FOXL3-OT1

Summary

FOXL3-OT1 (FOXL3 overlapping transcript 1, HGNC:54640) is a long non-coding RNA gene on chromosome 7p22.3.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 100288524 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54640
Approved symbol	FOXL3-OT1
Name	FOXL3 overlapping transcript 1
Location	7p22.3
Locus type	RNA, long non-coding
Status	Approved
Entrez	100288524
RNAcentral	URS000194B0D5 — lncRNA, 645 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000045791 (7:289554 C>A), RS1000676876 (7:289716 C>T), RS1000977396 (7:291235 C>G,T), RS1001029776 (7:291037 C>A,T), RS1001404146 (7:293509 A>T), RS1001766385 (7:289503 G>A), RS1002313969 (7:293205 C>G), RS1002617461 (7:292961 G>A), RS1003394209 (7:291903 A>G), RS1003921509 (7:293782 G>A), RS1003931507 (7:293572 A>C), RS1003937408 (7:292629 A>AT), RS1004022540 (7:292043 C>T), RS1004906027 (7:291566 C>G), RS1005105364 (7:289524 AC>A,ACC)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
butyraldehyde	increases expression	1
tebuconazole	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.