FBXW7-AS1

Summary

FBXW7-AS1 (FBXW7 antisense RNA 1, HGNC:52397) is a long non-coding RNA gene on chromosome 4q31.3. Dual receptor for both endothelin-1 and the signal sequence of vascular endothelial growth factor A.

Enables endothelin receptor activity and vascular endothelial growth factor binding activity. Involved in endothelin receptor signaling pathway and vascular endothelial growth factor signaling pathway. Located in plasma membrane.

Source: NCBI Gene 102191832 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52397
Approved symbol	FBXW7-AS1
Name	FBXW7 antisense RNA 1
Location	4q31.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	DEAR, DEspR
Ensembl gene	ENSG00000270751
Ensembl biotype	lncRNA
Entrez	102191832
RNAcentral	URS00019810A4 — lncRNA, 351 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000605147

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000605147 — 2 exons

Exon	Start	End
ENSE00003498917	152337655	152337737
ENSE00003665768	152337810	152338098

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 85.84.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.84	gold quality
hindlimb stylopod muscle	UBERON:0004252	77.73	gold quality
bone marrow cell	CL:0002092	75.35	gold quality
ventricular zone	UBERON:0003053	69.92	gold quality
skeletal muscle tissue	UBERON:0001134	69.81	gold quality
cortical plate	UBERON:0005343	68.05	gold quality
bone marrow	UBERON:0002371	67.88	gold quality
monocyte	CL:0000576	64.54	gold quality
primary visual cortex	UBERON:0002436	64.25	gold quality
prefrontal cortex	UBERON:0000451	63.91	gold quality
adrenal tissue	UBERON:0018303	63.44	gold quality
corpus callosum	UBERON:0002336	63.29	gold quality
superior frontal gyrus	UBERON:0002661	63.19	gold quality
lymph node	UBERON:0000029	62.02	gold quality
calcaneal tendon	UBERON:0003701	61.88	gold quality
skin of abdomen	UBERON:0001416	61.82	gold quality
tonsil	UBERON:0002372	61.58	silver quality
endometrium	UBERON:0001295	61.26	gold quality
islet of Langerhans	UBERON:0000006	60.99	gold quality
zone of skin	UBERON:0000014	60.99	gold quality
blood	UBERON:0000178	60.67	gold quality
duodenum	UBERON:0002114	60.56	gold quality
right coronary artery	UBERON:0001625	60.02	gold quality
skin of leg	UBERON:0001511	59.98	gold quality
liver	UBERON:0002107	59.73	gold quality
gall bladder	UBERON:0002110	59.64	gold quality
placenta	UBERON:0001987	59.21	gold quality
muscle of leg	UBERON:0001383	58.77	gold quality
gastrocnemius	UBERON:0001388	58.16	gold quality
kidney	UBERON:0002113	57.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• DEspR binds to endothelin-1 and to the signal peptide propeptide of VEGF-A (VEGF-sp), but no binding to VEGF-A (PMID:17446437)
• A single nucleotide polymorphism within the DEspR 5’-regulatory region associated with increased blood pressure in a male Sardinian cohort, was identified.[DEdpR] (PMID:21862670)
• DEspR activation would coordinate tumor progression events. (PMID:24465725)
• Data confirm translatability of DEspR, the full-length DEspR protein beyond codon#14, and elucidate DEspR-specific functionality. (PMID:27301377)
• DEspR(high) neutrophils are associated with critical illness in COVID-19. (PMID:34789851)
• DEspR+CD11b+ neutrophils are associated with poor outcomes and severity of acute respiratory distress syndrome in critically ill patients. (PMID:35379853)
• DEspR+CD11b+ neutrophils are associated with poor outcomes in patients with spontaneous intracerebral hemorrhage (sICH) and severity of sICH. (PMID:35959408)
• Human DEspR+CD11b+ neutrophil levels correlate with neutrophil to lymphocyte ratio (NLR) and circulating NET-forming neutrophil (vital NETosis) levels in sICH patients. (PMID:35959408)
• Human DEspR+ neutrophils are associated with hypertension in sICH patients. (PMID:36007264)
• DEspR+ neutrophils are increased in bronchoalveolar lavage fluid neutrophils in response to intra-bronchial bacteriotoxin (lipopolysaccharide) stimulation in healthy volunteers. (PMID:36275710)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.