FCRL5

Summary

FCRL5 (Fc receptor like 5, HGNC:18508) is a protein-coding gene on chromosome 1q23.1, encoding Fc receptor-like protein 5 (Q96RD9). Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor.

This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified.

Source: NCBI Gene 83416 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 165 total
• Druggable target: yes
• MANE Select transcript: NM_031281

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18508
Approved symbol	FCRL5
Name	Fc receptor like 5
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Aliases	FCRH5, IRTA2, BXMAS1, CD307e
Ensembl gene	ENSG00000143297
Ensembl biotype	protein_coding
OMIM	605877
Entrez	83416

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 5 protein_coding_CDS_not_defined, 4 protein_coding

ENST00000361835, ENST00000368189, ENST00000368190, ENST00000461387, ENST00000462218, ENST00000481082, ENST00000483875, ENST00000497286, ENST00000908742

RefSeq mRNA: 2 — MANE Select: NM_031281 NM_001195388, NM_031281

CCDS: CCDS1165

Canonical transcript exons

ENST00000361835 — 17 exons

Exon	Start	End
ENSE00001054960	157552332	157552515
ENSE00001264413	157527617	157527895
ENSE00001264419	157534614	157534892
ENSE00001264430	157539086	157539364
ENSE00001264598	157542859	157543137
ENSE00003479129	157549560	157549580
ENSE00003528854	157546943	157547197
ENSE00003544831	157518429	157518497
ENSE00003561540	157518700	157518782
ENSE00003568030	157544262	157544546
ENSE00003581045	157519743	157519770
ENSE00003583056	157513377	157515764
ENSE00003589093	157544831	157545082
ENSE00003596041	157524279	157524557
ENSE00003657132	157520431	157520547
ENSE00003669508	157515842	157515873
ENSE00003677470	157521017	157521292

Expression profiles

Bgee: expression breadth ubiquitous, 147 present calls, max score 93.29.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.4360 / max 224.8713, expressed in 93 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
15269	1.3701	92
201763	0.0336	17
201764	0.0183	11
15268	0.0140	7

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
spleen	UBERON:0002106	93.29	gold quality
lymph node	UBERON:0000029	92.66	gold quality
bone marrow cell	CL:0002092	90.93	gold quality
granulocyte	CL:0000094	89.85	gold quality
ileal mucosa	UBERON:0000331	89.73	gold quality
vermiform appendix	UBERON:0001154	89.71	gold quality
buccal mucosa cell	CL:0002336	85.27	gold quality
caecum	UBERON:0001153	85.22	gold quality
pylorus	UBERON:0001166	85.18	gold quality
tonsil	UBERON:0002372	84.52	gold quality
epithelium of nasopharynx	UBERON:0001951	80.77	gold quality
superficial temporal artery	UBERON:0001614	79.96	gold quality
mucosa of transverse colon	UBERON:0004991	79.53	gold quality
bone marrow	UBERON:0002371	77.99	gold quality
blood	UBERON:0000178	77.51	gold quality
rectum	UBERON:0001052	77.48	gold quality
colonic epithelium	UBERON:0000397	76.35	gold quality
sperm	CL:0000019	76.03	silver quality
small intestine Peyer’s patch	UBERON:0003454	76.00	gold quality
trabecular bone tissue	UBERON:0002483	75.80	gold quality
small intestine	UBERON:0002108	74.31	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.64	gold quality
duodenum	UBERON:0002114	72.60	gold quality
cardia of stomach	UBERON:0001162	71.01	gold quality
minor salivary gland	UBERON:0001830	70.81	gold quality
saliva-secreting gland	UBERON:0001044	70.34	gold quality
epithelial cell of pancreas	CL:0000083	70.18	gold quality
thymus	UBERON:0002370	69.22	silver quality
transverse colon	UBERON:0001157	68.81	gold quality
mouth mucosa	UBERON:0003729	68.80	gold quality

Single-cell (SCXA)

Detected in 11 experiment(s), a significant marker in 11.

Experiment	Marker?	Max mean expression
E-GEOD-180759	yes	449.91
E-GEOD-135922	yes	271.48
E-CURD-88	yes	110.75
E-CURD-46	yes	52.02
E-CURD-122	yes	50.92
E-HCAD-1	yes	47.20
E-HCAD-4	yes	46.42
E-MTAB-8410	yes	43.00
E-ANND-3	yes	34.99
E-HCAD-11	yes	22.81
E-MTAB-10553	yes	13.15

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): RBPJ

miRNA regulators (miRDB)

67 targeting FCRL5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-6079	99.84	68.54	1170
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-448	99.79	72.37	2103
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-5004-5P	99.68	66.63	1294
HSA-MIR-3934-5P	99.67	64.04	846
HSA-MIR-488-3P	99.61	68.79	1731
HSA-MIR-6752-5P	99.59	67.32	1243
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-1290	99.59	69.90	2079
HSA-MIR-12122	99.56	69.33	1672
HSA-MIR-4472	99.56	66.08	1478
HSA-MIR-1224-5P	99.48	65.59	803
HSA-MIR-6165	99.44	67.12	1389
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-5589-3P	99.29	68.30	1443
HSA-MIR-520E-5P	99.27	68.90	1513
HSA-MIR-485-5P	99.10	64.78	1889

Literature-anchored findings (GeneRIF, showing 20)

• Characterization and comparison of the structure and B-cell expression pattern of the entire family of IRTA genes, which includes 5 members contiguously located on chromosome. (PMID:11929751)
• IRTA2 is expressed on the surface of human lymphoma cell lines and hairy cell leukemia cells (PMID:15671532)
• results identify FcRH5 as a novel, direct target of EBNA2 that may contribute to the development of Epstein-Barr virus-associated tumors (PMID:16439682)
• IRTA2/FcRH5 may have a role in hairy cell leukemia (PMID:16681430)
• Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia. (PMID:18704934)
• Down-regulation of FCRL5 is associated with acute lymphoblastic leukemia. (PMID:18802695)
• Single-nucleotide polymorphism in the FCRL5 gene and HLA-B27 is associated with ankylosing spondylitis. (PMID:19775371)
• Three of the FCRL5 tag SNPs, rs6667109, rs3811035 and rs6692977 showed association with Graves’ disease. association with FCRL5 was secondary to linkage disequilibrium with the FCRL3, rs11264798 and rs10489678 SNPs. (PMID:20626413)
• Enhanced proliferation and downstream isotype expression upon FCRL5 stimulation could reflect a physiological role for FCRL5 in the expansion and development of antigen-primed B cells. (PMID:22028333)
• FcRL5 binds all immunoglobulin (Ig)G isotypes with varied efficiency. (PMID:22491254)
• FCRL5 is a new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality. Recognition of undamaged IgG molecules by FCRL5 could allow B cells to engage recently produced Abs. (PMID:23616577)
• Data suggest that expression of FCRL5 (but not FCRL4) on surface of atypical (perhaps dysfunctional) memory B-Lymphocytes is up-regulated by exposure to Plasmodium falciparum antigens in subjects in Uganda where malaria is endemic. (PMID:25993340)
• we found that FCRL5 expression is induced specifically upon BCR stimulation and dissected the molecular mechanism (PMID:27065451)
• this study revealed that the FCRL5+ tissue-like memory subset responds poorly to multiple stimuli compared with the FCRL5- subset, as reflected by reduced calcium mobilization and blunted cell proliferation (PMID:27076679)
• based on FCRL5 binding, we can discern distinct changes in the IgG2 molecule, including the disulfide isoform structure and charge variants related to deamidation. Since both IgG2 deamidation and conversion of disulfide isoforms occur in vivo, these findings elucidate the biological FCRL5 ligand. (PMID:29101848)
• FCRL5 has dual signaling capacity, while CD21 co-engagement serves as molecular switch, converting FCRL5 from a negative to a positive co-receptor; in tissues, B cells that co-express FCRL5 and CD21 could robustly respond to IgG immune complexes loaded with C3 fragments (PMID:30107486)
• This study identified novel Single nucleotide polymorphism in FCRL3 and FCRL5 significantly associated with the risk for asthma with comorbid allergic rhinitis in the Chinese population (PMID:30771554)
• Fc receptor-like 4 and 5 define human atypical memory B cells. (PMID:32805738)
• The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China. (PMID:32892204)
• SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease. (PMID:34936684)

Cross-species orthologs

0 orthologs

Paralogs (17): FCGR2B (ENSG00000072694), FCRLA (ENSG00000132185), FCRL2 (ENSG00000132704), FCGR2A (ENSG00000143226), FCGR1A (ENSG00000150337), FCRL3 (ENSG00000160856), FCRLB (ENSG00000162746), FCGR3B (ENSG00000162747), FCRL4 (ENSG00000163518), FCRL1 (ENSG00000163534), FCER1A (ENSG00000179639), FCRL6 (ENSG00000181036), C17orf99 (ENSG00000187997), FCGR3A (ENSG00000203747), FCGR2C (ENSG00000244682), PECAM1 (ENSG00000261371), MILR1 (ENSG00000271605)

Protein

Protein identifiers

Fc receptor-like protein 5 — Q96RD9 (reviewed: Q96RD9)

Alternative names: BXMAS1, Fc receptor homolog 5, Immune receptor translocation-associated protein 2

All UniProt accessions (1): Q96RD9

UniProt curated annotations — full annotation on UniProt →

Function. Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation. May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization.

Subunit / interactions. Interacts with CR2. Interacts with CD19.

Subcellular location. Cell membrane.

Tissue specificity. Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level).

Disease relevance. A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32).

Domain organisation. Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM).

Isoforms (5)

UniProt ID	Names	Canonical?
Q96RD9-1	1, IRTA2c	yes
Q96RD9-2	2
Q96RD9-3	3, IRTA2a
Q96RD9-4	4, IRTA2b
Q96RD9-5	5, IRTA2d

RefSeq proteins (2): NP_001182317, NP_112571* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003598	Ig_sub2	Domain
IPR003599	Ig_sub	Domain
IPR007110	Ig-like_dom	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR050488	Ig_Fc_receptor	Family

Pfam: PF13895

UniProt features (45 total): domain 8, disulfide bond 8, splice variant 8, sequence variant 7, short sequence motif 4, topological domain 2, sequence conflict 2, signal peptide 1, chain 1, region of interest 1, compositionally biased region 1, glycosylation site 1, transmembrane region 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
9LOD	ELECTRON MICROSCOPY	3.16
9LOC	ELECTRON MICROSCOPY	3.56

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96RD9-F1	76.51	0.26

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (8): 44–85, 211–260, 308–355, 401–448, 494–541, 587–634, 680–727, 773–819

Glycosylation sites (1): 383

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 66 (showing top): GOBP_SINGLE_FERTILIZATION, GOBP_B_CELL_ACTIVATION, GOCC_CELL_SURFACE, GOBP_FERTILIZATION, VECCHI_GASTRIC_CANCER_EARLY_DN, GOCC_SIDE_OF_MEMBRANE, GOCC_RECEPTOR_COMPLEX, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP, GOMF_CORECEPTOR_ACTIVITY, CHICAS_RB1_TARGETS_CONFLUENT, GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE, GOBP_LYMPHOCYTE_ACTIVATION, ZNF528_TARGET_GENES, ZNF768_TARGET_GENES

GO Biological Process (4): immune response (GO:0006955), cell surface receptor signaling pathway (GO:0007166), single fertilization (GO:0007338), B cell activation (GO:0042113)

GO Molecular Function (3): transmembrane signaling receptor activity (GO:0004888), coreceptor activity (GO:0015026), protein binding (GO:0005515)

GO Cellular Component (5): plasma membrane (GO:0005886), external side of plasma membrane (GO:0009897), cell surface (GO:0009986), signaling receptor complex (GO:0043235), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
signaling receptor activity	2
cellular anatomical structure	2
immune system process	1
response to stimulus	1
signal transduction	1
fertilization	1
lymphocyte activation	1
binding	1
membrane	1
cell periphery	1
plasma membrane	1
cell surface	1
side of membrane	1
protein-containing complex	1

Protein interactions and networks

STRING

1162 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FCRL5	GPRC5D	Q9NZD1	819
FCRL5	PIGR	P01833	774
FCRL5	BCL9	O00512	721
FCRL5	CR2	P20023	587
FCRL5	CD27	P26842	578
FCRL5	CD19	P15391	545
FCRL5	MUC1	P13931	538
FCRL5	SLAMF7	Q9NQ25	533
FCRL5	CD38	P28907	532
FCRL5	CEP70	Q8NHQ1	526
FCRL5	TNFRSF17	Q02223	506
FCRL5	CD72	P21854	475
FCRL5	MS4A2	Q01362	460
FCRL5	TBX21	Q9UL17	453
FCRL5	SDC1	P18827	442

IntAct

12 interactions, top by confidence:

A	B	Type	Score
FCRL5	AMOTL2	psi-mi:“MI:0915”(physical association)	0.560
CAGE1	FCRL5	psi-mi:“MI:0915”(physical association)	0.560
USHBP1	FCRL5	psi-mi:“MI:0915”(physical association)	0.560
FCRL5	FCRL4	psi-mi:“MI:0915”(physical association)	0.400
FCRL5	A2ML1	psi-mi:“MI:0914”(association)	0.350
FCRL5	AMOTL2	psi-mi:“MI:0915”(physical association)	0.000
FCRL5	CAGE1	psi-mi:“MI:0915”(physical association)	0.000
FCRL5	USHBP1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (14): A2ML1 (Affinity Capture-MS), ACPP (Affinity Capture-MS), SERPINB4 (Affinity Capture-MS), ME1 (Affinity Capture-MS), SERPINB3 (Affinity Capture-MS), TGM1 (Affinity Capture-MS), FCRL5 (Two-hybrid), FCRL5 (Two-hybrid), CAGE1 (Two-hybrid), FCRL5 (Affinity Capture-MS), FCRL4 (Affinity Capture-MS), FCRL5 (Affinity Capture-MS), FCRL5 (Affinity Capture-MS), FCRL5 (Affinity Capture-MS)

ESM2 similar proteins: A0A0K2S4Q6, A2A7V7, A6NI73, A8K4G0, O43699, O75019, O75022, O75023, O75871, O76036, P0C191, P20138, P24071, P40198, P59901, P80943, Q08708, Q13410, Q28110, Q3U497, Q496F6, Q64JA4, Q6GTX8, Q6ISS4, Q6PI73, Q6UXZ3, Q7TSN2, Q863H2, Q8C567, Q8K249, Q8MJZ2, Q8MJZ7, Q8N149, Q8N423, Q8N6C8, Q8NHJ6, Q8NHL6, Q8VBT3, Q8VCH2, Q95JB9

Diamond homologs: A0A0B4J1G0, A3RFZ7, E2RP87, G1T7E7, G1TR84, H0VDZ8, M3XWH1, O75015, P08101, P08508, P08637, P0DTI4, P12314, P12318, P12319, P12371, P20489, P26151, P27645, P31994, P31995, P79107, Q09TM2, Q09TM4, Q28110, Q28942, Q3B8P2, Q5DRQ8, Q60513, Q63203, Q6BAA4, Q6XPU4, Q8SPV8, Q8SPW2, Q920A9, Q92637, Q96PJ5, Q96RD9, Q9N2I5, A1YIY0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

165 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	121
Likely benign	22
Benign	6

Top pathogenic / likely-pathogenic (0)

SpliceAI

2626 predictions. Top by Δscore:

Variant	Effect	Δscore
1:157515874:C:CC	acceptor_gain	1.0000
1:157518499:T:C	acceptor_gain	1.0000
1:157518499:T:TC	acceptor_gain	1.0000
1:157518780:CTC:C	acceptor_gain	1.0000
1:157518782:CCTG:C	acceptor_loss	1.0000
1:157518783:C:CC	acceptor_gain	1.0000
1:157518783:CTGTG:C	acceptor_loss	1.0000
1:157518784:T:A	acceptor_loss	1.0000
1:157521012:CTTA:C	donor_loss	1.0000
1:157521013:TTACC:T	donor_loss	1.0000
1:157521014:TA:T	donor_loss	1.0000
1:157521015:A:AC	donor_gain	1.0000
1:157521016:C:A	donor_loss	1.0000
1:157521016:C:CC	donor_gain	1.0000
1:157521288:CGGAA:C	acceptor_gain	1.0000
1:157521293:C:CC	acceptor_gain	1.0000
1:157524558:C:CC	acceptor_gain	1.0000
1:157539365:C:CC	acceptor_gain	1.0000
1:157552326:ACT:A	donor_loss	1.0000
1:157552327:CTC:C	donor_loss	1.0000
1:157552328:TCA:T	donor_loss	1.0000
1:157552329:CACCC:C	donor_loss	1.0000
1:157552330:A:AC	donor_gain	1.0000
1:157552330:A:T	donor_loss	1.0000
1:157552330:AC:A	donor_gain	1.0000
1:157552331:C:CC	donor_gain	1.0000
1:157552331:CC:C	donor_gain	1.0000
1:157552346:A:AC	donor_gain	1.0000
1:157515869:GGCCA:G	acceptor_gain	0.9900
1:157515871:CCA:C	acceptor_gain	0.9900

AlphaMissense

6275 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:157544327:C:G	C260S	0.985
1:157544328:A:T	C260S	0.985
1:157542918:C:G	C355S	0.982
1:157542919:A:T	C355S	0.982
1:157544474:C:G	C211S	0.982
1:157544475:A:T	C211S	0.982
1:157539145:C:G	C448S	0.975
1:157539146:A:T	C448S	0.975
1:157544334:A:C	Y258D	0.973
1:157544422:G:C	F228L	0.973
1:157544422:G:T	F228L	0.973
1:157544424:A:G	F228L	0.973
1:157544474:C:T	C211Y	0.973
1:157544900:A:C	Y164D	0.973
1:157546996:C:G	C85S	0.973
1:157546997:A:T	C85S	0.973
1:157544475:A:G	C211R	0.972
1:157539140:C:G	A450P	0.971
1:157539286:C:G	C401S	0.971
1:157539287:A:T	C401S	0.971
1:157544428:G:C	F226L	0.971
1:157544428:G:T	F226L	0.971
1:157544430:A:G	F226L	0.971
1:157543059:C:G	C308S	0.969
1:157543060:A:T	C308S	0.969
1:157534673:C:G	C541S	0.968
1:157534674:A:T	C541S	0.968
1:157539144:G:C	C448W	0.967
1:157534668:C:G	A543P	0.966
1:157521076:C:G	C819S	0.965

dbSNP variants (sampled 300 via entrez): RS1000047883 (1:157531420 A>G), RS1000436157 (1:157548355 A>C), RS1000577338 (1:157548094 G>T), RS1000620773 (1:157553134 G>A), RS1000660992 (1:157526508 A>T), RS1000809787 (1:157520510 T>C), RS1000894800 (1:157538376 T>A), RS1001050827 (1:157532849 T>C), RS1001081329 (1:157515148 A>G), RS1001161999 (1:157516674 A>T), RS1001182070 (1:157549331 T>G), RS1001329775 (1:157543994 G>A), RS1001681569 (1:157516319 G>C,T), RS1001780949 (1:157522061 A>G), RS1001811921 (1:157521793 T>C)

Disease associations

OMIM: gene MIM:605877 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST001304_8	Renal sinus fat	8.000000e-06
GCST010724_2	HOMA-B (corrected for HOMA-IR)	3.000000e-07
GCST011096_4	Systemic lupus erythematosus	9.000000e-13
GCST90011866_6	Systemic lupus erythematosus	2.000000e-12

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004864	renal sinus adipose tissue measurement
EFO:0004469	HOMA-B

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066101 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

9 total (human), top 9 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
triphenyl phosphate	affects expression	1
testosterone undecanoate	affects cotreatment, increases expression	1
theaflavin-3,3’-digallate	affects expression	1
Arsenic Trioxide	increases expression	1
Benzo(a)pyrene	affects methylation	1
Endosulfan	decreases expression	1
Lead	decreases expression	1
Silicon Dioxide	decreases expression	1
Levonorgestrel	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.