FNDC7

Summary

FNDC7 (fibronectin type III domain containing 7, HGNC:26668) is a protein-coding gene on chromosome 1p13.3, encoding Fibronectin type III domain-containing protein 7 (Q5VTL7).

Predicted to be located in extracellular region.

Source: NCBI Gene 163479 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 114 total
• MANE Select transcript: NM_001144937

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26668
Approved symbol	FNDC7
Name	fibronectin type III domain containing 7
Location	1p13.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ35838
Ensembl gene	ENSG00000143107
Ensembl biotype	protein_coding
Entrez	163479

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000370017, ENST00000445274, ENST00000932418

RefSeq mRNA: 1 — MANE Select: NM_001144937 NM_001144937

CCDS: CCDS44185

Canonical transcript exons

ENST00000370017 — 13 exons

Exon	Start	End
ENSE00001067176	108733272	108733532
ENSE00001067177	108728632	108728886
ENSE00001067178	108730674	108730928
ENSE00001067184	108725750	108726004
ENSE00001067186	108727808	108728065
ENSE00001219160	108737495	108737524
ENSE00001219202	108741773	108741841
ENSE00001451521	108722335	108722592
ENSE00001451522	108718789	108719049
ENSE00001451523	108717777	108718031
ENSE00001597830	108712908	108712996
ENSE00001638834	108713511	108713529
ENSE00002161413	108741925	108742749

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 60.18.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0263 / max 32.0524, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
4364	0.0263	3

Top tissues by expression

217 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vastus lateralis	UBERON:0001379	60.18	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	59.99	gold quality
quadriceps femoris	UBERON:0001377	59.74	gold quality
lateral globus pallidus	UBERON:0002476	59.40	gold quality
buccal mucosa cell	CL:0002336	58.89	gold quality
biceps brachii	UBERON:0001507	58.39	gold quality
substantia nigra pars reticulata	UBERON:0001966	56.78	gold quality
parotid gland	UBERON:0001831	56.60	gold quality
endothelial cell	CL:0000115	56.37	gold quality
mucosa of paranasal sinus	UBERON:0005030	56.06	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	55.63	gold quality
myocardium	UBERON:0002349	54.41	gold quality
jejunal mucosa	UBERON:0000399	54.11	gold quality
sperm	CL:0000019	51.88	gold quality
heart right ventricle	UBERON:0002080	51.70	gold quality
oocyte	CL:0000023	51.17	gold quality
parietal pleura	UBERON:0002400	50.77	gold quality
jejunum	UBERON:0002115	50.64	gold quality
visceral pleura	UBERON:0002401	50.35	gold quality
upper leg skin	UBERON:0004262	49.02	silver quality
substantia nigra pars compacta	UBERON:0001965	48.50	gold quality
deltoid	UBERON:0001476	48.18	gold quality
skeletal muscle tissue	UBERON:0001134	47.03	gold quality
tendon of biceps brachii	UBERON:0008188	46.10	gold quality
lateral nuclear group of thalamus	UBERON:0002736	45.94	gold quality
left testis	UBERON:0004533	45.52	gold quality
amniotic fluid	UBERON:0000173	45.42	gold quality
muscle tissue	UBERON:0002385	45.41	gold quality
testis	UBERON:0000473	45.32	gold quality
globus pallidus	UBERON:0001875	44.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.55

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	fndc7a	ENSDARG00000077096
danio_rerio		ENSDARG00000108006
mus_musculus	Fndc7	ENSMUSG00000045326
rattus_norvegicus	Fndc7	ENSRNOG00000020421

Paralogs (25): TNC (ENSG00000041982), FCN1 (ENSG00000085265), ANGPT2 (ENSG00000091879), ANGPT4 (ENSG00000101280), FGL1 (ENSG00000104760), FN1 (ENSG00000115414), TNR (ENSG00000116147), ANGPTL1 (ENSG00000116194), TNN (ENSG00000120332), FGL2 (ENSG00000127951), FIBCD1 (ENSG00000130720), ANGPTL6 (ENSG00000130812), ANGPTL3 (ENSG00000132855), ANGPTL2 (ENSG00000136859), FCN3 (ENSG00000142748), ANGPT1 (ENSG00000154188), FCN2 (ENSG00000160339), MFAP4 (ENSG00000166482), ANGPTL4 (ENSG00000167772), TNXB (ENSG00000168477), FGG (ENSG00000171557), FGA (ENSG00000171560), FGB (ENSG00000171564), ANGPTL7 (ENSG00000171819), ANGPTL5 (ENSG00000187151)

Protein

Protein identifiers

Fibronectin type III domain-containing protein 7 — Q5VTL7 (reviewed: Q5VTL7)

All UniProt accessions (2): Q5VTL7, H7C2H6

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Secreted.

RefSeq proteins (1): NP_001138409* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003961	FN3_dom	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036116	FN3_sf	Homologous_superfamily

Pfam: PF00041

UniProt features (18 total): domain 8, sequence variant 4, glycosylation site 2, sequence conflict 2, signal peptide 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5VTL7-F1	86.58	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 230, 433

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 45 (showing top): GCANCTGNY_MYOD_Q6, TGACCTY_ERR1_Q2, YY1_02, BASAKI_YBX1_TARGETS_DN, WGTTNNNNNAAA_UNKNOWN, MTOR_UP.V1_UP, NABA_ECM_GLYCOPROTEINS, MIR6867_5P, GSE10240_IL22_VS_IL22_AND_IL17_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_DN, MIR6768_3P, MIR4795_5P, MIR4764_5P, MIR4712_3P, MIR3650, PBX1_01

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

196 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FNDC7	FNDC10	F2Z333	616
FNDC7	CLEC19A	Q6UXS0	589
FNDC7	ZPLD1	Q8TCW7	523
FNDC7	EEIG2	Q5T8I3	506
FNDC7	TMEM167B	Q9NRX6	475
FNDC7	WDR47	O94967	435
FNDC7	FANK1	Q8TC84	423
FNDC7	FRMD8	Q9BZ67	419
FNDC7	FUBP3	Q96I24	417
FNDC7	ICE2	Q659A1	405
FNDC7	SNX7	Q9UNH6	401
FNDC7	IGFN1	Q86VF2	380
FNDC7	LRFN5	Q96NI6	372
FNDC7	PRPF38B	Q5VTL8	369
FNDC7	F2RL3	Q96RI0	368

IntAct

0 interactions, top by confidence:

BioGRID (3): FNDC7 (Affinity Capture-MS), FNDC7 (Affinity Capture-RNA), FNDC7 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A2AED3, B0CLX4, B2RU80, B3DK56, B3EX02, E2RK30, F1NWE3, O14522, O70458, O70535, O88488, P08922, P08941, P08F94, P0C5E4, P17948, P20352, P23467, P28827, P28828, P35822, P35969, P35992, P42702, P42703, P53767, P97378, Q15262, Q2EY13, Q2EY15, Q2VWP7, Q2VWP9, Q589G5, Q5RFR6, Q5VJ70, Q5VTL7, Q5XNR9, Q62959, Q63132, Q65Z14

Diamond homologs: A2AED3, Q5VTL7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

114 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	103
Likely benign	9
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1745 predictions. Top by Δscore:

Variant	Effect	Δscore
1:108718787:A:AG	acceptor_gain	1.0000
1:108718788:G:GA	acceptor_gain	1.0000
1:108718788:GT:G	acceptor_gain	1.0000
1:108719050:G:GG	donor_gain	1.0000
1:108725872:G:GT	donor_gain	1.0000
1:108725872:G:T	donor_gain	1.0000
1:108718787:AGT:A	acceptor_gain	0.9900
1:108718788:GTG:G	acceptor_gain	0.9900
1:108718788:GTGT:G	acceptor_gain	0.9900
1:108718788:GTGTT:G	acceptor_gain	0.9900
1:108719046:ACAA:A	donor_gain	0.9900
1:108719049:AG:A	donor_loss	0.9900
1:108719050:G:T	donor_loss	0.9900
1:108719051:T:G	donor_loss	0.9900
1:108725915:C:G	donor_gain	0.9900
1:108727884:T:TA	acceptor_gain	0.9900
1:108730672:A:G	acceptor_gain	0.9900
1:108741771:A:AG	acceptor_gain	0.9900
1:108741771:AGT:A	acceptor_gain	0.9900
1:108741772:G:GG	acceptor_gain	0.9900
1:108741772:GT:G	acceptor_gain	0.9900
1:108741772:GTG:G	acceptor_gain	0.9900
1:108718989:GCC:G	donor_gain	0.9800
1:108719047:CAA:C	donor_gain	0.9800
1:108725748:A:AG	acceptor_gain	0.9800
1:108725749:G:GG	acceptor_gain	0.9800
1:108725835:C:G	donor_gain	0.9800
1:108725915:C:CG	donor_gain	0.9800
1:108733494:G:GT	donor_gain	0.9800
1:108741842:G:GG	donor_gain	0.9800

AlphaMissense

4750 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:108727872:G:C	W392C	0.990
1:108727872:G:T	W392C	0.990
1:108727870:T:A	W392R	0.987
1:108727870:T:C	W392R	0.987
1:108717839:T:A	W49R	0.984
1:108717839:T:C	W49R	0.984
1:108725971:A:C	S360R	0.982
1:108725973:T:A	S360R	0.982
1:108725973:T:G	S360R	0.982
1:108725812:T:A	W307R	0.981
1:108725812:T:C	W307R	0.981
1:108725814:G:C	W307C	0.981
1:108725814:G:T	W307C	0.981
1:108717841:G:C	W49C	0.980
1:108717841:G:T	W49C	0.980
1:108718848:T:A	W133R	0.980
1:108718848:T:C	W133R	0.980
1:108718977:T:G	Y176D	0.978
1:108718850:G:C	W133C	0.975
1:108718850:G:T	W133C	0.975
1:108717942:T:C	L83P	0.971
1:108733326:G:C	R645P	0.969
1:108733336:G:C	W648C	0.967
1:108733336:G:T	W648C	0.967
1:108733511:T:C	C707R	0.967
1:108733460:T:G	Y690D	0.966
1:108718984:T:A	I178K	0.963
1:108733374:T:C	L661P	0.962
1:108728696:G:C	W478C	0.960
1:108728696:G:T	W478C	0.960

dbSNP variants (sampled 300 via entrez): RS1000078062 (1:108722043 A>G), RS1000139608 (1:108732173 C>T), RS1000256864 (1:108739821 T>C), RS1000284737 (1:108740050 A>G,T), RS1000439215 (1:108733011 C>A,T), RS1000808795 (1:108732693 T>C), RS1000854563 (1:108714659 C>T), RS1001112678 (1:108720805 C>T), RS1001233561 (1:108725996 A>G,T), RS1001269360 (1:108738153 A>G), RS1001290550 (1:108738615 A>T), RS1001337532 (1:108731247 G>A), RS1001502529 (1:108713045 A>T), RS1001563956 (1:108722174 A>G), RS1001838591 (1:108727477 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

12 total (human), top 12 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
potassium chromate(VI)	affects cotreatment, increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
epigallocatechin gallate	affects cotreatment, increases expression	1
bisphenol S	decreases methylation	1
theaflavin-3,3’-digallate	affects expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Lead	decreases expression	1
Lipopolysaccharides	affects response to substance, increases expression	1
Antirheumatic Agents	increases expression	1
Permethrin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.