FBXW4

Summary

FBXW4 (F-box and WD repeat domain containing 4, HGNC:10847) is a protein-coding gene on chromosome 10q24.32, encoding F-box/WD repeat-containing protein 4 (P57775). Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.

Source: NCBI Gene 6468 — RefSeq curated summary.

At a glance

• Gene–disease (curated): split hand-foot malformation 3 (Limited, GenCC)
• GWAS associations: 1
• Clinical variants (ClinVar): 147 total — 1 pathogenic
• Phenotypes (HPO): 8
• Dosage sensitivity (ClinGen): haploinsufficiency no evidence, triplosensitivity no evidence
• MANE Select transcript: NM_022039

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10847
Approved symbol	FBXW4
Name	F-box and WD repeat domain containing 4
Location	10q24.32
Locus type	gene with protein product
Status	Approved
Aliases	Fbw4, dactylin
Ensembl gene	ENSG00000107829
Ensembl biotype	protein_coding
OMIM	608071
Entrez	6468

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 9 protein_coding, 3 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000331272, ENST00000457105, ENST00000470093, ENST00000482428, ENST00000489578, ENST00000664783, ENST00000919944, ENST00000919945, ENST00000919946, ENST00000945850, ENST00000945851, ENST00000945852, ENST00000945853

RefSeq mRNA: 2 — MANE Select: NM_022039 NM_001323541, NM_022039

CCDS: CCDS31271

Canonical transcript exons

ENST00000331272 — 9 exons

Exon	Start	End
ENSE00001333590	101694381	101695170
ENSE00002290987	101624745	101624810
ENSE00003465345	101612337	101612477
ENSE00003474993	101611628	101611769
ENSE00003477983	101673488	101673673
ENSE00003541215	101672915	101673047
ENSE00003637643	101676341	101676436
ENSE00003666781	101610666	101611410
ENSE00003678265	101667886	101667980

Expression profiles

Bgee: expression breadth ubiquitous, 281 present calls, max score 97.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.7908 / max 215.6569, expressed in 1707 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111094	7.3171	1681
111092	0.4737	188

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	97.99	gold quality
spinal cord	UBERON:0002240	97.67	gold quality
apex of heart	UBERON:0002098	97.05	gold quality
lower esophagus muscularis layer	UBERON:0035833	96.42	gold quality
lower esophagus	UBERON:0013473	96.41	gold quality
amygdala	UBERON:0001876	96.34	gold quality
putamen	UBERON:0001874	96.23	gold quality
inferior vagus X ganglion	UBERON:0005363	96.19	gold quality
muscle layer of sigmoid colon	UBERON:0035805	96.06	gold quality
gastrocnemius	UBERON:0001388	96.05	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	95.85	gold quality
muscle of leg	UBERON:0001383	95.77	gold quality
subthalamic nucleus	UBERON:0001906	95.74	gold quality
mucosa of stomach	UBERON:0001199	95.64	gold quality
ventral tegmental area	UBERON:0002691	95.64	gold quality
substantia nigra	UBERON:0002038	95.58	gold quality
right lung	UBERON:0002167	95.52	gold quality
sural nerve	UBERON:0015488	95.50	gold quality
midbrain	UBERON:0001891	95.46	gold quality
nucleus accumbens	UBERON:0001882	95.45	gold quality
skin of leg	UBERON:0001511	95.43	gold quality
fundus of stomach	UBERON:0001160	95.42	gold quality
saphenous vein	UBERON:0007318	95.38	gold quality
nipple	UBERON:0002030	95.24	gold quality
heart left ventricle	UBERON:0002084	95.18	gold quality
pituitary gland	UBERON:0000007	95.17	gold quality
adenohypophysis	UBERON:0002196	95.15	gold quality
right atrium auricular region	UBERON:0006631	95.07	gold quality
hypothalamus	UBERON:0001898	95.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

30 targeting FBXW4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-345-3P	99.89	70.23	1421
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-2681-5P	99.75	67.64	1655
HSA-MIR-29B-2-5P	99.67	68.98	1726
HSA-MIR-670-5P	99.67	69.94	1565
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-6080	99.43	69.43	373
HSA-MIR-330-3P	99.41	69.95	2521
HSA-MIR-125A-5P	99.36	70.59	1640
HSA-MIR-125B-5P	99.36	70.36	1662
HSA-MIR-6840-3P	98.68	65.95	1923
HSA-MIR-6764-3P	98.44	67.64	1153
HSA-MIR-6824-3P	98.44	67.62	1154
HSA-MIR-4646-5P	97.70	66.84	1692
HSA-MIR-3936	97.64	64.47	732
HSA-MIR-8057	97.64	66.54	897
HSA-MIR-665	97.60	65.64	1781
HSA-MIR-4732-3P	97.15	65.45	881
HSA-MIR-6822-3P	96.60	66.06	680
HSA-MIR-7109-3P	94.23	67.19	743

Functional genomics

ClinGen dosage: haploinsufficiency 0 (no evidence), triplosensitivity 0 (no evidence). ClinGen Gene Dosage Map

Literature-anchored findings (GeneRIF, showing 5)

• a complex rearrangement associated with a approximately 0.5 Mb tandem duplication ion containing a disrupted extra copy of the DACTYLIN gene and the entire LBX1 and beta-TRCP genes. (PMID:12913067)
• results indicate that genomic rearrangement of SHFM3 is rare among non-syndromic SHFM patients and emphasize the importance of screening for genomic rearrangements even in sporadic cases of SHFM (PMID:16235095)
• Genomic rearrangements involving the SHFM3 locus at chromosome 10q24 is associated with syndromic and non-syndromic split-hand/foot malformation (PMID:16761290)
• biochemical characterization of the novel F-box and WD40 containing protein, FBXW4 (PMID:23658844)
• CircFBXW4 Suppresses Colorectal Cancer Progression by Regulating the MiR-338-5p/SLC5A7 Axis. (PMID:38461489)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	fbxw4	ENSDARG00000033551
mus_musculus	Fbxw4	ENSMUSG00000040913
rattus_norvegicus	Fbxw4	ENSRNOG00000046211
drosophila_melanogaster	CG33969	FBGN0053969

Protein

Protein identifiers

F-box/WD repeat-containing protein 4 — P57775 (reviewed: P57775)

Alternative names: Dactylin, F-box and WD-40 domain-containing protein 4

All UniProt accessions (3): P57775, A0A384P5X9, A0A5F9UQ55

UniProt curated annotations — full annotation on UniProt →

Function. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.

Subunit / interactions. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with POUF51.

Tissue specificity. Expressed in brain, kidney, lung and liver.

Disease relevance. Split-hand/foot malformation 3 (SHFM3) [MIM:246560] A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have intellectual disability, ectodermal and craniofacial findings, and orofacial clefting. The disease is caused by variants affecting the gene represented in this entry.

RefSeq proteins (2): NP_001310470, NP_071322* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR001810	F-box_dom	Domain
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR036047	F-box-like_dom_sf	Homologous_superfamily
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR052301	SCF_F-box/WD-repeat	Family

Pfam: PF00400, PF12937

UniProt features (9 total): repeat 6, chain 1, domain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P57775-F1	90.91	0.79

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis
R-HSA-8951664	Neddylation
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation

MSigDB gene sets: 218 (showing top): PAX4_01, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, MODULE_255, RORA1_01, REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION, REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, MODULE_317, TGACCTY_ERR1_Q2, CEBPB_01, TCF4_Q5, KOYAMA_SEMA3B_TARGETS_UP, BLALOCK_ALZHEIMERS_DISEASE_UP

GO Biological Process (8): ubiquitin-dependent protein catabolic process (GO:0006511), Wnt signaling pathway (GO:0016055), embryonic limb morphogenesis (GO:0030326), SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146), positive regulation of mesenchymal cell proliferation (GO:0002053), embryonic digit morphogenesis (GO:0042733), cartilage development (GO:0051216), limb development (GO:0060173)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): ubiquitin ligase complex (GO:0000151), cytosol (GO:0005829), SCF ubiquitin ligase complex (GO:0019005)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Chaperonin-mediated protein folding	1
Post-translational protein modification	1
Class I MHC mediated antigen processing & presentation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein ubiquitination	1
modification-dependent protein catabolic process	1
cell surface receptor signaling pathway	1
limb morphogenesis	1
embryonic appendage morphogenesis	1
proteasome-mediated ubiquitin-dependent protein catabolic process	1
positive regulation of cell population proliferation	1
mesenchymal cell proliferation	1
regulation of mesenchymal cell proliferation	1
embryonic limb morphogenesis	1
embryonic morphogenesis	1
skeletal system development	1
animal organ development	1
connective tissue development	1
appendage development	1
binding	1
intracellular protein-containing complex	1
transferase complex	1
cytoplasm	1
cellular anatomical structure	1
cullin-RING ubiquitin ligase complex	1

Protein interactions and networks

STRING

658 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FBXW4	LBX1	P52954	894
FBXW4	POLL	Q9UGP5	874
FBXW4	BTRC	Q9Y297	794
FBXW4	SEM1	Q6ZVN7	738
FBXW4	SUFU	Q9UMX1	684
FBXW4	FBXW2	Q9UKT8	612
FBXW4	FBXW5	Q969U6	598
FBXW4	TLX1	P31314	577
FBXW4	FBXW8	Q8N3Y1	569
FBXW4	FGF8	P55075	558
FBXW4	DLX6	P56179	552
FBXW4	DLX5	P56178	541
FBXW4	FBXW9	Q5XUX1	532
FBXW4	SKP1	P34991	520
FBXW4	FBXW12	Q6X9E4	488

IntAct

24 interactions, top by confidence:

A	B	Type	Score
COPS6	RHOBTB1	psi-mi:“MI:0914”(association)	0.730
SKP1	FBXW4	psi-mi:“MI:0915”(physical association)	0.670
PRKN	FBXW4	psi-mi:“MI:0915”(physical association)	0.560
FBXW4	TXNDC9	psi-mi:“MI:0914”(association)	0.530
PFDN2	CDC40	psi-mi:“MI:0914”(association)	0.530
FBXW4	TCP1	psi-mi:“MI:0914”(association)	0.530
SKP1	FBXW4	psi-mi:“MI:0915”(physical association)	0.400
CUL1	FBXW4	psi-mi:“MI:0915”(physical association)	0.400
FBXW4	CDC37	psi-mi:“MI:0915”(physical association)	0.370
ECSIT	FBXW4	psi-mi:“MI:0915”(physical association)	0.370
MAST1	FBXW4	psi-mi:“MI:0915”(physical association)	0.370
FBXW4	RNF32	psi-mi:“MI:0915”(physical association)	0.370
SLX4IP	RNASEH1	psi-mi:“MI:0914”(association)	0.350
CUL4A	DDX39A	psi-mi:“MI:0914”(association)	0.350
ANKRD39	UBA6	psi-mi:“MI:0914”(association)	0.350
SKP1	BHLHE40	psi-mi:“MI:0914”(association)	0.350
SKP1	NDC80	psi-mi:“MI:0914”(association)	0.350
LCOR	FBXW4	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (107): CUL1 (Affinity Capture-Western), TCP1 (Affinity Capture-MS), CCT3 (Affinity Capture-MS), CCT7 (Affinity Capture-MS), CCT4 (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6A (Affinity Capture-MS), CCT2 (Affinity Capture-MS), PDCL3 (Affinity Capture-MS), CCT8 (Affinity Capture-MS), CCT5 (Affinity Capture-MS), PFDN5 (Affinity Capture-MS), PDRG1 (Affinity Capture-MS), TXNDC9 (Affinity Capture-MS), PDCL (Affinity Capture-MS)

ESM2 similar proteins: A2AA28, A4FV42, A4FV98, A6NDG6, D3YWP0, D3ZVU9, O15315, O35719, O70277, O75382, O94759, P21964, P57775, P81799, Q2TBS1, Q3UGX3, Q4R3I0, Q5E9V4, Q5H879, Q5RJL2, Q5SUV1, Q6DC64, Q7Z624, Q86WI3, Q86XA0, Q8BNV1, Q8C436, Q8CIW5, Q8IZ69, Q8N8L6, Q8N9F0, Q8VCX6, Q8WXB1, Q96AZ1, Q96FB5, Q96RR1, Q9BQD7, Q9BRQ3, Q9BUU2, Q9CQL0

Diamond homologs: A1C7E4, A1CBP8, A1DDL6, A1DHW6, A2QCU8, A2R3Z3, A4RJV3, A6ZQL5, A6ZZZ8, A7ETB3, A7THX0, A7TNS8, A8PTE4, A8Q2R5, B0XTS1, B6GZA1, B6Q4Z5, B8M7Q5, B8NGT5, C5FP68, D4AM37, D4D8P3, O42937, P0CS44, P0CS45, P25387, P36130, P47025, P57775, Q00659, Q01277, Q0CJD8, Q0CY32, Q0U2T3, Q1DIW7, Q2H139, Q2KJJ5, Q2U5Z8, Q2UFN8, Q4P8R5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 22 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
protein ubiquitination	5	10.9×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

147 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	97
Likely benign	22
Benign	8

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
625658	GRCh37/hg19 10q24.31-24.32(chr10:102822575-103558868)	Pathogenic

SpliceAI

1767 predictions. Top by Δscore:

Variant	Effect	Δscore
10:101611621:CACTT:C	donor_loss	1.0000
10:101611622:ACTTA:A	donor_loss	1.0000
10:101611623:CTTA:C	donor_loss	1.0000
10:101611624:TTACG:T	donor_loss	1.0000
10:101611625:TAC:T	donor_loss	1.0000
10:101611626:A:AC	donor_gain	1.0000
10:101611626:A:C	donor_loss	1.0000
10:101611626:ACGTG:A	donor_gain	1.0000
10:101611627:C:CG	donor_gain	1.0000
10:101611627:CG:C	donor_gain	1.0000
10:101611627:CGT:C	donor_gain	1.0000
10:101611627:CGTG:C	donor_gain	1.0000
10:101611627:CGTGC:C	donor_gain	1.0000
10:101611765:ATTTC:A	acceptor_gain	1.0000
10:101611766:TTTC:T	acceptor_gain	1.0000
10:101611767:TTC:T	acceptor_gain	1.0000
10:101611768:TC:T	acceptor_gain	1.0000
10:101611769:CC:C	acceptor_gain	1.0000
10:101611770:C:CA	acceptor_loss	1.0000
10:101611770:C:CC	acceptor_gain	1.0000
10:101611775:C:CT	acceptor_gain	1.0000
10:101611775:C:T	acceptor_gain	1.0000
10:101611776:A:T	acceptor_gain	1.0000
10:101612335:A:AC	donor_gain	1.0000
10:101612336:C:CC	donor_gain	1.0000
10:101612475:CCA:C	acceptor_gain	1.0000
10:101612476:CA:C	acceptor_gain	1.0000
10:101612476:CAC:C	acceptor_gain	1.0000
10:101612478:C:CC	acceptor_gain	1.0000
10:101670993:C:A	donor_gain	1.0000

AlphaMissense

3640 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:101624797:C:A	G262W	1.000
10:101672939:A:C	S217R	1.000
10:101672939:A:T	S217R	1.000
10:101672941:T:G	S217R	1.000
10:101612364:C:G	R317P	0.999
10:101624796:C:T	G262E	0.999
10:101611655:C:A	W364C	0.998
10:101611655:C:G	W364C	0.998
10:101611657:A:G	W364R	0.998
10:101611657:A:T	W364R	0.998
10:101611686:C:T	G354D	0.998
10:101611753:A:G	W332R	0.998
10:101611753:A:T	W332R	0.998
10:101612359:A:G	W319R	0.998
10:101612359:A:T	W319R	0.998
10:101624758:A:G	W275R	0.998
10:101624758:A:T	W275R	0.998
10:101624797:C:G	G262R	0.998
10:101624797:C:T	G262R	0.998
10:101672935:A:G	S219P	0.998
10:101672937:C:T	G218D	0.998
10:101672943:A:T	V216E	0.998
10:101673496:A:C	S178R	0.998
10:101673496:A:T	S178R	0.998
10:101673498:T:G	S178R	0.998
10:101611687:C:G	G354R	0.997
10:101612376:T:A	D313V	0.997
10:101667916:A:T	V247D	0.997
10:101667923:C:G	D245H	0.997
10:101611337:G:T	A398D	0.996

dbSNP variants (sampled 300 via entrez): RS1000066042 (10:101628379 C>A), RS1000077450 (10:101628734 C>T), RS1000099322 (10:101649661 A>G), RS1000125423 (10:101677604 A>C), RS1000147375 (10:101655212 G>T), RS1000168739 (10:101662735 C>T), RS1000221409 (10:101662548 T>A), RS1000274341 (10:101613905 G>A), RS1000368716 (10:101614333 C>G), RS1000387131 (10:101662839 C>G), RS1000508028 (10:101691178 T>G), RS1000519903 (10:101677196 A>G,T), RS1000520719 (10:101641054 C>T), RS1000551576 (10:101661238 T>A), RS1000565203 (10:101682703 G>T)

Disease associations

OMIM: gene MIM:608071 | disease phenotypes: MIM:246560

GenCC curated gene-disease

Disease	Classification	Inheritance
split hand-foot malformation 3	Limited	Autosomal dominant

Mondo (1): split hand-foot malformation 3 (MONDO:0009525)

Orphanet (1): Distal limb deficiencies-micrognathia syndrome (Orphanet:1307)

HPO phenotypes

8 total (8 of 8 shown, HPO-id order):

HPO	Term
HP:0000407	Sensorineural hearing impairment
HP:0000526	Aniridia
HP:0001171	Split hand
HP:0001839	Split foot
HP:0004050	Absent hand
HP:0004058	Hand monodactyly
HP:0006101	Finger syndactyly
HP:0012165	Oligodactyly

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006979_603	Heel bone mineral density	5.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009270	heel bone mineral density

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C565437	Limb Deficiencies, Distal, with Micrognathia (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, decreases expression, affects expression	7
Cisplatin	decreases expression, increases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
1,6-hexamethylene diisocyanate	increases methylation	1
sodium arsenite	increases expression	1
butyraldehyde	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
belinostat	decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Vorinostat	decreases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Carbamazepine	affects expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Hydralazine	affects cotreatment, increases expression	1
Silicon Dioxide	decreases expression	1
Thiram	increases expression	1
Aflatoxin B1	decreases methylation	1
Okadaic Acid	decreases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.