FIBCD1

Summary

FIBCD1 (fibrinogen C domain containing 1, HGNC:25922) is a protein-coding gene on chromosome 9q34.12, encoding Fibrinogen C domain-containing protein 1 (Q8N539). Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts.

FIBCD1 is a conserved type II transmembrane endocytic receptor that binds chitin and is located primarily in the intestinal brush border (Schlosser et al., 2009 [PubMed 19710473]).

Source: NCBI Gene 84929 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 137 total
• Druggable target: yes
• MANE Select transcript: NM_032843

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25922
Approved symbol	FIBCD1
Name	fibrinogen C domain containing 1
Location	9q34.12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ14810
Ensembl gene	ENSG00000130720
Ensembl biotype	protein_coding
OMIM	613357
Entrez	84929

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 10 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000372337, ENST00000372338, ENST00000444139, ENST00000448616, ENST00000451466, ENST00000463475, ENST00000486250, ENST00000872083, ENST00000872084, ENST00000933855, ENST00000933856, ENST00000933857

RefSeq mRNA: 2 — MANE Select: NM_032843 NM_001145106, NM_032843

CCDS: CCDS6937

Canonical transcript exons

ENST00000372338 — 7 exons

Exon	Start	End
ENSE00001457570	130902440	130904323
ENSE00001613459	130924237	130924396
ENSE00001636266	130923744	130923880
ENSE00001767299	130911792	130911888
ENSE00001772617	130905234	130905413
ENSE00001920779	130938536	130939247
ENSE00003515123	130929567	130930046

Expression profiles

Bgee: expression breadth ubiquitous, 180 present calls, max score 90.47.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7253 / max 41.7642, expressed in 545 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
102808	1.0504	372
102807	0.3998	198
102806	0.2402	140
102805	0.0348	9

Top tissues by expression

232 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	90.47	gold quality
right adrenal gland cortex	UBERON:0035827	83.30	gold quality
pancreatic ductal cell	CL:0002079	82.49	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.28	gold quality
right adrenal gland	UBERON:0001233	80.96	gold quality
heart right ventricle	UBERON:0002080	80.50	gold quality
adrenal cortex	UBERON:0001235	79.71	gold quality
left adrenal gland cortex	UBERON:0035825	79.59	gold quality
left testis	UBERON:0004533	79.40	gold quality
vena cava	UBERON:0004087	79.28	gold quality
mucosa of transverse colon	UBERON:0004991	79.27	gold quality
left adrenal gland	UBERON:0001234	78.95	gold quality
left ventricle myocardium	UBERON:0006566	78.93	gold quality
right testis	UBERON:0004534	78.47	gold quality
cardiac muscle of right atrium	UBERON:0003379	77.80	gold quality
parotid gland	UBERON:0001831	77.57	gold quality
testis	UBERON:0000473	77.11	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	76.94	silver quality
oocyte	CL:0000023	76.78	silver quality
gingival epithelium	UBERON:0001949	76.58	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.70	silver quality
superficial temporal artery	UBERON:0001614	75.06	gold quality
biceps brachii	UBERON:0001507	74.28	silver quality
cerebellar vermis	UBERON:0004720	74.26	silver quality
gingiva	UBERON:0001828	74.05	gold quality
tendon of biceps brachii	UBERON:0008188	73.98	gold quality
body of tongue	UBERON:0011876	73.72	gold quality
adrenal gland	UBERON:0002369	73.44	gold quality
upper arm skin	UBERON:0004263	73.29	gold quality
Ammon’s horn	UBERON:0001954	73.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.43

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

104 targeting FIBCD1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-6744-5P	99.93	66.82	748
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-22-3P	99.93	68.13	917
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-4503	99.85	71.45	1869
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-6745	99.74	65.33	1321
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-4524A-3P	99.72	66.85	2406
HSA-MIR-1296-3P	99.72	64.04	636
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306
HSA-MIR-3689B-3P	99.70	65.71	2311
HSA-MIR-3689C	99.70	65.71	2311
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-6887-3P	99.66	67.83	1778
HSA-MIR-6762-3P	99.66	66.94	1188

Literature-anchored findings (GeneRIF, showing 10)

• FIBCD1 is a high-affinity receptor for chitin and chitin fragments, and may play an important role in controlling the exposure of intestine to chitin and chitin fragments (PMID:19710473)
• The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition. (PMID:19892701)
• The high affinity ligand N-acetylmannosamine (ManNAc) binds FIBCD1 in the S1 site, predominantly via the acetyl group with the oxygen and acetamide nitrogen hydrogen-bonded to the protein and the methyl group inserted into a hydrophobic pocket. (PMID:24293368)
• FIBCD1 is expressed in epithelial cells derived from all three germ layers. Endodermal-derived epithelial cells throughout the gastrointestinal tract and the respiratory system showed high expression of FIBCD1 and also mesodermal-derived cells in the genitourinary system and ectodermal-derived epidermis and sebaceous glands cells expressed FIBCD1. (PMID:29220632)
• FIBCD1 may be a novel biomarker to evaluate the prognosis of gastric cancer. (PMID:29659669)
• thses findings support FIBCD1 as a lung epithelial pattern recognition receptor that recognizes the complex Aspergillus fumigatus cell wall polysaccharides and modulates the lung epithelial inflammatory response by suppressing inflammatory mediators and mucins (PMID:30279687)
• The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy. (PMID:35501350)
• FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder. (PMID:35916241)
• The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells. (PMID:36888604)
• Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen-associated carbohydrate motifs. (PMID:38072065)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	fibcd1b	ENSDARG00000060393
danio_rerio	fibcd1a	ENSDARG00000074640
mus_musculus	Fibcd1	ENSMUSG00000026841
rattus_norvegicus	Fibcd1	ENSRNOG00000009735

Paralogs (25): TNC (ENSG00000041982), FCN1 (ENSG00000085265), ANGPT2 (ENSG00000091879), ANGPT4 (ENSG00000101280), FGL1 (ENSG00000104760), FN1 (ENSG00000115414), TNR (ENSG00000116147), ANGPTL1 (ENSG00000116194), TNN (ENSG00000120332), FGL2 (ENSG00000127951), ANGPTL6 (ENSG00000130812), ANGPTL3 (ENSG00000132855), ANGPTL2 (ENSG00000136859), FCN3 (ENSG00000142748), FNDC7 (ENSG00000143107), ANGPT1 (ENSG00000154188), FCN2 (ENSG00000160339), MFAP4 (ENSG00000166482), ANGPTL4 (ENSG00000167772), TNXB (ENSG00000168477), FGG (ENSG00000171557), FGA (ENSG00000171560), FGB (ENSG00000171564), ANGPTL7 (ENSG00000171819), ANGPTL5 (ENSG00000187151)

Protein

Protein identifiers

Fibrinogen C domain-containing protein 1 — Q8N539 (reviewed: Q8N539)

All UniProt accessions (4): Q8N539, A3KFJ8, H0Y4Y8, X6RDH7

UniProt curated annotations — full annotation on UniProt →

Function. Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.

Subunit / interactions. Homotetramer; disulfide-linked.

Subcellular location. Membrane.

Tissue specificity. Expressed in the small and large intestinal epithelial cells with a highly polarized localization to the apical surface corresponding to the brush border and in the ducts of the salivary gland.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8N539-1	1	yes
Q8N539-2	2

RefSeq proteins (2): NP_001138578, NP_116232* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002181	Fibrinogen_a/b/g_C_dom	Domain
IPR014716	Fibrinogen_a/b/g_C_1	Homologous_superfamily
IPR020837	Fibrinogen_CS	Conserved_site
IPR036056	Fibrinogen-like_C	Homologous_superfamily
IPR050373	Fibrinogen_C-term_domain	Family

Pfam: PF00147

UniProt features (50 total): strand 14, mutagenesis site 7, helix 7, site 4, splice variant 3, topological domain 2, disulfide bond 2, region of interest 2, binding site 2, chain 1, glycosylation site 1, transmembrane region 1, sequence conflict 1, turn 1, domain 1, compositionally biased region 1

Structure

Experimental structures (PDB)

8 structures.

PDB	Method	Resolution (Å)
6ZQX	X-RAY DIFFRACTION	1.84
6ZQY	X-RAY DIFFRACTION	1.85
6ZQR	X-RAY DIFFRACTION	1.93
6ZR0	X-RAY DIFFRACTION	1.94
6ZR3	X-RAY DIFFRACTION	1.97
4M7H	X-RAY DIFFRACTION	2
6ZR4	X-RAY DIFFRACTION	2
4M7F	X-RAY DIFFRACTION	2.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N539-F1	80.61	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (4): 405 (implicated in ligand binding); 415 (implicated in ligand binding); 431 (implicated in ligand binding); 432 (implicated in ligand binding)

Ligand- & substrate-binding residues (2): 393; 395

Disulfide bonds (2): 244–273, 401–414

Glycosylation sites (1): 340

Mutagenesis-validated functional residues (7):

Position	Phenotype
393	complete loss of binding to acetylated bovine serum albumin and reduced binding to chitin; when associated with a-395.
395	complete loss of binding to acetylated bovine serum albumin and reduced binding to chitin; when associated with n-395.
405	significantly reduced binding to acetylated bovine serum albumin and loss of binding to chitin; when associated with s-4
415	complete loss of binding to acetylated bovine serum albumin and chitin.
431	significantly reduced binding to acetylated bovine serum albumin and loss of binding to chitin; when associated with s-4
432	complete loss of binding to acetylated bovine serum albumin and chitin.
443	slight reduction in binding to acetylated bovine serum albumin and no effect on binding to chitin.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 79 (showing top): EFC_Q6, IRF7_01, MASSARWEH_TAMOXIFEN_RESISTANCE_UP, RFX1_01, WANG_SMARCE1_TARGETS_UP, TAL1BETAITF2_01, MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3, MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3, MIKKELSEN_MCV6_HCP_WITH_H3K27ME3, MIKKELSEN_NPC_HCP_WITH_H3K27ME3, MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN, GOMF_CHITIN_BINDING, chr9q34, GOCC_EXTERNAL_ENCAPSULATING_STRUCTURE, GSE14415_NATURAL_TREG_VS_TCONV_DN

GO Biological Process (0):

GO Molecular Function (3): chitin binding (GO:0008061), metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (2): obsolete extracellular space (GO:0005615), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
carbohydrate derivative binding	1
cation binding	1
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

564 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FIBCD1	ALB	P02768	495
FIBCD1	WFIKKN2	Q8TEU8	456
FIBCD1	QRFP	P83859	441
FIBCD1	OR10W1	Q8NGF6	422
FIBCD1	IGFBP2	P18065	400
FIBCD1	MPPED1	O15442	398
FIBCD1	NOD2	Q9HC29	392
FIBCD1	CLEC7A	Q9BXN2	386
FIBCD1	TMTC4	Q5T4D3	371
FIBCD1	OR9I1	Q8NGQ6	371
FIBCD1	OR2L2	Q8NH16	366
FIBCD1	SOCS3	O14543	360
FIBCD1	WFS1	O76024	358
FIBCD1	PEX5L	Q8IYB4	351
FIBCD1	ZNF586	Q9NXT0	348

IntAct

15 interactions, top by confidence:

A	B	Type	Score
NRP1	CSNK2A2	psi-mi:“MI:0914”(association)	0.790
FIBCD1	MAL	psi-mi:“MI:0915”(physical association)	0.720
MAL	FIBCD1	psi-mi:“MI:0915”(physical association)	0.720
TNFSF8	LGALS8	psi-mi:“MI:0914”(association)	0.530
CLDND1	TNFRSF10B	psi-mi:“MI:0914”(association)	0.350
TSPAN3	SCAMP3	psi-mi:“MI:0914”(association)	0.350
TMUB2	TMEM259	psi-mi:“MI:0914”(association)	0.350
CD80	RIMOC1	psi-mi:“MI:0914”(association)	0.350
GDPD5	TMEM120B	psi-mi:“MI:0914”(association)	0.350
SAAL1	TMEM223	psi-mi:“MI:0914”(association)	0.350
MAL	FIBCD1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (8): FIBCD1 (Two-hybrid), FIBCD1 (Affinity Capture-RNA), MAL (Two-hybrid), FIBCD1 (Phenotypic Suppression), FIBCD1 (Affinity Capture-MS), FIBCD1 (Affinity Capture-MS), FIBCD1 (Affinity Capture-MS), FIBCD1 (Affinity Capture-MS)

ESM2 similar proteins: A2AV25, A5PJQ2, O35764, O43278, O43827, O70165, O95841, O95897, P02675, P02678, P04115, P12804, P14480, P30203, P33573, Q0P4P2, Q14314, Q1RMR1, Q24K15, Q29041, Q29042, Q29RY7, Q2KJ51, Q2TNK5, Q568Y7, Q5EA66, Q5FB95, Q5I2E5, Q5XK91, Q640P2, Q6AX44, Q6TMA8, Q8BM13, Q8IUK5, Q8K0E8, Q8N539, Q8NI99, Q8R0Z6, Q8R1Q3, Q91ZV7

Diamond homologs: A0A8J8, A2AV25, D8VNS7, D8VNS8, D8VNS9, D8VNT0, E2IYB3, E9PV24, O00602, O08538, O15123, O18920, O35460, O35462, O35608, O43827, O70165, O70497, O75636, O77802, O93526, O95841, P02671, P02675, P02676, P02678, P02679, P02680, P04115, P06399, P10039, P12799, P12804, P14448, P14480, P17634, P19477, P21520, P22105, P24821

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

137 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	119
Likely benign	9
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1316 predictions. Top by Δscore:

Variant	Effect	Δscore
9:130905231:CAC:C	donor_loss	1.0000
9:130905232:A:AC	donor_gain	1.0000
9:130905233:C:CC	donor_gain	1.0000
9:130905233:CCTG:C	donor_gain	1.0000
9:130905411:GCCC:G	acceptor_loss	1.0000
9:130905412:CC:C	acceptor_gain	1.0000
9:130905413:CC:C	acceptor_gain	1.0000
9:130905414:C:CC	acceptor_gain	1.0000
9:130905415:T:C	acceptor_loss	1.0000
9:130905420:T:TC	acceptor_gain	1.0000
9:130911787:CTCA:C	donor_loss	1.0000
9:130911790:A:AT	donor_loss	1.0000
9:130911884:AACAC:A	acceptor_gain	1.0000
9:130911885:ACAC:A	acceptor_gain	1.0000
9:130911886:CAC:C	acceptor_gain	1.0000
9:130911886:CACC:C	acceptor_gain	1.0000
9:130911889:C:CA	acceptor_loss	1.0000
9:130911889:C:CC	acceptor_gain	1.0000
9:130911890:T:G	acceptor_loss	1.0000
9:130923736:ACACT:A	donor_loss	1.0000
9:130923737:CACTC:C	donor_loss	1.0000
9:130923738:ACTC:A	donor_loss	1.0000
9:130923739:CTCA:C	donor_loss	1.0000
9:130923740:TCA:T	donor_loss	1.0000
9:130923741:C:CG	donor_loss	1.0000
9:130923742:A:AC	donor_gain	1.0000
9:130923742:ACCGT:A	donor_gain	1.0000
9:130923743:C:CC	donor_gain	1.0000
9:130923743:C:CT	donor_loss	1.0000
9:130923743:CCGT:C	donor_gain	1.0000

AlphaMissense

2977 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:130904139:C:A	W437C	1.000
9:130904139:C:G	W437C	1.000
9:130904141:A:G	W437R	1.000
9:130904141:A:T	W437R	1.000
9:130904208:G:C	C414W	1.000
9:130904209:C:T	C414Y	1.000
9:130904220:C:A	W410C	1.000
9:130904220:C:G	W410C	1.000
9:130904222:A:G	W410R	1.000
9:130904222:A:T	W410R	1.000
9:130904247:A:C	C401W	1.000
9:130904248:C:A	C401F	1.000
9:130904248:C:G	C401S	1.000
9:130904248:C:T	C401Y	1.000
9:130904249:A:T	C401S	1.000
9:130904290:A:G	F387S	1.000
9:130904140:C:G	W437S	0.999
9:130904182:T:C	Y423C	0.999
9:130904183:A:C	Y423D	0.999
9:130904188:C:A	G421V	0.999
9:130904188:C:T	G421E	0.999
9:130904189:C:A	G421W	0.999
9:130904190:A:C	N420K	0.999
9:130904190:A:T	N420K	0.999
9:130904196:G:C	N418K	0.999
9:130904196:G:T	N418K	0.999
9:130904200:G:A	S417F	0.999
9:130904200:G:T	S417Y	0.999
9:130904207:G:C	H415D	0.999
9:130904209:C:A	C414F	0.999

dbSNP variants (sampled 300 via entrez): RS1000000314 (9:130928131 T>A), RS1000011666 (9:130902133 T>C), RS1000021119 (9:130933026 T>A), RS1000066641 (9:130909705 T>C), RS1000109547 (9:130927850 G>A), RS1000145613 (9:130923791 C>T), RS1000202996 (9:130919306 A>G), RS1000265589 (9:130923639 T>C,G), RS1000392947 (9:130920669 C>G), RS1000392988 (9:130915468 C>T), RS1000424873 (9:130919566 C>T), RS1000713593 (9:130917247 C>T), RS1000730943 (9:130937111 T>A), RS1000756267 (9:130919768 G>A,T), RS1000905587 (9:130908768 C>G,T)

Disease associations

OMIM: gene MIM:613357 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST006479_86	Diverticular disease	1.000000e-06
GCST008667_2	Smoking status (heavy vs never)	4.000000e-07
GCST010988_435	Adult body size	1.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009959	diverticular disease
EFO:0006527	smoking status measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523397 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
entinostat	increases expression, affects cotreatment	2
aminomethylphosphonic acid (AMPA)	decreases expression	1
bisphenol A	decreases methylation	1
kojic acid	decreases expression	1
ethyl-p-hydroxybenzoate	decreases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
sodium arsenite	increases expression	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
aflatoxin B2	decreases methylation	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Amiodarone	increases expression	1
Atrazine	increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Cadmium	decreases reaction, increases abundance, increases palmitoylation	1
Diazinon	increases methylation	1
Estradiol	affects cotreatment, increases expression	1
Fluorouracil	decreases expression	1
Plant Extracts	decreases expression, affects cotreatment	1
Silicon Dioxide	decreases expression	1
Testosterone	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	affects expression	1
2,4-Dichlorophenoxyacetic Acid	decreases expression	1
Aflatoxin B1	decreases methylation	1
Cadmium Chloride	increases abundance, increases palmitoylation, decreases reaction	1
Okadaic Acid	decreases expression	1

ChEMBL screening assays

4 unique, capped per target: 4 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4419299	Binding	Binding affinity to V5-His tagged FIBCD1 ecto-domain (54 to 461 residues) (unknown origin) assessed as reduction in binding between FIBCD1 and acetylated BSA at 50 mM by ELISA relative to control	Fibcd1 for the prevention and treatment of diseases

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.