FBXO3

Summary

FBXO3 (F-box protein 3, HGNC:13582) is a protein-coding gene on chromosome 11p13, encoding F-box only protein 3 (Q9UK99). Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3’ end.

Source: NCBI Gene 26273 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 55 total
• MANE Select transcript: NM_012175

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13582
Approved symbol	FBXO3
Name	F-box protein 3
Location	11p13
Locus type	gene with protein product
Status	Approved
Aliases	FBX3, FBA
Ensembl gene	ENSG00000110429
Ensembl biotype	protein_coding
OMIM	609089
Entrez	26273

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 9 protein_coding, 3 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000265651, ENST00000448981, ENST00000526785, ENST00000526952, ENST00000527772, ENST00000529137, ENST00000530013, ENST00000530401, ENST00000531080, ENST00000532057, ENST00000532927, ENST00000533103, ENST00000534136, ENST00000873667, ENST00000958856

RefSeq mRNA: 2 — MANE Select: NM_012175 NM_012175, NM_033406

CCDS: CCDS44566, CCDS7887

Canonical transcript exons

ENST00000265651 — 11 exons

Exon	Start	End
ENSE00002153872	33774394	33774520
ENSE00002163474	33740944	33742084
ENSE00003464155	33768851	33769014
ENSE00003499738	33755771	33755975
ENSE00003530684	33770741	33770830
ENSE00003568026	33754455	33754500
ENSE00003589083	33748777	33748892
ENSE00003610864	33747130	33747320
ENSE00003615313	33758487	33758601
ENSE00003646248	33751523	33751607
ENSE00003661823	33750539	33750661

Expression profiles

Bgee: expression breadth ubiquitous, 290 present calls, max score 98.10.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 16.4290 / max 132.9588, expressed in 1777 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
119223	16.3384	1777
119220	0.0906	17

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	98.10	gold quality
biceps brachii	UBERON:0001507	97.67	gold quality
amniotic fluid	UBERON:0000173	97.26	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	97.10	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.25	gold quality
triceps brachii	UBERON:0001509	94.65	gold quality
diaphragm	UBERON:0001103	94.64	gold quality
body of tongue	UBERON:0011876	94.45	gold quality
calcaneal tendon	UBERON:0003701	94.41	gold quality
choroid plexus epithelium	UBERON:0003911	94.39	gold quality
islet of Langerhans	UBERON:0000006	94.36	gold quality
esophagus squamous epithelium	UBERON:0006920	94.18	gold quality
endothelial cell	CL:0000115	93.67	gold quality
heart right ventricle	UBERON:0002080	93.57	gold quality
cortical plate	UBERON:0005343	93.55	gold quality
vastus lateralis	UBERON:0001379	93.25	gold quality
muscle of leg	UBERON:0001383	93.13	gold quality
palpebral conjunctiva	UBERON:0001812	93.03	gold quality
metanephric glomerulus	UBERON:0004736	92.88	gold quality
muscle organ	UBERON:0001630	92.83	gold quality
skeletal muscle organ	UBERON:0014892	92.83	gold quality
renal glomerulus	UBERON:0000074	92.75	gold quality
oral cavity	UBERON:0000167	92.66	gold quality
gastrocnemius	UBERON:0001388	92.59	gold quality
adrenal tissue	UBERON:0018303	92.54	gold quality
eye	UBERON:0000970	92.36	gold quality
skeletal muscle tissue	UBERON:0001134	92.29	gold quality
epithelium of esophagus	UBERON:0001976	92.18	gold quality
epithelium of nasopharynx	UBERON:0001951	91.87	gold quality
nasopharynx	UBERON:0001728	91.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

69 targeting FBXO3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-146A-5P	99.96	68.93	988
HSA-MIR-146B-5P	99.96	69.13	977
HSA-MIR-7153-5P	99.94	68.89	1006
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-219A-5P	99.91	73.36	735
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-8087	99.90	69.55	1351
HSA-MIR-4782-3P	99.88	73.31	735
HSA-MIR-6766-3P	99.88	73.38	732
HSA-MIR-3140-3P	99.88	68.47	2069
HSA-MIR-323A-3P	99.79	70.30	1739
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-4517	99.76	69.19	1867
HSA-MIR-6885-3P	99.75	70.36	3187
HSA-MIR-4719	99.73	72.10	3329
HSA-MIR-4428	99.73	66.41	1733
HSA-MIR-4699-3P	99.71	70.15	3142

Literature-anchored findings (GeneRIF, showing 9)

• Fbx3 formed SCF(Fbx3) ubiquitin ligase and promoted the degradation of HIPK2 and p300 by the ubiquitin-proteasome pathway (PMID:18809579)
• controls TRAF adaptor stability to regulate inflammation (PMID:23542741)
• Virulence factor NSs of rift valley fever virus recruits the FBXO3 to degrade subunit p62 of general transcription factor TFIIH. (PMID:24403578)
• Fbxo3 promotes the proteasomal degradation of Smurf1. Fbxo3 promotes the poly-ubiquitination of Smurf1. (PMID:25721664)
• we report the X-ray structure of the human FBxo3 ApaG domain, residues 278-407, at 2.0 A resolution (PMID:27010866)
• AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity. (PMID:27365398)
• reveal that FBXO46 is a crucial proteasomal regulator of FBXO31 and thereby prevents senescence in normal growth conditions (PMID:30171069)
• FBXO3 potentiates vascular inflammation and atherosclerosis that can be effectively mitigated by a small molecule inhibitor. (PMID:30448480)
• FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis. (PMID:38134227)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	fbxo3	ENSDARG00000029242
mus_musculus	Fbxo3	ENSMUSG00000027180
rattus_norvegicus	Fbxo3	ENSRNOG00000009549

Paralogs (1): POLDIP2 (ENSG00000004142)

Protein

Protein identifiers

F-box only protein 3 — Q9UK99 (reviewed: Q9UK99)

All UniProt accessions (6): Q9UK99, B4E3U2, E9PJM3, E9PL46, G3V1E0, Q49AF1

UniProt curated annotations — full annotation on UniProt →

Function. Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS). The SCF(FBXO3) complex specifically recognizes FBXL2 phosphorylated at ‘Thr-404’ and promotes its ubiquitination. (Microbial infection) Associates with the Rift valley fever virus NSs to form a remodeled E3 ligase that triggers efficient proteasomal degradation of targeted proteins. The filamentous E3 ligase targets the TFIIH complex leading to robust inhibition of antiviral immunity and enhances viral pathogenesis.

Subunit / interactions. Part of a SCF (SKP1-cullin-F-box) protein ligase complex SCF(FBXO3) consisting of FBXO3, SKP1, CUL1 and RBX1. Interacts with PML, interaction is direct and takes place either alone or within the SCF complex. (Microbial infection) Interacts (via ApaG domain) with Rift valley fever virus NSs helical filament; this interaction forms a filamentous E3 which mediates degradation of TFIIH complex through interaction with GT2H1.

Subcellular location. Nucleus.

Pathway. Protein modification; protein ubiquitination.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9UK99-1	1	yes
Q9UK99-2	2
Q9UK99-3	3

RefSeq proteins (2): NP_036307, NP_208385 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001810	F-box_dom	Domain
IPR007474	ApaG_domain	Domain
IPR018958	Knr4/Smi1-like_dom	Domain
IPR036047	F-box-like_dom_sf	Homologous_superfamily
IPR036767	ApaG_sf	Homologous_superfamily
IPR037883	Knr4/Smi1-like_sf	Homologous_superfamily
IPR052121	F-box_SCF_Substrate_Recog	Family

Pfam: PF04379, PF09346, PF12937

UniProt features (25 total): strand 7, sequence conflict 6, splice variant 3, domain 2, helix 2, chain 1, turn 1, region of interest 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
5HDW	X-RAY DIFFRACTION	2
9KBD	ELECTRON MICROSCOPY	3.7
9KBF	ELECTRON MICROSCOPY	3.74

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UK99-F1	88.38	0.82

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 156 (showing top): BENPORATH_ES_WITH_H3K27ME3, GOBP_INFLAMMATORY_RESPONSE, CHUNG_BLISTER_CYTOTOXICITY_DN, GCM_ZNF198, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GGGTGGRR_PAX4_03, SP1_Q2_01, RODWELL_AGING_KIDNEY_NO_BLOOD_DN, WANG_LMO4_TARGETS_DN, GOBP_REGULATION_OF_RESPONSE_TO_STRESS, GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBP_RESPONSE_TO_LIPID, GCM_SUFU, GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS

GO Biological Process (5): proteolysis (GO:0006508), protein ubiquitination (GO:0016567), SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146), response to lipopolysaccharide (GO:0032496), transcription by RNA polymerase II (GO:0006366)

GO Molecular Function (3): ubiquitin-protein transferase activity (GO:0004842), ubiquitin-like ligase-substrate adaptor activity (GO:1990756), protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), SCF ubiquitin ligase complex (GO:0019005)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
protein metabolic process	1
protein modification by small protein conjugation	1
proteasome-mediated ubiquitin-dependent protein catabolic process	1
response to molecule of bacterial origin	1
response to lipid	1
response to oxygen-containing compound	1
DNA-templated transcription	1
ubiquitin-like protein transferase activity	1
enzyme-substrate adaptor activity	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
cytoplasm	1
cullin-RING ubiquitin ligase complex	1

Protein interactions and networks

STRING

994 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FBXO3	SKP1	P34991	952
FBXO3	CUL1	Q13616	934
FBXO3	KIAA1549L	Q6ZVL6	872
FBXO3	FBXL2	Q9UKC9	723
FBXO3	POLD2	P49005	669
FBXO3	C11orf91	Q3C1V1	604
FBXO3	FBXL15	Q9H469	596
FBXO3	CEACAM1	P13688	585
FBXO3	SAP30	O75446	525
FBXO3	LMO2	P25791	500
FBXO3	FBXL3	Q9UKT7	496
FBXO3	CUL7	Q14999	487
FBXO3	FBXO11	Q86XK2	453
FBXO3	PRIMPOL	Q96LW4	453
FBXO3	RPE	Q96AT9	450

IntAct

56 interactions, top by confidence:

A	B	Type	Score
SKP1	FBXO3	psi-mi:“MI:0915”(physical association)	0.920
FBXO3	SKP1	psi-mi:“MI:0914”(association)	0.920
FBXO3	SKP1	psi-mi:“MI:0915”(physical association)	0.920
FBXO3	CUL1	psi-mi:“MI:0915”(physical association)	0.740
COPS6	RHOBTB1	psi-mi:“MI:0914”(association)	0.730
CUL4A	COPS2	psi-mi:“MI:0914”(association)	0.640
SKP1	MYCBP2	psi-mi:“MI:0914”(association)	0.640
CUL1	FBXO21	psi-mi:“MI:0914”(association)	0.600
tat	PPM1G	psi-mi:“MI:0914”(association)	0.560
FBXO3	tat	psi-mi:“MI:0915”(physical association)	0.560
IGFBP4	CETN3	psi-mi:“MI:0914”(association)	0.530
NOTCH2	ZNF316	psi-mi:“MI:0914”(association)	0.530
SKP1	FBXO3	psi-mi:“MI:0915”(physical association)	0.400
FBXO3	HSP90AB1	psi-mi:“MI:0915”(physical association)	0.400
	FBXO3	psi-mi:“MI:0915”(physical association)	0.370
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
CUL1	LGALS8	psi-mi:“MI:0914”(association)	0.350
COPS5	FBLL1	psi-mi:“MI:0914”(association)	0.350
NEDD8	DDX3X	psi-mi:“MI:0914”(association)	0.350
CUL3	PXDNL	psi-mi:“MI:0914”(association)	0.350
NEDD8	FBXO21	psi-mi:“MI:0914”(association)	0.350
IDS	COCH	psi-mi:“MI:0914”(association)	0.350
TNIP3	RNH1	psi-mi:“MI:0914”(association)	0.350

BioGRID (112): FBXO3 (Affinity Capture-Western), FBXO3 (Affinity Capture-MS), SMURF1 (Reconstituted Complex), SMURF1 (Affinity Capture-Western), FBXO3 (Affinity Capture-Western), SMURF1 (Biochemical Activity), SKP1 (Two-hybrid), FBXO3 (Affinity Capture-MS), FBXO3 (Affinity Capture-MS), FBXO3 (Affinity Capture-MS), FBXO3 (Affinity Capture-Western), AIRE (Affinity Capture-Western), FBXO3 (Affinity Capture-MS), FBXO3 (Affinity Capture-MS), FBXO3 (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2QC33, A0FKG7, A6H7H7, F1N9S8, O95453, P0C0T1, P42694, P50747, P69341, Q0IIH8, Q0VGM9, Q13572, Q28559, Q4R528, Q5BJZ6, Q5F480, Q5R699, Q5RC51, Q5ZIA0, Q5ZIW7, Q640G7, Q6DDJ3, Q6DFV5, Q6DG88, Q6DJB3, Q6GR37, Q6NYU2, Q6PZ02, Q6PZ03, Q6PZ05, Q7T0P6, Q80UY1, Q80YV4, Q811C2, Q8BGE6, Q8BYN3, Q8C9S8, Q8N4J0, Q8VDG3, Q8WYN0

Diamond homologs: A0L065, A1RMU9, A3D187, A3QBA2, A4W6F6, A4Y434, A4Z2J6, A5EA34, A6H7H7, A6U5R0, A6UZ95, A6WK58, A6WVX4, A7HQ48, A7ICI5, A7ZHE3, A7ZW02, A8FRV1, A8G9N9, A8H0V1, A8ILE7, A9L437, A9M7Z1, A9VZN6, B0CJT2, B0RUI4, B0UC46, B1LXV0, B1XC51, B1ZJ42, B2III9, B2S946, B2VGP5, B3PNM4, B3QCE1, B4F2I3, B5ENR7, B5YZ88, B5ZNW9, B6IPQ9

SIGNOR signaling

8 interactions.

A	Effect	B	Mechanism
FBXO3	“down-regulates quantity by destabilization”	HIPK2	binding
FBXO3	“down-regulates quantity by destabilization”	EP300	binding
FBXO3	“up-regulates activity”	“Cullin 1-RBX1-Skp1”	binding
FBXO3	“down-regulates quantity by destabilization”	SMURF1	binding
FBXO3	“down-regulates quantity by destabilization”	SQSTM1	binding
FBXO3	“down-regulates quantity by destabilization”	FBXL2	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 60 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Neddylation	9	10.7×	4e-05

GO biological processes:

GO term	Partners	Fold	FDR
intrinsic apoptotic signaling pathway	5	33.2×	2e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

55 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2032 predictions. Top by Δscore:

Variant	Effect	Δscore
11:33742080:ATTTC:A	acceptor_gain	1.0000
11:33742081:TTTC:T	acceptor_gain	1.0000
11:33742083:TC:T	acceptor_gain	1.0000
11:33742084:CC:C	acceptor_gain	1.0000
11:33742086:T:C	acceptor_gain	1.0000
11:33747234:AT:A	donor_gain	1.0000
11:33747235:T:TA	donor_gain	1.0000
11:33747239:T:TA	donor_gain	1.0000
11:33748772:CATA:C	donor_loss	1.0000
11:33748773:ATAC:A	donor_loss	1.0000
11:33748776:C:CA	donor_loss	1.0000
11:33748776:CCAA:C	donor_gain	1.0000
11:33748779:A:AC	donor_gain	1.0000
11:33748780:C:CC	donor_gain	1.0000
11:33748780:CTA:C	donor_gain	1.0000
11:33750533:TCTCA:T	donor_loss	1.0000
11:33750534:CTCAC:C	donor_loss	1.0000
11:33750535:TCACC:T	donor_loss	1.0000
11:33750536:CACCT:C	donor_loss	1.0000
11:33750537:A:AG	donor_loss	1.0000
11:33750538:C:CA	donor_loss	1.0000
11:33750657:CATAT:C	acceptor_gain	1.0000
11:33750659:TAT:T	acceptor_gain	1.0000
11:33750662:C:CC	acceptor_gain	1.0000
11:33751609:T:C	acceptor_loss	1.0000
11:33758485:A:AC	donor_gain	1.0000
11:33758485:A:T	donor_loss	1.0000
11:33758485:AC:A	donor_gain	1.0000
11:33758486:C:CA	donor_loss	1.0000
11:33758486:C:CC	donor_gain	1.0000

AlphaMissense

3092 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:33747172:G:C	F399L	1.000
11:33747172:G:T	F399L	1.000
11:33747173:A:G	F399S	1.000
11:33747174:A:G	F399L	1.000
11:33747236:C:A	G378V	1.000
11:33747236:C:T	G378E	1.000
11:33747237:C:G	G378R	1.000
11:33747237:C:T	G378R	1.000
11:33747274:G:C	S365R	1.000
11:33747274:G:T	S365R	1.000
11:33747276:T:G	S365R	1.000
11:33748785:C:T	G347E	1.000
11:33748791:C:T	G345E	1.000
11:33748792:C:G	G345R	1.000
11:33748792:C:T	G345R	1.000
11:33748832:C:A	W331C	1.000
11:33748832:C:G	W331C	1.000
11:33748833:C:G	W331S	1.000
11:33748834:A:G	W331R	1.000
11:33748834:A:T	W331R	1.000
11:33748839:C:G	R329P	1.000
11:33748840:G:C	R329G	1.000
11:33748840:G:T	R329S	1.000
11:33748848:A:C	L326W	1.000
11:33748848:A:G	L326S	1.000
11:33750545:C:G	R309P	1.000
11:33750553:G:C	F306L	1.000
11:33750553:G:T	F306L	1.000
11:33750555:A:G	F306L	1.000
11:33750580:G:C	S297R	1.000

dbSNP variants (sampled 300 via entrez): RS1000005304 (11:33769984 T>G), RS1000030172 (11:33775729 C>G), RS1000159511 (11:33762745 AC>A), RS1000302687 (11:33755044 T>C), RS1000386894 (11:33741713 C>T), RS1000432753 (11:33748489 CA>C), RS1000804625 (11:33749674 C>CT), RS1000817270 (11:33747952 G>A), RS1000853467 (11:33741700 A>G), RS1001135004 (11:33762558 A>C), RS1001312825 (11:33763125 C>G), RS1001364879 (11:33755267 T>C), RS1001653188 (11:33762258 G>A), RS1001705556 (11:33762596 G>A), RS1001860740 (11:33755115 A>C)

Disease associations

OMIM: gene MIM:609089 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002097_15	Coronary artery calcification	4.000000e-06
GCST007565_99	Morning person	1.000000e-27
GCST007576_296	Chronotype	1.000000e-27
GCST010136_39	Fruit consumption	1.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004723	coronary artery calcification
EFO:0008328	chronotype measurement
EFO:0008111	diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — E3 ubiquitin ligase components

Most potent curated ligand interactions (1 total), top 1:

Ligand	Action	Affinity	Parameter
BC-1215	Inhibition	5.64	pIC50

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Arsenic	affects expression, decreases expression, increases abundance, affects cotreatment, increases expression	4
Valproic Acid	decreases methylation, increases expression, affects expression, decreases expression	4
bisphenol A	affects cotreatment, increases methylation, increases expression	2
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	2
Air Pollutants	increases oxidation, affects cotreatment, decreases expression, increases abundance	2
Cadmium	increases abundance, increases expression, decreases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, decreases expression	2
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
alpha-pinene	increases oxidation, increases abundance, affects cotreatment, decreases expression	1
sodium arsenate	decreases expression, increases abundance	1
trichostatin A	affects expression	1
beta-lapachone	decreases expression, increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
methacrylaldehyde	affects cotreatment, decreases expression, increases oxidation, increases abundance	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	decreases methylation	1
jinfukang	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Vorinostat	increases expression	1
Leflunomide	decreases expression	1
Acetaminophen	decreases expression	1
Acrolein	affects cotreatment, decreases expression, increases oxidation, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Calcitriol	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E0U7	Ubigene Hep G2 FBXO3 KO	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.