FCAMR

Summary

FCAMR (Fc alpha and mu receptor, HGNC:24692) is a protein-coding gene on chromosome 1q32.1, encoding High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (Q8WWV6). Functions as a receptor for the Fc fragment of IgA and IgM.

Predicted to enable IgA binding activity; IgM binding activity; and transmembrane signaling receptor activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane.

Source: NCBI Gene 83953 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 91 total
• MANE Select transcript: NM_001170631

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24692
Approved symbol	FCAMR
Name	Fc alpha and mu receptor
Location	1q32.1
Locus type	gene with protein product
Status	Approved
Aliases	FKSG87, FCA/MR, CD351, Fcalpha/muR
Ensembl gene	ENSG00000162897
Ensembl biotype	protein_coding
OMIM	605484
Entrez	83953

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 3 protein_coding, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000324852, ENST00000324863, ENST00000400962, ENST00000450945, ENST00000486178

RefSeq mRNA: 4 — MANE Select: NM_001170631 NM_001122979, NM_001170631, NM_001424868, NM_032029

CCDS: CCDS41460, CCDS53468

Canonical transcript exons

ENST00000324852 — 8 exons

Exon	Start	End
ENSE00001623209	206957967	206958676
ENSE00001907335	206970087	206970460
ENSE00003492078	206960422	206961223
ENSE00003569434	206965715	206965858
ENSE00003613607	206959679	206959797
ENSE00003613903	206967052	206967112
ENSE00003661573	206967583	206967651
ENSE00003685934	206962213	206962551

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 97.33.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1300 / max 17.4653, expressed in 44 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
17147	0.1300	44

Top tissues by expression

228 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	97.33	gold quality
adult mammalian kidney	UBERON:0000082	82.83	gold quality
ileal mucosa	UBERON:0000331	82.76	gold quality
kidney	UBERON:0002113	77.32	gold quality
lymph node	UBERON:0000029	74.09	gold quality
vermiform appendix	UBERON:0001154	70.72	gold quality
right lobe of liver	UBERON:0001114	70.07	gold quality
mucosa of transverse colon	UBERON:0004991	66.71	gold quality
tonsil	UBERON:0002372	66.33	gold quality
liver	UBERON:0002107	65.81	gold quality
cortex of kidney	UBERON:0001225	64.41	gold quality
caecum	UBERON:0001153	64.14	gold quality
rectum	UBERON:0001052	62.51	gold quality
adult organism	UBERON:0007023	60.86	gold quality
duodenum	UBERON:0002114	60.79	gold quality
deltoid	UBERON:0001476	59.05	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	58.90	gold quality
renal medulla	UBERON:0000362	58.37	gold quality
cardiac muscle of right atrium	UBERON:0003379	55.69	gold quality
cerebellar vermis	UBERON:0004720	55.57	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
metanephros cortex	UBERON:0010533	53.96	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
epithelial cell of pancreas	CL:0000083	53.41	gold quality
metanephros	UBERON:0000081	52.87	gold quality
gall bladder	UBERON:0002110	52.50	gold quality
superior surface of tongue	UBERON:0007371	51.76	gold quality
colonic epithelium	UBERON:0000397	51.67	gold quality
quadriceps femoris	UBERON:0001377	51.19	gold quality
myocardium	UBERON:0002349	50.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.76

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

45 targeting FCAMR, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6079	99.84	68.54	1170
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-4524A-3P	99.72	66.85	2406
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-4527	99.66	67.43	714
HSA-MIR-6503-5P	99.62	66.96	597
HSA-MIR-7106-5P	99.53	67.47	3574
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-199A-5P	99.51	69.71	1107
HSA-MIR-199B-5P	99.51	69.74	1098
HSA-MIR-766-5P	99.47	67.91	2225
HSA-MIR-4505	99.27	67.81	2678
HSA-MIR-6799-5P	99.14	65.72	2093
HSA-MIR-485-5P	99.10	64.78	1889
HSA-MIR-6884-5P	99.10	64.50	1987

Literature-anchored findings (GeneRIF, showing 9)

• Comprehensive survey of naturally occurring polymorphisms in rhesus macaques and in humans. (PMID:18379868)
• These results indicate for the first time that Fcalpha/muR protein is expressed by human intestinal tissues (PMID:19338768)
• the cytoplasmic portion of human Fcalpha/microR is required in the internalization. (PMID:19393604)
• LPS, through the TLR4 receptor, activates the p38MAPK and NF-kappaB pathways and up-regulate the expression of Fcamr in human macrophages (PMID:19682689)
• These results suggest that the cytoplasmic portion is required for the dimer formation and thus for efficient cell surface expression of Fcalpha/microR. (PMID:19945166)
• ADAM10 and ADAM17 are involved in the shedding of FcalphaR (PMID:20059578)
• A significantly worse survival was found in patients with IgA serum levels>2.85 g/l compared to patients with lower IgA serum levels. (PMID:25845491)
• rs3125923 FCAMR gene represents a validated SNP to predict grade 3-4 Taxane-induced peripheral neuropathy . Genetically determined AA race represents the most significant predictor of TIPN. (PMID:26138065)
• A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution. (PMID:28355232)

Cross-species orthologs

26 orthologs

Organism	Symbol	Gene ID
danio_rerio	si:dkey-1c7.1	ENSDARG00000074334
danio_rerio	si:ch211-264f5.2	ENSDARG00000078547
danio_rerio	si:ch211-114l13.12	ENSDARG00000088019
danio_rerio	si:dkey-1c7.2	ENSDARG00000088556
danio_rerio	si:ch211-215e19.8	ENSDARG00000098106
danio_rerio	si:ch211-215e19.3	ENSDARG00000098216
danio_rerio	si:ch211-9d9.8	ENSDARG00000098437
danio_rerio	si:ch211-9d9.7	ENSDARG00000098965
danio_rerio	pigrl2.4	ENSDARG00000099599
danio_rerio	pigrl3.5	ENSDARG00000099938
danio_rerio	si:dkeyp-104b3.2	ENSDARG00000100258
danio_rerio	si:dkeyp-104b3.18	ENSDARG00000101129
danio_rerio	si:ch211-215e19.6	ENSDARG00000101360
danio_rerio	pigr	ENSDARG00000101890
danio_rerio	si:dkeyp-104b3.1	ENSDARG00000103575
danio_rerio	si:ch211-215e19.4	ENSDARG00000103678
danio_rerio	si:ch211-215e19.7	ENSDARG00000103852
danio_rerio	si:dkeyp-104b3.21	ENSDARG00000103964
danio_rerio		ENSDARG00000104859
danio_rerio		ENSDARG00000104962
danio_rerio		ENSDARG00000105181
danio_rerio		ENSDARG00000113188
danio_rerio		ENSDARG00000113965
danio_rerio	pigrl2.3	ENSDARG00000116660
mus_musculus	Fcamr	ENSMUSG00000026415
rattus_norvegicus	Fcamr	ENSRNOG00000004393

Paralogs (13): TREM2 (ENSG00000095970), TMIGD3 (ENSG00000121933), CD300LG (ENSG00000161649), TREML1 (ENSG00000161911), FCMR (ENSG00000162894), PIGR (ENSG00000162896), CD300C (ENSG00000167850), CD300A (ENSG00000167851), CD300LB (ENSG00000178789), CD300LF (ENSG00000186074), CD300E (ENSG00000186407), CD300LD (ENSG00000204345), CD300H (ENSG00000284690)

Protein

Protein identifiers

High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor — Q8WWV6 (reviewed: Q8WWV6)

Alternative names: Fc alpha/mu receptor

All UniProt accessions (2): F8W7R9, Q8WWV6

UniProt curated annotations — full annotation on UniProt →

Function. Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.

Subunit / interactions. Interacts with IGHM; this interaction facilitates the endocytosis of IgM-coated microbes or IgM-antigen immune complexes.

Subcellular location. Cell membrane.

Tissue specificity. Expressed by mesangial cells.

Post-translational modifications. N-glycosylated.

Induction. Up-regulated by IFNG/IFN-gamma in mesangial cells.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoforms (5)

UniProt ID	Names	Canonical?
Q8WWV6-1	1	yes
Q8WWV6-2	2
Q8WWV6-4	4
Q8WWV6-5	5
Q8WWV6-6	6

RefSeq proteins (4): NP_001116451, NP_001164102, NP_001411797, NP_114418 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003599	Ig_sub	Domain
IPR007110	Ig-like_dom	Domain
IPR013106	Ig_V-set	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR050671	CD300_family_receptors	Family

Pfam: PF07686

UniProt features (25 total): splice variant 6, compositionally biased region 5, region of interest 4, topological domain 2, sequence conflict 2, signal peptide 1, chain 1, glycosylation site 1, disulfide bond 1, transmembrane region 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WWV6-F1	56.08	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 82–153

Glycosylation sites (1): 167

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-202733	Cell surface interactions at the vascular wall

MSigDB gene sets: 47 (showing top): NIKOLSKY_BREAST_CANCER_1Q32_AMPLICON, GOBP_ADAPTIVE_IMMUNE_RESPONSE, REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL, TGGAAA_NFAT_Q4_01, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, KRIEG_KDM3A_TARGETS_NOT_HYPOXIA, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, STK33_SKM_UP, STK33_UP, GSE13522_CTRL_VS_T_CRUZI_BRAZIL_STRAIN_INF_SKIN_UP, MIR6875_3P, MIR369_3P, MIR9902, MIR4524A_3P, MIR4493

GO Biological Process (3): adaptive immune response (GO:0002250), signal transduction (GO:0007165), immune system process (GO:0002376)

GO Molecular Function (1): transmembrane signaling receptor activity (GO:0004888)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Hemostasis	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
immune response	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
biological_process	1
signaling receptor activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

670 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FCAMR	FCAR	P24071	844
FCAMR	FCGR1A	P12314	646
FCAMR	FCER1G	P30273	577
FCAMR	FCER1A	P12319	550
FCAMR	FCGR2A	P12318	507
FCAMR	ERAP1	Q9NZ08	437
FCAMR	FCGRT	P55899	436
FCAMR	UBD	O15205	423
FCAMR	FABP5	Q01469	407
FCAMR	FAM53A	Q6NSI3	406
FCAMR	JCHAIN	P01591	402
FCAMR	FCMR	O60667	393
FCAMR	FCER2	P06734	374
FCAMR	PIGR	P01833	371
FCAMR	CD300LG	Q6UXG3	370

IntAct

4 interactions, top by confidence:

A	B	Type	Score
FCAMR	PILRA	psi-mi:“MI:0915”(physical association)	0.400
NRG1	FCAMR	psi-mi:“MI:0915”(physical association)	0.400
FCAMR	TP53	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (1): TP53 (Two-hybrid)

ESM2 similar proteins: A0A1B0GV85, A1KXC4, A6QLF8, B1ARY8, O14594, O35188, O55145, O60279, O60667, O95196, P07141, P09603, P40225, P40226, P42705, P55066, P55067, P70628, P78423, Q149B8, Q17R60, Q28645, Q2LA85, Q2TB54, Q3TNW5, Q52S86, Q58Y74, Q5IS41, Q5M871, Q5R770, Q5T2D2, Q6PIX9, Q6UXF1, Q6ZVL6, Q7Z434, Q80XH2, Q8BHE4, Q8BT18, Q8C0D9, Q8CAE9

Diamond homologs: A1KXC4, O60667, O70570, P01832, P01833, P0DUB1, P15083, P81265, Q2TB54, Q5M871, Q5R770, Q8WWV6, A5D7B2, Q3LRV9, Q9UGN4, A0A0K2S4Q6, A2A7V7, Q1ERP8, Q29244, Q3U497, Q496F6, Q6UXG3, Q7TSN2, Q8K249, Q8TDQ1, Q8VCH2, A2TGX5, A8K4G0, O95944, Q08708, Q6UXN2, Q566E6, Q6SJQ7, Q9NZC2, Q6UXZ3, G3X8R9, P0DMS9, Q6SJQ0, Q8K558, Q2LA85

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

91 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	81
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1306 predictions. Top by Δscore:

Variant	Effect	Δscore
1:206958672:CTGAG:C	acceptor_gain	1.0000
1:206958677:C:CC	acceptor_gain	1.0000
1:206959673:A:C	donor_gain	1.0000
1:206958673:TGAG:T	acceptor_gain	0.9900
1:206958673:TGAGC:T	acceptor_loss	0.9900
1:206958674:GAG:G	acceptor_gain	0.9900
1:206959672:A:AC	donor_gain	0.9900
1:206959672:AACT:A	donor_gain	0.9900
1:206959677:A:AC	donor_gain	0.9900
1:206959678:C:CC	donor_gain	0.9900
1:206959678:CAGGT:C	donor_gain	0.9900
1:206959700:T:TA	donor_gain	0.9900
1:206959793:AAGTA:A	acceptor_gain	0.9900
1:206959798:C:CC	acceptor_gain	0.9900
1:206959803:G:GC	acceptor_gain	0.9900
1:206962262:T:TA	donor_gain	0.9900
1:206965855:GAACC:G	acceptor_loss	0.9900
1:206965857:ACCT:A	acceptor_loss	0.9900
1:206965860:T:A	acceptor_loss	0.9900
1:206958675:AG:A	acceptor_gain	0.9800
1:206959685:T:TA	donor_gain	0.9800
1:206959795:GTA:G	acceptor_gain	0.9800
1:206959796:TA:T	acceptor_gain	0.9800
1:206961037:C:A	donor_gain	0.9800
1:206965709:TTGTA:T	donor_loss	0.9800
1:206965710:TGTAC:T	donor_loss	0.9800
1:206965711:GTA:G	donor_loss	0.9800
1:206965712:TACC:T	donor_loss	0.9800
1:206965713:ACCTG:A	donor_loss	0.9800
1:206970082:TTCA:T	donor_loss	0.9800

AlphaMissense

3694 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000295826 (1:206971462 C>T), RS1000445185 (1:206964289 T>A), RS1000720958 (1:206960110 T>C), RS1000748260 (1:206958718 A>G,T), RS1000786172 (1:206962907 C>A,T), RS1000861154 (1:206970546 TGGGCAGGA>T), RS1001292557 (1:206968922 A>G), RS1001862623 (1:206969328 T>A), RS1001893655 (1:206969058 C>G), RS1002069785 (1:206958199 C>T), RS1002326013 (1:206963415 C>G,T), RS1002384466 (1:206969197 C>T), RS1002487679 (1:206968990 C>A,T), RS1002680396 (1:206963642 G>C,T), RS1002801423 (1:206960358 C>G)

Disease associations

OMIM: gene MIM:605484 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST004224_3	Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction)	2.000000e-06
GCST004224_4	Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction)	2.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007908	traffic air pollution measurement
EFO:0007938	coronary atherosclerosis measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

10 total (human), top 10 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
theaflavin-3,3’-digallate	affects expression	1
Acetaminophen	decreases expression	1
Air Pollutants	increases abundance, increases response to substance	1
Arsenic	affects methylation	1
Vehicle Emissions	increases abundance, increases response to substance	1
Benzo(a)pyrene	increases methylation	1
Cadmium	decreases expression	1
Ethyl Methanesulfonate	decreases expression	1
Methyl Methanesulfonate	decreases expression	1
Aflatoxin B1	decreases expression, decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.