FOXD3-AS1

Summary

FOXD3-AS1 (FOXD3 antisense RNA 1, HGNC:40241) is a long non-coding RNA gene on chromosome 1p31.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40241
Approved symbol	FOXD3-AS1
Name	FOXD3 antisense RNA 1
Location	1p31.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	pasFOXD3, FAST
Ensembl gene	ENSG00000230798
Ensembl biotype	lncRNA
Entrez	100996301
RNAcentral	URS000075AAAF — lncRNA, 963 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 54 — 54 lncRNA

ENST00000418244, ENST00000426393, ENST00000427268, ENST00000431294, ENST00000449386, ENST00000685680, ENST00000686286, ENST00000686369, ENST00000686639, ENST00000686970, ENST00000688951, ENST00000689015, ENST00000689123, ENST00000690254, ENST00000690333, ENST00000690549, ENST00000691303, ENST00000691511, ENST00000692879, ENST00000697579, ENST00000717712, ENST00000717713, ENST00000717714, ENST00000717715, ENST00000717739, ENST00000717740, ENST00000717742, ENST00000717743, ENST00000717744, ENST00000717745, ENST00000717746, ENST00000717747, ENST00000717748, ENST00000717749, ENST00000717765, ENST00000717766, ENST00000717767, ENST00000717768, ENST00000717769, ENST00000717770, ENST00000717771, ENST00000717845, ENST00000717846, ENST00000717847, ENST00000717848, ENST00000717849, ENST00000717850, ENST00000717910, ENST00000717911, ENST00000717912, ENST00000717913, ENST00000717914, ENST00000717915, ENST00000717916

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000418244 — 4 exons

Exon	Start	End
ENSE00001714683	63321367	63321463
ENSE00003937567	63322316	63322507
ENSE00004033386	63321665	63322080
ENSE00004033388	63320878	63321190

Expression profiles

Bgee: expression breadth ubiquitous, 143 present calls, max score 94.49.

FANTOM5 (CAGE): breadth broad, TPM avg 4.3079 / max 302.8454, expressed in 512 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
12643	1.9840	437
12637	0.8042	65
12638	0.6773	60
12644	0.3278	157
12642	0.3055	148
12640	0.1261	44
12639	0.0829	39

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibial nerve	UBERON:0001323	94.49	gold quality
sural nerve	UBERON:0015488	86.68	gold quality
buccal mucosa cell	CL:0002336	84.17	silver quality
right testis	UBERON:0004534	80.19	gold quality
left testis	UBERON:0004533	80.07	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.63	gold quality
muscle layer of sigmoid colon	UBERON:0035805	77.32	gold quality
pancreatic ductal cell	CL:0002079	76.89	silver quality
testis	UBERON:0000473	76.47	gold quality
lower esophagus muscularis layer	UBERON:0035833	74.68	gold quality
lower esophagus	UBERON:0013473	74.60	gold quality
hindlimb stylopod muscle	UBERON:0004252	73.75	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	73.43	gold quality
mucosa of stomach	UBERON:0001199	70.75	gold quality
muscle of leg	UBERON:0001383	70.68	gold quality
gastrocnemius	UBERON:0001388	70.58	gold quality
ganglionic eminence	UBERON:0004023	67.94	gold quality
colon	UBERON:0001155	67.06	gold quality
tendon of biceps brachii	UBERON:0008188	66.98	gold quality
large intestine	UBERON:0000059	66.04	gold quality
endocervix	UBERON:0000458	65.81	gold quality
colonic epithelium	UBERON:0000397	65.47	silver quality
right atrium auricular region	UBERON:0006631	65.33	gold quality
skeletal muscle tissue	UBERON:0001134	65.15	gold quality
left coronary artery	UBERON:0001626	65.07	gold quality
apex of heart	UBERON:0002098	64.66	gold quality
esophagus	UBERON:0001043	64.59	gold quality
transverse colon	UBERON:0001157	64.40	gold quality
cardiac atrium	UBERON:0002081	64.34	gold quality
secondary oocyte	CL:0000655	64.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.18

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 17)

• lncRNA FOXD3-AS1 has significantly high expression in breast cancer cell lines comparing with the normal tissue; besides, findings suggested that lncRNA FOXD3-AS1 could play a potential diagnostics or prognostic biomarker for patients with breast cancer (PMID:31017311)
• FOXD3-AS1 promotes colorectal cancer (CRC) progression by regulating miR-135a-5p/SIRT1 axis, shedding lights on the way to CRC treatments (PMID:31058315)
• LncRNA FOXD3-AS1 promotes proliferation, invasion and migration of cutaneous malignant melanoma by regulating miR-325/MAP3K2 axis. (PMID:31541886)
• Inhibition of LncRNA FOXD3-AS1 suppresses the aggressive biological behaviors of thyroid cancer via elevating miR-296-5p and inactivating TGF-beta1/Smads signaling pathway. (PMID:31678422)
• FOXD3-AS1 Contributes to the Progression of Melanoma Via miR-127-3p/FJX1 Axis. (PMID:32354225)
• Long non-coding RNA FOXD3-AS1 regulates the expression and secretion of IL-25 in nasal epithelial cells to inhibit Th2 type immunoreaction in allergic rhinitis. (PMID:32671514)
• FOXD3-AS1 suppresses the progression of non-small cell lung cancer by regulating miR-150/SRCIN1axis. (PMID:32924985)
• Long non-coding RNA FOXD3-AS1 silencing exerts tumor suppressive effects in nasopharyngeal carcinoma by downregulating FOXD3 expression via microRNA-185-3p upregulation. (PMID:33204001)
• FOXD3AS1/miR1283p/LIMK1 axis regulates cervical cancer progression. (PMID:33760158)
• Long non-coding RNA FOXD3 antisense RNA 1 augments anti-estrogen resistance in breast cancer cells through the microRNA-363/ trefoil factor 1/ phosphatidylinositol 3-kinase/protein kinase B axis. (PMID:34424807)
• Exosomal lncRNA FOXD3-AS1 upregulates ELAVL1 expression and activates PI3K/Akt pathway to enhance lung cancer cell proliferation, invasion, and 5-fluorouracil resistance. (PMID:34605863)
• Oncogenic Forkhead box D3 antisense RNA 1 promotes cell survival and confers temozolomide resistance in glioblastoma cells through the miR-128-3p/WEE1 G2 checkpoint kinase axis. (PMID:35191808)
• LncRNA FOXD3-AS1 promotes breast cancer progression by mediating ARF6. (PMID:35678943)
• LncRNA FOXD3-AS1/miR-128-3p axis-mediated IGF2BP3 in glioma stimulates cancer angiogenesis and progression. (PMID:37587892)
• Mechanism of lncRNA FOXD3-AS1/miR-338-3p in the malignant progression of nasopharyngeal carcinoma through ceRNA. (PMID:37605586)
• Reduction of GAS5 and FOXD3-AS1 long non-coding RNAs in patients with bipolar disorder. (PMID:37620425)
• LncRNA FOXD3-AS1 Contributes to Glioblastoma Progression Via Sponging miR-3918 to Upregulate CCND1. (PMID:38497174)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.