◎ Sugi Atlas

Atlas / Gene / FGF11

FGF11

gene
On this page

Also known as FHF3FLJ16061MGC45269MGC102953

Summary

FGF11 (fibroblast growth factor 11, HGNC:3667) is a protein-coding gene on chromosome 17p13.1, encoding Fibroblast growth factor 11 (Q92914). Probably involved in nervous system development and function.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 2256 — RefSeq curated summary.

At a glance

  • GWAS associations: 2
  • Clinical variants (ClinVar): 48 total — 1 pathogenic
  • MANE Select transcript: NM_004112

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:3667
Approved symbolFGF11
Namefibroblast growth factor 11
Location17p13.1
Locus typegene with protein product
StatusApproved
AliasesFHF3, FLJ16061, MGC45269, MGC102953
Ensembl geneENSG00000161958
Ensembl biotypeprotein_coding
OMIM601514
Entrez2256

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 retained_intron

ENST00000293829, ENST00000572907, ENST00000575082, ENST00000575235, ENST00000575398, ENST00000576328, ENST00000874610

RefSeq mRNA: 2 — MANE Select: NM_004112 NM_001303460, NM_004112

CCDS: CCDS11105

Canonical transcript exons

ENST00000293829 — 5 exons

ExonStartEnd
ENSE0000126460974430767444937
ENSE0000126462074395127439813
ENSE0000290189674425947442792
ENSE0000354118674417767441879
ENSE0000365503174414717441581

Expression profiles

Bgee: expression breadth ubiquitous, 139 present calls, max score 94.20.

FANTOM5 (CAGE): breadth broad, TPM avg 4.3470 / max 69.7377, expressed in 774 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter IDTPM avgSamples expressed
1591932.9438628
1591970.7813304
1591950.3985223
1591960.1709103
1591940.052420

Top tissues by expression

140 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
lower esophagus mucosaUBERON:003583494.20gold quality
left adrenal gland cortexUBERON:003582590.87gold quality
right adrenal glandUBERON:000123390.20gold quality
left adrenal glandUBERON:000123490.06gold quality
right adrenal gland cortexUBERON:003582789.64gold quality
adrenal glandUBERON:000236988.46gold quality
esophagus mucosaUBERON:000246985.43gold quality
skin of abdomenUBERON:000141685.37gold quality
zone of skinUBERON:000001485.26gold quality
skin of legUBERON:000151185.23gold quality
right atrium auricular regionUBERON:000663185.18gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099183.60gold quality
vaginaUBERON:000099681.40gold quality
ganglionic eminenceUBERON:000402381.38gold quality
embryoUBERON:000092281.37gold quality
amygdalaUBERON:000187680.69gold quality
temporal lobeUBERON:000187180.65gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047380.35silver quality
substantia nigraUBERON:000203880.28gold quality
Ammon’s hornUBERON:000195479.19gold quality
putamenUBERON:000187478.97gold quality
apex of heartUBERON:000209878.55gold quality
ectocervixUBERON:001224978.45gold quality
hindlimb stylopod muscleUBERON:000425278.06gold quality
gastrocnemiusUBERON:000138877.98gold quality
heartUBERON:000094877.94gold quality
caudate nucleusUBERON:000187377.94gold quality
skeletal muscle tissueUBERON:000113477.73gold quality
lymph nodeUBERON:000002977.68gold quality
skeletal muscle organUBERON:001489277.30gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-ANND-3no0.29

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

79 targeting FGF11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-6867-5P100.0082.213464
HSA-MIR-4533100.0069.482758
HSA-MIR-574-5P100.0066.01989
HSA-MIR-6748-5P100.0065.811057
HSA-MIR-4481100.0066.421669
HSA-MIR-450099.9972.722367
HSA-MIR-10401-5P99.9965.79948
HSA-LET-7A-5P99.9872.291790
HSA-LET-7B-5P99.9872.311790
HSA-LET-7C-5P99.9872.291790
HSA-LET-7E-5P99.9872.291790
HSA-LET-7F-5P99.9872.561784
HSA-LET-7G-5P99.9872.371784
HSA-LET-7I-5P99.9872.371788
HSA-MIR-98-5P99.9872.331787
HSA-LET-7D-5P99.9671.761632
HSA-MIR-445899.9671.641650
HSA-MIR-6508-5P99.9270.672465
HSA-MIR-7162-3P99.8968.161682
HSA-MIR-137-3P99.8774.742401
HSA-MIR-612499.8769.783551
HSA-MIR-808099.8267.521342
HSA-MIR-3180-5P99.8269.122422
HSA-MIR-6756-5P99.8267.972466
HSA-MIR-807699.7868.521170
HSA-MIR-149-3P99.7268.223963
HSA-MIR-117999.7168.701040
HSA-MIR-6766-5P99.6867.702325
HSA-MIR-130399.6569.771662
HSA-MIR-24-3P99.5969.971934

Literature-anchored findings (GeneRIF, showing 12)

  • these results concluded that infiltrating CD4(+) T cells could promote PCa metastasis via modulation of FGF11–>miRNA-541–>AR–>MMP9 signaling. (PMID:25135278)
  • Study found that FGF11 expression can be induced through HIF-1 binding sites in its promoter region suggesting that FGF11 acts as a novel modulator of hypoxia-induced pathological processes such as tumor progression. (PMID:26323829)
  • Exosomal miR-24-3p is involved in tumour pathogenesis by mediating T-cell suppression via repression of FGF11, and may serve as a potential prognostic biomarker in nasopharyngeal carcinoma (NPC). (PMID:27538493)
  • these results suggest a cross-regulation between HIF-1alpha and FGF11, through which hypoxia-induced FGF11 reinforces hypoxia responses by enhancing the stability of HIF-1alpha. (PMID:28027390)
  • FGF11 as a novel factor driving pathological bone resorption in osteolytic disease and as a potential target for the development of new anti-resorptive therapeutic agents (PMID:28097375)
  • Endothelial miR-342-3p expression was significantly compromised in T2DM organisms and this inhibition powerfully blocked vasculogenesis in vivo by repressing endothelial proliferation and migration. From a mechanistic standpoint, miR-342-3p promoted the transactivation of fibroblast growth factor 11 (FGF11) by directly targeting its 3’ untranslated regions (3’UTRs). (PMID:29852165)
  • FGF11 indirectly controls the expression of PPARgamma through modifying the expression of multiple PPARgamma regulators, thereby mediating adipogenesis. (PMID:30984550)
  • Targeted sequencing of Parkinson’s disease loci genes highlights SYT11, FGF20 and other associations. (PMID:33349842)
  • Fibroblast growth factor 11 (FGF11) promotes non-small cell lung cancer (NSCLC) progression by regulating hypoxia signaling pathway. (PMID:34404435)
  • Hypoxia promotes thyroid cancer progression through HIF1alpha/FGF11 feedback loop. (PMID:35430272)
  • Expression and purification of intracrine human FGF 11 and study of its FGFR-dependent biological activity. (PMID:36318359)
  • Fibroblast Growth Factor 11 Inhibits Hepatitis B Virus Gene Expression Through FXRalpha Suppression. (PMID:37646922)

Cross-species orthologs

4 orthologs

OrganismSymbolGene ID
danio_reriofgf11bENSDARG00000043907
danio_reriofgf11aENSDARG00000069662
mus_musculusFgf11ENSMUSG00000042826
rattus_norvegicusFgf11ENSRNOG00000014882

Paralogs (21): FGF10 (ENSG00000070193), FGF22 (ENSG00000070388), FGF4 (ENSG00000075388), FGF20 (ENSG00000078579), FGF14 (ENSG00000102466), FGF9 (ENSG00000102678), FGF21 (ENSG00000105550), FGF8 (ENSG00000107831), FGF6 (ENSG00000111241), FGF1 (ENSG00000113578), FGF12 (ENSG00000114279), FGF23 (ENSG00000118972), FGF13 (ENSG00000129682), FGF5 (ENSG00000138675), FGF2 (ENSG00000138685), FGF7 (ENSG00000140285), FGF18 (ENSG00000156427), FGF17 (ENSG00000158815), FGF19 (ENSG00000162344), FGF3 (ENSG00000186895), FGF16 (ENSG00000196468)

Protein

Protein identifiers

Fibroblast growth factor 11 — Q92914 (reviewed: Q92914)

Alternative names: Fibroblast growth factor homologous factor 3

All UniProt accessions (3): A0A7U3JVZ5, Q92914, I3L4N4

UniProt curated annotations — full annotation on UniProt →

Function. Probably involved in nervous system development and function.

Tissue specificity. Nervous system.

Similarity. Belongs to the heparin-binding growth factors family.

RefSeq proteins (2): NP_001290389, NP_004103* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR002209Fibroblast_GF_famFamily
IPR008996IL1/FGFHomologous_superfamily

Pfam: PF00167

UniProt features (3 total): chain 1, region of interest 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q92914-F181.900.63

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-5576892Phase 0 - rapid depolarisation

MSigDB gene sets: 181 (showing top): RNGTGGGC_UNKNOWN, MODULE_92, BENPORATH_ES_WITH_H3K27ME3, KEGG_MAPK_SIGNALING_PATHWAY, GCANCTGNY_MYOD_Q6, GOBP_NEUROGENESIS, GOMF_GROWTH_FACTOR_ACTIVITY, GGGTGGRR_PAX4_03, USF_C, SP1_Q2_01, GOBP_CELL_CELL_SIGNALING, KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP, AP1_Q4_01, MYOD_01, KEGG_PATHWAYS_IN_CANCER

GO Biological Process (4): signal transduction (GO:0007165), cell-cell signaling (GO:0007267), nervous system development (GO:0007399), neurogenesis (GO:0022008)

GO Molecular Function (3): growth factor activity (GO:0008083), sodium channel regulator activity (GO:0017080), protein binding (GO:0005515)

GO Cellular Component (2): nucleus (GO:0005634), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
Cardiac conduction1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cell communication2
signaling2
cellular process1
regulation of cellular process1
cellular response to stimulus1
system development1
nervous system development1
cell differentiation1
receptor ligand activity1
sodium channel activity1
ion channel regulator activity1
binding1
intracellular membrane-bounded organelle1
intracellular anatomical structure1
cellular anatomical structure1

Protein interactions and networks

STRING

1246 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
FGF11FGF17O60258683
FGF11FGFR4P22455618
FGF11FGFR1P11362614
FGF11FGF23Q9GZV9610
FGF11KLQ9UEF7572
FGF11APODP05090567
FGF11FGFR2P18443560
FGF11FGFR3P22607552
FGF11FGF19O95750517
FGF11FGF21Q9NSA1516
FGF11KLBQ86Z14505
FGF11FRS2Q8WU20434
FGF11RAP2AP10114429
FGF11EGFP01133427
FGF11TGFB1P01137424

IntAct

16 interactions, top by confidence:

ABTypeScore
RPL22FGF11psi-mi:“MI:0915”(physical association)0.560
HMBOX1FGF11psi-mi:“MI:0915”(physical association)0.560
FGF11THAP1psi-mi:“MI:0915”(physical association)0.560
FGF11STAC3psi-mi:“MI:0915”(physical association)0.560
FGF11CHD1psi-mi:“MI:0914”(association)0.530
NOLC1FGF11psi-mi:“MI:0914”(association)0.350
FGF11ZSWIM8psi-mi:“MI:0914”(association)0.350
FGF11HMBOX1psi-mi:“MI:0915”(physical association)0.000
FGF11STAC3psi-mi:“MI:0915”(physical association)0.000
FGF11THAP1psi-mi:“MI:0915”(physical association)0.000

BioGRID (175): HIF1A (Affinity Capture-Western), FGF11 (Affinity Capture-Western), MATR3 (Affinity Capture-MS), DHX15 (Affinity Capture-MS), DHRS2 (Affinity Capture-MS), AKAP8 (Affinity Capture-MS), PEG3 (Affinity Capture-MS), HSP90AA1 (Affinity Capture-MS), PSMD3 (Affinity Capture-MS), SRSF3 (Affinity Capture-MS), CCT2 (Affinity Capture-MS), AIFM1 (Affinity Capture-MS), FASN (Affinity Capture-MS), HSP90AB2P (Affinity Capture-MS), YWHAQ (Affinity Capture-MS)

ESM2 similar proteins: A6P7H6, O35622, O57341, O76093, O88182, O89101, P03968, P03969, P12226, P13109, P15655, P19596, P20003, P21781, P36363, P37237, P41444, P48798, P48800, P48808, P61150, P61328, P61329, P70377, P70378, P70379, P79150, Q02195, Q0VCA0, Q5D0X0, Q5MK86, Q5MPA9, Q5RAY8, Q5RDS9, Q60487, Q6DTM3, Q6GLR6, Q6PGN3, Q6SJP8, Q7M303

Diamond homologs: A0MTF4, A6P7H6, M3X9S6, O15520, O35565, O43320, O54769, P03968, P03969, P05230, P05524, P08620, P09038, P10767, P11403, P11487, P12034, P12226, P13109, P15655, P15656, P19596, P20002, P20003, P21658, P21781, P31371, P34004, P36363, P36364, P36386, P48798, P48799, P48800, P48801, P48802, P48803, P48804, P48805, P48806

SIGNOR signaling

9 interactions.

AEffectBMechanism
FGF11“down-regulates activity”SCN8Abinding
FGF11“down-regulates activity”SCN5Abinding
FGF11“down-regulates activity”SCN1Abinding
FGF11“down-regulates activity”SCN9Abinding
FGF11“down-regulates activity”SCN2Abinding
FGF11“down-regulates activity”SCN4Abinding
FGF11“down-regulates activity”SCN11Abinding
FGF11“down-regulates activity”SCN10Abinding
FGF11“down-regulates activity”SCN3Abinding

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic1
Likely pathogenic0
Uncertain significance39
Likely benign0
Benign2

Top pathogenic / likely-pathogenic (1)

Variant IDHGVSClassification
3906906GRCh37/hg19 17p13.1(chr17:7041106-7413020)x1Pathogenic

SpliceAI

908 predictions. Top by Δscore:

VariantEffectΔscore
17:7441469:A:AGacceptor_gain1.0000
17:7441470:G:GGacceptor_gain1.0000
17:7441543:G:GTdonor_gain1.0000
17:7441566:GA:Gdonor_gain1.0000
17:7441582:G:GGdonor_gain1.0000
17:7441590:G:Tdonor_gain1.0000
17:7441591:G:GTdonor_gain1.0000
17:7441591:G:Tdonor_gain1.0000
17:7441770:CTGCA:Cacceptor_loss1.0000
17:7441771:TGCAG:Tacceptor_loss1.0000
17:7441772:GCA:Gacceptor_loss1.0000
17:7441773:CAGCC:Cacceptor_loss1.0000
17:7441774:A:AGacceptor_gain1.0000
17:7441774:A:Tacceptor_loss1.0000
17:7441775:G:GGacceptor_gain1.0000
17:7441775:GC:Gacceptor_gain1.0000
17:7441775:GCC:Gacceptor_gain1.0000
17:7441775:GCCC:Gacceptor_gain1.0000
17:7441775:GCCCA:Gacceptor_gain1.0000
17:7441875:GTTCG:Gdonor_gain1.0000
17:7441893:GC:Gdonor_gain1.0000
17:7441894:C:Gdonor_gain1.0000
17:7442576:G:Aacceptor_gain1.0000
17:7442592:A:ACacceptor_loss1.0000
17:7442592:A:AGacceptor_gain1.0000
17:7442593:G:GGacceptor_gain1.0000
17:7442593:GCC:Gacceptor_gain1.0000
17:7442593:GCCGC:Gacceptor_gain1.0000
17:7442745:T:Gdonor_gain1.0000
17:7442791:GG:Gdonor_gain1.0000

AlphaMissense

1440 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
17:7441863:G:TG131V0.999
17:7442619:T:CF145S0.999
17:7442772:T:CF196S0.999
17:7441788:T:CL106P0.998
17:7441818:T:AI116N0.998
17:7441862:G:AG131R0.998
17:7441862:G:CG131R0.998
17:7441863:G:AG131E0.998
17:7442661:C:TS159F0.998
17:7442735:G:AG184R0.998
17:7442735:G:CG184R0.998
17:7441782:T:CF104S0.997
17:7442614:T:GC143W0.997
17:7442619:T:GF145C0.997
17:7442654:T:GY157D0.997
17:7442696:T:AW171R0.997
17:7442696:T:CW171R0.997
17:7442736:G:AG184E0.997
17:7442745:T:AV187D0.997
17:7441501:T:AL75Q0.996
17:7441525:T:AL83H0.996
17:7441854:A:TN128I0.996
17:7442612:T:CC143R0.996
17:7442661:C:AS159Y0.996
17:7442706:G:AG174D0.996
17:7442766:C:AA194D0.996
17:7442771:T:CF196L0.996
17:7442773:T:AF196L0.996
17:7442773:T:GF196L0.996
17:7439634:C:AA5D0.995

dbSNP variants (sampled 300 via entrez): RS1000241010 (17:7444971 C>T), RS1000283469 (17:7440891 C>G,T), RS1000399265 (17:7440732 G>A,T), RS1000730306 (17:7439600 G>A,C), RS1001067658 (17:7439857 G>A), RS1001211203 (17:7443810 C>A), RS1001242391 (17:7443505 C>T), RS1001271364 (17:7445330 G>C,T), RS1001289554 (17:7442176 T>A), RS1001646359 (17:7436543 C>T), RS1002212696 (17:7438229 TCCGCCCCCTGCC>T), RS1002246485 (17:7442282 TA>T,TAA), RS1003213424 (17:7440834 C>A), RS1004001172 (17:7439066 G>C), RS1004024128 (17:7437493 G>A,C,T)

Disease associations

OMIM: gene MIM:601514 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

StudyTraitp-value
GCST010002_119Refractive error3.000000e-22
GCST010703_158Brain morphology (MOSTest)3.000000e-09

EFO canonical traits (1, from GWAS)

EFO IDTrait name
EFO:0004346neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

ChemicalActions (top 5)PubMed papers
Oxygenincreases expression3
entinostatincreases expression, affects cotreatment2
Arsenicaffects expression, affects cotreatment, increases expression2
nickel chlorideincreases expression1
CGP 52608affects binding, increases reaction1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, increases expression1
abrinedecreases expression1
dorsomorphinaffects cotreatment, increases expression1
jinfukangaffects cotreatment, decreases expression1
(+)-JQ1 compounddecreases expression1
Resveratrolaffects cotreatment, decreases expression1
Sunitinibincreases expression1
Vorinostatdecreases expression1
Acetaminophendecreases expression1
Air Pollutantsincreases abundance, decreases methylation1
Benzo(a)pyreneaffects methylation, increases methylation1
Chelating Agentsaffects binding, increases expression1
Cisplatinaffects cotreatment, decreases expression1
Copperincreases expression, affects binding1
Estradiolaffects cotreatment, increases expression1
Folic Aciddecreases expression1
Phthalic Acidsincreases methylation1
Plant Extractsaffects cotreatment, decreases expression1
Smokedecreases expression1
Thimerosaldecreases expression1
Tobacco Smoke Pollutionincreases expression1
Urethanedecreases expression1
1-Methyl-4-phenylpyridiniumincreases expression1
Particulate Matterdecreases methylation, increases abundance1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot