000130266.66gold quality
ectocervixUBERON:001224966.51gold quality
endocervixUBERON:000045866.31gold quality
right ovaryUBERON:000211866.05gold quality
left ovaryUBERON:000211966.04gold quality
body of uterusUBERON:000985365.70gold quality
right lobe of liverUBERON:000111464.74gold quality
olfactory segment of nasal mucosaUBERON:000538664.26gold quality
bloodUBERON:000017864.10gold quality
secondary oocyteCL:000065564.09gold quality
left ventricle myocardiumUBERON:000656664.05gold quality
ovaryUBERON:000099263.99gold quality
myocardiumUBERON:000234963.79gold quality
vena cavaUBERON:000408763.79gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-ANND-3no2.20

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

8 targeting FBXO24, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-3912-5P99.9566.11925
HSA-MIR-4762-5P99.5768.541424
HSA-MIR-7151-5P99.3767.82613
HSA-MIR-939-3P98.9765.072347
HSA-MIR-6884-3P98.0565.32750
HSA-MIR-7113-5P97.8867.331735
HSA-MIR-444897.0466.22752
HSA-MIR-6772-3P97.0465.89784

Literature-anchored findings (GeneRIF, showing 4)

  • SCF-FBXO24 regulates cell proliferation by mediating ubiquitination and degradation of PRMT6. (PMID:32828318)
  • FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting LSD1 for Ubiquitination. (PMID:37540490)
  • FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility. (PMID:38470475)
  • FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration. (PMID:38735474)

Cross-species orthologs

2 orthologs

OrganismSymbolGene ID
mus_musculusFbxo24ENSMUSG00000089984
rattus_norvegicusFbxo24ENSRNOG00000024922

Paralogs (1): MYCBP2 (ENSG00000005810)

Protein

Protein identifiers

F-box only protein 24 — O75426 (reviewed: O75426)

All UniProt accessions (5): O75426, A4D2D3, C9J4S8, C9K0U2, F8WC52

UniProt curated annotations — full annotation on UniProt →

Function. Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Specifically recognizes the deacetylated form of nucleoside diphosphate kinase A/NME1 and targets it for ubiquitin-mediated degradation. Functions as a key regulator of cell proliferation by targeting PRMT6 for ubiquitination and proteasomal degradation, leading to cell cycle inhibition. Also mediates ‘Lys-6’-linked polyubiquitination of the mitochondrial S-adenosylmethionine transporter SLC25A26, targeting it for degradation and thereby maintaining mitochondrial function during spermiogenesis. Promotes ubiquitination and degradation of mitochondrial aspartyl-tRNA synthetase DARS2, contributing to immunosuppressive activity. In the nucleus, targets FOXK2 for ubiquitin-mediated degradation, a process that critically modulates mitochondrial respiration and cellular bioenergetics in lung epithelial cells.

Subunit / interactions. Directly interacts with SKP1 and CUL1. Interacts with NME1. Interacts with PRMT6. Interacts with DARS2. Interacts with FOXK2. Interacts with RELA.

Subcellular location. Mitochondrion. Nucleus.

Induction. By bacterial infection.

Isoforms (4)

UniProt IDNamesCanonical?
O75426-11yes
O75426-22
O75426-33
O75426-44

RefSeq proteins (3): NP_001156971, NP_036304, NP_277041* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR000408Reg_chr_condensRepeat
IPR001810F-box_domDomain
IPR009091RCC1/BLIP-IIHomologous_superfamily
IPR036047F-box-like_dom_sfHomologous_superfamily
IPR052866F-box_protein_24Family

Pfam: PF00415, PF12937

UniProt features (9 total): splice variant 5, chain 1, domain 1, repeat 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-O75426-F177.360.33

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 145 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, GOBP_SINGLE_FERTILIZATION, AREB6_03, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GCAAGGA_MIR502, AREB6_01, AP4_Q6, TGACCTY_ERR1_Q2, GOBP_MALE_GAMETE_GENERATION, CAGCTG_AP4_Q5, CAGCAGG_MIR370, GOBP_CILIUM_ORGANIZATION, BACH2_01, TGIF_01, GOBP_RNA_SPLICING

GO Biological Process (11): mRNA splicing, via spliceosome (GO:0000398), chromatin organization (GO:0006325), mitochondrion organization (GO:0007005), spermatogenesis (GO:0007283), single fertilization (GO:0007338), protein ubiquitination (GO:0016567), SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146), piRNA processing (GO:0034587), axoneme assembly (GO:0035082), protein catabolic process (GO:0030163), cilium organization (GO:0044782)

GO Molecular Function (3): ubiquitin-protein transferase activity (GO:0004842), ubiquitin-like ligase-substrate adaptor activity (GO:1990756), protein binding (GO:0005515)

GO Cellular Component (4): ubiquitin ligase complex (GO:0000151), nucleus (GO:0005634), cytoplasm (GO:0005737), SCF ubiquitin ligase complex (GO:0019005)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
organelle organization2
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile1
mRNA processing1
cellular component organization1
developmental process involved in reproduction1
male gamete generation1
fertilization1
protein modification by small protein conjugation1
proteasome-mediated ubiquitin-dependent protein catabolic process1
regulatory ncRNA processing1
microtubule bundle formation1
cellular component assembly1
cilium assembly1
macromolecule catabolic process1
protein metabolic process1
plasma membrane bounded cell projection organization1
ubiquitin-like protein transferase activity1
enzyme-substrate adaptor activity1
binding1
intracellular protein-containing complex1
transferase complex1
intracellular membrane-bounded organelle1
intracellular anatomical structure1
cellular anatomical structure1
cullin-RING ubiquitin ligase complex1

Protein interactions and networks

STRING

490 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
FBXO24RCC1P18754675
FBXO24NUDCD2Q8WVJ2589
FBXO24CUL1Q13616582
FBXO24SKP1P34991580
FBXO24FBXL12Q9NXK8521
FBXO24NUDCD3Q8IVD9456
FBXO24MAP3K6O95382440
FBXO24FBXO28Q9NVF7440
FBXO24DOT1LQ8TEK3410
FBXO24CASKIN2Q8WXE0407
FBXO24PDRG1Q9NUG6366
FBXO24RPL17P18621364
FBXO24INSRP06213355
FBXO24MRPL12P52815351
FBXO24TEX29Q8N6K0348
FBXO24CTNNA1P35221348

IntAct

22 interactions, top by confidence:

ABTypeScore
NUDCD2FBXO24psi-mi:“MI:0915”(physical association)0.620
HSP90AB1FBXO24psi-mi:“MI:0915”(physical association)0.560
FBXO24HSP90AB1psi-mi:“MI:0914”(association)0.560
FBXO24PRMT6psi-mi:“MI:0915”(physical association)0.400
Hacd3FBXO24psi-mi:“MI:0915”(physical association)0.400
FBXO24HSP90AB1psi-mi:“MI:0915”(physical association)0.400
FBXO24psi-mi:“MI:0915”(physical association)0.400
FBXO24HSF2psi-mi:“MI:0915”(physical association)0.400
FBXO24NUDCpsi-mi:“MI:0915”(physical association)0.400
FBXO24NUDCD3psi-mi:“MI:0915”(physical association)0.400
FBXO24HSP90AA1psi-mi:“MI:0915”(physical association)0.400
FKBPLFBXO24psi-mi:“MI:0915”(physical association)0.400
STUB1FBXO24psi-mi:“MI:0915”(physical association)0.400
CACYBPFBXO24psi-mi:“MI:0915”(physical association)0.400
FBXO24PTGES3psi-mi:“MI:0915”(physical association)0.400
FBXO24AARSD1psi-mi:“MI:0915”(physical association)0.400
FBXO24PPP5Cpsi-mi:“MI:0915”(physical association)0.400
FBXO24psi-mi:“MI:0915”(physical association)0.400
FBXO24PSME3psi-mi:“MI:0914”(association)0.350

BioGRID (24): FBXO24 (Biochemical Activity), NME1 (Affinity Capture-Western), SKP1 (Affinity Capture-Western), CUL1 (Affinity Capture-Western), NME1 (Reconstituted Complex), PRMT6 (Affinity Capture-Western), FBXO24 (Affinity Capture-Western), FBXO24 (Affinity Capture-RNA), FAM192A (Affinity Capture-MS), PSME3 (Affinity Capture-MS), NUDCD2 (Affinity Capture-MS), FBXO24 (Affinity Capture-MS), FBXO24 (Affinity Capture-MS), FBXO24 (Affinity Capture-Western), KDM1A (Affinity Capture-Western)

ESM2 similar proteins: A0A2R8Y7D0, A3KMV1, A6NDN8, B9EHT4, D3YWQ0, F1MAB7, O23702, O54788, O75426, O76075, P04413, P0C5J9, P49897, P55073, Q1LZC5, Q28969, Q2T9Z2, Q2VPJ9, Q39491, Q3MHJ7, Q3TGW2, Q4R327, Q57VU6, Q58CZ0, Q5BIR3, Q5I3B1, Q5R4R7, Q5R686, Q5SPX3, Q5XI74, Q6DN07, Q6NXT1, Q6P7W2, Q6QN11, Q6X4W1, Q7L9B9, Q7TPD7, Q80TL4, Q8K485, Q8TBC3

Diamond homologs: O75426, Q4R327, Q52KW8, Q8BK67, Q8IS20, Q9D417, Q9P258, Q0D2D2, Q15751, F1RD40, O75592, P0C5Y8, P52499, Q15034, Q54VW7, Q5BIW4, Q5GLZ8, Q6NRS1, Q6NYE2, Q6PAV2, Q7TPH6, Q920R0, Q947D2, Q96Q42, Q9CYF5, Q9UII4

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 15 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO termPartnersFoldFDR
protein folding644.3×3e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

103 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance85
Likely benign4
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1467 predictions. Top by Δscore:

VariantEffectΔscore
7:100585876:CTCA:Cdonor_loss1.0000
7:100585879:A:ACdonor_gain1.0000
7:100585879:A:Cdonor_loss1.0000
7:100585879:ACCAG:Adonor_gain1.0000
7:100585880:C:CCdonor_gain1.0000
7:100585880:CCAG:Cdonor_gain1.0000
7:100585880:CCAGC:Cdonor_gain1.0000
7:100591857:G:GTdonor_gain1.0000
7:100591899:GGAT:Gdonor_gain1.0000
7:100591900:G:GTdonor_gain1.0000
7:100591900:GAT:Gdonor_gain1.0000
7:100591902:TG:Tdonor_loss1.0000
7:100591903:G:GGdonor_gain1.0000
7:100594381:A:AGacceptor_gain1.0000
7:100594382:G:GGacceptor_gain1.0000
7:100594382:GA:Gacceptor_gain1.0000
7:100594540:AGG:Adonor_loss1.0000
7:100594541:GG:Gdonor_loss1.0000
7:100594542:G:GAdonor_loss1.0000
7:100594543:T:Gdonor_loss1.0000
7:100600170:G:Tdonor_gain1.0000
7:100585879:AC:Adonor_gain0.9900
7:100585880:CC:Cdonor_gain0.9900
7:100585880:CCA:Cdonor_gain0.9900
7:100585883:G:Adonor_gain0.9900
7:100590246:G:GTdonor_gain0.9900
7:100590335:G:GTdonor_gain0.9900
7:100591665:A:AGacceptor_gain0.9900
7:100591665:AGA:Aacceptor_loss0.9900
7:100591666:G:GCacceptor_gain0.9900

AlphaMissense

3763 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
7:100591793:A:TD150V0.999
7:100592895:T:AV224D0.999
7:100592930:T:CF236L0.999
7:100592932:C:AF236L0.999
7:100592932:C:GF236L0.999
7:100595651:A:TN384I0.999
7:100595652:C:AN384K0.999
7:100595652:C:GN384K0.999
7:100595660:G:AG387E0.999
7:100595669:G:AG390E0.999
7:100592828:T:GY202D0.998
7:100592832:T:AV203D0.998
7:100592903:T:GY227D0.998
7:100592942:T:CF240L0.998
7:100592944:C:AF240L0.998
7:100592944:C:GF240L0.998
7:100595617:G:TD373Y0.998
7:100595618:A:TD373V0.998
7:100595645:G:TG382V0.998
7:100595659:G:TG387W0.998
7:100595660:G:TG387V0.998
7:100595668:G:AG390R0.998
7:100595668:G:CG390R0.998
7:100600125:G:AG434D0.998
7:100600131:G:AG436D0.998
7:100600152:T:CL443P0.998
7:100591792:G:CD150H0.997
7:100591792:G:TD150Y0.997
7:100591808:T:AL155H0.997
7:100592826:T:CL201P0.997

dbSNP variants (sampled 300 via entrez): RS1000083112 (7:100587590 A>C,G), RS1000253922 (7:100590493 G>A), RS1000303269 (7:100590720 C>T), RS1000601810 (7:100597616 A>G), RS1000870684 (7:100584604 G>T), RS1000880483 (7:100592969 A>C,G), RS1000931548 (7:100598609 G>A), RS1001198639 (7:100599344 C>T), RS1001403486 (7:100585632 TAAAGAGAA>T), RS1001434217 (7:100591741 G>A,C), RS1001651244 (7:100599868 C>T), RS1002217176 (7:100598880 G>A), RS1002248734 (7:100584752 G>C), RS1002256134 (7:100593515 C>A), RS1002307073 (7:100593963 G>A,T)

Disease associations

OMIM: gene MIM:609097 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

StudyTraitp-value
GCST010702_48Subcortical volume (MOSTest)6.000000e-10
GCST010703_289Brain morphology (MOSTest)6.000000e-15
GCST90002397_306Mean spheric corpuscular volume1.000000e-14

EFO canonical traits (1, from GWAS)

EFO IDTrait name
EFO:0004346neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

ChemicalActions (top 5)PubMed papers
propionaldehydedecreases expression1
bisphenol Adecreases expression1
2,4,5,2’,4’,5’-hexachlorobiphenyldecreases expression1
3,4,5,3’,4’-pentachlorobiphenyldecreases expression1
perfluorooctanoic aciddecreases expression1
S-(1,2-dichlorovinyl)cysteineaffects response to substance, increases expression1
abrinedecreases expression1
2,2’,4,4’-tetrabromodiphenyl etherdecreases expression1
bisphenol Saffects cotreatment, decreases methylation1
Fulvestrantdecreases methylation, affects cotreatment1
Acetaminophenincreases expression1
Dichlorodiphenyl Dichloroethylenedecreases expression1
Endosulfanincreases expression1
Estradioldecreases expression1
Lipopolysaccharidesaffects response to substance, increases expression1
Smokedecreases expression1
Tobacco Smoke Pollutiondecreases expression1
Triclosanincreases expression1
Urethaneincreases expression1
Valproic Acidincreases methylation1
Cyclosporinedecreases expression1
Aflatoxin B1decreases expression1
Okadaic Aciddecreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 74

This page pulls from 74 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot