FNDC3A

Summary

FNDC3A (fibronectin type III domain containing 3A, HGNC:20296) is a protein-coding gene on chromosome 13q14.2, encoding Fibronectin type-III domain-containing protein 3A (Q9Y2H6). Mediates spermatid-Sertoli adhesion during spermatogenesis.

Enables RNA binding activity. Predicted to be involved in spermatid development. Predicted to act upstream of or within Sertoli cell development; cell-cell adhesion; and fertilization. Located in Golgi apparatus.

Source: NCBI Gene 22862 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 174 total
• MANE Select transcript: NM_001079673

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20296
Approved symbol	FNDC3A
Name	fibronectin type III domain containing 3A
Location	13q14.2
Locus type	gene with protein product
Status	Approved
Aliases	bA203I16.5, KIAA0970
Ensembl gene	ENSG00000102531
Ensembl biotype	protein_coding
OMIM	615794
Entrez	22862

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 11 protein_coding, 2 nonsense_mediated_decay

ENST00000378383, ENST00000398316, ENST00000484074, ENST00000492622, ENST00000497644, ENST00000541916, ENST00000851214, ENST00000851215, ENST00000934563, ENST00000934564, ENST00000934565, ENST00000971118, ENST00000971119

RefSeq mRNA: 3 — MANE Select: NM_001079673 NM_001079673, NM_001278438, NM_014923

CCDS: CCDS41886, CCDS9413

Canonical transcript exons

ENST00000492622 — 26 exons

Exon	Start	End
ENSE00000682481	49178568	49178654
ENSE00000682482	49185964	49186102
ENSE00000939645	49172043	49172096
ENSE00001129122	49188515	49188633
ENSE00001129131	49187122	49187190
ENSE00001129140	49175367	49175541
ENSE00001129152	49167244	49167303
ENSE00001335285	49145778	49145935
ENSE00001342700	49174435	49174559
ENSE00001342704	49168613	49168751
ENSE00001378011	49191015	49191120
ENSE00001422888	48975912	48976177
ENSE00001922094	49207081	49209779
ENSE00003479083	49201800	49201966
ENSE00003532194	49203157	49203284
ENSE00003561019	49197725	49197874
ENSE00003636520	49198362	49198574
ENSE00003657943	49191209	49191384
ENSE00003685468	49196877	49196990
ENSE00003689909	49197982	49198265
ENSE00003717332	49114655	49114731
ENSE00003722749	49075289	49075364
ENSE00003724153	49006152	49006289
ENSE00003741829	49131137	49131374
ENSE00003743912	49138747	49138805
ENSE00003748826	49136332	49136601

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 97.11.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 55.1087 / max 938.9419, expressed in 1816 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
135111	23.3222	1762
135091	17.3667	1794
135096	8.7795	1547
135090	1.4164	817
135100	1.2326	311
135098	0.6050	238
135099	0.5125	159
135093	0.4626	225
135095	0.3671	178
135097	0.3391	131

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus epididymis	UBERON:0004359	97.11	gold quality
caput epididymis	UBERON:0004358	96.64	gold quality
adrenal tissue	UBERON:0018303	96.44	gold quality
jejunal mucosa	UBERON:0000399	96.43	gold quality
cardia of stomach	UBERON:0001162	96.40	gold quality
cauda epididymis	UBERON:0004360	96.24	gold quality
germinal epithelium of ovary	UBERON:0001304	96.15	gold quality
decidua	UBERON:0002450	96.11	gold quality
islet of Langerhans	UBERON:0000006	95.61	gold quality
mucosa of paranasal sinus	UBERON:0005030	95.57	gold quality
placenta	UBERON:0001987	95.49	gold quality
body of pancreas	UBERON:0001150	95.20	gold quality
urethra	UBERON:0000057	95.19	gold quality
blood vessel layer	UBERON:0004797	95.18	gold quality
tibia	UBERON:0000979	95.13	gold quality
seminal vesicle	UBERON:0000998	94.95	gold quality
pericardium	UBERON:0002407	94.93	gold quality
superficial temporal artery	UBERON:0001614	94.90	gold quality
stromal cell of endometrium	CL:0002255	94.87	gold quality
endometrium	UBERON:0001295	94.79	gold quality
pancreas	UBERON:0001264	94.66	gold quality
epithelium of nasopharynx	UBERON:0001951	94.63	gold quality
pylorus	UBERON:0001166	94.48	gold quality
trigeminal ganglion	UBERON:0001675	94.33	gold quality
parotid gland	UBERON:0001831	94.31	gold quality
jejunum	UBERON:0002115	94.30	gold quality
colonic epithelium	UBERON:0000397	94.28	gold quality
lower lobe of lung	UBERON:0008949	94.20	gold quality
mammary duct	UBERON:0001765	94.12	gold quality
parietal pleura	UBERON:0002400	94.05	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-CURD-122	yes	38.33
E-CURD-119	yes	32.73
E-CURD-88	yes	13.55
E-HCAD-35	yes	7.45
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

241 targeting FNDC3A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4775	99.98	75.00	6394

Literature-anchored findings (GeneRIF, showing 4)

• We report the 1st characterization of new gene we named HUGO, and its associated deduced protein sequence. HUGO proteins are mainly composed of a proline-rich region at N-terminus, 8 type III-fibronectin modules, and transmembranous helix at C-terminus. (PMID:18218838)
• The results of this study concluded that FNDC3A influences the prevalence of autism spectrum disorder. (PMID:23639254)
• FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy. (PMID:32963011)
• The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis. (PMID:32966780)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	fndc3a	ENSDARG00000105503
mus_musculus	Fndc3a	ENSMUSG00000033487
rattus_norvegicus	Fndc3a	ENSRNOG00000014478
drosophila_melanogaster	mtgo	FBGN0259735
caenorhabditis_elegans		WBGENE00007944

Paralogs (11): MYOM2 (ENSG00000036448), FNDC3B (ENSG00000075420), MYBPC2 (ENSG00000086967), MYOM1 (ENSG00000101605), OBSL1 (ENSG00000124006), MYBPH (ENSG00000133055), MYBPC3 (ENSG00000134571), MYOM3 (ENSG00000142661), IGSF22 (ENSG00000179057), MYBPC1 (ENSG00000196091), MYBPHL (ENSG00000221986)

Protein

Protein identifiers

Fibronectin type-III domain-containing protein 3A — Q9Y2H6 (reviewed: Q9Y2H6)

Alternative names: Human gene expressed in odontoblasts

All UniProt accessions (4): Q9Y2H6, A0A087X1M6, G5E9X3, H7C507

UniProt curated annotations — full annotation on UniProt →

Function. Mediates spermatid-Sertoli adhesion during spermatogenesis.

Subcellular location. Golgi apparatus membrane.

Tissue specificity. Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to a lesser extent in the brain, liver, lung and kidney.

Similarity. Belongs to the FNDC3 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y2H6-1	1, HUGO1	yes
Q9Y2H6-2	2, HUGO2

RefSeq proteins (3): NP_001073141, NP_001265367, NP_055738 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003961	FN3_dom	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036116	FN3_sf	Homologous_superfamily
IPR050617	E3_ligase_FN3/SPRY	Family

Pfam: PF00041

UniProt features (74 total): strand 47, domain 9, modified residue 4, sequence conflict 4, compositionally biased region 2, splice variant 2, chain 1, transmembrane region 1, region of interest 1, sequence variant 1, helix 1, turn 1

Structure

Experimental structures (PDB)

6 structures.

PDB	Method	Resolution (Å)
1WK0	SOLUTION NMR
1X3D	SOLUTION NMR
1X4X	SOLUTION NMR
1X5X	SOLUTION NMR
2CRM	SOLUTION NMR
2CRZ	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y2H6-F1	78.12	0.46

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 203, 207, 213, 384

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 351 (showing top): AAGCAAT_MIR137, GOBP_EPITHELIUM_DEVELOPMENT, TAATAAT_MIR126, GOBP_EPITHELIAL_CELL_DEVELOPMENT, GOCC_SECRETORY_GRANULE, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GOBP_SERTOLI_CELL_DEVELOPMENT, GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP, TAKADA_GASTRIC_CANCER_COPY_NUMBER_DN, GOBP_MALE_GAMETE_GENERATION, GOBP_CELL_CELL_ADHESION, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GOBP_REPRODUCTIVE_SYSTEM_DEVELOPMENT, ATTACAT_MIR3803P, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

GO Biological Process (4): spermatid development (GO:0007286), fertilization (GO:0009566), Sertoli cell development (GO:0060009), cell-cell adhesion (GO:0098609)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (9): Golgi membrane (GO:0000139), acrosomal vesicle (GO:0001669), cytoplasm (GO:0005737), Golgi apparatus (GO:0005794), cytosol (GO:0005829), vesicle membrane (GO:0012506), membrane (GO:0016020), endomembrane system (GO:0012505), cytoplasmic vesicle (GO:0031410)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cytoplasm	3
germ cell development	1
spermatid differentiation	1
sexual reproduction	1
reproductive process	1
epithelial cell development	1
developmental process involved in reproduction	1
Sertoli cell differentiation	1
cell adhesion	1
nucleic acid binding	1
binding	1
Golgi apparatus	1
bounding membrane of organelle	1
secretory granule	1
intracellular anatomical structure	1
endomembrane system	1
intracellular membrane-bounded organelle	1
organelle membrane	1
vesicle	1
vacuole	1
plasma membrane	1
intracellular vesicle	1

Protein interactions and networks

STRING

1334 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FNDC3A	MLNR	O43193	649
FNDC3A	CDADC1	Q9BWV3	649
FNDC3A	CAB39L	Q9H9S4	627
FNDC3A	LPAR6	P43657	531
FNDC3A	RCBTB2	O95199	531
FNDC3A	SETDB2	Q96T68	508
FNDC3A	FNDC4	Q9H6D8	505
FNDC3A	PHF11	Q9UIL8	496
FNDC3A	CYSLTR2	Q9NS75	490
FNDC3A	HLA-DRB1	P01911	453
FNDC3A	ITM2B	Q9Y287	453
FNDC3A	LAMA4	Q16363	446
FNDC3A	TMPPE	Q6ZT21	417
FNDC3A	PSD3	Q9NYI0	414
FNDC3A	FBLN7	Q53RD9	409

IntAct

81 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
NIPAL1	ESYT2	psi-mi:“MI:0914”(association)	0.640
ADCY9	NEMP1	psi-mi:“MI:0914”(association)	0.640
IGF1R	PIK3R2	psi-mi:“MI:2364”(proximity)	0.590
INSR	PIK3R2	psi-mi:“MI:2364”(proximity)	0.570
DLK1	TCAF2	psi-mi:“MI:0914”(association)	0.530
BTNL3	FAM171A2	psi-mi:“MI:0914”(association)	0.530
SPINT2	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
TMEM51	WWP2	psi-mi:“MI:0914”(association)	0.530
SLC30A2	RER1	psi-mi:“MI:0914”(association)	0.530
IL27RA	B4GALT5	psi-mi:“MI:0914”(association)	0.530
SYT3	PGK2	psi-mi:“MI:0914”(association)	0.530
MAGEA4	MAGEB16	psi-mi:“MI:0914”(association)	0.530
DLK1	SCAMP3	psi-mi:“MI:0914”(association)	0.530
MAGEA4	MAGEA8	psi-mi:“MI:0914”(association)	0.530
THAP7	FNDC3A	psi-mi:“MI:0915”(physical association)	0.400
TRIT1	FNDC3A	psi-mi:“MI:0915”(physical association)	0.400
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
	SYNGR1	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
CCDC47	ESYT2	psi-mi:“MI:0914”(association)	0.350
ABTB2	IFT56	psi-mi:“MI:0914”(association)	0.350
PCDH10	TMEM223	psi-mi:“MI:0914”(association)	0.350
TTMP	TMEM223	psi-mi:“MI:0914”(association)	0.350
AVPR2	GXYLT2	psi-mi:“MI:0914”(association)	0.350
CLEC2D	TMEM120B	psi-mi:“MI:0914”(association)	0.350
OR1M1	NBAS	psi-mi:“MI:0914”(association)	0.350
ZDHHC12	NBAS	psi-mi:“MI:0914”(association)	0.350

BioGRID (377): FNDC3A (Affinity Capture-MS), FNDC3A (Affinity Capture-MS), FNDC3A (Affinity Capture-MS), FNDC3A (Affinity Capture-MS), FNDC3A (Affinity Capture-MS), FNDC3A (Proximity Label-MS), FNDC3A (Proximity Label-MS), FNDC3A (Affinity Capture-MS), FNDC3A (Affinity Capture-MS), FNDC3A (Affinity Capture-MS), FNDC3A (Affinity Capture-MS), FNDC3A (Affinity Capture-MS), FNDC3A (Affinity Capture-MS), FNDC3A (Affinity Capture-MS), FNDC3A (Affinity Capture-MS)

ESM2 similar proteins: A0A087WV53, A2AAJ9, A2ABU4, A2RUH7, E7F6H7, O00423, O01761, O14576, O54785, O70468, O88485, O88599, P16419, P22607, P26453, P52179, P53670, P53671, P54296, P56741, P70402, Q00872, Q02173, Q05623, Q05BC3, Q0DYP5, Q13203, Q14168, Q14324, Q14896, Q29RQ3, Q32L23, Q4V8C3, Q5FW53, Q5PQM4, Q5VST9, Q5VTT5, Q5XI81, Q5XKE0, Q60992

Diamond homologs: A2ASQ1, A2ASS6, A3KN33, A8DYP0, B4F785, O00468, O35474, O43854, O55005, O88516, O89026, O94779, P00740, P25304, P29294, P35590, Q05793, Q06561, Q16787, Q4LDE5, Q4VBE4, Q5R7K9, Q5RBN1, Q63HQ2, Q7TPD3, Q8N9C0, Q8TER0, Q8WZ42, Q95ND7, Q96MS0, Q9HCK4, Q9NYJ7, Q9NYQ8, Q9Y2H6, Q9Y6N7, Q9Z2I4, D3YXG0, D3Z7H8, D3ZEY0, D4A1J9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

174 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	131
Likely benign	10
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

4457 predictions. Top by Δscore:

Variant	Effect	Δscore
13:49006146:TTTCA:T	acceptor_loss	1.0000
13:49006147:TTCAG:T	acceptor_loss	1.0000
13:49006148:TCAGA:T	acceptor_loss	1.0000
13:49006149:CAGAA:C	acceptor_loss	1.0000
13:49006150:A:AG	acceptor_gain	1.0000
13:49006150:A:C	acceptor_loss	1.0000
13:49006151:G:GA	acceptor_gain	1.0000
13:49006151:GA:G	acceptor_gain	1.0000
13:49006151:GAAT:G	acceptor_gain	1.0000
13:49006151:GAATT:G	acceptor_gain	1.0000
13:49006288:AGGTA:A	donor_loss	1.0000
13:49006291:T:G	donor_loss	1.0000
13:49075284:TTAA:T	acceptor_loss	1.0000
13:49075285:TAA:T	acceptor_loss	1.0000
13:49075286:A:AG	acceptor_gain	1.0000
13:49075286:AAG:A	acceptor_gain	1.0000
13:49075287:A:G	acceptor_gain	1.0000
13:49075287:A:T	acceptor_loss	1.0000
13:49075288:G:GG	acceptor_gain	1.0000
13:49075288:GGTT:G	acceptor_gain	1.0000
13:49075361:ACAG:A	donor_loss	1.0000
13:49075362:CAG:C	donor_loss	1.0000
13:49075364:GGTAA:G	donor_loss	1.0000
13:49075365:G:A	donor_loss	1.0000
13:49075366:T:G	donor_loss	1.0000
13:49131132:TGTA:T	acceptor_loss	1.0000
13:49131134:TA:T	acceptor_loss	1.0000
13:49131135:AGGT:A	acceptor_loss	1.0000
13:49131136:G:GA	acceptor_loss	1.0000
13:49131368:GAT:G	donor_gain	1.0000

AlphaMissense

7822 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:49168746:T:A	W391R	1.000
13:49168746:T:C	W391R	1.000
13:49145809:T:C	L284P	0.999
13:49168735:T:C	L387P	0.999
13:49168748:G:C	W391C	0.999
13:49168748:G:T	W391C	0.999
13:49174545:T:A	N447K	0.999
13:49174545:T:G	N447K	0.999
13:49175470:T:A	W487R	0.999
13:49175470:T:C	W487R	0.999
13:49175472:G:C	W487C	0.999
13:49175472:G:T	W487C	0.999
13:49186099:T:A	W585R	0.999
13:49186099:T:C	W585R	0.999
13:49191117:T:A	W683R	0.999
13:49191117:T:C	W683R	0.999
13:49196985:T:A	W779R	0.999
13:49196985:T:C	W779R	0.999
13:49196987:G:C	W779C	0.999
13:49196987:G:T	W779C	0.999
13:49197758:T:G	Y792D	0.999
13:49197765:T:C	L794P	0.999
13:49203201:T:A	W1067R	0.999
13:49203201:T:C	W1067R	0.999
13:49203203:G:C	W1067C	0.999
13:49203203:G:T	W1067C	0.999
13:49207148:G:C	R1117P	0.999
13:49145814:T:A	W286R	0.998
13:49145814:T:C	W286R	0.998
13:49168615:T:A	V347D	0.998

dbSNP variants (sampled 300 via entrez): RS1000002133 (13:49141984 C>T), RS1000002524 (13:49053130 C>T), RS1000010205 (13:49117012 G>T), RS1000018539 (13:49116256 G>A), RS1000058265 (13:48983429 T>A), RS1000073205 (13:49164751 G>T), RS1000076084 (13:48983643 C>G), RS1000086698 (13:49064551 C>T), RS1000099423 (13:49023127 A>C), RS1000121873 (13:49109298 C>A), RS1000124876 (13:49152712 C>T), RS1000148675 (13:49087235 T>C), RS1000154395 (13:49103865 T>C), RS1000155248 (13:49072766 G>A), RS1000173915 (13:49090210 CAG>C)

Disease associations

OMIM: gene MIM:615794 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST003226_25	Pelvic organ prolapse	9.000000e-06
GCST005537_114	Chronic inflammatory diseases (ankylosing spondylitis, Crohn’s disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy)	1.000000e-07
GCST008154_42	Trunk fat mass	9.000000e-06
GCST008180_14	Spontaneous preterm birth with premature rupture of membranes	7.000000e-06
GCST010241_97	Apolipoprotein A1 levels	1.000000e-12
GCST010242_369	HDL cholesterol levels	2.000000e-10
GCST010796_5080	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-08
GCST010796_5081	Electrocardiogram morphology (amplitude at temporal datapoints)	4.000000e-08
GCST010796_5082	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-08

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0006917	spontaneous preterm birth
EFO:0004614	apolipoprotein A 1 measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004327	electrocardiography

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, affects expression, decreases methylation, affects cotreatment	8
sodium arsenite	increases abundance, increases expression, affects binding, increases reaction, decreases expression	5
trichostatin A	affects cotreatment, decreases expression	3
Cyclosporine	increases expression	3
Cadmium Chloride	decreases reaction, increases abundance, increases palmitoylation, increases expression	3
bisphenol A	affects methylation, affects cotreatment, decreases expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
zinc chromate	increases abundance, increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
aflatoxin B2	decreases methylation	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	increases abundance, increases expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
entinostat	decreases expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Fulvestrant	affects cotreatment, affects methylation	1
Acetaminophen	decreases expression	1
Arsenic	increases abundance, increases expression	1
Benzo(a)pyrene	decreases methylation	1
Cadmium	decreases reaction, increases abundance, increases palmitoylation	1
Caffeine	decreases phosphorylation	1
Doxorubicin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.