FKBP15

Summary

FKBP15 (FKBP prolyl isomerase family member 15, HGNC:23397) is a protein-coding gene on chromosome 9q32, encoding FK506-binding protein 15 (Q5T1M5). May be involved in the cytoskeletal organization of neuronal growth cones.

Predicted to enable actin binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in endocytosis. Located in membrane.

Source: NCBI Gene 23307 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 211 total
• MANE Select transcript: NM_015258

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23397
Approved symbol	FKBP15
Name	FKBP prolyl isomerase family member 15
Location	9q32
Locus type	gene with protein product
Status	Approved
Aliases	PPP1R76, FKBP133, WAFL
Ensembl gene	ENSG00000119321
Ensembl biotype	protein_coding
OMIM	617398
Entrez	23307

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 11 protein_coding, 10 nonsense_mediated_decay, 6 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000238256, ENST00000414250, ENST00000446284, ENST00000462889, ENST00000489645, ENST00000493847, ENST00000685068, ENST00000685945, ENST00000686727, ENST00000686828, ENST00000687395, ENST00000688113, ENST00000688949, ENST00000689059, ENST00000689480, ENST00000690399, ENST00000690630, ENST00000691254, ENST00000691776, ENST00000691917, ENST00000692890, ENST00000693271, ENST00000693409, ENST00000852798, ENST00000852799, ENST00000937400, ENST00000937401, ENST00000947249

RefSeq mRNA: 1 — MANE Select: NM_015258 NM_015258

CCDS: CCDS48007

Canonical transcript exons

ENST00000238256 — 28 exons

Exon	Start	End
ENSE00001691631	113221191	113221277
ENSE00003473361	113211477	113211592
ENSE00003479758	113207212	113207296
ENSE00003548766	113186249	113186363
ENSE00003549454	113184695	113184804
ENSE00003657296	113187793	113187899
ENSE00003678475	113184292	113184399
ENSE00003889744	113173453	113173605
ENSE00003889787	113183751	113183845
ENSE00003889969	113202961	113203035
ENSE00003890390	113174428	113174583
ENSE00003890565	113171581	113171706
ENSE00003890940	113169224	113169942
ENSE00003891780	113161006	113166155
ENSE00003891833	113176537	113176673
ENSE00003892068	113193492	113193549
ENSE00003892157	113194027	113194169
ENSE00003892217	113182766	113182868
ENSE00003892412	113198855	113198923
ENSE00003892649	113178630	113178801
ENSE00003892809	113190471	113190578
ENSE00003893890	113188389	113188491
ENSE00003894195	113199814	113199963
ENSE00003894511	113202531	113202629
ENSE00003894545	113206509	113206578
ENSE00003894915	113170522	113170629
ENSE00003895312	113196932	113197078
ENSE00003895937	113168460	113168556

Expression profiles

Bgee: expression breadth ubiquitous, 293 present calls, max score 95.01.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 33.7676 / max 247.0974, expressed in 1819 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
102089	16.4021	1807
102090	7.6708	1768
102092	3.2442	1467
102086	2.9359	542
102093	1.1845	716
102091	1.1322	629
102087	0.8200	179
102085	0.3779	118

Top tissues by expression

299 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	95.01	gold quality
mononuclear cell	CL:0000842	95.01	gold quality
leukocyte	CL:0000738	94.76	gold quality
olfactory bulb	UBERON:0002264	93.14	gold quality
CA1 field of hippocampus	UBERON:0003881	92.30	gold quality
granulocyte	CL:0000094	92.08	gold quality
type B pancreatic cell	CL:0000169	92.07	gold quality
cardia of stomach	UBERON:0001162	91.46	gold quality
blood	UBERON:0000178	91.32	gold quality
superficial temporal artery	UBERON:0001614	90.96	gold quality
cervix squamous epithelium	UBERON:0006922	90.57	gold quality
lateral globus pallidus	UBERON:0002476	90.54	gold quality
pharyngeal mucosa	UBERON:0000355	90.49	gold quality
subthalamic nucleus	UBERON:0001906	90.41	gold quality
trabecular bone tissue	UBERON:0002483	90.30	gold quality
mucosa of paranasal sinus	UBERON:0005030	89.95	gold quality
diaphragm	UBERON:0001103	89.94	gold quality
vena cava	UBERON:0004087	89.84	silver quality
inferior vagus X ganglion	UBERON:0005363	89.79	gold quality
superior surface of tongue	UBERON:0007371	89.68	gold quality
hair follicle	UBERON:0002073	89.67	silver quality
pylorus	UBERON:0001166	89.41	gold quality
cervix epithelium	UBERON:0004801	89.28	gold quality
mucosa of urinary bladder	UBERON:0001259	89.25	gold quality
penis	UBERON:0000989	89.09	gold quality
dorsal plus ventral thalamus	UBERON:0001897	89.09	gold quality
ventral tegmental area	UBERON:0002691	89.04	gold quality
synovial joint	UBERON:0002217	88.86	gold quality
body of tongue	UBERON:0011876	88.84	gold quality
tongue	UBERON:0001723	88.79	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-CURD-112	yes	13.97
E-MTAB-9543	yes	13.69
E-ANND-3	yes	12.75

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

32 targeting FKBP15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-7856-5P	99.75	69.99	2901
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-3714	99.71	70.74	2671
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-7974	99.24	65.48	1137
HSA-MIR-4477B	99.23	70.49	1733
HSA-MIR-296-3P	99.21	66.56	474
HSA-MIR-4528	99.18	69.77	1936
HSA-MIR-877-3P	99.09	68.10	1637
HSA-MIR-3168	99.08	67.75	1384
HSA-MIR-622	98.99	66.48	1050
HSA-MIR-4709-3P	98.88	68.04	1594
HSA-MIR-6754-3P	98.84	66.60	889
HSA-MIR-4635	98.74	67.63	1339
HSA-MIR-6761-5P	98.71	68.03	1504
HSA-MIR-6840-3P	98.68	65.95	1923
HSA-MIR-4726-3P	98.49	63.89	1385
HSA-MIR-6867-3P	98.12	66.07	1305
HSA-MIR-4287	97.55	67.24	1247
HSA-MIR-4685-3P	97.55	67.35	1255
HSA-MIR-643	97.35	67.91	805

Literature-anchored findings (GeneRIF, showing 2)

• findings are compatible with a model whereby WAFL is involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. (PMID:19121306)
• WAFL may play an important role in endocytosis and subsequent membrane trafficking by interacting with AP2 through KIAA0196 and KIAA1033 (PMID:20376207)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	fkbp15a	ENSDARG00000095142
danio_rerio	fkbp15b	ENSDARG00000099294
mus_musculus	Fkbp15	ENSMUSG00000066151
rattus_norvegicus	Fkbp15	ENSRNOG00000024663
caenorhabditis_elegans		WBGENE00001429
caenorhabditis_elegans	fkb-5	WBGENE00001430

Paralogs (18): FKBP4 (ENSG00000004478), FKBP6 (ENSG00000077800), FKBP7 (ENSG00000079150), FKBP1A (ENSG00000088832), FKBP5 (ENSG00000096060), FKBP3 (ENSG00000100442), FKBP8 (ENSG00000105701), FKBP14 (ENSG00000106080), FKBP1B (ENSG00000119782), FKBP9 (ENSG00000122642), TTC9 (ENSG00000133985), FKBP11 (ENSG00000134285), FKBP10 (ENSG00000141756), TTC9C (ENSG00000162222), FKBP2 (ENSG00000173486), TTC9B (ENSG00000174521), FKBP1C (ENSG00000198225), FKBPL (ENSG00000204315)

Protein

Protein identifiers

FK506-binding protein 15 — Q5T1M5 (reviewed: Q5T1M5)

Alternative names: 133 kDa FK506-binding protein, WASP- and FKBP-like protein

All UniProt accessions (11): A0A8I5KQM8, A0A8I5KRH4, A0A8I5KRZ8, A0A8I5KUP6, A0A8I5KV70, A0A8I5KX71, A0A8I5KXA6, Q5T1M5, A0A8I5KXH0, A0A8I5QJ94, A0A8I5QJL3

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase. Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.

Subunit / interactions. Interacts with WIP and actin. Interacts with TBC1D23.

Subcellular location. Cytoplasm. Cell projection. Axon. Early endosome.

Domain organisation. The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity. The central coiled-coil region is responsible for association with early endosomes.

Similarity. Belongs to the FKBP-type PPIase family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q5T1M5-1	1	yes
Q5T1M5-2	2
Q5T1M5-3	3

RefSeq proteins (1): NP_056073* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001179	PPIase_FKBP_dom	Domain
IPR046357	PPIase_dom_sf	Homologous_superfamily
IPR056598	FKBP-15_dom	Domain

Pfam: PF00254, PF23649

UniProt features (54 total): modified residue 29, compositionally biased region 6, region of interest 6, sequence variant 5, coiled-coil region 3, splice variant 3, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T1M5-F1	64.81	0.30

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (29): 1, 14, 23, 92, 307, 311, 326, 344, 346, 356, 619, 939, 940, 941, 956, 979, 1024, 1056, 1061, 1065 …

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 139 (showing top): RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, GOBP_VESICLE_MEDIATED_TRANSPORT, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN, GNF2_MYD88, MORF_PML, GOMF_ACTIN_BINDING, SENESE_HDAC1_TARGETS_UP, GOCC_NEURON_PROJECTION, MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN, MORF_IKBKG, GOBP_IMPORT_INTO_CELL, GOBP_ENDOCYTOSIS, OSMAN_BLADDER_CANCER_DN, MARSON_BOUND_BY_E2F4_UNSTIMULATED, GOCC_AXON

GO Biological Process (1): endocytosis (GO:0006897)

GO Molecular Function (4): peptidyl-prolyl cis-trans isomerase activity (GO:0003755), actin binding (GO:0003779), protein binding (GO:0005515), isomerase activity (GO:0016853)

GO Cellular Component (8): early endosome (GO:0005769), actin cytoskeleton (GO:0015629), membrane (GO:0016020), growth cone (GO:0030426), cytoplasm (GO:0005737), endosome (GO:0005768), axon (GO:0030424), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
vesicle budding from membrane	1
membrane invagination	1
vesicle-mediated transport	1
import into cell	1
cis-trans isomerase activity	1
catalytic activity, acting on a protein	1
cytoskeletal protein binding	1
binding	1
catalytic activity	1
endosome	1
cytoskeleton	1
site of polarized growth	1
distal axon	1
intracellular anatomical structure	1
endomembrane system	1
cytoplasmic vesicle	1
neuron projection	1

Protein interactions and networks

STRING

1022 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FKBP15	WASHC4	Q2M389	739
FKBP15	TBC1D5	Q92609	709
FKBP15	WASHC5	Q12768	705
FKBP15	WASHC2C	Q9Y4E1	705
FKBP15	VPS29	Q9UBQ0	591
FKBP15	WASHC2A	Q641Q2	585
FKBP15	CAPZA1	P52907	550
FKBP15	WASHC1	A8K0Z3	536
FKBP15	TBC1D23	Q9NUY8	534
FKBP15	CCDC93	Q567U6	520
FKBP15	FKBP7	Q9Y680	513
FKBP15	CCDC22	O60826	496
FKBP15	EHD1	Q9H4M9	491
FKBP15	TCP10L	Q8TDR4	487
FKBP15	WASHC3	Q9Y3C0	461

IntAct

84 interactions, top by confidence:

A	B	Type	Score
STRN3	STRN	psi-mi:“MI:2364”(proximity)	0.880
VPS29	VPS26C	psi-mi:“MI:0914”(association)	0.760
WWOX	ENTREP3	psi-mi:“MI:0914”(association)	0.720
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
FKBP15	VPS35	psi-mi:“MI:0403”(colocalization)	0.640
WWOX	DVL2	psi-mi:“MI:0914”(association)	0.560
Vps29	FKBP15	psi-mi:“MI:0915”(physical association)	0.550
rep	SLC27A2	psi-mi:“MI:0914”(association)	0.530
STX11	EXOC5	psi-mi:“MI:0914”(association)	0.530
NUP62	RGPD8	psi-mi:“MI:0914”(association)	0.530
BAG2	HGS	psi-mi:“MI:0914”(association)	0.530
COMMD10	VPS26C	psi-mi:“MI:0914”(association)	0.530
ITPRID2	PIGR	psi-mi:“MI:0914”(association)	0.530
ZYX	TBC1D10B	psi-mi:“MI:0914”(association)	0.530
WASHC3	WASH3P	psi-mi:“MI:0914”(association)	0.530
ITPRID2	CBL	psi-mi:“MI:0914”(association)	0.530
AIPL1	SUPT5H	psi-mi:“MI:0914”(association)	0.510
FKBP15	Vps35	psi-mi:“MI:0915”(physical association)	0.480
Vps35	FKBP15	psi-mi:“MI:0915”(physical association)	0.480
PPP1CA	FKBP15	psi-mi:“MI:0407”(direct interaction)	0.440
FKBP15	WASHC1	psi-mi:“MI:0403”(colocalization)	0.430
FKBP15	DPEP1	psi-mi:“MI:0915”(physical association)	0.400
FKBP15	WASHC2C	psi-mi:“MI:0915”(physical association)	0.370
FKBP15	FKBP15	psi-mi:“MI:0915”(physical association)	0.370
CTR9	POLR2B	psi-mi:“MI:0914”(association)	0.350

BioGRID (143): FKBP15 (Affinity Capture-MS), FKBP15 (Affinity Capture-MS), FKBP15 (Affinity Capture-MS), FKBP15 (Proximity Label-MS), FKBP15 (Affinity Capture-MS), FKBP15 (Affinity Capture-MS), FKBP15 (Affinity Capture-MS), FKBP15 (Affinity Capture-MS), FKBP15 (Affinity Capture-MS), FKBP15 (Affinity Capture-MS), KIAA0196 (Affinity Capture-Western), FKBP15 (Affinity Capture-Western), KIAA1033 (Affinity Capture-MS), TTBK2 (Affinity Capture-MS), KIAA0196 (Affinity Capture-MS)

ESM2 similar proteins: A0A7P0TBJ1, A0A804C8T0, A1YB07, A2RRV3, A4IG66, A4IIE8, D4A4K3, O35625, O70239, P57095, Q02225, Q08AY9, Q09YK4, Q09YM8, Q0VDN7, Q108T9, Q1JPG0, Q1LXR6, Q2IBF8, Q2KJD6, Q2QL82, Q2QLF8, Q2QLG9, Q32N92, Q503U3, Q58D79, Q5BLE2, Q5T1M5, Q5XJS0, Q62141, Q6DFB7, Q6GR21, Q6NRB7, Q6P7D5, Q6P9Q6, Q7L4E1, Q86YS3, Q8BHS8, Q8BK03, Q8BQP8

Diamond homologs: G0SC91, O04287, O42123, O42993, O46638, O60046, O74191, O94746, P0A0W2, P0A0W3, P0C1B0, P0C1J3, P0C1J5, P0C1J6, P0C1J7, P0CP94, P0CP95, P0CP96, P0CP97, P0CP98, P0CP99, P0CY37, P18203, P20080, P20081, P26883, P26884, P26885, P27124, P30416, P38911, P45878, P48375, P54397, P56989, P62942, P62943, P68106, P68107, P97534

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
FKBP15	“up-regulates activity”	ACTB	binding
FKBP15	“up-regulates activity”	WIPF1	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 97 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
endocytic recycling	7	23.1×	1e-05
retrograde transport, endosome to Golgi	7	17.8×	2e-05
exocytosis	8	15.0×	2e-05
protein transport	11	6.0×	3e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

211 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	160
Likely benign	12
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

4242 predictions. Top by Δscore:

Variant	Effect	Δscore
9:113168557:C:CC	acceptor_gain	1.0000
9:113169939:CCAT:C	acceptor_gain	1.0000
9:113169940:CATC:C	acceptor_gain	1.0000
9:113169943:C:CC	acceptor_gain	1.0000
9:113170516:CTGTA:C	donor_loss	1.0000
9:113170517:TGTA:T	donor_loss	1.0000
9:113170518:GTAC:G	donor_loss	1.0000
9:113170519:TA:T	donor_loss	1.0000
9:113170521:C:CT	donor_loss	1.0000
9:113170625:TTGAC:T	acceptor_gain	1.0000
9:113170626:TGAC:T	acceptor_gain	1.0000
9:113170627:GAC:G	acceptor_gain	1.0000
9:113170628:AC:A	acceptor_gain	1.0000
9:113170629:CCTG:C	acceptor_gain	1.0000
9:113170630:C:CA	acceptor_loss	1.0000
9:113170630:C:CC	acceptor_gain	1.0000
9:113170631:T:C	acceptor_loss	1.0000
9:113170632:G:C	acceptor_gain	1.0000
9:113170632:G:GC	acceptor_gain	1.0000
9:113170634:G:C	acceptor_gain	1.0000
9:113170639:C:CT	acceptor_gain	1.0000
9:113170640:A:T	acceptor_gain	1.0000
9:113171576:CTCA:C	donor_loss	1.0000
9:113171577:TCA:T	donor_loss	1.0000
9:113171578:CA:C	donor_loss	1.0000
9:113171579:A:T	donor_loss	1.0000
9:113171580:C:CA	donor_loss	1.0000
9:113171580:CCTT:C	donor_gain	1.0000
9:113171702:AAACA:A	acceptor_gain	1.0000
9:113171703:AACA:A	acceptor_gain	1.0000

AlphaMissense

7958 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:113197035:C:G	R254P	0.998
9:113202581:A:G	W150R	0.998
9:113202581:A:T	W150R	0.998
9:113207227:A:T	V80D	0.998
9:113182780:C:G	A634P	0.997
9:113183769:A:G	L598P	0.997
9:113202578:A:G	S151P	0.997
9:113206534:A:T	V100D	0.997
9:113206538:C:G	A99P	0.997
9:113184705:A:G	L533P	0.996
9:113176565:A:G	L732P	0.995
9:113190544:C:G	R367P	0.995
9:113190553:A:G	L364S	0.995
9:113199953:G:T	A170D	0.995
9:113178774:C:G	A648P	0.994
9:113190539:C:G	A369P	0.994
9:113190541:A:G	M368T	0.994
9:113190550:A:G	I365T	0.994
9:113190550:A:T	I365N	0.994
9:113198887:G:T	R229S	0.994
9:113202541:A:G	F163S	0.994
9:113207221:G:T	A82E	0.994
9:113184302:C:G	R569P	0.993
9:113202598:T:A	D144V	0.993
9:113202599:C:G	D144H	0.993
9:113176574:A:G	L729P	0.992
9:113184739:C:G	A522P	0.992
9:113190538:G:T	A369D	0.992
9:113190550:A:C	I365S	0.992
9:113202567:A:C	F154L	0.992

dbSNP variants (sampled 300 via entrez): RS1000063211 (9:113212751 C>T), RS1000092763 (9:113167206 T>C), RS1000097616 (9:113212990 T>C), RS1000118432 (9:113162019 G>C), RS1000165771 (9:113212390 T>C), RS1000167199 (9:113173836 G>A,T), RS1000202125 (9:113219007 A>G), RS1000222147 (9:113185382 C>T), RS1000262391 (9:113174297 A>T), RS1000281414 (9:113212595 CTT>C), RS1000413814 (9:113206713 T>A,C), RS1000445174 (9:113174802 A>G), RS1000503265 (9:113166215 C>T), RS1000658150 (9:113188803 T>C), RS1000774911 (9:113172900 G>C)

Disease associations

OMIM: gene MIM:617398 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

4 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs10981694	FKBP15, SLC31A1	3	0.50	1	cisplatin
rs4979223	FKBP15, SLC31A1	3	5.75	1	Platinum compounds
rs4978536	FKBP15, SLC31A1	3	2.50	1	Platinum compounds
rs2233914	FKBP15, SLC31A1	3	5.50	1	Platinum compounds

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, decreases methylation	2
sodium arsenite	increases abundance, increases expression	2
Cadmium Chloride	increases expression	2
FR900359	affects phosphorylation	1
bisphenol F	affects cotreatment, increases expression	1
sodium arsenate	decreases expression	1
mono-(2-ethylhexyl)phthalate	decreases expression	1
manganese chloride	increases abundance, increases expression	1
coumarin	affects phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
abrine	increases expression	1
Air Pollutants, Occupational	decreases expression	1
Arsenic	increases abundance, increases expression	1
Caffeine	increases phosphorylation	1
Dexamethasone	increases expression, affects cotreatment	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Formaldehyde	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Manganese	increases abundance, increases expression	1
Methamphetamine	affects response to substance	1
Nickel	decreases expression	1
Tretinoin	increases expression	1
Valproic Acid	decreases methylation	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	decreases methylation	1
Antirheumatic Agents	decreases expression	1
Palmitic Acid	decreases phosphorylation	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SN59	HAP1 FKBP15 (-) 1	Cancer cell line	Male
CVCL_SN60	HAP1 FKBP15 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.