FOXJ3

Summary

FOXJ3 (forkhead box J3, HGNC:29178) is a protein-coding gene on chromosome 1p34.2, encoding Forkhead box protein J3 (Q9UPW0). Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration.

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus.

Source: NCBI Gene 22887 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 110 total
• MANE Select transcript: NM_014947

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29178
Approved symbol	FOXJ3
Name	forkhead box J3
Location	1p34.2
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1041
Ensembl gene	ENSG00000198815
Ensembl biotype	protein_coding
OMIM	616035
Entrez	22887

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 protein_coding

ENST00000361346, ENST00000361776, ENST00000372571, ENST00000372572, ENST00000372573, ENST00000422278, ENST00000445886, ENST00000454417, ENST00000545068, ENST00000861681, ENST00000861682, ENST00000940310, ENST00000940311, ENST00000959443

RefSeq mRNA: 4 — MANE Select: NM_014947 NM_001198850, NM_001198851, NM_001198852, NM_014947

CCDS: CCDS30689, CCDS55594

Canonical transcript exons

ENST00000361346 — 13 exons

Exon	Start	End
ENSE00001418309	42335059	42335235
ENSE00003842693	42176548	42179825
ENSE00003889347	42265115	42265189
ENSE00003890108	42311050	42311110
ENSE00003890964	42278348	42278672
ENSE00003891575	42227883	42227966
ENSE00003891651	42191303	42191719
ENSE00003891838	42205762	42205863
ENSE00003892715	42194890	42195064
ENSE00003892801	42189303	42189404
ENSE00003894403	42188737	42188928
ENSE00003895014	42181917	42182024
ENSE00003895355	42199102	42199230

Expression profiles

Bgee: expression breadth ubiquitous, 294 present calls, max score 97.73.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.3955 / max 449.1848, expressed in 1820 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
11986	33.0021	1820
11985	1.8272	986
11984	1.1654	695
11983	0.5272	310
11988	0.5159	214
11981	0.3577	160

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
middle temporal gyrus	UBERON:0002771	97.73	gold quality
endothelial cell	CL:0000115	97.32	gold quality
Brodmann (1909) area 23	UBERON:0013554	97.15	gold quality
tibia	UBERON:0000979	96.42	gold quality
germinal epithelium of ovary	UBERON:0001304	96.19	gold quality
visceral pleura	UBERON:0002401	95.86	gold quality
parietal pleura	UBERON:0002400	95.81	gold quality
cerebellar vermis	UBERON:0004720	95.81	gold quality
pleura	UBERON:0000977	95.60	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	95.07	gold quality
deltoid	UBERON:0001476	94.89	gold quality
cervix squamous epithelium	UBERON:0006922	94.80	silver quality
colonic epithelium	UBERON:0000397	94.79	gold quality
vastus lateralis	UBERON:0001379	94.61	gold quality
paraflocculus	UBERON:0005351	94.61	gold quality
quadriceps femoris	UBERON:0001377	94.60	gold quality
squamous epithelium	UBERON:0006914	94.49	gold quality
esophagus squamous epithelium	UBERON:0006920	94.43	gold quality
cartilage tissue	UBERON:0002418	94.40	gold quality
gingival epithelium	UBERON:0001949	94.33	gold quality
skin of hip	UBERON:0001554	94.26	gold quality
secondary oocyte	CL:0000655	94.06	gold quality
gluteal muscle	UBERON:0002000	94.05	gold quality
synovial joint	UBERON:0002217	94.05	gold quality
triceps brachii	UBERON:0001509	94.02	gold quality
parotid gland	UBERON:0001831	94.01	gold quality
hair follicle	UBERON:0002073	93.97	gold quality
penis	UBERON:0000989	93.83	gold quality
Brodmann (1909) area 10	UBERON:0013541	93.74	gold quality
skeletal muscle tissue	UBERON:0001134	93.69	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.40
E-MTAB-6678	yes	6.38

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

2 targets.

Target	Regulation
E2F1	Activation
MEF2C	Activation

miRNA regulators (miRDB)

204 targeting FOXJ3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-548AJ-3P	99.96	73.38	5345

Literature-anchored findings (GeneRIF, showing 8)

• FOXJ3 is identified as a novel cell cycle reguulator that may regulate a network of zinc finger proteins. (PMID:22740631)
• FOXJ3 may be associated with the development of rheumatoid arthritis. (PMID:23933633)
• This study demonstrated that miR-517a-3p promoted lung cancer cell proliferation and invasion by targeting of FOXJ3 expression (PMID:24846831)
• FOXO3-dependent gene regulation is generally mediated not through uniquely bound regions but through regions occupied by both FOXK2 and FOXO3 where both factors play a regulatory role. (PMID:26578569)
• The found the stimulation effects of miR-425-5p on prostate cancer (PCa) cell behaviors were fulfilled through directly regulating the expression of FOXJ3, which validated FOXJ3 as a functional target of miR-425-5p in PCa. (PMID:30720162)
• Integrin Subunit Alpha 5 (ITGA5) Gene Circular RNA Sponges microRNA-107 in Colorectal Carcinoma Cells and Tissues and Regulates the Expression of the Forkhead Box J3 (FOXJ3) Gene. (PMID:32305992)
• Circular RNA circSLC8A1 inhibits the proliferation and invasion of non-small cell lung cancer cells through targeting the miR-106b-5p /FOXJ3 axis. (PMID:34724864)
• FOXJ3 Regulates Cell Proliferation and Motility Through Modulating Snail Expression in Breast Cancer Cells. (PMID:37351974)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Foxj3	ENSMUSG00000032998
rattus_norvegicus	Foxj3	ENSRNOG00000061851

Paralogs (41): FOXP3 (ENSG00000049768), FOXC1 (ENSG00000054598), FOXJ2 (ENSG00000065970), FOXF1 (ENSG00000103241), FOXN1 (ENSG00000109101), FOXM1 (ENSG00000111206), FOXP1 (ENSG00000114861), FOXO3 (ENSG00000118689), FOXA2 (ENSG00000125798), FOXA1 (ENSG00000129514), FOXJ1 (ENSG00000129654), FOXK2 (ENSG00000141568), FOXO1 (ENSG00000150907), FOXH1 (ENSG00000160973), FOXQ1 (ENSG00000164379), FOXK1 (ENSG00000164916), FOXD4 (ENSG00000170122), FOXA3 (ENSG00000170608), FOXB1 (ENSG00000171956), FOXR1 (ENSG00000176302), FOXL1 (ENSG00000176678), FOXC2 (ENSG00000176692), FOXE1 (ENSG00000178919), FOXS1 (ENSG00000179772), FOXL2 (ENSG00000183770), FOXO4 (ENSG00000184481), FOXD4L1 (ENSG00000184492), FOXD4L4 (ENSG00000184659), FOXD2 (ENSG00000186564), FOXI2 (ENSG00000186766), FOXE3 (ENSG00000186790), FOXD3 (ENSG00000187140), FOXD4L3 (ENSG00000187559), FOXR2 (ENSG00000189299), FOXO6 (ENSG00000204060), FOXB2 (ENSG00000204612), FOXD4L5 (ENSG00000204779), FOXI3 (ENSG00000214336), FOXL3 (ENSG00000248767), FOXD1 (ENSG00000251493)

Protein

Protein identifiers

Forkhead box protein J3 — Q9UPW0 (reviewed: Q9UPW0)

All UniProt accessions (5): C9JVP0, C9JXI1, Q9UPW0, F6VXT0, H7C1Y6

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration. Plays an important role in spermatogenesis. Required for the survival of spermatogonia and participates in spermatocyte meiosis.

Subcellular location. Nucleus.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9UPW0-1	1	yes
Q9UPW0-2	2

RefSeq proteins (4): NP_001185779, NP_001185780, NP_001185781, NP_055762* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001766	Fork_head_dom	Domain
IPR018122	TF_fork_head_CS_1	Conserved_site
IPR030456	TF_fork_head_CS_2	Conserved_site
IPR036388	WH-like_DNA-bd_sf	Homologous_superfamily
IPR036390	WH_DNA-bd_sf	Homologous_superfamily
IPR045912	FOXJ2/3-like	Family

Pfam: PF00250

UniProt features (18 total): compositionally biased region 5, modified residue 4, region of interest 3, sequence variant 2, chain 1, DNA-binding region 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UPW0-F1	54.24	0.11

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 223, 295, 489, 606

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 271 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_DN, RNGTGGGC_UNKNOWN, LOPEZ_MESOTHELIOMA_SURVIVAL_DN, HNF3ALPHA_Q6, TGCACTT_MIR519C_MIR519B_MIR519A, MORF_UBE2I, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GENTILE_RESPONSE_CLUSTER_D3, GOBP_MALE_GAMETE_GENERATION, AATGGAG_MIR136, MORF_TERF1, MORF_RAF1, GOBP_ORGANELLE_FISSION, MYCMAX_01

GO Biological Process (7): regulation of transcription by RNA polymerase II (GO:0006357), male meiosis I (GO:0007141), spermatogenesis (GO:0007283), cell differentiation (GO:0030154), positive regulation of transcription by RNA polymerase II (GO:0045944), regulation of DNA-templated transcription (GO:0006355), meiotic cell cycle (GO:0051321)

GO Molecular Function (8): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), sequence-specific DNA binding (GO:0043565), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), protein binding (GO:0005515)

GO Cellular Component (2): chromatin (GO:0000785), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	2
male gamete generation	2
regulation of transcription by RNA polymerase II	2
meiosis I	1
male meiotic nuclear division	1
meiotic cell cycle	1
developmental process involved in reproduction	1
cellular developmental process	1
positive regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cell cycle	1
sexual reproduction	1
reproductive process	1
meiotic nuclear division	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
DNA binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1486 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FOXJ3	SOX6	P35712	644
FOXJ3	HES5	Q5TA89	521
FOXJ3	PAX6	P26367	445
FOXJ3	PDGFRA	P16234	431
FOXJ3	ZBTB18	Q99592	430
FOXJ3	MTF1	Q14872	396
FOXJ3	DICER1	Q9UPY3	387
FOXJ3	RARG	P13631	378
FOXJ3	RCVRN	P35243	375
FOXJ3	ESRRA	P11474	375
FOXJ3	TFAM	Q00059	374
FOXJ3	RPGRIP1L	Q68CZ1	373
FOXJ3	PDCD10	Q9BUL8	371
FOXJ3	TCF7	P36402	359
FOXJ3	NF1	P21359	349

IntAct

15 interactions, top by confidence:

A	B	Type	Score
NEK6	FOXJ3	psi-mi:“MI:0915”(physical association)	0.560
NEDD4	FOXJ3	psi-mi:“MI:0407”(direct interaction)	0.440
YAP1	FOXJ3	psi-mi:“MI:0407”(direct interaction)	0.440
MED23	FOXJ3	psi-mi:“MI:0915”(physical association)	0.370
FOXJ3	SMARCA5	psi-mi:“MI:0914”(association)	0.350
FOXJ3	RPA2	psi-mi:“MI:0914”(association)	0.350
TBK1	FMNL1	psi-mi:“MI:0914”(association)	0.350
TBK1	UBR5	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
ENG	IGKV2-28	psi-mi:“MI:0914”(association)	0.350
FOXJ3	SERPINB7	psi-mi:“MI:0914”(association)	0.350
NEK6	FOXJ3	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (43): ALB (Affinity Capture-MS), TP53 (Affinity Capture-MS), RANGAP1 (Affinity Capture-MS), SMARCA5 (Affinity Capture-MS), UBR2 (Affinity Capture-MS), ZBTB10 (Affinity Capture-MS), RPA2 (Affinity Capture-MS), USP11 (Affinity Capture-MS), FOXJ1 (Affinity Capture-MS), PSMB4 (Affinity Capture-MS), ZBTB2 (Affinity Capture-MS), FOXJ3 (Affinity Capture-RNA), FOXJ3 (Affinity Capture-RNA), FOXJ3 (Affinity Capture-MS), FOXJ3 (Affinity Capture-RNA)

ESM2 similar proteins: A0A096MJY4, A0A486WWJ9, A2ICN5, A2VDZ3, A4UTP7, A8WL06, B7ZR65, H2LBU8, O89038, P10071, P40791, P55197, P55879, Q02078, Q03413, Q03414, Q06413, Q0VGT2, Q14814, Q2KIA0, Q2MJT0, Q32NP8, Q4VYR7, Q5IS56, Q5R444, Q5REW7, Q5U4X3, Q60929, Q61602, Q63943, Q6DFF5, Q6DIF3, Q6F2E7, Q7ZY13, Q8BUR3, Q8CFN5, Q91660, Q91661, Q9DE25, Q9EPK5

Diamond homologs: A0A078BQN7, A0A1W2PRP0, A0A8V0YY16, A1L1S5, A3KNJ3, A8MTJ6, A8XJN7, B5RHS5, D3Z120, F1R8Z9, O00358, O17617, O43638, O54743, O60129, O88470, P32027, P32028, P32030, P32315, P42128, P55316, P56260, P58012, P79772, P85037, P91278, Q00939, Q01167, Q02360, Q12946, Q12947, Q12948, Q12950, Q12951, Q12952, Q13461, Q19802, Q1A1A1, Q1A1A2

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
FOXJ3	“up-regulates quantity by expression”	MEF2C	“transcriptional regulation”

Disease & clinical

Clinical variants and AI predictions

ClinVar

110 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	87
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2834 predictions. Top by Δscore:

Variant	Effect	Δscore
1:42189298:CTCA:C	donor_loss	1.0000
1:42189299:TCAC:T	donor_loss	1.0000
1:42189300:CA:C	donor_loss	1.0000
1:42194885:CTCA:C	donor_loss	1.0000
1:42194886:TCAC:T	donor_loss	1.0000
1:42194887:CA:C	donor_loss	1.0000
1:42194888:A:AC	donor_gain	1.0000
1:42194889:C:CC	donor_gain	1.0000
1:42194889:C:G	donor_loss	1.0000
1:42195062:CAC:C	acceptor_gain	1.0000
1:42195065:C:CC	acceptor_gain	1.0000
1:42199095:GACTT:G	donor_loss	1.0000
1:42199096:ACTT:A	donor_loss	1.0000
1:42199097:CT:C	donor_loss	1.0000
1:42199098:TTA:T	donor_loss	1.0000
1:42199099:TA:T	donor_loss	1.0000
1:42199100:A:AC	donor_gain	1.0000
1:42199100:ACC:A	donor_loss	1.0000
1:42199101:C:CC	donor_gain	1.0000
1:42205760:A:AC	donor_gain	1.0000
1:42205761:C:CC	donor_gain	1.0000
1:42205769:G:C	donor_gain	1.0000
1:42227881:AC:A	donor_gain	1.0000
1:42227882:CC:C	donor_gain	1.0000
1:42227964:CCC:C	acceptor_gain	1.0000
1:42227965:CC:C	acceptor_gain	1.0000
1:42227965:CCC:C	acceptor_gain	1.0000
1:42227966:CC:C	acceptor_gain	1.0000
1:42227967:C:CC	acceptor_gain	1.0000
1:42265109:TCCTA:T	donor_loss	1.0000

AlphaMissense

4136 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:42179725:C:A	W618C	1.000
1:42179725:C:G	W618C	1.000
1:42179726:C:G	W618S	1.000
1:42179727:A:G	W618R	1.000
1:42179727:A:T	W618R	1.000
1:42179731:A:C	F616L	1.000
1:42179731:A:T	F616L	1.000
1:42179732:A:C	F616C	1.000
1:42179732:A:G	F616S	1.000
1:42179733:A:G	F616L	1.000
1:42188838:A:G	F515S	1.000
1:42188847:A:G	L512P	1.000
1:42188859:A:G	L508P	1.000
1:42188890:A:G	W498R	1.000
1:42188890:A:T	W498R	1.000
1:42188905:C:G	A493P	1.000
1:42188925:A:G	L486P	1.000
1:42189333:A:G	W475R	1.000
1:42189333:A:T	W475R	1.000
1:42189347:G:T	A470D	1.000
1:42189368:A:G	L463P	1.000
1:42194928:A:G	L299P	1.000
1:42194937:A:G	F296S	1.000
1:42227954:C:G	A153P	1.000
1:42227955:C:A	W152C	1.000
1:42227955:C:G	W152C	1.000
1:42227956:C:G	W152S	1.000
1:42227957:A:C	W152G	1.000
1:42227957:A:G	W152R	1.000
1:42227957:A:T	W152R	1.000

dbSNP variants (sampled 300 via entrez): RS1000000261 (1:42265511 G>C), RS1000005230 (1:42263492 T>C), RS1000006415 (1:42290127 T>C), RS1000071445 (1:42218778 C>A), RS1000072289 (1:42313369 T>C), RS1000113606 (1:42271334 T>C), RS1000119354 (1:42326021 G>A,C), RS1000160560 (1:42282535 C>T), RS1000184202 (1:42239633 T>A), RS1000188194 (1:42198320 C>G), RS1000240923 (1:42307330 T>C), RS1000294137 (1:42217992 T>G), RS1000297521 (1:42225378 C>A), RS1000316545 (1:42289149 T>C), RS1000324471 (1:42295359 C>T)

Disease associations

OMIM: gene MIM:616035 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects methylation, decreases expression	2
Valproic Acid	affects expression, decreases expression	2
Cadmium Chloride	decreases expression, increases abundance	2
aristolochic acid I	decreases expression	1
GSK-J4	increases expression	1
FR900359	increases phosphorylation	1
geraniol	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	increases abundance, increases expression	1
aflatoxin B2	increases methylation	1
coumarin	decreases phosphorylation	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
deguelin	increases expression	1
jinfukang	decreases expression	1
Sunitinib	increases expression	1
Leflunomide	increases expression	1
Arsenic	increases abundance, increases expression	1
Vehicle Emissions	affects expression, increases abundance	1
Benzo(a)pyrene	increases methylation	1
Cadmium	decreases expression, increases abundance	1
Doxorubicin	decreases expression	1
Estradiol	decreases expression	1
Methotrexate	decreases expression	1
Phenobarbital	affects expression	1
Silicon Dioxide	decreases expression	1
Tretinoin	decreases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.