FBXO6

Summary

FBXO6 (F-box protein 6, HGNC:13585) is a protein-coding gene on chromosome 1p36.22, encoding F-box only protein 6 (Q9NRD1). Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.

Source: NCBI Gene 26270 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 63 total
• MANE Select transcript: NM_018438

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13585
Approved symbol	FBXO6
Name	F-box protein 6
Location	1p36.22
Locus type	gene with protein product
Status	Approved
Aliases	FBX6, FBG2, FBS2, Fbx6b
Ensembl gene	ENSG00000116663
Ensembl biotype	protein_coding
OMIM	605647
Entrez	26270

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 10 protein_coding, 1 retained_intron

ENST00000376753, ENST00000449067, ENST00000474239, ENST00000907480, ENST00000907481, ENST00000907482, ENST00000907483, ENST00000907484, ENST00000938498, ENST00000961666, ENST00000961667

RefSeq mRNA: 1 — MANE Select: NM_018438 NM_018438

CCDS: CCDS133

Canonical transcript exons

ENST00000376753 — 6 exons

Exon	Start	End
ENSE00000818922	11671928	11672023
ENSE00000818923	11673277	11673412
ENSE00001816039	11664200	11664255
ENSE00001958879	11673615	11674354
ENSE00003525177	11668656	11668944
ENSE00003678106	11671266	11671392

Expression profiles

Bgee: expression breadth ubiquitous, 210 present calls, max score 92.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.5803 / max 115.5012, expressed in 1636 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
628	5.8035	1561
627	1.3907	448
626	0.8391	236
629	0.5469	280

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	92.25	gold quality
leukocyte	CL:0000738	88.96	gold quality
monocyte	CL:0000576	88.95	gold quality
hindlimb stylopod muscle	UBERON:0004252	87.55	gold quality
gastrocnemius	UBERON:0001388	85.85	gold quality
bronchial epithelial cell	CL:0002328	85.21	gold quality
muscle of leg	UBERON:0001383	85.16	gold quality
blood	UBERON:0000178	83.87	gold quality
right lobe of liver	UBERON:0001114	83.77	gold quality
bronchus	UBERON:0002185	83.39	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.81	gold quality
ileal mucosa	UBERON:0000331	82.58	gold quality
right adrenal gland	UBERON:0001233	82.54	gold quality
right uterine tube	UBERON:0001302	82.46	gold quality
apex of heart	UBERON:0002098	82.28	gold quality
right adrenal gland cortex	UBERON:0035827	82.26	gold quality
pancreatic ductal cell	CL:0002079	82.06	gold quality
vermiform appendix	UBERON:0001154	81.87	gold quality
left adrenal gland	UBERON:0001234	81.83	gold quality
body of pancreas	UBERON:0001150	81.76	gold quality
lower esophagus	UBERON:0013473	81.47	gold quality
lower esophagus muscularis layer	UBERON:0035833	81.45	gold quality
palpebral conjunctiva	UBERON:0001812	81.31	gold quality
left adrenal gland cortex	UBERON:0035825	81.21	gold quality
lower esophagus mucosa	UBERON:0035834	81.04	gold quality
duodenum	UBERON:0002114	81.02	gold quality
spleen	UBERON:0002106	80.74	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	80.55	gold quality
cortical plate	UBERON:0005343	80.41	gold quality
body of stomach	UBERON:0001161	80.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.73

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting FBXO6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-4645-3P	99.76	69.33	993
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-542-3P	99.34	67.58	1270
HSA-MIR-504-3P	99.30	67.18	1745
HSA-MIR-133A-5P	99.28	69.13	941
HSA-MIR-7151-3P	99.04	69.72	2370
HSA-MIR-4724-5P	98.87	67.75	1324
HSA-MIR-4501	98.72	67.19	921
HSA-MIR-6747-3P	97.73	64.84	1596
HSA-MIR-6807-5P	97.51	64.25	1046
HSA-MIR-6879-3P	93.93	64.00	759

Literature-anchored findings (GeneRIF, showing 12)

• Fbs2 is a novel member of F-box protein family that recognizes N-glycans and plays a role in ERAD (PMID:12939278)
• Fbx6-dependent Chk1 degradation contributes to S phase checkpoint termination and that a defect in this mechanism might increase tumor cell resistance to certain anticancer drugs. (PMID:19716789)
• systematical identification of the FBXO6-interacting glycoproteins, critical for clarifying its substrates as well as biological functions. (PMID:22268729)
• Two interacting proteins of human FBXO6 protein have been found using the service in the study. (PMID:22292078)
• It might inhibit cadmium-induced ER stress by functioning as a ubiquitin ligase in the ERAD system, thereby attenuating the cell death induced by subsequent JNK1 activation. (PMID:25374377)
• FBXO6 as a functional E3 ubiquitin ligase for Ero1L that plays a critical role in inhibiting endoplasmic reticulum stress-induced apoptosis. (PMID:27855403)
• Fbxo6 is a novel regulator of mitosis by controlling chromosome separation via interacting with the spindle checkpoint proteins Mad2 and BubR1. (PMID:30526252)
• Fbxo6 confers drug-sensitization to cisplatin via inhibiting the activation of Chk1 in non-small cell lung cancer (PMID:31140586)
• our studies have identified a general but, to our knowledge, previously unrecognized role and a novel noncanonical mechanism of FBXO6 in modulating IFN-I-mediated antiviral immune responses (PMID:31308089)
• FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer. (PMID:33767133)
• The USP18-FBXO6 axis maintains the malignancy of ovarian cancer. (PMID:35063764)
• Structural basis of sugar recognition by SCF[FBS2] ubiquitin ligase involved in NGLY1 deficiency. (PMID:39171510)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Fbxo6	ENSMUSG00000055401
rattus_norvegicus	Fbxo6	ENSRNOG00000009217

Paralogs (5): FBXO2 (ENSG00000116661), FBXO44 (ENSG00000132879), FBXO27 (ENSG00000161243), NCCRP1 (ENSG00000188505), FBXO17 (ENSG00000269190)

Protein

Protein identifiers

F-box only protein 6 — Q9NRD1 (reviewed: Q9NRD1)

Alternative names: F-box protein that recognizes sugar chains 2, F-box/G-domain protein 2

All UniProt accessions (2): Q9NRD1, J3KQ72

UniProt curated annotations — full annotation on UniProt →

Function. Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on ‘Ser-345’), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

Subunit / interactions. Interacts with VCP. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with CHEK1 and CUL1.

Subcellular location. Cytoplasm.

Pathway. Protein modification; protein ubiquitination.

RefSeq proteins (1): NP_060908* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001810	F-box_dom	Domain
IPR007397	F-box-assoc_dom	Domain
IPR008979	Galactose-bd-like_sf	Homologous_superfamily
IPR036047	F-box-like_dom_sf	Homologous_superfamily
IPR039752	F-box_only	Family

Pfam: PF04300, PF12937

UniProt features (21 total): sequence conflict 11, domain 2, modified residue 2, sequence variant 2, chain 1, region of interest 1, compositionally biased region 1, mutagenesis site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NRD1-F1	88.67	0.82

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 258, 284

Mutagenesis-validated functional residues (1):

Position	Phenotype
241–242	abolishes interaction with glycosylated concanavalin-a in vitro.

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis
R-HSA-8951664	Neddylation
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation

MSigDB gene sets: 178 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_UP, GOBP_RESPONSE_TO_NITROGEN_COMPOUND, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION, REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION, GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, GOBP_CELL_CYCLE_PHASE_TRANSITION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS, BEIER_GLIOMA_STEM_CELL_DN, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1, GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE

GO Biological Process (10): DNA damage checkpoint signaling (GO:0000077), DNA repair (GO:0006281), proteolysis (GO:0006508), glycoprotein catabolic process (GO:0006516), response to unfolded protein (GO:0006986), protein ubiquitination (GO:0016567), SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146), ERAD pathway (GO:0036503), ubiquitin-dependent protein catabolic process (GO:0006511), DNA damage response (GO:0006974)

GO Molecular Function (3): carbohydrate binding (GO:0030246), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515)

GO Cellular Component (4): cytoplasm (GO:0005737), cytosol (GO:0005829), SCF ubiquitin ligase complex (GO:0019005), endoplasmic reticulum quality control compartment (GO:0044322)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Chaperonin-mediated protein folding	1
Post-translational protein modification	1
Class I MHC mediated antigen processing & presentation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
binding	2
DNA integrity checkpoint signaling	1
signal transduction in response to DNA damage	1
DNA metabolic process	1
DNA damage response	1
protein metabolic process	1
glycoprotein metabolic process	1
protein catabolic process	1
carbohydrate derivative catabolic process	1
response to topologically incorrect protein	1
protein modification by small protein conjugation	1
proteasome-mediated ubiquitin-dependent protein catabolic process	1
proteasomal protein catabolic process	1
response to endoplasmic reticulum stress	1
response to chemical	1
protein ubiquitination	1
modification-dependent protein catabolic process	1
cellular response to stress	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
intracellular anatomical structure	1
cytoplasm	1
cullin-RING ubiquitin ligase complex	1
endoplasmic reticulum	1

Protein interactions and networks

STRING

964 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FBXO6	SKP1	P34991	880
FBXO6	CUL1	Q13616	845
FBXO6	BTRC	Q9Y297	842
FBXO6	MAD2L2	Q9UI95	687
FBXO6	CCNF	P41002	677
FBXO6	PRKN	O60260	670
FBXO6	FOXI1	Q12951	666
FBXO6	SKP2	Q13309	636
FBXO6	FBXO2	Q9UK22	627
FBXO6	SLC35F6	Q8N357	624
FBXO6	CHEK1	O14757	622
FBXO6	DDB1	Q16531	618
FBXO6	UBQLN4	Q9NRR5	600
FBXO6	OTUD4	Q01804	591
FBXO6	SLC26A4	O43511	548

IntAct

35 interactions, top by confidence:

A	B	Type	Score
EMC2	EMC8	psi-mi:“MI:0914”(association)	0.940
SKP1	FBXO6	psi-mi:“MI:0915”(physical association)	0.840
FBXO6	CUL1	psi-mi:“MI:0915”(physical association)	0.800
EMC7	EMC8	psi-mi:“MI:0914”(association)	0.790
MORF4L1	SIN3B	psi-mi:“MI:0914”(association)	0.730
FBXO6	MAN2B1	psi-mi:“MI:0914”(association)	0.640
POGLUT1	CLGN	psi-mi:“MI:0914”(association)	0.530
LGALS3BP	FBXO6	psi-mi:“MI:0915”(physical association)	0.500
HSP90AB1	FBXO6	psi-mi:“MI:0915”(physical association)	0.400
ORC4	FBXO6	psi-mi:“MI:0915”(physical association)	0.370
FBXO6	GNS	psi-mi:“MI:0914”(association)	0.350
	NBAS	psi-mi:“MI:0914”(association)	0.350
NTRK3	ILVBL	psi-mi:“MI:0914”(association)	0.350
SKP1	RNASET2	psi-mi:“MI:0914”(association)	0.350
SEC11A	MIA3	psi-mi:“MI:0914”(association)	0.350
COPS7B	CPSF4	psi-mi:“MI:0914”(association)	0.350
UXS1	HRAS	psi-mi:“MI:0914”(association)	0.350
EPDR1	DUSP14	psi-mi:“MI:0914”(association)	0.350
FBXO6	TMEM131L	psi-mi:“MI:0914”(association)	0.350
GPC3	PXDNL	psi-mi:“MI:0914”(association)	0.350
MFSD6	EIF3CL	psi-mi:“MI:0914”(association)	0.350
SLC22A14	CLGN	psi-mi:“MI:0914”(association)	0.350
SLC3A1	ILVBL	psi-mi:“MI:0914”(association)	0.350
SLC44A2	CLGN	psi-mi:“MI:0914”(association)	0.350
SLC4A5	ESYT2	psi-mi:“MI:0914”(association)	0.350
env	PLSCR1	psi-mi:“MI:0914”(association)	0.350
SKP1	NDC80	psi-mi:“MI:0914”(association)	0.350

BioGRID (996): UBB (Affinity Capture-MS), COPS2 (Affinity Capture-MS), TOR1B (Affinity Capture-MS), H6PD (Affinity Capture-MS), PRCP (Affinity Capture-MS), POGLUT1 (Affinity Capture-MS), GRN (Affinity Capture-MS), ERO1LB (Affinity Capture-MS), KDELC2 (Affinity Capture-MS), CUL1 (Affinity Capture-MS), POFUT1 (Affinity Capture-MS), NAGLU (Affinity Capture-MS), COPS6 (Affinity Capture-MS), MAN2B1 (Affinity Capture-MS), SGSH (Affinity Capture-MS)

ESM2 similar proteins: A1A5G2, B3DLA6, E1BGQ2, E3SCZ8, O15392, O70201, O88597, O95453, P23727, P26450, P27986, P42694, P61798, P69341, Q13572, Q14457, Q4A1L4, Q4A1L5, Q5F407, Q5F480, Q5M939, Q5R685, Q5R878, Q5RAH9, Q5RC51, Q5ZIA0, Q5ZKS6, Q63787, Q6DC64, Q6DDJ3, Q6DFV5, Q6DJB3, Q6GP52, Q6GR37, Q6I6F4, Q6J1J1, Q6NRC7, Q6NYU2, Q7T0P6, Q80YV4

Diamond homologs: G3X9C2, Q17QK6, Q3SX24, Q568V3, Q6AY27, Q6DIA9, Q6ZVX7, Q80UW2, Q8NI29, Q923V4, Q96EF6, Q9H4M3, Q9N0C8, Q9NRD1, Q9QZM8, Q9UK22, Q8BK26, Q9QZN4

SIGNOR signaling

4 interactions.

A	Effect	B	Mechanism
FBXO6	“down-regulates quantity by destabilization”	CHEK1	binding
FBXO6	“up-regulates activity”	“Cullin 1-RBX1-Skp1”	binding
FBXO6	“down-regulates quantity by destabilization”	ERO1A	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	45
Likely benign	8
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1048 predictions. Top by Δscore:

Variant	Effect	Δscore
1:11668651:CACAG:C	acceptor_loss	1.0000
1:11668653:CA:C	acceptor_loss	1.0000
1:11668654:A:AG	acceptor_gain	1.0000
1:11668654:A:C	acceptor_loss	1.0000
1:11668654:AG:A	acceptor_gain	1.0000
1:11668655:G:A	acceptor_loss	1.0000
1:11668655:G:GG	acceptor_gain	1.0000
1:11668655:GG:G	acceptor_gain	1.0000
1:11668655:GGCC:G	acceptor_gain	1.0000
1:11668655:GGCCA:G	acceptor_gain	1.0000
1:11668857:G:GT	donor_gain	1.0000
1:11668916:G:GT	donor_gain	1.0000
1:11671369:G:GT	donor_gain	1.0000
1:11671391:GA:G	donor_gain	1.0000
1:11671393:G:GG	donor_gain	1.0000
1:11671926:A:AG	acceptor_gain	1.0000
1:11671926:AGAAT:A	acceptor_gain	1.0000
1:11671927:G:GA	acceptor_gain	1.0000
1:11671927:GA:G	acceptor_gain	1.0000
1:11671927:GAAT:G	acceptor_gain	1.0000
1:11671927:GAATG:G	acceptor_gain	1.0000
1:11672019:GACTG:G	donor_gain	1.0000
1:11672022:TGGT:T	donor_loss	1.0000
1:11672023:GGT:G	donor_loss	1.0000
1:11672024:G:GC	donor_loss	1.0000
1:11672025:T:G	donor_loss	1.0000
1:11673272:A:AG	acceptor_gain	1.0000
1:11673273:C:G	acceptor_gain	1.0000
1:11673273:CCAGG:C	acceptor_loss	1.0000
1:11673274:CAGGT:C	acceptor_loss	1.0000

AlphaMissense

1926 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:11673726:A:C	S253R	0.994
1:11673728:C:A	S253R	0.994
1:11673728:C:G	S253R	0.994
1:11671310:T:A	W111R	0.992
1:11671310:T:C	W111R	0.992
1:11673404:T:A	W213R	0.992
1:11673404:T:C	W213R	0.992
1:11671940:G:C	K142N	0.991
1:11671940:G:T	K142N	0.991
1:11671280:T:A	W101R	0.987
1:11671280:T:C	W101R	0.987
1:11672019:G:C	D169H	0.987
1:11673664:T:C	F232S	0.987
1:11668788:T:A	W44R	0.986
1:11668788:T:C	W44R	0.986
1:11671312:G:C	W111C	0.986
1:11671312:G:T	W111C	0.986
1:11668818:T:A	W54R	0.985
1:11668818:T:C	W54R	0.985
1:11673406:G:C	W213C	0.985
1:11673406:G:T	W213C	0.985
1:11673708:G:T	G247W	0.985
1:11671376:T:C	F133L	0.984
1:11671378:T:A	F133L	0.984
1:11671378:T:G	F133L	0.984
1:11671941:T:C	S143P	0.984
1:11673682:A:T	D238V	0.984
1:11668820:G:C	W54C	0.983
1:11668820:G:T	W54C	0.983
1:11673627:T:C	F220L	0.983

dbSNP variants (sampled 300 via entrez): RS1000097533 (1:11663779 C>T), RS1000360701 (1:11673952 G>C), RS1000531437 (1:11664097 A>G), RS1001269221 (1:11663454 TCAC>T), RS1001430674 (1:11668274 A>C), RS1001560158 (1:11665855 G>A), RS1001860568 (1:11668569 G>A), RS1001919310 (1:11672246 A>C,T), RS1002259374 (1:11672110 C>A), RS1002565995 (1:11673190 G>A), RS1002638671 (1:11664307 G>A), RS1002755035 (1:11670682 C>A), RS1002975218 (1:11664072 G>A), RS1003451206 (1:11666261 A>G), RS1003537915 (1:11671514 C>G,T)

Disease associations

OMIM: gene MIM:605647 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010654_5	Arterial stiffness (brachial-femoral pulse wave velocity)	1.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004517	arterial stiffness measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, increases expression	2
Estradiol	affects expression, affects cotreatment, decreases expression	2
Nickel	increases expression	2
Valproic Acid	affects expression, decreases expression	2
Aflatoxin B1	decreases expression, affects expression	2
Cadmium Chloride	decreases expression, decreases reaction, increases expression, increases phosphorylation, decreases response to substance	2
FR900359	increases phosphorylation	1
lasiocarpine	decreases expression	1
chlortoluron	decreases expression	1
2,2’-methylenebis(4-methyl-6-tert-butylphenol)	affects expression, affects response to substance	1
beta-lapachone	increases expression	1
benzo(e)pyrene	increases methylation	1
di-n-butylphosphoric acid	affects expression	1
NCS 382	increases expression	1
ICG 001	increases expression	1
(+)-JQ1 compound	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Sunitinib	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	increases abundance, decreases expression	1
Benzo(a)pyrene	increases methylation, decreases methylation	1
Cadmium	decreases response to substance	1
Curcumin	increases expression	1
Diuron	decreases expression	1
Doxorubicin	decreases expression	1
Methapyrilene	increases methylation	1
Tretinoin	increases expression	1
1-Methyl-4-phenylpyridinium	affects expression	1
Cyclosporine	decreases expression	1
Copper Sulfate	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E1X3	HAP1 FBXO6 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.