FGF14-AS2

Summary

FGF14-AS2 (FGF14 antisense RNA 2, HGNC:44368) is a long non-coding RNA gene on chromosome 13q33.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44368
Approved symbol	FGF14-AS2
Name	FGF14 antisense RNA 2
Location	13q33.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000272143
Ensembl biotype	lncRNA
Entrez	283481
RNAcentral	URS000075E86F — lncRNA, 1144 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000606448

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000606448 — 1 exons

Exon	Start	End
ENSE00004192884	102394578	102395707

Expression profiles

Bgee: expression breadth ubiquitous, 206 present calls, max score 88.70.

FANTOM5 (CAGE): breadth broad, TPM avg 1.9166 / max 26.1485, expressed in 736 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
135915	1.9166	736

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.70	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	85.73	gold quality
oviduct epithelium	UBERON:0004804	85.21	gold quality
spinal cord	UBERON:0002240	83.77	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.76	gold quality
calcaneal tendon	UBERON:0003701	82.63	gold quality
corpus epididymis	UBERON:0004359	81.92	gold quality
secondary oocyte	CL:0000655	78.42	gold quality
tibial nerve	UBERON:0001323	77.78	gold quality
mucosa of stomach	UBERON:0001199	77.72	gold quality
tendon	UBERON:0000043	77.52	gold quality
adipose tissue	UBERON:0001013	76.77	gold quality
medial globus pallidus	UBERON:0002477	76.57	gold quality
substantia nigra	UBERON:0002038	76.22	gold quality
hypothalamus	UBERON:0001898	76.14	gold quality
right adrenal gland	UBERON:0001233	76.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	76.09	gold quality
lower esophagus	UBERON:0013473	76.04	gold quality
subcutaneous adipose tissue	UBERON:0002190	75.60	gold quality
adenohypophysis	UBERON:0002196	75.56	gold quality
right atrium auricular region	UBERON:0006631	75.35	gold quality
islet of Langerhans	UBERON:0000006	75.13	gold quality
putamen	UBERON:0001874	75.12	gold quality
caput epididymis	UBERON:0004358	75.02	gold quality
left adrenal gland cortex	UBERON:0035825	74.86	gold quality
apex of heart	UBERON:0002098	74.84	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	74.73	gold quality
left adrenal gland	UBERON:0001234	74.63	gold quality
heart left ventricle	UBERON:0002084	74.60	gold quality
amygdala	UBERON:0001876	74.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.75

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Overexpression of Long Non-Coding RNA FGF14-AS2 Inhibits Colorectal Cancer Proliferation Via the RERG/Ras/ERK Signaling by Sponging microRNA-1288-3p. (PMID:32654025)
• LncRNA FGF14-AS2 represses growth of prostate carcinoma cells via modulating miR-96-5p/AJAP1 axis. (PMID:34655124)
• YTHDF2-mediated FGF14-AS2 decay promotes osteolytic metastasis of breast cancer by enhancing RUNX2 mRNA translation. (PMID:36216883)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.