FIBIN

Summary

FIBIN (fin bud initiation factor homolog, HGNC:33747) is a protein-coding gene on chromosome 11p14.2, encoding Fin bud initiation factor homolog (Q8TAL6).

Predicted to enable protein homodimerization activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular region.

Source: NCBI Gene 387758 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 35 total
• MANE Select transcript: NM_203371

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33747
Approved symbol	FIBIN
Name	fin bud initiation factor homolog
Location	11p14.2
Locus type	gene with protein product
Status	Approved
Aliases	MGC24932
Ensembl gene	ENSG00000176971
Ensembl biotype	protein_coding
OMIM	617085
Entrez	387758

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000318627

RefSeq mRNA: 1 — MANE Select: NM_203371 NM_203371

CCDS: CCDS7861

Canonical transcript exons

ENST00000318627 — 1 exons

Exon	Start	End
ENSE00001219478	26994112	26997087

Expression profiles

Bgee: expression breadth ubiquitous, 233 present calls, max score 98.45.

FANTOM5 (CAGE): breadth broad, TPM avg 3.7748 / max 94.3134, expressed in 766 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
113530	3.2197	741
113532	0.3422	218
113533	0.2129	123

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	98.45	gold quality
tibia	UBERON:0000979	98.25	gold quality
descending thoracic aorta	UBERON:0002345	97.68	gold quality
thoracic aorta	UBERON:0001515	97.14	gold quality
ascending aorta	UBERON:0001496	97.03	gold quality
dorsal root ganglion	UBERON:0000044	96.24	gold quality
tibial nerve	UBERON:0001323	95.97	gold quality
aorta	UBERON:0000947	95.89	gold quality
cartilage tissue	UBERON:0002418	95.53	gold quality
cardiac muscle of right atrium	UBERON:0003379	95.43	gold quality
tibial artery	UBERON:0007610	94.98	gold quality
popliteal artery	UBERON:0002250	94.97	gold quality
tendon	UBERON:0000043	94.87	gold quality
lower lobe of lung	UBERON:0008949	94.65	gold quality
left coronary artery	UBERON:0001626	94.44	gold quality
coronary artery	UBERON:0001621	94.01	gold quality
tibialis anterior	UBERON:0001385	93.82	gold quality
synovial joint	UBERON:0002217	93.56	gold quality
pericardium	UBERON:0002407	93.25	gold quality
kidney epithelium	UBERON:0004819	93.19	silver quality
mucosa of stomach	UBERON:0001199	92.95	gold quality
saphenous vein	UBERON:0007318	92.79	gold quality
urethra	UBERON:0000057	92.77	gold quality
upper arm skin	UBERON:0004263	92.76	silver quality
seminal vesicle	UBERON:0000998	92.45	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.96	gold quality
left ventricle myocardium	UBERON:0006566	91.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	91.39	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	91.38	gold quality
lower esophagus	UBERON:0013473	91.29	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-MTAB-9906	yes	1711.05
E-ANND-3	yes	22.49
E-MTAB-8410	yes	15.78
E-CURD-112	yes	5.87

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

113 targeting FIBIN, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-3605-5P	99.96	67.12	932
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-301B-3P	99.90	73.19	1836
HSA-MIR-130A-3P	99.90	73.31	1861
HSA-MIR-130B-3P	99.90	73.27	1850
HSA-MIR-301A-3P	99.90	73.15	1839
HSA-MIR-3666	99.90	73.24	1833
HSA-MIR-4295	99.90	73.11	1838
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-3686	99.90	70.53	2432

Literature-anchored findings (GeneRIF, showing 1)

• The novel DNA methylation marker FIBIN suppresses non-small cell lung cancer metastasis by negatively regulating ANXA2. (PMID:38697447)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	fibina	ENSDARG00000039949
danio_rerio	fibinb	ENSDARG00000087196
mus_musculus	Fibin	ENSMUSG00000074971
rattus_norvegicus	Fibin	ENSRNOG00000073909

Protein

Protein identifiers

Fin bud initiation factor homolog — Q8TAL6 (reviewed: Q8TAL6)

All UniProt accessions (1): Q8TAL6

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Homodimer; disulfide-linked. Seems to also exist as monomers.

Subcellular location. Secreted. Golgi apparatus. Endoplasmic reticulum.

Similarity. Belongs to the FIBIN family.

RefSeq proteins (1): NP_976249* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026772	Fibin	Family

Pfam: PF15819

UniProt features (5 total): disulfide bond 2, signal peptide 1, chain 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TAL6-F1	76.63	0.18

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (2): 52, 64

Glycosylation sites (1): 30

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 101 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_UP, HNF1_Q6, GGGTGGRR_PAX4_03, PAPASPYRIDONOS_UNSTABLE_ATEROSCLEROTIC_PLAQUE_DN, RIGGI_EWING_SARCOMA_PROGENITOR_DN, SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN, CTGYNNCTYTAA_UNKNOWN, YAMAZAKI_TCEB3_TARGETS_DN, TGGAAA_NFAT_Q4_01, GOMF_PROTEIN_DIMERIZATION_ACTIVITY, GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP, GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY, chr11p14, MIKKELSEN_IPS_ICP_WITH_H3K4ME3_AND_H327ME3, MIKKELSEN_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3

GO Biological Process (1): biological_process (GO:0008150)

GO Molecular Function (2): protein homodimerization activity (GO:0042803), molecular_function (GO:0003674)

GO Cellular Component (4): extracellular region (GO:0005576), endoplasmic reticulum (GO:0005783), Golgi apparatus (GO:0005794), cellular_component (GO:0005575)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	2
endomembrane system	2
intracellular membrane-bounded organelle	2
identical protein binding	1
protein dimerization activity	1
cellular anatomical structure	1

Protein interactions and networks

STRING

860 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FIBIN	GLT8D2	Q9H1C3	476
FIBIN	L3MBTL4	Q8NA19	454
FIBIN	RHNO1	Q9BSD3	395
FIBIN	RANBP3L	Q86VV4	387
FIBIN	SUSD5	O60279	378
FIBIN	UCMA	Q8WVF2	351
FIBIN	E9PNW1	E9PNW1	350
FIBIN	PLCD3	Q8N3E9	350
FIBIN	FAM180A	Q6UWF9	337
FIBIN	POMGNT1	Q8WZA1	336
FIBIN	USHBP1	Q8N6Y0	335
FIBIN	CMBL	Q96DG6	333
FIBIN	ACSF2	Q96CM8	333
FIBIN	BBOX1	O75936	330
FIBIN	ZNF536	O15090	330
FIBIN	ZNF219	Q9P2Y4	330

IntAct

2 interactions, top by confidence:

A	B	Type	Score
FIBIN	MAN2B1	psi-mi:“MI:0914”(association)	0.350

BioGRID (68): PCSK9 (Affinity Capture-MS), GALNT18 (Affinity Capture-MS), LAMB1 (Affinity Capture-MS), FOXRED2 (Affinity Capture-MS), ADAMTS7 (Affinity Capture-MS), KLHL13 (Affinity Capture-MS), EDEM3 (Affinity Capture-MS), SEMA4B (Affinity Capture-MS), PLAU (Affinity Capture-MS), CACNA2D2 (Affinity Capture-MS), PTPRU (Affinity Capture-MS), MEGF8 (Affinity Capture-MS), MAN2A2 (Affinity Capture-MS), MAN2B1 (Affinity Capture-MS), MAN2A1 (Affinity Capture-MS)

ESM2 similar proteins: A0A1B0GVD1, A0A1S4F550, A0A3B7TNM4, A1IGX5, A4UZ23, A6H7E2, A8R0V4, B9UJ97, C0HMB7, F4J1G1, O57571, P01580, P0C137, P0C139, P0C142, P28341, P29078, P33493, P34404, P34566, P42161, P46402, P52473, P52546, Q01640, Q03956, Q09220, Q09304, Q17F11, Q1WM28, Q25BC0, Q4ZH68, Q5E9H1, Q5U2T4, Q62574, Q67402, Q6CVF1, Q7T3D0, Q80A33, Q8MKF5

Diamond homologs: A1IGX5, A4UZ23, Q5E9H1, Q5U2T4, Q8TAL6, Q9CQS3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

35 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	33
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

84 predictions. Top by Δscore:

Variant	Effect	Δscore
11:26994479:G:A	acceptor_gain	0.6100
11:26994767:C:CA	acceptor_gain	0.5200
11:26994770:G:GC	acceptor_gain	0.5200
11:26994854:GAC:G	acceptor_gain	0.5000
11:26994478:T:TA	acceptor_gain	0.4900
11:26994696:GG:G	donor_gain	0.4600
11:26994697:GG:G	donor_gain	0.4600
11:26994847:C:CA	acceptor_gain	0.4600
11:26994787:G:GT	acceptor_gain	0.4300
11:26994314:G:A	donor_gain	0.4200
11:26994767:CGGG:C	acceptor_gain	0.4000
11:26994768:G:A	acceptor_gain	0.4000
11:26994784:G:GT	acceptor_gain	0.4000
11:26994770:GAGGA:G	acceptor_gain	0.3900
11:26994771:AGGAG:A	acceptor_gain	0.3900
11:26994439:G:GT	donor_gain	0.3600
11:26994765:TGCGG:T	acceptor_gain	0.3600
11:26994766:GCGGG:G	acceptor_gain	0.3600
11:26994694:CAGGG:C	donor_loss	0.3500
11:26994695:AGGGT:A	donor_loss	0.3500
11:26994697:GGTG:G	donor_loss	0.3500
11:26994698:G:T	donor_loss	0.3500
11:26994699:T:TC	donor_loss	0.3500
11:26994700:G:GT	donor_loss	0.3500
11:26994785:C:CT	acceptor_gain	0.3500
11:26994786:T:TT	acceptor_gain	0.3500
11:26994482:TAAA:T	donor_gain	0.3400
11:26994483:AAAA:A	donor_gain	0.3400
11:26994484:AAAA:A	donor_gain	0.3400
11:26994701:AGTG:A	donor_loss	0.3400

AlphaMissense

1397 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:26994945:T:C	L140P	0.998
11:26994680:T:A	C52S	0.997
11:26994680:T:C	C52R	0.997
11:26994681:G:C	C52S	0.997
11:26994882:T:C	L119P	0.997
11:26994936:T:C	L137P	0.997
11:26994635:T:C	F37L	0.996
11:26994637:C:A	F37L	0.996
11:26994637:C:G	F37L	0.996
11:26994682:C:G	C52W	0.996
11:26994626:C:G	H34D	0.995
11:26994681:G:A	C52Y	0.995
11:26994692:T:C	F56L	0.995
11:26994693:T:C	F56S	0.995
11:26994694:C:A	F56L	0.995
11:26994694:C:G	F56L	0.995
11:26994636:T:C	F37S	0.994
11:26994632:T:G	Y36D	0.993
11:26994636:T:G	F37C	0.993
11:26994648:G:T	G41V	0.993
11:26994681:G:T	C52F	0.993
11:26994911:G:C	A129P	0.993
11:26994936:T:A	L137H	0.993
11:26994957:T:C	F144S	0.993
11:26994618:G:T	G31V	0.992
11:26994693:T:G	F56C	0.992
11:26994836:A:C	S104R	0.992
11:26994838:C:A	S104R	0.992
11:26994838:C:G	S104R	0.992
11:26994956:T:C	F144L	0.992

dbSNP variants (sampled 300 via entrez): RS1000876451 (11:26994324 G>A), RS1001328568 (11:26994022 C>T), RS1001766556 (11:26995203 C>T), RS1002218994 (11:26994832 C>A,T), RS1002515128 (11:26993593 C>A), RS1003687607 (11:26995435 G>A,C), RS1004088729 (11:26997027 T>C), RS1004115040 (11:26996489 A>T), RS1005060591 (11:26994466 C>T), RS1005343618 (11:26993048 G>A), RS1005396039 (11:26992584 G>C), RS1006155247 (11:26993331 C>T), RS1006616360 (11:26992226 G>A,C), RS1008152690 (11:26996419 A>C,G), RS1008585788 (11:26997563 G>A)

Disease associations

OMIM: gene MIM:617085 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST002875_88	Diisocyanate-induced asthma	1.000000e-06
GCST005411_5	Thrombin-activatable fibrinolysis inhibitor activation peptide	9.000000e-07
GCST008839_324	Height	4.000000e-19

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0006995	response to diisocyanate

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, decreases methylation, increases expression	3
methylmercuric chloride	increases expression	2
sodium arsenite	decreases expression, increases expression	2
Vorinostat	affects cotreatment, increases expression	2
Air Pollutants	decreases expression, increases abundance	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Tunicamycin	increases expression	2
bisphenol A	affects cotreatment, increases methylation	1
lead acetate	decreases expression	1
ethyl-p-hydroxybenzoate	increases expression	1
mono-(2-ethylhexyl)phthalate	increases abundance, increases methylation	1
ferrous chloride	decreases expression	1
cupric chloride	decreases expression	1
hydroquinone	increases expression	1
avobenzone	decreases expression	1
2-ethyl-5-carboxypentyl phthalate	increases abundance, increases methylation	1
mono(2-ethyl-5-oxohexyl)phthalate	increases abundance, increases methylation	1
deguelin	increases expression	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
mono(2-ethyl-5-hydroxyhexyl) phthalate	increases abundance, increases methylation	1
thifluzamide	increases expression	1
dorsomorphin	increases expression, affects cotreatment	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Calcitriol	decreases expression	1
Estradiol	affects cotreatment, decreases expression	1
Formaldehyde	increases expression	1
Nickel	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.