FOXC2-AS1

Summary

FOXC2-AS1 (FOXC2 antisense RNA 1, HGNC:50665) is a long non-coding RNA gene on chromosome 16q24.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50665
Approved symbol	FOXC2-AS1
Name	FOXC2 antisense RNA 1
Location	16q24.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	ODRUL
Ensembl gene	ENSG00000260944
Ensembl biotype	lncRNA
Entrez	103752587
RNAcentral	URS000050E6E3 — lncRNA, 319 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000563280, ENST00000809048, ENST00000809049, ENST00000809050, ENST00000809051, ENST00000809052, ENST00000809053, ENST00000809054, ENST00000809055, ENST00000809056, ENST00000809057

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000563280 — 2 exons

Exon	Start	End
ENSE00004204455	86564956	86565318
ENSE00004204463	86567617	86567929

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 93.05.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5532 / max 16.8180, expressed in 341 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
158447	0.5233	333
207996	0.0299	9

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.05	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.92	gold quality
hindlimb stylopod muscle	UBERON:0004252	70.48	gold quality
stromal cell of endometrium	CL:0002255	68.72	gold quality
calcaneal tendon	UBERON:0003701	68.16	gold quality
ascending aorta	UBERON:0001496	67.37	gold quality
thoracic aorta	UBERON:0001515	67.18	gold quality
tibial artery	UBERON:0007610	67.15	gold quality
popliteal artery	UBERON:0002250	67.03	gold quality
descending thoracic aorta	UBERON:0002345	66.27	gold quality
gall bladder	UBERON:0002110	66.13	gold quality
left coronary artery	UBERON:0001626	65.63	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	64.40	gold quality
prefrontal cortex	UBERON:0000451	59.27	gold quality
smooth muscle tissue	UBERON:0001135	59.15	gold quality
right coronary artery	UBERON:0001625	58.96	gold quality
blood	UBERON:0000178	57.68	gold quality
muscle of leg	UBERON:0001383	57.55	gold quality
endometrium	UBERON:0001295	57.25	gold quality
liver	UBERON:0002107	57.12	gold quality
monocyte	CL:0000576	56.62	gold quality
islet of Langerhans	UBERON:0000006	56.56	gold quality
heart	UBERON:0000948	56.40	gold quality
lymph node	UBERON:0000029	56.36	gold quality
kidney	UBERON:0002113	56.25	gold quality
heart left ventricle	UBERON:0002084	55.98	gold quality
tibial nerve	UBERON:0001323	55.75	gold quality
fundus of stomach	UBERON:0001160	55.37	gold quality
right lobe of liver	UBERON:0001114	55.27	gold quality
gastrocnemius	UBERON:0001388	55.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Nrf2-mediated lncRNA ODRUL was indispensable for silver nanoparticle-induced toxicity in erythroid cells. (PMID:28351005)
• a high level of FOXC2-AS1 was associated with poor prognosis of BC patients. (PMID:29562954)
• lncRNA FOXC2-AS1 accelerated the tumor progression of prostate cancer cells by regulating the proliferation and tumor growth through miR-1253/EZH2 axis. (PMID:30389560)
• Expression level of FOXC2-AS1 in lung cancer (LCa) specimens was considerably higher than in normal tissues and correlated with higher incidence of distant metastasis and lower overall survival rate. miR-107 expression was found significantly reduced in LCa cell lines and tissues and showed a negative correlation with FOXC2-AS1. Luciferase reporter gene assay verified direct binding of FOXC2-AS1 to downstream miRNA-107. (PMID:30720176)
• LncRNA FOXC2-AS1 enhances FOXC2 mRNA stability to promote colorectal cancer progression via activation of Ca(2+)-FAK signal pathway. (PMID:32513911)
• LncRNA FOXC2-AS1 stimulates proliferation of melanoma via silencing p15 by recruiting EZH2. (PMID:32964984)
• H3K27ac-induced FOXC2-AS1 accelerates tongue squamous cell carcinoma by upregulating E2F3. (PMID:34358374)
• LncRNA ODRUL regulates progression of osteosarcoma by regulating IL-6 via sponging miR-6874-3p. (PMID:35114192)
• FOXC2-AS1/FOXC2 axis mediates matrix stiffness-induced trans-differentiation of hepatic stellate cells into fibrosis-promoting myofibroblasts. (PMID:37705741)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.