FIRRM

Summary

FIRRM (FIGNL1 interacting regulator of recombination and mitosis, HGNC:25565) is a protein-coding gene on chromosome 1q24.2, encoding FIGNL1-interacting regulator of recombination and mitosis (Q9NSG2). Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities.

Enables protein kinase binding activity. Involved in several processes, including chromosome segregation; interstrand cross-link repair; and regulation of protein kinase activity. Located in several cellular components, including midbody; nuclear lumen; and spindle midzone.

Source: NCBI Gene 55732 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 89 total
• MANE Select transcript: NM_001320047

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25565
Approved symbol	FIRRM
Name	FIGNL1 interacting regulator of recombination and mitosis
Location	1q24.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10706, Apolo1, FLIP, MEICA1
Ensembl gene	ENSG00000000460
Ensembl biotype	protein_coding
Entrez	55732

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 18 protein_coding, 3 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000286031, ENST00000359326, ENST00000413811, ENST00000459772, ENST00000466580, ENST00000472795, ENST00000481744, ENST00000496973, ENST00000498289, ENST00000909928, ENST00000909929, ENST00000909930, ENST00000909931, ENST00000909932, ENST00000909933, ENST00000909934, ENST00000937558, ENST00000937559, ENST00000937560, ENST00000937561, ENST00000937562, ENST00000937563

RefSeq mRNA: 11 — MANE Select: NM_001320047 NM_001320047, NM_001320048, NM_001320050, NM_001320051, NM_001363739, NM_001366768, NM_001366769, NM_001366770, NM_001366771, NM_001366772, NM_001366773

CCDS: CCDS1285, CCDS81400, CCDS81401, CCDS86030

Canonical transcript exons

ENST00000359326 — 25 exons

Exon	Start	End
ENSE00001360154	169798857	169798958
ENSE00001412460	169795040	169795115
ENSE00001421089	169795829	169795983
ENSE00003458738	169843674	169843769
ENSE00003464527	169823408	169823472
ENSE00003482569	169847690	169847803
ENSE00003487522	169832417	169832506
ENSE00003492238	169802621	169802725
ENSE00003493429	169836927	169837112
ENSE00003495412	169803169	169803309
ENSE00003498128	169806004	169806088
ENSE00003509056	169807791	169807929
ENSE00003531480	169804075	169804240
ENSE00003533613	169850265	169850345
ENSE00003546572	169829263	169829449
ENSE00003569239	169821679	169821759
ENSE00003572071	169851817	169851936
ENSE00003576155	169849500	169849604
ENSE00003583959	169842417	169842539
ENSE00003589762	169830259	169830341
ENSE00003593747	169830696	169830747
ENSE00003596167	169800883	169800971
ENSE00003666669	169827711	169827840
ENSE00003669213	169852790	169854080
ENSE00003714797	169827051	169827199

Expression profiles

Bgee: expression breadth ubiquitous, 177 present calls, max score 88.46.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.2823 / max 182.1816, expressed in 1635 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
6538	12.2823	1635

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.46	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.16	gold quality
ventricular zone	UBERON:0003053	84.69	gold quality
ganglionic eminence	UBERON:0004023	82.14	gold quality
embryo	UBERON:0000922	81.08	gold quality
calcaneal tendon	UBERON:0003701	79.80	gold quality
right testis	UBERON:0004534	78.71	gold quality
testis	UBERON:0000473	78.51	gold quality
left testis	UBERON:0004533	78.03	gold quality
monocyte	CL:0000576	76.10	gold quality
mononuclear cell	CL:0000842	75.86	gold quality
leukocyte	CL:0000738	75.67	gold quality
stromal cell of endometrium	CL:0002255	75.50	gold quality
rectum	UBERON:0001052	75.36	gold quality
islet of Langerhans	UBERON:0000006	74.19	gold quality
granulocyte	CL:0000094	72.88	gold quality
right hemisphere of cerebellum	UBERON:0014890	72.75	gold quality
tibial nerve	UBERON:0001323	72.56	gold quality
right ovary	UBERON:0002118	72.35	gold quality
lymph node	UBERON:0000029	72.28	gold quality
body of uterus	UBERON:0009853	72.28	gold quality
cerebellar hemisphere	UBERON:0002245	72.21	gold quality
left ovary	UBERON:0002119	72.15	gold quality
ectocervix	UBERON:0012249	72.15	gold quality
cerebellar cortex	UBERON:0002129	72.03	gold quality
adrenal tissue	UBERON:0018303	71.96	gold quality
vermiform appendix	UBERON:0001154	71.92	gold quality
popliteal artery	UBERON:0002250	71.61	gold quality
tibial artery	UBERON:0007610	71.61	gold quality
endocervix	UBERON:0000458	71.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.09

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

12 targeting FIRRM, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-6715A-3P	99.83	68.05	1473
HSA-MIR-6083	99.47	68.73	2393
HSA-MIR-4727-5P	99.23	67.55	1154
HSA-MIR-6738-3P	99.03	67.14	1326
HSA-MIR-5001-3P	98.91	67.28	1394

Literature-anchored findings (GeneRIF, showing 3)

• Knockdown of C1orf112 by siRNA in HeLa cells significantly suppressed their growth. (PMID:23039964)
• Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation. (PMID:34260926)
• FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress. (PMID:38286805)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	firrm	ENSDARG00000042120
mus_musculus	Firrm	ENSMUSG00000041406
rattus_norvegicus	Firrm	ENSRNOG00000059276

Protein

Protein identifiers

FIGNL1-interacting regulator of recombination and mitosis — Q9NSG2 (reviewed: Q9NSG2)

Alternative names: FIDGETIN-like-1 interacting protein, POLO1-associating protein

All UniProt accessions (4): A0A1B0GTJ9, A0A1B0GUP7, A0A1B0GV14, Q9NSG2

UniProt curated annotations — full annotation on UniProt →

Function. Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities. Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis. In complex with FIGL1 may regulate homologous recombination.

Subunit / interactions. Interacts (via its N-terminal region) with PLK1; controls PLK1 kinase activity. Interacts (via the KVVXF motif) with PPP1CC; controls PLK1 kinase activity. Interacts with FIGNL1; may regulate homologous recombination.

Subcellular location. Chromosome. Centromere. Kinetochore. Nucleus. Midbody. Cytoplasm. Cytoskeleton. Spindle.

Post-translational modifications. Phosphorylation at Ser-43 by PLK1 strengthens FIRRM-PLK1 interaction. Phosphorylation at Ser-744 by PLK1 negatively regulates its interaction with PPP1CC.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NSG2-1	1	yes
Q9NSG2-2	2
Q9NSG2-3	3

RefSeq proteins (11): NP_001306976, NP_001306977, NP_001306979, NP_001306980, NP_001350668, NP_001353697, NP_001353698, NP_001353699, NP_001353700, NP_001353701, NP_001353702 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR027902	DUF4487	Family

Pfam: PF14868

UniProt features (13 total): mutagenesis site 4, modified residue 3, sequence conflict 2, splice variant 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NSG2-F1	86.78	0.56

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 43, 744, 792

Mutagenesis-validated functional residues (4):

Position	Phenotype
744	decreased binding to ppp1cc. does not rescue the mitotic defects seen in firrm-depleted cells.
43	decreased binding to plk1.
43	increased binding to plk1.
744	does not affect binding to ppp1cc. rescues the mitotic defects seen in firrm-depleted cells.

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-2500257	Resolution of Sister Chromatid Cohesion
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-912446	Meiotic recombination

MSigDB gene sets: 183 (showing top): REACTOME_MEIOTIC_RECOMBINATION, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GOBP_REGULATION_OF_PHOSPHORYLATION, CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN, GOBP_REGULATION_OF_TRANSFERASE_ACTIVITY, WEI_MYCN_TARGETS_WITH_E_BOX, WCTCNATGGY_UNKNOWN, GOBP_DNA_DAMAGE_RESPONSE, GOBP_INTERSTRAND_CROSS_LINK_REPAIR, GOBP_MITOTIC_CELL_CYCLE, FISCHER_DREAM_TARGETS, ZHANG_BREAST_CANCER_PROGENITORS_UP, VANTVEER_BREAST_CANCER_ESR1_DN, REACTOME_DNA_REPAIR, HAN_SATB1_TARGETS_DN

GO Biological Process (4): mitotic cell cycle (GO:0000278), chromosome segregation (GO:0007059), interstrand cross-link repair (GO:0036297), regulation of protein kinase activity (GO:0045859)

GO Molecular Function (2): protein kinase binding (GO:0019901), protein binding (GO:0005515)

GO Cellular Component (12): chromosome, centromeric region (GO:0000775), kinetochore (GO:0000776), nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytosol (GO:0005829), midbody (GO:0030496), spindle midzone (GO:0051233), chromosome (GO:0005694), cytoplasm (GO:0005737), spindle (GO:0005819), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitotic Prometaphase	1
Resolution of D-Loop Structures	1
Meiosis	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membraneless organelle	5
cellular anatomical structure	5
nuclear lumen	2
cell cycle	1
mitotic nuclear division	1
cell cycle process	1
DNA repair	1
regulation of protein phosphorylation	1
protein kinase activity	1
regulation of kinase activity	1
kinase binding	1
binding	1
chromosomal region	1
condensed chromosome, centromeric region	1
supramolecular complex	1
intracellular membrane-bounded organelle	1
cytoplasm	1
spindle	1
intracellular anatomical structure	1
microtubule cytoskeleton	1

Protein interactions and networks

STRING

900 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FIRRM	PARPBP	Q9NWS1	536
FIRRM	ZFYVE28	Q9HCC9	502
FIRRM	HGH1	P0CB43	473
FIRRM	TMEM268	Q5VZI3	465
FIRRM	NCAPH	Q15003	438
FIRRM	EGFLAM	Q63HQ2	435
FIRRM	RAD54L	Q92698	431
FIRRM	SGO2	Q562F6	419
FIRRM	KIF18B	Q86Y91	419
FIRRM	KIF15	Q9NS87	417
FIRRM	CABIN1	Q9Y6J0	412
FIRRM	ARHGAP11A	Q6P4F7	405
FIRRM	NCAPG	Q9BPX3	400
FIRRM	TPX2	Q9ULW0	374
FIRRM	FIGNL1	Q6PIW4	370

IntAct

89 interactions, top by confidence:

A	B	Type	Score
P4HA3	FIRRM	psi-mi:“MI:0915”(physical association)	0.560
FIGNL1	FIRRM	psi-mi:“MI:0915”(physical association)	0.560
FIRRM	FIGNL1	psi-mi:“MI:0915”(physical association)	0.560
SLC15A1	METTL15	psi-mi:“MI:0914”(association)	0.530
PDCD1	RTL8C	psi-mi:“MI:0914”(association)	0.530
SPINT2	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
PTGER3	PIK3R2	psi-mi:“MI:0914”(association)	0.530
FCGRT	GOLIM4	psi-mi:“MI:0914”(association)	0.530
EPHA1	EXOC5	psi-mi:“MI:0914”(association)	0.530
CHRM3	PLD2	psi-mi:“MI:0914”(association)	0.530
HLA-B	LTN1	psi-mi:“MI:0914”(association)	0.530
GPR17	IPO8	psi-mi:“MI:0914”(association)	0.530
ILVBL	SLC33A1	psi-mi:“MI:0914”(association)	0.530
OPALIN	BTAF1	psi-mi:“MI:0914”(association)	0.530
FIGNL1	CALD1	psi-mi:“MI:0914”(association)	0.350
FIRRM	ALDH3A2	psi-mi:“MI:0914”(association)	0.350
UNC93B1		psi-mi:“MI:0914”(association)	0.350
GP	IPO5	psi-mi:“MI:0914”(association)	0.350
SLC16A11	ESYT2	psi-mi:“MI:0914”(association)	0.350
GPR17	TMEM120B	psi-mi:“MI:0914”(association)	0.350
C11orf87	KLRG2	psi-mi:“MI:0914”(association)	0.350
LRRC25	POTEF	psi-mi:“MI:0914”(association)	0.350
P2RY10	POTEF	psi-mi:“MI:0914”(association)	0.350
EFNB1	KRBA1	psi-mi:“MI:0914”(association)	0.350
TACSTD2	RIMOC1	psi-mi:“MI:0914”(association)	0.350
SIGLECL1	RBFOX3	psi-mi:“MI:0914”(association)	0.350
CLEC4A	RBFOX3	psi-mi:“MI:0914”(association)	0.350
C5AR1	TCAF2	psi-mi:“MI:0914”(association)	0.350

BioGRID (88): C1orf112 (Affinity Capture-MS), C1orf112 (Affinity Capture-MS), C1orf112 (Affinity Capture-MS), C1orf112 (Affinity Capture-MS), C1orf112 (Affinity Capture-MS), C1orf112 (Affinity Capture-MS), ALDH3A2 (Affinity Capture-MS), TSSC4 (Affinity Capture-MS), DENND4C (Affinity Capture-MS), C1orf112 (Affinity Capture-MS), FIGNL1 (Affinity Capture-MS), SPATA5L1 (Affinity Capture-MS), C5orf30 (Affinity Capture-MS), TMEM263 (Affinity Capture-MS), C1orf112 (Affinity Capture-MS)

ESM2 similar proteins: A0JM49, A2AKG8, B0V0U5, B1AUR6, C5J7W8, E1BGH8, E1C231, E1C2Z0, E7FGT5, E7FH61, E9Q3L2, F6S215, O08662, O60287, O94822, P42356, P57678, P78527, P97313, Q13315, Q13535, Q14146, Q1RLU1, Q2TAW0, Q3TQQ9, Q3URQ0, Q571H0, Q5RDK1, Q5VW36, Q5WNI9, Q5XI94, Q5ZM41, Q62388, Q6A009, Q6DFV1, Q6PQD5, Q6ZRQ5, Q7SY48, Q86XI2, Q8BKX6

Diamond homologs: Q3TQQ9, Q5TYP4, Q5XI94, Q9NSG2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 121 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Class A/1 (Rhodopsin-like receptors)	10	10.4×	1e-05
GPCR ligand binding	10	9.0×	3e-05
Peptide ligand-binding receptors	7	7.3×	3e-03
Signaling by GPCR	10	5.6×	1e-03
G alpha (i) signalling events	10	5.5×	1e-03

GO biological processes:

GO term	Partners	Fold	FDR
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	6	18.0×	3e-04
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	6	12.6×	1e-03
phospholipase C-activating G protein-coupled receptor signaling pathway	8	10.1×	3e-04
positive regulation of cytosolic calcium ion concentration	8	9.0×	6e-04
adenylate cyclase-activating G protein-coupled receptor signaling pathway	7	7.6×	4e-03
G protein-coupled receptor signaling pathway	15	5.2×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

89 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	5
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

7063 predictions. Top by Δscore:

Variant	Effect	Δscore
1:169692934:ATGC:A	donor_gain	1.0000
1:169703444:CAA:C	acceptor_gain	1.0000
1:169704564:TCA:T	donor_loss	1.0000
1:169704565:CA:C	donor_loss	1.0000
1:169704566:A:AT	donor_loss	1.0000
1:169704754:C:CC	acceptor_gain	1.0000
1:169704757:CAA:C	acceptor_gain	1.0000
1:169704758:A:T	acceptor_gain	1.0000
1:169704759:A:AC	acceptor_gain	1.0000
1:169704759:A:C	acceptor_gain	1.0000
1:169707462:C:CT	acceptor_gain	1.0000
1:169707463:A:T	acceptor_gain	1.0000
1:169710433:TA:T	donor_loss	1.0000
1:169710434:A:AC	donor_gain	1.0000
1:169710434:ACC:A	donor_loss	1.0000
1:169710435:C:CC	donor_gain	1.0000
1:169710435:CCA:C	donor_gain	1.0000
1:169710435:CCAC:C	donor_loss	1.0000
1:169710513:AATAT:A	acceptor_gain	1.0000
1:169710514:ATAT:A	acceptor_gain	1.0000
1:169710515:TAT:T	acceptor_gain	1.0000
1:169710516:AT:A	acceptor_gain	1.0000
1:169710516:ATCT:A	acceptor_loss	1.0000
1:169710517:TC:T	acceptor_loss	1.0000
1:169710518:C:CC	acceptor_gain	1.0000
1:169710518:CTGCA:C	acceptor_loss	1.0000
1:169710519:T:A	acceptor_loss	1.0000
1:169710524:A:AC	acceptor_gain	1.0000
1:169725799:CTG:C	acceptor_gain	1.0000
1:169725802:C:CC	acceptor_gain	1.0000

AlphaMissense

5620 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:169806072:T:A	W183R	0.994
1:169806072:T:C	W183R	0.994
1:169806064:C:A	A180D	0.993
1:169830325:T:A	W461R	0.992
1:169830325:T:C	W461R	0.992
1:169807795:A:C	S190R	0.990
1:169807797:C:A	S190R	0.990
1:169807797:C:G	S190R	0.990
1:169806075:A:G	K184E	0.989
1:169821727:T:C	F251L	0.988
1:169821729:T:A	F251L	0.988
1:169821729:T:G	F251L	0.988
1:169804154:T:C	L131P	0.987
1:169836978:T:A	W531R	0.987
1:169836978:T:C	W531R	0.987
1:169804135:T:C	F125L	0.984
1:169804137:C:A	F125L	0.984
1:169804137:C:G	F125L	0.984
1:169806077:G:C	K184N	0.984
1:169806077:G:T	K184N	0.984
1:169821715:A:G	K247E	0.984
1:169827803:T:A	W364R	0.983
1:169827803:T:C	W364R	0.983
1:169821743:T:C	L256P	0.980
1:169806076:A:C	K184T	0.979
1:169821717:A:C	K247N	0.979
1:169821717:A:T	K247N	0.979
1:169821725:G:C	R250P	0.977
1:169821728:T:C	F251S	0.977
1:169823411:T:C	F263L	0.977

dbSNP variants (sampled 300 via entrez): RS1000148262 (1:169844885 G>T), RS1000155314 (1:169820689 A>G), RS1000168905 (1:169817396 A>T), RS1000192717 (1:169831316 A>G), RS1000214862 (1:169850981 T>C), RS1000262694 (1:169807498 T>C), RS1000293417 (1:169781952 G>A), RS1000321546 (1:169810983 C>T), RS1000343181 (1:169788590 G>C,T), RS1000357893 (1:169795914 G>A,T), RS1000387204 (1:169823001 C>G), RS1000417877 (1:169813150 G>A,T), RS1000436565 (1:169844489 T>G), RS1000452095 (1:169817200 A>C), RS1000474727 (1:169837635 T>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST008310_1	Cardiac Troponin-T levels	3.000000e-08
GCST010481_6	Acute anterior uveitis in ankylosing spondylitis	6.000000e-07
GCST90002380_116	Basophil percentage of white cells	7.000000e-10
GCST90002382_16	Eosinophil percentage of white cells	6.000000e-11
GCST90002393_164	Monocyte count	4.000000e-11
GCST90002393_165	Monocyte count	5.000000e-12
GCST90002394_90	Monocyte percentage of white cells	4.000000e-11

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0005043	cardiac troponin T measurement
EFO:0007992	basophil percentage of leukocytes
EFO:0007991	eosinophil percentage of leukocytes
EFO:0005091	monocyte count
EFO:0007989	monocyte percentage of leukocytes

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	decreases expression	3
sodium arsenite	decreases expression, affects cotreatment, increases abundance	2
Air Pollutants	affects cotreatment, increases abundance, increases expression, decreases expression	2
Tretinoin	decreases expression, increases expression	2
Valproic Acid	decreases expression	2
Cadmium Chloride	decreases expression	2
afuresertib	decreases expression	1
FR900359	increases phosphorylation	1
bisphenol F	decreases methylation	1
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
lasiocarpine	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
bisphenol A	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
perfluorooctanoic acid	decreases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
epigallocatechin gallate	decreases expression, affects cotreatment	1
phenethyl isothiocyanate	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
deguelin	decreases expression	1
ICG 001	increases expression	1
jinfukang	affects cotreatment, decreases expression	1
Dasatinib	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SG17	HAP1 C1orf112 (-) 1	Cancer cell line	Male
CVCL_SG18	HAP1 C1orf112 (-) 2	Cancer cell line	Male
CVCL_XM27	HAP1 C1orf112 (-) 3	Cancer cell line	Male
CVCL_XM28	HAP1 C1orf112 (-) 4	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.