FLVCR1-DT

Summary

FLVCR1-DT (FLVCR1 divergent transcript, HGNC:39077) is a long non-coding RNA gene on chromosome 1q32.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39077
Approved symbol	FLVCR1-DT
Name	FLVCR1 divergent transcript
Location	1q32.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LQK1
Ensembl gene	ENSG00000198468
Ensembl biotype	lncRNA
OMIM	610864
Entrez	642946
RNAcentral	URS000075BC20 — lncRNA, 942 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000356684, ENST00000424044, ENST00000426161, ENST00000651970, ENST00000665265, ENST00000703061, ENST00000824419

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000356684 — 2 exons

Exon	Start	End
ENSE00004233595	212852105	212854309
ENSE00004233601	212857766	212858157

Expression profiles

Bgee: expression breadth ubiquitous, 221 present calls, max score 91.51.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 1.9168 / max 21.6690, expressed in 1052 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
17428	1.9168	1052

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	91.51	gold quality
pancreatic ductal cell	CL:0002079	88.73	silver quality
ileal mucosa	UBERON:0000331	84.66	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.00	gold quality
islet of Langerhans	UBERON:0000006	78.89	gold quality
granulocyte	CL:0000094	77.87	gold quality
nasal cavity epithelium	UBERON:0005384	76.49	gold quality
pituitary gland	UBERON:0000007	74.93	gold quality
jejunal mucosa	UBERON:0000399	74.73	gold quality
duodenum	UBERON:0002114	73.92	gold quality
lymph node	UBERON:0000029	73.67	gold quality
adenohypophysis	UBERON:0002196	73.55	gold quality
secondary oocyte	CL:0000655	73.18	gold quality
corpus epididymis	UBERON:0004359	72.82	gold quality
endothelial cell	CL:0000115	72.41	silver quality
blood	UBERON:0000178	72.33	gold quality
upper arm skin	UBERON:0004263	72.33	gold quality
pylorus	UBERON:0001166	72.32	gold quality
vermiform appendix	UBERON:0001154	72.27	gold quality
nasal cavity mucosa	UBERON:0001826	72.18	gold quality
cardia of stomach	UBERON:0001162	71.76	gold quality
bone marrow cell	CL:0002092	71.56	silver quality
leukocyte	CL:0000738	71.54	gold quality
jejunum	UBERON:0002115	71.35	gold quality
caecum	UBERON:0001153	71.26	gold quality
deltoid	UBERON:0001476	70.88	gold quality
monocyte	CL:0000576	70.87	gold quality
trabecular bone tissue	UBERON:0002483	70.83	silver quality
adult mammalian kidney	UBERON:0000082	70.60	gold quality
right atrium auricular region	UBERON:0006631	70.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.85

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• FLVCR1-AS1 played a positive role in hepatocellular carcinoma development and progression according to the study in its mechanism (PMID:29574975)
• High expression of FLVCR1-AS1 in lung cancer.FLVCR1-AS1 role in the proliferation, migration, and invasion of lung cancer cells via the Wnt/beta-catenin signaling pathway. (PMID:30697812)
• Downregulation of FLVCR1-AS1 inhibited proliferation, migration and invasion of glioma cells. FLVCR1-AS1 directly targeted miR-4731-5p/E2F2 axis. (PMID:31699367)
• Long noncoding RNA FLVCR1AS1 promotes glioma cell proliferation and invasion by negatively regulating miR30b3p. (PMID:32626942)
• LncRNA FLVCR1-AS1 accelerates osteosarcoma cells to proliferate, migrate and invade via activating wnt/beta-catenin pathway. (PMID:33099956)
• lncRNA FLVCR1AS1 drives colorectal cancer progression via modulation of the miR381/RAP2A axis. (PMID:33313944)
• Long non-coding RNA FLVCR1-AS1 functions as a ceRNA to aggravate cervical cancer cell growth by the miR-381-3p/MAGT1 axis. (PMID:35430713)
• LncRNA FLVCR1-AS1 mediates miR-23a-5p/SLC7A11 axis to promote malignant behavior of cervical cancer cells. (PMID:35465835)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.