FOXD1-AS1

Summary

FOXD1-AS1 (FOXD1 antisense RNA 1, HGNC:50658) is a long non-coding RNA gene on chromosome 5q13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50658
Approved symbol	FOXD1-AS1
Name	FOXD1 antisense RNA 1
Location	5q13.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_00009423
Ensembl gene	ENSG00000247993
Ensembl biotype	lncRNA
Entrez	106144539
RNAcentral	URS00000B5795 — lncRNA, 424 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000514661

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000514661 — 2 exons

Exon	Start	End
ENSE00002032530	73446357	73446755
ENSE00002087330	73446960	73446984

Expression profiles

Bgee: expression breadth ubiquitous, 150 present calls, max score 96.31.

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibial nerve	UBERON:0001323	96.31	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.51	gold quality
stromal cell of endometrium	CL:0002255	84.93	gold quality
lower esophagus muscularis layer	UBERON:0035833	81.97	gold quality
lower esophagus	UBERON:0013473	81.93	gold quality
cortical plate	UBERON:0005343	79.65	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.34	silver quality
descending thoracic aorta	UBERON:0002345	78.15	gold quality
tendon of biceps brachii	UBERON:0008188	77.38	gold quality
metanephros cortex	UBERON:0010533	76.89	gold quality
lower esophagus mucosa	UBERON:0035834	76.73	gold quality
calcaneal tendon	UBERON:0003701	76.72	gold quality
tendon	UBERON:0000043	76.30	gold quality
hypothalamus	UBERON:0001898	75.17	gold quality
left testis	UBERON:0004533	74.89	gold quality
colonic epithelium	UBERON:0000397	74.02	silver quality
esophagus	UBERON:0001043	73.49	gold quality
right testis	UBERON:0004534	73.39	gold quality
ganglionic eminence	UBERON:0004023	72.61	gold quality
testis	UBERON:0000473	71.84	gold quality
right adrenal gland	UBERON:0001233	70.27	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.17	gold quality
tibial artery	UBERON:0007610	70.12	gold quality
left adrenal gland	UBERON:0001234	70.11	gold quality
popliteal artery	UBERON:0002250	69.97	gold quality
left adrenal gland cortex	UBERON:0035825	69.75	gold quality
adenohypophysis	UBERON:0002196	69.67	gold quality
aorta	UBERON:0000947	69.51	gold quality
right adrenal gland cortex	UBERON:0035827	69.37	gold quality
skin of leg	UBERON:0001511	69.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• FOXD1-AS1 regulates FOXD1 translation and promotes gastric cancer progression and chemoresistance by activating the PI3K/AKT/mTOR pathway. (PMID:32460412)
• FOXD1-AS1 upregulates FOXD1 to promote oral squamous cell carcinoma progression. (PMID:34403535)
• FOXD1-AS1 promotes malignant behaviours of prostate cancer cells via the miR-3167/YWHAZ axis. (PMID:34674391)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.