FILNC1

Summary

FILNC1 (FOXO induced long non-coding RNA 1, HGNC:53755) is a long non-coding RNA gene on chromosome 6q24.1.

This gene produces a long non-coding RNA that is induced by forkhead box O proteins and plays a role in stress-induced apoptosis. Knock down of transcripts at this locus results in increased renal tumor growth and alteration in genes involved in glucose metabolism. This RNA interacts with heterogeneous nuclear ribonucleoprotein D and prevents it from binding to Myc mRNA, therefore suppressing Myc activity. Alternative splicing and transcriptional start site usage results in multiple transcript variants.

Source: NCBI Gene 100132735 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53755
Approved symbol	FILNC1
Name	FOXO induced long non-coding RNA 1
Location	6q24.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231426
Ensembl biotype	lncRNA
OMIM	621322
Entrez	100132735
RNAcentral	URS00008B354E — lncRNA, 1294 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000414038, ENST00000431609, ENST00000642381, ENST00000644936, ENST00000646293, ENST00000647189, ENST00000647420, ENST00000668346, ENST00000801711, ENST00000801712, ENST00000824669, ENST00000824670, ENST00000824671

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414038 — 3 exons

Exon	Start	End
ENSE00001750107	139856764	139856819
ENSE00003819691	139859285	139860476
ENSE00004191325	139854829	139854977

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 78.91.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4949 / max 87.3680, expressed in 96 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
70155	0.1990	65
70156	0.1807	42
70157	0.1153	13

Top tissues by expression

204 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.91	gold quality
stromal cell of endometrium	CL:0002255	71.28	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.90	gold quality
metanephros cortex	UBERON:0010533	64.43	gold quality
placenta	UBERON:0001987	63.94	gold quality
leukocyte	CL:0000738	63.07	gold quality
monocyte	CL:0000576	63.04	gold quality
sural nerve	UBERON:0015488	62.42	gold quality
adult mammalian kidney	UBERON:0000082	61.66	gold quality
cortex of kidney	UBERON:0001225	59.96	gold quality
kidney	UBERON:0002113	58.93	gold quality
ganglionic eminence	UBERON:0004023	56.97	gold quality
metanephros	UBERON:0000081	55.10	gold quality
buccal mucosa cell	CL:0002336	55.03	silver quality
granulocyte	CL:0000094	54.66	gold quality
hindlimb stylopod muscle	UBERON:0004252	54.23	silver quality
calcaneal tendon	UBERON:0003701	54.09	gold quality
vermiform appendix	UBERON:0001154	53.29	gold quality
decidua	UBERON:0002450	53.27	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	51.25	gold quality
adipose tissue	UBERON:0001013	50.70	gold quality
prefrontal cortex	UBERON:0000451	50.28	gold quality
islet of Langerhans	UBERON:0000006	50.12	gold quality
gastrocnemius	UBERON:0001388	50.06	gold quality
smooth muscle tissue	UBERON:0001135	49.31	gold quality
ovary	UBERON:0000992	49.21	gold quality
lower lobe of lung	UBERON:0008949	49.01	silver quality
left lobe of thyroid gland	UBERON:0001120	48.41	gold quality
caecum	UBERON:0001153	48.39	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	47.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• FOXO induced long non-coding RNA 1 (FILNC1) is induced upon energy stress through FoxO transcription factors, and inhibits c-Myc-mediated energy metabolism and renal tumor development. (PMID:28978906)
• Upon energy stress FoxOs induce the expression of the long non-coding RNA FILNC1, which inhibits survival of RCC by downregulating c-Myc and c-Myc-dependent metabolic rewiring. (PMID:28978906)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.