FKBPL

Summary

FKBPL (FKBP prolyl isomerase like, HGNC:13949) is a protein-coding gene on chromosome 6p21.32, encoding FK506-binding protein-like (Q9UIM3). May be involved in response to X-ray.

The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle.

Source: NCBI Gene 63943 — RefSeq curated summary.

At a glance

• GWAS associations: 22
• Clinical variants (ClinVar): 42 total
• MANE Select transcript: NM_022110

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13949
Approved symbol	FKBPL
Name	FKBP prolyl isomerase like
Location	6p21.32
Locus type	gene with protein product
Status	Approved
Aliases	DIR1, NG7, WISp39
Ensembl gene	ENSG00000204315
Ensembl biotype	protein_coding
OMIM	617076
Entrez	63943

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 protein_coding

ENST00000375156, ENST00000887777, ENST00000930347, ENST00000930348, ENST00000930349, ENST00000958763

RefSeq mRNA: 1 — MANE Select: NM_022110 NM_022110

CCDS: CCDS4738

Canonical transcript exons

ENST00000375156 — 2 exons

Exon	Start	End
ENSE00001864878	32130095	32130288
ENSE00001901420	32128707	32129854

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 85.31.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.2412 / max 48.9123, expressed in 1459 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
72888	2.5391	1363
72887	0.7020	394

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.31	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.87	gold quality
lower esophagus mucosa	UBERON:0035834	82.42	gold quality
esophagus mucosa	UBERON:0002469	79.16	gold quality
skin of leg	UBERON:0001511	78.09	gold quality
zone of skin	UBERON:0000014	77.55	gold quality
granulocyte	CL:0000094	77.09	gold quality
skin of abdomen	UBERON:0001416	76.95	gold quality
mucosa of transverse colon	UBERON:0004991	76.89	gold quality
islet of Langerhans	UBERON:0000006	76.42	gold quality
apex of heart	UBERON:0002098	75.82	gold quality
body of stomach	UBERON:0001161	75.48	gold quality
esophagus	UBERON:0001043	75.34	gold quality
blood	UBERON:0000178	74.89	gold quality
stromal cell of endometrium	CL:0002255	74.75	gold quality
right adrenal gland	UBERON:0001233	74.57	gold quality
ventricular zone	UBERON:0003053	74.49	gold quality
fundus of stomach	UBERON:0001160	74.37	gold quality
right adrenal gland cortex	UBERON:0035827	74.30	gold quality
pancreas	UBERON:0001264	74.23	gold quality
gastrocnemius	UBERON:0001388	74.16	gold quality
ganglionic eminence	UBERON:0004023	74.12	gold quality
right lobe of thyroid gland	UBERON:0001119	74.08	gold quality
left lobe of thyroid gland	UBERON:0001120	73.86	gold quality
placenta	UBERON:0001987	73.72	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.72	gold quality
muscle of leg	UBERON:0001383	73.62	gold quality
body of pancreas	UBERON:0001150	73.58	gold quality
left adrenal gland	UBERON:0001234	73.56	gold quality
descending thoracic aorta	UBERON:0002345	73.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.90

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ESR1

Literature-anchored findings (GeneRIF, showing 16)

• Results demonstrate the importance of posttranslational stabilization of p21 protein by WISp39 in regulating cellular p21 activity. (PMID:15664193)
• FKBPL can be classed as a new member of the FKBP protein family with a role in steroid receptor complexes and signaling. (PMID:18669603)
• Findings suggest that FKBPL may have prognostic value based on its impact on tumor proliferative capacity and sensitivity to endocrine therapies, which improve outcome. (PMID:20103631)
• Alterations in the gene for FKBPL in azoospermic patients. (PMID:20210997)
• Genome-wide association study of age-related macular degeneration identifies TNXB, FKBPL and NOTCH4 as candidate susceptibility genes. (PMID:22694956)
• FKBPL and and its peptide derivative, AD-01 regulate expression of CD44. (PMID:23457460)
• high levels of FKBPL and RBCK1 correlated with increased patient survival, whereas high RBCK1 predicted for a poor response to tamoxifen. (PMID:23912458)
• FKBPL is an important regulator of developmental and pathological angiogenesis. (PMID:25767277)
• WISp39 preferentially interacts with phosphorylated Coronin 1B, allowing it to complex with Slingshot phosphatase to dephosphorylate and activate Cofilin. (PMID:25800056)
• The data suggests a role for FKBPL as a prognostic factor for BCSS, with the potential to be routinely evaluated within the clinic. (PMID:25906750)
• This study identified two low-frequency nonsynonymous variants at FKBPL (rs200847762, OR = 0.34, 95% CI = 0.20-0.57, P = 4.31 x 10-5) and ARPC1B (rs1045012, OR = 0.56, 95% CI = 0.43-0.74, P = 4.30 x 10-5) associated with breast cancer risk. (PMID:27479355)
• Role of A Novel Angiogenesis FKBPL-CD44 Pathway in Preeclampsia Risk Stratification and Mesenchymal Stem Cell Treatment. (PMID:32617576)
• FKBPL and SIRT-1 Are Downregulated by Diabetes in Pregnancy Impacting on Angiogenesis and Endothelial Function. (PMID:34149611)
• A novel mutation in FK506 binding protein-like (FKBPL) causes male infertility. (PMID:34212559)
• Loss of Expression of Antiangiogenic Protein FKBPL in Endometrioid Endometrial Carcinoma: Implications for Clinical Practice. (PMID:36295491)
• FK506-Binding Protein like (FKBPL) Has an Important Role in Heart Failure with Preserved Ejection Fraction Pathogenesis with Potential Diagnostic Utility. (PMID:36830764)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	fkbpl	ENSDARG00000095322
mus_musculus	Fkbpl	ENSMUSG00000033739
rattus_norvegicus	Fkbpl	ENSRNOG00000000432
caenorhabditis_elegans	fkb-2	WBGENE00001427
caenorhabditis_elegans		WBGENE00001429
caenorhabditis_elegans	fkb-5	WBGENE00001430
caenorhabditis_elegans	fkb-8	WBGENE00001433

Paralogs (18): FKBP4 (ENSG00000004478), FKBP6 (ENSG00000077800), FKBP7 (ENSG00000079150), FKBP1A (ENSG00000088832), FKBP5 (ENSG00000096060), FKBP3 (ENSG00000100442), FKBP8 (ENSG00000105701), FKBP14 (ENSG00000106080), FKBP15 (ENSG00000119321), FKBP1B (ENSG00000119782), FKBP9 (ENSG00000122642), TTC9 (ENSG00000133985), FKBP11 (ENSG00000134285), FKBP10 (ENSG00000141756), TTC9C (ENSG00000162222), FKBP2 (ENSG00000173486), TTC9B (ENSG00000174521), FKBP1C (ENSG00000198225)

Protein

Protein identifiers

FK506-binding protein-like — Q9UIM3 (reviewed: Q9UIM3)

Alternative names: WAF-1/CIP1 stabilizing protein 39

All UniProt accessions (2): A0A024RCQ6, Q9UIM3

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.

Subunit / interactions. Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.

Tissue specificity. Ubiquitously expressed with higher levels in testis.

RefSeq proteins (1): NP_071393* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR019734	TPR_rpt	Repeat
IPR050754	FKBP4/5/8-like	Family

Pfam: PF00515, PF13432

UniProt features (10 total): repeat 3, mutagenesis site 2, chain 1, region of interest 1, modified residue 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UIM3-F1	77.00	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 3

Mutagenesis-validated functional residues (2):

Position	Phenotype
287	abolishes hsp90ab1 binding; when associated with a-291.
291	abolishes hsp90ab1 binding; when associated with a-287.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint

MSigDB gene sets: 135 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_UP, GOBP_MORPHOGENESIS_OF_AN_EPITHELIUM, GOBP_EPITHELIUM_DEVELOPMENT, GOBP_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE, MARTINEZ_RB1_TARGETS_UP, DOANE_RESPONSE_TO_ANDROGEN_DN, GOBP_BLOOD_VESSEL_MORPHOGENESIS, GOBP_RESPONSE_TO_RADIATION, CYTAGCAAY_UNKNOWN, GOBP_RESPONSE_TO_ABIOTIC_STIMULUS, GOBP_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE, FISCHER_DREAM_TARGETS, GOBP_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE, GOBP_TISSUE_MORPHOGENESIS, GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT

GO Biological Process (3): response to radiation (GO:0009314), regulation of blood vessel branching (GO:1905553), regulation of angiogenesis (GO:0045765)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (2): extracellular region (GO:0005576), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
G2/M Transition	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
response to abiotic stimulus	1
branching involved in blood vessel morphogenesis	1
regulation of angiogenesis	1
regulation of morphogenesis of a branching structure	1
regulation of morphogenesis of an epithelium	1
angiogenesis	1
regulation of anatomical structure morphogenesis	1
regulation of vasculature development	1
binding	1
cytoplasm	1

Protein interactions and networks

STRING

1748 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FKBPL	HSP90AA1	P07900	930
FKBPL	HSP90AB1	P08238	929
FKBPL	ESR1	P03372	621
FKBPL	EGFL8	Q99944	545
FKBPL	DCTN2	Q13561	541
FKBPL	MSH5	O43196	507
FKBPL	CORO1B	Q9BR76	490
FKBPL	ST13	P50502	469
FKBPL	FKBP15	Q5T1M5	456
FKBPL	PPID	Q08752	435
FKBPL	MMRN2	Q9H8L6	434
FKBPL	TRIM39	Q9HCM9	433
FKBPL	GPSM3	Q9Y4H4	422
FKBPL	FKBP3	Q00688	417
FKBPL	USP19	O94966	410
FKBPL	ATF6B	Q99941	410

IntAct

72 interactions, top by confidence:

A	B	Type	Score
CSNK1A1	FAM83G	psi-mi:“MI:0914”(association)	0.900
ANKRD49	FKBPL	psi-mi:“MI:0915”(physical association)	0.860
CSNK1E	PER2	psi-mi:“MI:0914”(association)	0.850
CSNK1D	PER2	psi-mi:“MI:0914”(association)	0.810
ANKRD49	CSNK1E	psi-mi:“MI:0914”(association)	0.640
FKBPL	CALCOCO2	psi-mi:“MI:0915”(physical association)	0.560
CALCOCO2	FKBPL	psi-mi:“MI:0915”(physical association)	0.560
CSNK1E	ZSWIM8	psi-mi:“MI:0914”(association)	0.530
FKBPL	BRAF	psi-mi:“MI:0914”(association)	0.530
FKBPL	MATR3	psi-mi:“MI:0915”(physical association)	0.400
FKBPL	IRS4	psi-mi:“MI:0915”(physical association)	0.400
FKBPL	CFLAR	psi-mi:“MI:0915”(physical association)	0.400
FKBPL	PSMD3	psi-mi:“MI:0915”(physical association)	0.400
FKBPL	FBXO24	psi-mi:“MI:0915”(physical association)	0.400
FKBPL	BAG2	psi-mi:“MI:0915”(physical association)	0.400
FKBPL	MOS	psi-mi:“MI:0915”(physical association)	0.400
FKBPL	RAF1	psi-mi:“MI:0915”(physical association)	0.400
GNAZ	FKBPL	psi-mi:“MI:0915”(physical association)	0.400
GNA15	FKBPL	psi-mi:“MI:0915”(physical association)	0.400
FKBPL	HSPA2	psi-mi:“MI:0915”(physical association)	0.400
MLF1	FKBPL	psi-mi:“MI:0915”(physical association)	0.400
FKBPL	NLRP12	psi-mi:“MI:0915”(physical association)	0.400
NR1H3	FKBPL	psi-mi:“MI:0915”(physical association)	0.400
SKP2	FKBPL	psi-mi:“MI:0915”(physical association)	0.400
KEAP1	FKBPL	psi-mi:“MI:0915”(physical association)	0.400
FKBPL	SIM2	psi-mi:“MI:0915”(physical association)	0.400
FKBPL	RCN2	psi-mi:“MI:0915”(physical association)	0.400
EFTUD2	FKBPL	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (65): FKBPL (Two-hybrid), FKBPL (Affinity Capture-MS), FKBPL (Affinity Capture-MS), FKBPL (Affinity Capture-MS), NADSYN1 (Affinity Capture-MS), RBCK1 (Affinity Capture-MS), BRAF (Affinity Capture-MS), RNF31 (Affinity Capture-MS), CSNK1E (Affinity Capture-MS), PLS1 (Affinity Capture-MS), EDRF1 (Affinity Capture-MS), FKBPL (Affinity Capture-MS), CTU1 (Affinity Capture-MS), FKBPL (Synthetic Lethality), UNC119 (Two-hybrid)

ESM2 similar proteins: A0JN53, A6NE52, A7E3N7, A8MYJ7, D3ZVB0, D4A615, E1BD59, G3MZC5, O15287, O43299, O75064, O94812, P58660, P60330, Q0P5G1, Q14674, Q1JPD6, Q2VPB7, Q3HNM7, Q3TAP4, Q3U829, Q58EX7, Q5BK61, Q6DT37, Q6NZL6, Q6ZNJ1, Q6ZQA0, Q76MJ5, Q7Z614, Q80TE0, Q80TT2, Q80UW5, Q80VA5, Q8BGI5, Q8BUI3, Q8BYG0, Q8C0Q3, Q8C159, Q8C3R1, Q8CIE4

Diamond homologs: A4K2V0, F4IRM4, F4JTI1, F4K487, K7TQE3, O35450, O48802, Q07617, Q3KRD5, Q6MG81, Q9CYG7, Q9UIM3, O00170, O08915, O97628, Q554J3, Q5FWY5, Q7YRC1, Q924K1, Q95MN7, Q95MN8, Q95MN9, Q95MP0, Q95MP1, Q9JLG9, Q9NZN9, Q9QVC8, A4IFF3, F1RBN2, H9IWW7, P15705, Q02790, Q28IV3, Q32PZ3, Q5RAP0, Q5U2X2, Q68FQ7, Q6NU95, Q75Q39, Q80ZX8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 67 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
regulation of circadian rhythm	6	25.1×	7e-05
circadian regulation of gene expression	5	18.9×	2e-03
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	5	17.0×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

42 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	32
Likely benign	6
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

106 predictions. Top by Δscore:

Variant	Effect	Δscore
6:32129852:CAC:C	acceptor_gain	0.9900
6:32129853:ACCTG:A	acceptor_loss	0.9900
6:32129855:C:CC	acceptor_gain	0.9900
6:32129851:GCAC:G	acceptor_gain	0.9800
6:32129852:CACC:C	acceptor_gain	0.9800
6:32129853:AC:A	acceptor_gain	0.9700
6:32129854:CC:C	acceptor_gain	0.9700
6:32130039:C:A	donor_gain	0.9700
6:32129850:AGCAC:A	acceptor_gain	0.9600
6:32130090:AGTAC:A	donor_loss	0.9600
6:32130091:GTAC:G	donor_loss	0.9600
6:32130092:TACC:T	donor_loss	0.9600
6:32130093:A:C	donor_loss	0.9600
6:32130094:C:T	donor_loss	0.9600
6:32129856:T:G	acceptor_loss	0.9400
6:32130095:C:G	donor_loss	0.9300
6:32130115:G:C	donor_gain	0.9100
6:32129855:C:T	acceptor_gain	0.9000
6:32129970:T:A	donor_gain	0.8600
6:32130035:AATTC:A	donor_gain	0.8400
6:32130154:T:A	donor_gain	0.8400
6:32130030:T:TA	donor_gain	0.8300
6:32130097:G:A	donor_gain	0.8200
6:32130158:T:TA	donor_gain	0.8200
6:32130146:A:AC	donor_gain	0.7700
6:32130038:T:TA	donor_gain	0.7600
6:32129868:C:T	acceptor_gain	0.7500
6:32130110:G:A	donor_gain	0.7500
6:32129868:C:CT	acceptor_gain	0.7100
6:32129824:A:T	acceptor_gain	0.6900

AlphaMissense

2230 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:32129428:G:T	P118H	0.992
6:32129463:C:A	K106N	0.989
6:32129463:C:G	K106N	0.989
6:32128855:A:G	L309P	0.987
6:32128737:A:C	F348L	0.986
6:32128737:A:T	F348L	0.986
6:32128739:A:G	F348L	0.986
6:32129205:G:C	F192L	0.986
6:32129205:G:T	F192L	0.986
6:32129207:A:G	F192L	0.986
6:32128816:G:T	A322D	0.983
6:32128998:A:C	C261W	0.982
6:32128909:C:G	R291P	0.981
6:32128913:A:C	Y290D	0.981
6:32129095:G:T	A229D	0.981
6:32129008:A:G	L258P	0.980
6:32129294:A:G	C163R	0.980
6:32128999:C:T	C261Y	0.979
6:32128956:A:C	C275W	0.978
6:32128897:G:T	A295D	0.975
6:32129005:G:T	A259D	0.975
6:32129131:C:T	G217D	0.975
6:32129409:G:C	C124W	0.975
6:32128898:C:G	A295P	0.974
6:32128920:C:A	K287N	0.974
6:32128920:C:G	K287N	0.974
6:32129429:G:A	P118S	0.973
6:32128903:C:T	G293E	0.972
6:32128957:C:T	C275Y	0.972
6:32128958:A:G	C275R	0.972

dbSNP variants (sampled 300 via entrez): RS1000439018 (6:32131347 C>G), RS1000814463 (6:32129672 G>A,C), RS1001180453 (6:32131495 A>G), RS1001729851 (6:32131089 T>C), RS1001790787 (6:32131533 G>T), RS1004554070 (6:32131010 G>A,C), RS1005498688 (6:32131106 G>A), RS1006195348 (6:32128657 GCCCCC>G,GC,GCCCC,GCCCCCC), RS1006599742 (6:32130227 G>A), RS1007599659 (6:32128476 G>A,C), RS1008037338 (6:32131640 G>A,T), RS1008993377 (6:32129919 C>T), RS1009941406 (6:32129806 G>A), RS1011564375 (6:32131960 T>G), RS1012030948 (6:32131560 A>T)

Disease associations

OMIM: gene MIM:617076 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

22 associations (top):

Study	Trait	p-value
GCST001942_21	Prostate cancer	5.000000e-09
GCST003450_2	Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia	3.000000e-09
GCST004131_25	Inflammatory bowel disease	2.000000e-31
GCST004133_79	Ulcerative colitis	5.000000e-65
GCST004521_114	Autism spectrum disorder or schizophrenia	3.000000e-17
GCST004521_117	Autism spectrum disorder or schizophrenia	3.000000e-15
GCST004521_118	Autism spectrum disorder or schizophrenia	3.000000e-15
GCST004521_126	Autism spectrum disorder or schizophrenia	2.000000e-10
GCST004521_154	Autism spectrum disorder or schizophrenia	3.000000e-08
GCST004521_17	Autism spectrum disorder or schizophrenia	2.000000e-12
GCST004521_170	Autism spectrum disorder or schizophrenia	4.000000e-14
GCST004521_173	Autism spectrum disorder or schizophrenia	4.000000e-14
GCST004521_209	Autism spectrum disorder or schizophrenia	5.000000e-16
GCST004521_211	Autism spectrum disorder or schizophrenia	5.000000e-15
GCST004521_213	Autism spectrum disorder or schizophrenia	5.000000e-13
GCST004521_226	Autism spectrum disorder or schizophrenia	4.000000e-12
GCST004521_296	Autism spectrum disorder or schizophrenia	6.000000e-18
GCST004521_45	Autism spectrum disorder or schizophrenia	2.000000e-16
GCST004521_81	Autism spectrum disorder or schizophrenia	1.000000e-14
GCST005542_1	Sarcoidosis (non-Lofgren’s syndrome without extrapulmonary manifestations)	7.000000e-06
GCST005580_265	Intraocular pressure	3.000000e-10
GCST005830_112	Hand grip strength	4.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004695	intraocular pressure measurement
EFO:0006941	grip strength measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — Peptidyl-prolyl cis/trans isomerases

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	increases expression, affects binding, increases activity	1
bisphenol A	increases expression	1
sodium arsenite	decreases expression	1
manganese chloride	increases abundance, increases expression	1
ferrous chloride	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
2-palmitoylglycerol	increases expression	1
abrine	increases expression	1
jinfukang	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Fulvestrant	increases response to substance	1
Leflunomide	decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	increases expression	1
Coumestrol	increases expression	1
Cyclophosphamide	increases expression	1
Estradiol	increases phosphorylation, decreases reaction	1
Fluorouracil	increases expression	1
Manganese	increases abundance, increases expression	1
Methyl Methanesulfonate	increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Tamoxifen	decreases reaction, increases phosphorylation, increases response to substance	1
Urethane	increases expression	1
Epirubicin	increases expression	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.