FLYWCH1

Summary

FLYWCH1 (FLYWCH-type zinc finger 1, HGNC:25404) is a protein-coding gene on chromosome 16p13.3, encoding FLYWCH-type zinc finger-containing protein 1 (Q4VC44). Transcription cofactor.

Enables transcription coactivator binding activity and transcription corepressor activity. Involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and pericentric heterochromatin. Part of transcription regulator complex.

Source: NCBI Gene 84256 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 261 total — 1 pathogenic
• MANE Select transcript: NM_001308068

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25404
Approved symbol	FLYWCH1
Name	FLYWCH-type zinc finger 1
Location	16p13.3
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp761A132
Ensembl gene	ENSG00000059122
Ensembl biotype	protein_coding
OMIM	620431
Entrez	84256

Gene structure

Transcript identifiers

Ensembl transcripts: 40 — 35 protein_coding, 4 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000253928, ENST00000344592, ENST00000416288, ENST00000570425, ENST00000570752, ENST00000570759, ENST00000571140, ENST00000571580, ENST00000571983, ENST00000573525, ENST00000573564, ENST00000574985, ENST00000575604, ENST00000575679, ENST00000905924, ENST00000905925, ENST00000905926, ENST00000905927, ENST00000905928, ENST00000905929, ENST00000905930, ENST00000905931, ENST00000905932, ENST00000905933, ENST00000905934, ENST00000905935, ENST00000905936, ENST00000905937, ENST00000905938, ENST00000944619, ENST00000944620, ENST00000944621, ENST00000944622, ENST00000944623, ENST00000944624, ENST00000944625, ENST00000944626, ENST00000944627, ENST00000944628, ENST00000944629

RefSeq mRNA: 3 — MANE Select: NM_001308068 NM_001308068, NM_020912, NM_032296

CCDS: CCDS45390, CCDS76809

Canonical transcript exons

ENST00000253928 — 10 exons

Exon	Start	End
ENSE00000664466	2933716	2933979
ENSE00001158896	2933130	2933582
ENSE00001280703	2930410	2930880
ENSE00001423348	2914176	2914289
ENSE00001693676	2929613	2930010
ENSE00002638091	2948688	2951208
ENSE00002642277	2911931	2912154
ENSE00003489377	2937121	2937384
ENSE00003635884	2940032	2940092
ENSE00003689820	2938184	2938456

Expression profiles

Bgee: expression breadth ubiquitous, 249 present calls, max score 95.97.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.3815 / max 155.8396, expressed in 1792 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
152338	9.1004	1773
152337	3.1002	1468
152336	0.1809	64

Top tissues by expression

257 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	95.97	gold quality
cerebellar hemisphere	UBERON:0002245	95.87	gold quality
cerebellar cortex	UBERON:0002129	95.75	gold quality
right uterine tube	UBERON:0001302	95.67	gold quality
mucosa of stomach	UBERON:0001199	95.41	gold quality
cerebellum	UBERON:0002037	94.99	gold quality
right coronary artery	UBERON:0001625	94.85	gold quality
apex of heart	UBERON:0002098	94.53	gold quality
right frontal lobe	UBERON:0002810	94.23	gold quality
granulocyte	CL:0000094	94.08	gold quality
tibial nerve	UBERON:0001323	94.04	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.62	gold quality
right ovary	UBERON:0002118	93.49	gold quality
ectocervix	UBERON:0012249	93.31	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	93.21	gold quality
sural nerve	UBERON:0015488	93.19	gold quality
skin of leg	UBERON:0001511	93.09	gold quality
hypothalamus	UBERON:0001898	93.03	gold quality
left ovary	UBERON:0002119	93.02	gold quality
kidney epithelium	UBERON:0004819	92.92	silver quality
adenohypophysis	UBERON:0002196	92.84	gold quality
spinal cord	UBERON:0002240	92.83	gold quality
skin of abdomen	UBERON:0001416	92.77	gold quality
Brodmann (1909) area 9	UBERON:0013540	92.74	gold quality
nucleus accumbens	UBERON:0001882	92.72	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	92.63	gold quality
gastrocnemius	UBERON:0001388	92.60	gold quality
spleen	UBERON:0002106	92.56	gold quality
lower esophagus muscularis layer	UBERON:0035833	92.54	gold quality
lower esophagus	UBERON:0013473	92.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.11

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
ZEB1	Repression

JASPAR motifs

Motif	Name	Family
MA2513.1	FLYWCH1	FLYWCH1

JASPAR matrix evidence (PMIDs): PMID:39605530

miRNA regulators (miRDB)

45 targeting FLYWCH1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-6857-5P	99.87	65.32	985
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-6079	99.84	68.54	1170
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-3660	99.68	67.33	1149
HSA-MIR-4526	99.68	67.07	1136
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-4663	99.62	65.33	957
HSA-MIR-143-3P	99.49	69.05	1457
HSA-MIR-6740-3P	99.48	68.49	1392
HSA-MIR-513A-3P	99.39	70.63	3620
HSA-MIR-513C-3P	99.39	70.63	3620
HSA-MIR-3911	99.38	66.95	1087
HSA-MIR-544B	99.18	67.41	1632
HSA-MIR-4784	99.15	67.41	1733
HSA-MIR-6510-5P	99.14	66.59	1081
HSA-MIR-3606-3P	99.11	69.84	3254
HSA-MIR-10524-5P	99.05	66.08	963
HSA-MIR-3619-5P	99.00	68.87	2308
HSA-MIR-3150B-3P	98.81	67.21	1728
HSA-MIR-214-3P	98.71	68.12	2128
HSA-MIR-761	98.71	68.07	2051
HSA-MIR-198	98.70	67.32	920
HSA-MIR-12114	98.70	63.45	730
HSA-MIR-2467-3P	98.65	67.18	1969
HSA-MIR-3928-5P	98.50	67.48	980
HSA-MIR-6806-3P	98.50	67.31	980
HSA-MIR-6780A-3P	98.42	67.49	1518

Literature-anchored findings (GeneRIF, showing 6)

• Identifies the human FLYWCH1 protein (AB046772/KIAA1552) as containing five FLYWCH domain copies. (PMID:15094203)
• eQTLs acting across multiple tissues are significant carriers of inherited risk for CAD. FLYWCH1, PSORSIC3, and G3BP1 are novel master regulatory genes in CAD that may be suitable targets. (PMID:25578447)
• FLYWCH1 variant of uncertain significance in candidate gene was identified in Familial Mitral Valve Prolapse. (PMID:29762926)
• Study uncovers a new molecular mechanism by which FLYWCH1 with a possible tumor suppressive role represses beta-catenin-induced ZEB1 and increases cadherin-mediated cell attachment preventing colorectal cancer metastasis. (PMID:30097457)
• we identify for the first time FLYWCH1 as a potential negative regulator of the downstream targets of the Wnt/beta-catenin pathway in AML cells. Hence, FLYWCH1 might be an intrinsic inhibitory factor of the oncogenic nuclear beta-catenin in AML cells. (PMID:31167387)
• FLYWCH1, a Multi-Functional Zinc Finger Protein Contributes to the DNA Repair Pathway. (PMID:33924684)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Flywch1	ENSMUSG00000040097
rattus_norvegicus	Flywch1	ENSRNOG00000004333

Paralogs (1): FLYWCH2 (ENSG00000162076)

Protein

Protein identifiers

FLYWCH-type zinc finger-containing protein 1 — Q4VC44 (reviewed: Q4VC44)

All UniProt accessions (8): Q4VC44, I3L0R3, I3L188, I3L1A7, I3L231, I3L287, I3L4V9, J3KNW1

UniProt curated annotations — full annotation on UniProt →

Function. Transcription cofactor. Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding. May play a role in DNA-damage response signaling. Binds specifically to DNA sequences at peri-centromeric chromatin loci.

Subunit / interactions. Interacts with CTNNB1 (when unphosphorylated), perhaps preventing interaction of CTNNB1 with TCF4, and thereby regulating transcription activation; phosphorylation of CTNNB1 may inhibit the interaction.

Subcellular location. Nucleus. Chromosome. Centromere.

Induction. Up-regulated by ultraviolet (UV) light (at protein level).

Isoforms (5)

UniProt ID	Names	Canonical?
Q4VC44-1	1	yes
Q4VC44-2	2
Q4VC44-3	3
Q4VC44-4	4
Q4VC44-5	5

RefSeq proteins (3): NP_001294997, NP_065963, NP_115672 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007588	Znf_FLYWCH	Domain
IPR029279	FLYWCH_N	Domain
IPR040312	FWCH1/FWCH2	Family

Pfam: PF04500, PF15423, PF16662

UniProt features (34 total): modified residue 6, strand 6, zinc finger region 5, splice variant 5, cross-link 3, region of interest 3, helix 2, chain 1, sequence conflict 1, turn 1, compositionally biased region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2RPR	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q4VC44-F1	64.71	0.15

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 21, 261, 371, 503, 591, 696, 134, 393, 685

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 71 (showing top): GSE45365_NK_CELL_VS_BCELL_DN, RICKMAN_METASTASIS_DN, GOBP_DNA_DAMAGE_RESPONSE, CUI_TCF21_TARGETS_2_UP, AP4_01, LEIN_NEURON_MARKERS, GOCC_CHROMOSOMAL_REGION, GOCC_NUCLEAR_BODY, GOCC_TRANSCRIPTION_REGULATOR_COMPLEX, GOCC_PERICENTRIC_HETEROCHROMATIN, GOCC_HETEROCHROMATIN, NIKOLSKY_BREAST_CANCER_16P13_AMPLICON, GOMF_TRANSCRIPTION_COREGULATOR_BINDING, GOMF_TRANSCRIPTION_COACTIVATOR_BINDING, GOMF_TRANSCRIPTION_FACTOR_BINDING

GO Biological Process (2): negative regulation of transcription by RNA polymerase II (GO:0000122), DNA damage response (GO:0006974)

GO Molecular Function (6): transcription coactivator binding (GO:0001223), DNA binding (GO:0003677), transcription corepressor activity (GO:0003714), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (8): nucleoplasm (GO:0005654), transcription regulator complex (GO:0005667), pericentric heterochromatin (GO:0005721), cytosol (GO:0005829), nuclear body (GO:0016604), chromosome, centromeric region (GO:0000775), nucleus (GO:0005634), chromosome (GO:0005694)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
negative regulation of DNA-templated transcription	2
cellular anatomical structure	2
intracellular membraneless organelle	2
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
cellular response to stress	1
transcription coregulator binding	1
nucleic acid binding	1
transcription coregulator activity	1
transition metal ion binding	1
binding	1
cation binding	1
nuclear lumen	1
protein-containing complex	1
chromosome, centromeric region	1
heterochromatin	1
cytoplasm	1
nucleoplasm	1
chromosomal region	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

730 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FLYWCH1	PAQR4	Q8N4S7	478
FLYWCH1	CFAP58	Q5T655	459
FLYWCH1	PRSS33	Q8NF86	418
FLYWCH1	HCFC1R1	Q9NWW0	414
FLYWCH1	RERGL	Q9H628	400
FLYWCH1	PRSS41	Q7RTY9	398
FLYWCH1	RNF169	Q8NCN4	392
FLYWCH1	BICDL2	A1A5D9	380
FLYWCH1	PURG	Q9UJV8	375
FLYWCH1	TMEM235	A6NFC5	370
FLYWCH1	OR1C1	Q15619	367
FLYWCH1	KREMEN2	Q8NCW0	358
FLYWCH1	ANKRD9	Q96BM1	356
FLYWCH1	RFTN2	Q52LD8	339
FLYWCH1	PKMYT1	Q99640	339

IntAct

56 interactions, top by confidence:

A	B	Type	Score
GOLGA6L9	FLYWCH1	psi-mi:“MI:0915”(physical association)	0.560
FLYWCH1	GMCL1	psi-mi:“MI:0915”(physical association)	0.560
	FLYWCH1	psi-mi:“MI:0915”(physical association)	0.560
HSF2BP	FLYWCH1	psi-mi:“MI:0915”(physical association)	0.560
LHX2	FLYWCH1	psi-mi:“MI:0915”(physical association)	0.560
FLYWCH1	CCDC125	psi-mi:“MI:0915”(physical association)	0.560
FLYWCH1	PICK1	psi-mi:“MI:0915”(physical association)	0.560
FLYWCH1	HOOK2	psi-mi:“MI:0915”(physical association)	0.560
TRAF2	FLYWCH1	psi-mi:“MI:0915”(physical association)	0.560
FLYWCH1	MTUS2	psi-mi:“MI:0915”(physical association)	0.560
FLYWCH1	KIFC3	psi-mi:“MI:0915”(physical association)	0.560
FLYWCH1	PPP1R16B	psi-mi:“MI:0915”(physical association)	0.560
PLOD3	COL4A1	psi-mi:“MI:0914”(association)	0.530
HTATSF1	FLYWCH1	psi-mi:“MI:0915”(physical association)	0.400
FLYWCH1	HMGN2	psi-mi:“MI:0915”(physical association)	0.400
Dctn3		psi-mi:“MI:0914”(association)	0.350
Mad2l1	MAD1L1	psi-mi:“MI:0914”(association)	0.350
KIF11	ILVBL	psi-mi:“MI:0914”(association)	0.350
Hsf1	OFD1	psi-mi:“MI:0914”(association)	0.350
Gpkow	BDP1	psi-mi:“MI:0914”(association)	0.350
Ufl1	PRSS1	psi-mi:“MI:0914”(association)	0.350
NFATC1	SMARCA5	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
AFG2A	ESYT2	psi-mi:“MI:0914”(association)	0.350
AFG2B	MMP24OS	psi-mi:“MI:0914”(association)	0.350
PTBP3		psi-mi:“MI:0914”(association)	0.350
MDC1	SMCHD1	psi-mi:“MI:2364”(proximity)	0.270
FLYWCH1	GOLGA6L9	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (40): FLYWCH1 (Affinity Capture-MS), HTATSF1 (Affinity Capture-MS), FLYWCH1 (Affinity Capture-MS), FLYWCH1 (Affinity Capture-MS), FLYWCH1 (Affinity Capture-MS), FLYWCH1 (Affinity Capture-MS), FLYWCH1 (Affinity Capture-MS), FLYWCH1 (Affinity Capture-MS), FLYWCH1 (Affinity Capture-MS), FLYWCH1 (Affinity Capture-MS), FLYWCH1 (Proximity Label-MS), FLYWCH1 (Affinity Capture-MS), SETDB1 (Two-hybrid), GMCL1 (Two-hybrid), HOOK2 (Two-hybrid)

ESM2 similar proteins: A0A0J9YWL9, A0A0J9YY54, A5D7L8, A6NEF3, A6NI86, B2KFW1, B4DH59, D3YZV8, E9Q6E9, F1LWT0, F6QRE9, H0YKK7, O15069, P17040, P17564, P21263, P51843, P62521, P79386, Q0P6D6, Q13342, Q2EG98, Q2KI51, Q3BBV2, Q4VC44, Q5F378, Q5QGU6, Q63560, Q6ITT4, Q6P5H2, Q6ZQX7, Q86T75, Q8CHD8, Q8IWY8, Q8N660, Q8N693, Q99PG2, Q9BE18, Q9BG93, Q9BG94

Diamond homologs: Q4VC44, Q5R9P4, Q8CI03, Q96CP2, Q9CQE9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

261 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	211
Likely benign	19
Benign	4

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
3243524	NC_000016.9:g.(?2550259)(3154076_?)del	Pathogenic

SpliceAI

2054 predictions. Top by Δscore:

Variant	Effect	Δscore
16:2912136:G:T	donor_gain	1.0000
16:2930876:GCTGG:G	donor_gain	1.0000
16:2930878:TGG:T	donor_gain	1.0000
16:2930879:GG:G	donor_gain	1.0000
16:2930879:GGG:G	donor_gain	1.0000
16:2930879:GGGT:G	donor_loss	1.0000
16:2930880:GG:G	donor_gain	1.0000
16:2930880:GGT:G	donor_loss	1.0000
16:2930881:G:GG	donor_gain	1.0000
16:2933124:CTCTA:C	acceptor_loss	1.0000
16:2933125:TCTA:T	acceptor_loss	1.0000
16:2933126:CTAG:C	acceptor_loss	1.0000
16:2933127:TAGG:T	acceptor_loss	1.0000
16:2933128:A:AG	acceptor_gain	1.0000
16:2933128:AG:A	acceptor_gain	1.0000
16:2933129:G:GA	acceptor_gain	1.0000
16:2933129:G:T	acceptor_loss	1.0000
16:2933129:GG:G	acceptor_gain	1.0000
16:2933129:GGA:G	acceptor_gain	1.0000
16:2933129:GGAC:G	acceptor_gain	1.0000
16:2933129:GGACA:G	acceptor_gain	1.0000
16:2933580:CGGGT:C	donor_loss	1.0000
16:2933582:GGTGA:G	donor_loss	1.0000
16:2933583:G:A	donor_loss	1.0000
16:2933583:G:GG	donor_gain	1.0000
16:2933584:T:G	donor_loss	1.0000
16:2937385:G:GA	donor_loss	1.0000
16:2937385:G:GG	donor_gain	1.0000
16:2938178:TTTCA:T	acceptor_loss	1.0000
16:2938179:TTCAG:T	acceptor_loss	1.0000

AlphaMissense

4593 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:2937219:T:A	W538R	1.000
16:2937219:T:C	W538R	1.000
16:2933814:T:A	W450R	0.999
16:2933814:T:C	W450R	0.999
16:2933816:G:C	W450C	0.999
16:2933816:G:T	W450C	0.999
16:2937163:T:C	L519P	0.999
16:2937177:T:C	F524L	0.999
16:2937179:C:A	F524L	0.999
16:2937179:C:G	F524L	0.999
16:2937183:T:G	Y526D	0.999
16:2937221:G:C	W538C	0.999
16:2937221:G:T	W538C	0.999
16:2937225:T:C	C540R	0.999
16:2937227:C:G	C540W	0.999
16:2937249:T:C	C548R	0.999
16:2937255:A:C	S550R	0.999
16:2937257:C:A	S550R	0.999
16:2937257:C:G	S550R	0.999
16:2937262:C:A	A552D	0.999
16:2938255:T:G	Y617D	0.999
16:2938291:T:A	W629R	0.999
16:2938291:T:C	W629R	0.999
16:2938293:G:C	W629C	0.999
16:2938293:G:T	W629C	0.999
16:2938297:T:A	C631S	0.999
16:2938297:T:C	C631R	0.999
16:2938298:G:C	C631S	0.999
16:2938299:C:G	C631W	0.999
16:2938321:T:C	C639R	0.999

dbSNP variants (sampled 300 via entrez): RS1000041829 (16:2917957 C>A), RS1000186042 (16:2951332 GCCT>G), RS1000240596 (16:2917836 G>C,T), RS1000280817 (16:2932327 G>T), RS1000297428 (16:2917529 G>A,T), RS1000357701 (16:2937574 T>G), RS1000401570 (16:2913262 T>C), RS1000404055 (16:2926348 A>C), RS1000421486 (16:2921791 T>G), RS1000623650 (16:2933052 C>A,T), RS1000728078 (16:2914163 A>C,G), RS1000739076 (16:2938560 G>A,T), RS1000817380 (16:2939116 T>A), RS1000878396 (16:2925823 C>T), RS1001034503 (16:2938899 A>C)

Disease associations

OMIM: gene MIM:620431 | disease phenotypes: MIM:308350, MIM:616044, MIM:180860

GenCC curated gene-disease

Mondo (3): developmental and epileptic encephalopathy, 1 (MONDO:0010632), autosomal dominant nonsyndromic hearing loss 65 (MONDO:0014470), Silver-Russell syndrome (MONDO:0008394)

Orphanet (2): Rare autosomal dominant non-syndromic sensorineural deafness type DFNA (Orphanet:90635), Silver-Russell syndrome (Orphanet:813)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003262_490	Post bronchodilator FEV1	1.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004314	forced expiratory volume

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D056730	Silver-Russell Syndrome	C05.660.207.925; C16.131.077.855; C16.131.260.870; C16.320.180.870; C16.320.240.937; C16.320.447.750

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	4
Valproic Acid	increases expression, increases methylation	2
aristolochic acid I	increases expression	1
FR900359	decreases phosphorylation	1
TAK-243	decreases sumoylation	1
propionaldehyde	increases expression	1
titanium dioxide	decreases methylation	1
arsenite	affects binding, decreases reaction	1
cobaltous chloride	increases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	decreases expression	1
2-palmitoylglycerol	increases expression	1
nutlin 3	affects cotreatment, increases expression	1
ICG 001	increases expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Acetaminophen	increases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Caffeine	increases phosphorylation	1
Cisplatin	affects cotreatment, increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Methyl Methanesulfonate	increases expression	1
Phthalic Acids	increases methylation	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1S8	Abcam HeLa FLYWCH1 KO	Cancer cell line	Female

Clinical trials (associated diseases)

11 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT06457906	PHASE3	RECRUITING	SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC
NCT04180501	PHASE2	UNKNOWN	SRS Sequential Sindilimab in Brain Metastasis of NSLSC
NCT04899908	PHASE2	ACTIVE_NOT_RECRUITING	Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
NCT07162246	PHASE2	RECRUITING	Combined Gamma Knife/Linac Radiosurgery for Large Brain Tumors / Metastases
NCT01520467	Not specified	UNKNOWN	Aromatase Inhibitor in Bone Maturation, Children With Silver Russell or Prader-Willi Syndrome
NCT03915106	Not specified	RECRUITING	Quality of Life (HRQoL) of AIS Patients Who Require Bracing or Surgery Using SRS-22 Questionnaire
NCT05070234	Not specified	UNKNOWN	Genetic Diagnosis and Human Growth Hormone Treatment in Small for Gestational Age Children With Short Stature
NCT05945576	Not specified	RECRUITING	IDMet (RaDiCo Cohort) (RaDiCo-IDMet)
NCT06466720	Not specified	ACTIVE_NOT_RECRUITING	Measuring and Mapping Cognitive Decline After Brain Radiosurgery
NCT06852001	Not specified	NOT_YET_RECRUITING	Efficacy of the RayerKnife X Stereotactic Radiotherapy System in the Treatment of Brain Metastases
NCT07405112	Not specified	COMPLETED	Impact of Curve Magnitude on Pain and Body Image in Patients With Adolescents Idiopathic Scoliosis