FGFBP1

gene
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Also known as HBP17FGFBP

Summary

FGFBP1 (fibroblast growth factor binding protein 1, HGNC:19695) is a protein-coding gene on chromosome 4p15.32, encoding Fibroblast growth factor-binding protein 1 (Q14512). Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs.

This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4.

Source: NCBI Gene 9982 — RefSeq curated summary.

At a glance

  • GWAS associations: 1
  • Clinical variants (ClinVar): 42 total
  • MANE Select transcript: NM_005130

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:19695
Approved symbolFGFBP1
Namefibroblast growth factor binding protein 1
Location4p15.32
Locus typegene with protein product
StatusApproved
AliasesHBP17, FGFBP
Ensembl geneENSG00000137440
Ensembl biotypeprotein_coding
OMIM607737
Entrez9982

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000382333, ENST00000888688, ENST00000888689, ENST00000955057

RefSeq mRNA: 1 — MANE Select: NM_005130 NM_005130

CCDS: CCDS3418

Canonical transcript exons

ENST00000382333 — 3 exons

ExonStartEnd
ENSE000014917481593557715936652
ENSE000014917521593825115938471
ENSE000014917541593868715938740

Expression profiles

Bgee: expression breadth ubiquitous, 171 present calls, max score 98.66.

FANTOM5 (CAGE): breadth broad, TPM avg 18.0681 / max 2528.5457, expressed in 241 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
5147016.6681221
514711.4000138

Top tissues by expression

282 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
pharyngeal mucosaUBERON:000035598.66gold quality
tongue squamous epitheliumUBERON:000691998.57gold quality
gingivaUBERON:000182898.48gold quality
gingival epitheliumUBERON:000194998.37gold quality
esophagus mucosaUBERON:000246998.14gold quality
cervix squamous epitheliumUBERON:000692298.10gold quality
oral cavityUBERON:000016798.02gold quality
cervix epitheliumUBERON:000480197.47gold quality
squamous epitheliumUBERON:000691497.28gold quality
lower esophagus mucosaUBERON:003583496.76gold quality
esophagus squamous epitheliumUBERON:000692096.36gold quality
epithelium of esophagusUBERON:000197695.97gold quality
mucosa of transverse colonUBERON:000499195.41gold quality
penisUBERON:000098995.37gold quality
mammalian vulvaUBERON:000099793.32gold quality
skin of abdomenUBERON:000141692.26gold quality
zone of skinUBERON:000001489.90gold quality
skin of legUBERON:000151189.76gold quality
body of tongueUBERON:001187689.65gold quality
upper leg skinUBERON:000426288.23gold quality
ileal mucosaUBERON:000033188.05gold quality
vaginaUBERON:000099687.22gold quality
olfactory segment of nasal mucosaUBERON:000538684.57gold quality
islet of LangerhansUBERON:000000684.47gold quality
rectumUBERON:000105283.55gold quality
mucosa of sigmoid colonUBERON:000499382.86gold quality
colonic mucosaUBERON:000031782.73gold quality
skin of hipUBERON:000155480.86gold quality
tongueUBERON:000172380.72gold quality
tracheaUBERON:000312680.35gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

ExperimentMarker?Max mean expression
E-HCAD-1yes243.31
E-MTAB-8142yes116.76
E-MTAB-10596no1737.90
E-ANND-3no0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): AP1, CEBPB, CEBPG, CREB3L1, ETS1, FOS, HIC1, JUN, JUND, KLF5, MYC, RARA, SP1, USF1

miRNA regulators (miRDB)

16 targeting FGFBP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-548P99.9872.253784
HSA-MIR-10527-5P99.9172.283754
HSA-MIR-556-3P99.7468.751203
HSA-MIR-6832-5P99.5864.821132
HSA-MIR-4762-3P99.4369.722363
HSA-MIR-149-5P99.2567.161315
HSA-MIR-429199.2068.882969
HSA-MIR-7109-5P99.1866.131057
HSA-MIR-548L99.0670.902560
HSA-MIR-92299.0267.231838
HSA-MIR-6512-5P98.7669.291195
HSA-MIR-6887-5P98.5668.491295
HSA-MIR-6795-5P98.5268.511277
HSA-MIR-770397.6467.00965
HSA-MIR-6736-3P96.9865.221342
HSA-MIR-500B-3P96.4965.401087

Literature-anchored findings (GeneRIF, showing 16)

  • Upregulation of FGF-BP expression after injury stimulates FGF activity at the wound site, thus enhancing the process of epithelial repair. (PMID:15806171)
  • the FGF interaction domain is contained in the C terminus of FGF-BP1 (PMID:16257968)
  • FGF-BP can be rate-limiting for tumor growth and serves as an angiogenic switch molecule, and that it represents an increasingly promising target molecule in anti-tumor therapy[review] (PMID:16324873)
  • The upregulation of FGF-BP by regenerating renal tubular epithelial cells may provide a mechanism by which the regenerative and angiogenic activity of FGF-2 in renal capillaries can be modulated in children with HIV-HUS and other renal disease. (PMID:16352855)
  • KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization. (PMID:19411256)
  • KLF5 may promote breast cancer cell proliferation at least partially through directly activating the FGF-BP mRNA transcription. (PMID:19668233)
  • Sequence variation in FGFBP1 may contribute to variation in bone mineral density, possibly influencing osteoporosis risk. (PMID:20450993)
  • FGFBP1 associates with hypertension and that systematic analysis of signaling pathways can identify previously undescribed genetic associations. (PMID:21436287)
  • overexpression of FGFBP1 or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer. (PMID:23592278)
  • Up-regulated Sox12 induced by FoxQ1 promotes hepatocellular carcinoma invasion and metastasis by transactivating Twist1 and FGFBP1 expression. (PMID:25704764)
  • These findings indicate that the miR-146a-CREB3L1-FGFBP1 signaling axis plays an important role in the regulation of angiogenesis in human umbilical vein endothelial cells. (PMID:27121396)
  • Genetic polymorphism in the human FGFBP1 gene was associated with higher gene expression and an increased risk of familial Hypertension. (PMID:29158353)
  • The Expression and Prognostic Value of FGF2, FGFR3, and FGFBP1 in Esophageal Squamous Cell Carcinoma. (PMID:33381388)
  • FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer. (PMID:34117747)
  • Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway. (PMID:34341336)
  • HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes. (PMID:37076641)

Cross-species orthologs

2 orthologs

OrganismSymbolGene ID
mus_musculusFgfbp1ENSMUSG00000048373
rattus_norvegicusFgfbp1ENSRNOG00000003095

Paralogs (2): FGFBP2 (ENSG00000137441), FGFBP3 (ENSG00000174721)

Protein

Protein identifiers

Fibroblast growth factor-binding protein 1Q14512 (reviewed: Q14512)

Alternative names: 17 kDa heparin-binding growth factor-binding protein

All UniProt accessions (1): Q14512

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.

Subunit / interactions. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2.

Subcellular location. Secreted. Extracellular space. Cell membrane.

Tissue specificity. Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas.

Induction. Up-regulated in epithelial cells after skin injury. Keratinocyte mitogens.

Miscellaneous. Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell carcinomas, some colon cancer cell lines and tumors.

Similarity. Belongs to the fibroblast growth factor-binding protein family.

RefSeq proteins (1): NP_005121* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR010510FGF1-bdFamily

Pfam: PF06473

UniProt features (12 total): disulfide bond 5, region of interest 2, signal peptide 1, chain 1, mutagenesis site 1, compositionally biased region 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q14512-F174.060.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (5): 214–222, 68–85, 94–127, 103–139, 197–234

Glycosylation sites (1): 169

Mutagenesis-validated functional residues (1):

PositionPhenotype
214strongly reduces interaction with fgf2.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-190377FGFR2b ligand binding and activation

MSigDB gene sets: 165 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_UP, MODULE_92, GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, JAEGER_METASTASIS_DN, REACTOME_SIGNALING_BY_FGFR, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GOBP_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS, GOCC_CELL_SURFACE, SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN, GOBP_CELL_CELL_SIGNALING, GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION, BILD_HRAS_ONCOGENIC_SIGNATURE, MARTINEZ_RB1_TARGETS_UP, GOBP_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION

GO Biological Process (9): signal transduction (GO:0007165), cell-cell signaling (GO:0007267), negative regulation of cell population proliferation (GO:0008285), fibroblast growth factor receptor signaling pathway (GO:0008543), positive regulation of fibroblast growth factor receptor signaling pathway (GO:0045743), myoblast proliferation (GO:0051450), positive regulation of cell migration involved in sprouting angiogenesis (GO:0090050), positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis (GO:1903589), positive regulation of myoblast proliferation (GO:2000288)

GO Molecular Function (4): heparin binding (GO:0008201), fibroblast growth factor binding (GO:0017134), growth factor binding (GO:0019838), protein binding (GO:0005515)

GO Cellular Component (5): extracellular region (GO:0005576), obsolete extracellular space (GO:0005615), plasma membrane (GO:0005886), cell surface (GO:0009986), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
FGFR2 ligand binding and activation1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure3
cell communication2
signaling2
cell population proliferation2
cellular process1
regulation of cellular process1
cellular response to stimulus1
regulation of cell population proliferation1
negative regulation of cellular process1
cell surface receptor protein tyrosine kinase signaling pathway1
cellular response to fibroblast growth factor stimulus1
fibroblast growth factor receptor signaling pathway1
positive regulation of signal transduction1
regulation of fibroblast growth factor receptor signaling pathway1
cell migration involved in sprouting angiogenesis1
positive regulation of blood vessel endothelial cell migration1
regulation of cell migration involved in sprouting angiogenesis1
positive regulation of endothelial cell proliferation1
blood vessel endothelial cell proliferation involved in sprouting angiogenesis1
regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis1
positive regulation of cell population proliferation1
myoblast proliferation1
regulation of myoblast proliferation1
glycosaminoglycan binding1
sulfur compound binding1
growth factor binding1
protein binding1
binding1
membrane1
cell periphery1

Protein interactions and networks

STRING

912 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
FGFBP1FGF1P05230991
FGFBP1FGF7P21781980
FGFBP1FGF2P09038977
FGFBP1FGF22Q9HCT0976
FGFBP1FGF10O15520974
FGFBP1FGF13Q92913952
FGFBP1FGF18O76093946
FGFBP1FGF20Q9NP95945
FGFBP1FGF5P12034945
FGFBP1FGF16O43320944
FGFBP1FGF6P10767942
FGFBP1FGF17O60258942
FGFBP1FGF9P31371941
FGFBP1FGF3P11487940
FGFBP1FGF4P08620938

IntAct

42 interactions, top by confidence:

ABTypeScore
FGFBP1FGF2psi-mi:“MI:0407”(direct interaction)0.620
ASPHFGFBP1psi-mi:“MI:0915”(physical association)0.560
AKT1FGFBP1psi-mi:“MI:2364”(proximity)0.470
FGFBP1AKT1psi-mi:“MI:0915”(physical association)0.470
FGFBP1H1-0psi-mi:“MI:0915”(physical association)0.400
POLR3Apsi-mi:“MI:0914”(association)0.350
ENO1psi-mi:“MI:0914”(association)0.350
DDX3Xpsi-mi:“MI:0914”(association)0.350
PES1psi-mi:“MI:0914”(association)0.350
HNRNPDLpsi-mi:“MI:0914”(association)0.350
IGF2BP3psi-mi:“MI:0914”(association)0.350
GTPBP10psi-mi:“MI:0914”(association)0.350
FGFBP1ZNF724psi-mi:“MI:0914”(association)0.350
ESYT2psi-mi:“MI:0914”(association)0.350
FGFBP1psi-mi:“MI:0914”(association)0.350
EIF3Fpsi-mi:“MI:0914”(association)0.350
SULF2IGLL5psi-mi:“MI:0914”(association)0.350
FBXW7FGFBP1psi-mi:“MI:2364”(proximity)0.270

BioGRID (257): FGFBP1 (Affinity Capture-MS), ASPH (Two-hybrid), FGFBP1 (Affinity Capture-Western), FGFBP1 (Proximity Label-MS), HSPG2 (Two-hybrid), HSPG2 (Affinity Capture-Western), YTHDC2 (Affinity Capture-MS), NOC3L (Affinity Capture-MS), NOL8 (Affinity Capture-MS), PRPF4B (Affinity Capture-MS), URB1 (Affinity Capture-MS), NOC4L (Affinity Capture-MS), KNOP1 (Affinity Capture-MS), UTP3 (Affinity Capture-MS), RRP8 (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8QHQ6, A0A8M9PDM1, A6PWV3, A6QL94, D3Z690, F5HC71, O02699, O12980, O77515, P04401, P05402, P0DJF3, P0DP43, P12401, P17150, P18917, P19159, P20826, P21583, P21702, P33579, P33580, P46685, P52173, P79169, Q08125, Q14512, Q28586, Q29030, Q4R6V5, Q5VZ72, Q60440, Q62575, Q6AY06, Q6P7N7, Q920I0, Q95J76, Q95MD2, Q95N18, Q9CQ58

Diamond homologs: O70514, Q14512, Q9MZ06, Q9QY10

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

42 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance34
Likely benign7
Benign1

Top pathogenic / likely-pathogenic (0)

SpliceAI

409 predictions. Top by Δscore:

VariantEffectΔscore
4:15936649:TCAC:Tacceptor_gain1.0000
4:15936650:CAC:Cacceptor_gain1.0000
4:15936650:CACC:Cacceptor_gain1.0000
4:15936652:CCTGT:Cacceptor_loss1.0000
4:15936653:C:CCacceptor_gain1.0000
4:15936653:C:CGacceptor_loss1.0000
4:15936654:T:Aacceptor_loss1.0000
4:15936657:T:Cacceptor_gain1.0000
4:15936648:TTCAC:Tacceptor_gain0.9900
4:15936651:AC:Aacceptor_gain0.9900
4:15936652:CC:Cacceptor_gain0.9900
4:15936656:T:TCacceptor_gain0.9900
4:15936661:C:CTacceptor_gain0.9900
4:15936656:T:Cacceptor_gain0.9800
4:15936662:A:Tacceptor_gain0.9800
4:15936657:T:TCacceptor_gain0.9700
4:15936655:G:GCacceptor_gain0.9600
4:15936592:A:Tacceptor_gain0.9500
4:15936591:CAG:Cacceptor_gain0.9100
4:15938245:TCTTA:Tdonor_loss0.8800
4:15938246:CTTAC:Cdonor_loss0.8800
4:15938247:TTA:Tdonor_loss0.8800
4:15938248:TA:Tdonor_loss0.8800
4:15938249:ACCT:Adonor_loss0.8800
4:15938250:C:Adonor_loss0.8800
4:15938681:TTTTA:Tdonor_loss0.8600
4:15938682:TTTAC:Tdonor_loss0.8600
4:15938683:TTACC:Tdonor_loss0.8600
4:15938684:TA:Tdonor_loss0.8600
4:15938685:ACC:Adonor_loss0.8600

AlphaMissense

1540 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
4:15936294:C:AW113C0.997
4:15936294:C:GW113C0.997
4:15936346:A:CF96C0.996
4:15936423:C:AW70C0.996
4:15936423:C:GW70C0.996
4:15936430:C:GC68S0.995
4:15936431:A:TC68S0.995
4:15936217:C:GC139S0.994
4:15936218:A:TC139S0.994
4:15936253:C:GC127S0.994
4:15936254:A:TC127S0.994
4:15936379:C:GC85S0.994
4:15936380:A:TC85S0.994
4:15936341:C:AG98C0.992
4:15936325:C:GC103S0.991
4:15936326:A:TC103S0.991
4:15936352:C:GC94S0.991
4:15936353:A:TC94S0.991
4:15936454:A:CF60C0.991
4:15936345:A:CF96L0.989
4:15936345:A:TF96L0.989
4:15936346:A:GF96S0.989
4:15936347:A:GF96L0.989
4:15936429:G:CC68W0.989
4:15936380:A:GC85R0.988
4:15936218:A:GC139R0.987
4:15936352:C:TC94Y0.987
4:15936425:A:GW70R0.987
4:15936425:A:TW70R0.987
4:15936254:A:GC127R0.986

dbSNP variants (sampled 300 via entrez): RS1000377112 (4:15939363 T>G), RS1000895275 (4:15937499 G>A), RS1000968673 (4:15937260 G>A,C), RS1001447723 (4:15935277 C>T), RS1001663628 (4:15940377 G>A), RS1002356079 (4:15937222 A>G), RS1002431269 (4:15936920 C>T), RS1002746902 (4:15935815 C>G,T), RS1003211312 (4:15937713 A>C), RS1003796482 (4:15940518 C>T), RS1004100744 (4:15940695 C>A), RS1004446997 (4:15935258 G>A,T), RS1004908788 (4:15938689 G>A,C), RS1004972729 (4:15935490 T>G), RS1005501553 (4:15940079 G>T)

Disease associations

OMIM: gene MIM:607737 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

StudyTraitp-value
GCST90026413_11Severe insulin-deficient type 2 diabetes7.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

2 variants.

VariantGenesLevelScore#Clin annotsDrugs
rs2245964FGFBP10.000
rs16892645FGFBP10.000

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
sodium arsenitedecreases expression, increases expression4
Tobacco Smoke Pollutionaffects expression, decreases expression, increases expression3
Cadmium Chlorideincreases expression, decreases expression3
bisphenol Adecreases expression2
perfluorooctanoic aciddecreases expression, increases expression2
chloropicrindecreases expression2
dimethylarsinous aciddecreases expression2
Air Pollutantsincreases expression, decreases expression, increases abundance2
bisphenol Fdecreases expression1
propionaldehydeincreases expression1
lead acetatedecreases expression1
ethyl-p-hydroxybenzoateincreases expression1
methylparabendecreases expression1
sulforaphanedecreases expression1
butyraldehydeincreases expression1
cupric chloridedecreases expression1
perfluorodecanoic aciddecreases expression1
epigallocatechin gallateincreases expression1
pentanalincreases expression1
seocalcitoldecreases expression1
CGP 52608affects binding, increases reaction1
monomethylarsonous aciddecreases expression1
abrinedecreases expression1
2,2’,4,4’-tetrabromodiphenyl etherincreases expression1
bisphenol Sdecreases expression1
fatostatindecreases expression1
(+)-JQ1 compounddecreases expression1
Zoledronic Acidincreases expression1
Aldehydesincreases expression1
Arsenicaffects methylation1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_A1T8SEES3-1V human FGFBP1, clone1Embryonic stem cellMale
CVCL_A1T9SEES3-1V human FGFBP1, clone2Embryonic stem cellMale
CVCL_A1U0SEES3-1V human FGFBP1, clone3Embryonic stem cellMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.