FMR1-AS1

Summary

FMR1-AS1 (FMR1 antisense RNA 1, HGNC:39081) is a long non-coding RNA gene on chromosome Xq27.3.

Predicted to be involved in negative regulation of apoptotic process.

Source: NCBI Gene 100126270 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39081
Approved symbol	FMR1-AS1
Name	FMR1 antisense RNA 1
Location	Xq27.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	ASFMR1, FMR4, FMR5
Ensembl gene	ENSG00000268066
Ensembl biotype	lncRNA
OMIM	300805
Entrez	100126270
RNAcentral	URS00008121A2 — lncRNA, 2387 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 10 lncRNA, 1 retained_intron

ENST00000594922, ENST00000596112, ENST00000598667, ENST00000601841, ENST00000745732, ENST00000745733, ENST00000745734, ENST00000745735, ENST00000745736, ENST00000745737, ENST00000745738

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000594922 — 2 exons

Exon	Start	End
ENSE00003067084	147909431	147910995
ENSE00003107773	147911378	147911817

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 59.99.

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	59.99	silver quality
ventricular zone	UBERON:0003053	59.14	silver quality
ganglionic eminence	UBERON:0004023	55.61	silver quality
lymph node	UBERON:0000029	53.78	gold quality
liver	UBERON:0002107	52.59	silver quality
skeletal muscle tissue	UBERON:0001134	52.13	silver quality
duodenum	UBERON:0002114	49.46	gold quality
prefrontal cortex	UBERON:0000451	49.38	gold quality
gall bladder	UBERON:0002110	49.37	silver quality
blood	UBERON:0000178	48.39	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	48.23	gold quality
calcaneal tendon	UBERON:0003701	46.95	silver quality
urinary bladder	UBERON:0001255	46.37	silver quality
cortex of kidney	UBERON:0001225	46.21	silver quality
myometrium	UBERON:0001296	45.95	silver quality
placenta	UBERON:0001987	45.91	silver quality
islet of Langerhans	UBERON:0000006	45.61	silver quality
pancreas	UBERON:0001264	45.50	silver quality
vermiform appendix	UBERON:0001154	45.03	silver quality
right lobe of liver	UBERON:0001114	44.97	silver quality
muscle of leg	UBERON:0001383	44.93	silver quality
heart left ventricle	UBERON:0002084	44.92	silver quality
cerebral cortex	UBERON:0000956	44.84	silver quality
adult mammalian kidney	UBERON:0000082	44.56	silver quality
gastrocnemius	UBERON:0001388	44.34	silver quality
lung	UBERON:0002048	43.84	silver quality
tibial artery	UBERON:0007610	43.72	silver quality
popliteal artery	UBERON:0002250	43.65	silver quality
small intestine	UBERON:0002108	43.63	silver quality
left ovary	UBERON:0002119	42.97	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• ASFMR1 may contribute to the variable phenotypes associated with the CGG repeat expansion. (PMID:17921506)
• FMR4 is a chromatin-associated transcript. FMR4 alters the chromatin state and the expression of several hundred genes in human neural precursor cells. (PMID:27001315)
• Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NF-kappaB/c-Myc signaling in female esophageal carcinoma. (PMID:30736860)
• Correlation of FMR4 expression levels to ovarian reserve markers in FMR1 premutation carriers. (PMID:38760837)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.