FOXP4-AS1

Summary

FOXP4-AS1 (FOXP4 antisense RNA 1, HGNC:50332) is a long non-coding RNA gene on chromosome 6p21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50332
Approved symbol	FOXP4-AS1
Name	FOXP4 antisense RNA 1
Location	6p21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000234753
Ensembl biotype	lncRNA
Entrez	101060264
RNAcentral	URS00007E36F3 — lncRNA, 588 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 46 — 46 lncRNA

ENST00000414386, ENST00000432751, ENST00000439386, ENST00000440194, ENST00000454812, ENST00000691406, ENST00000701272, ENST00000727791, ENST00000727792, ENST00000727793, ENST00000727794, ENST00000727795, ENST00000727796, ENST00000727797, ENST00000727798, ENST00000727799, ENST00000727800, ENST00000727801, ENST00000727802, ENST00000727803, ENST00000727804, ENST00000727805, ENST00000727806, ENST00000727807, ENST00000727808, ENST00000727809, ENST00000727810, ENST00000727811, ENST00000727812, ENST00000727813, ENST00000727814, ENST00000727815, ENST00000727816, ENST00000727817, ENST00000727818, ENST00000727819, ENST00000727820, ENST00000727821, ENST00000727822, ENST00000727823, ENST00000727824, ENST00000727825, ENST00000727826, ENST00000727827, ENST00000727828, ENST00000727829

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414386 — 2 exons

Exon	Start	End
ENSE00004053708	41523862	41524225
ENSE00004053725	41546089	41546344

Expression profiles

Bgee: expression breadth ubiquitous, 153 present calls, max score 74.26.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7944 / max 25.7371, expressed in 361 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
73548	0.6352	308
73547	0.1593	74

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	74.26	gold quality
body of pancreas	UBERON:0001150	74.01	gold quality
sural nerve	UBERON:0015488	72.62	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	72.45	gold quality
colonic epithelium	UBERON:0000397	72.04	gold quality
calcaneal tendon	UBERON:0003701	71.93	gold quality
body of stomach	UBERON:0001161	70.69	gold quality
pancreas	UBERON:0001264	70.25	gold quality
stomach	UBERON:0000945	70.08	gold quality
ventricular zone	UBERON:0003053	70.01	gold quality
rectum	UBERON:0001052	68.83	gold quality
bone marrow cell	CL:0002092	67.91	silver quality
ganglionic eminence	UBERON:0004023	67.21	gold quality
fundus of stomach	UBERON:0001160	65.88	gold quality
islet of Langerhans	UBERON:0000006	65.60	gold quality
left lobe of thyroid gland	UBERON:0001120	65.39	gold quality
thyroid gland	UBERON:0002046	65.18	gold quality
vermiform appendix	UBERON:0001154	63.98	gold quality
right lobe of thyroid gland	UBERON:0001119	63.66	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.49	gold quality
omental fat pad	UBERON:0010414	62.73	gold quality
peritoneum	UBERON:0002358	62.66	gold quality
transverse colon	UBERON:0001157	62.59	gold quality
adipose tissue of abdominal region	UBERON:0007808	62.43	gold quality
gall bladder	UBERON:0002110	61.92	gold quality
monocyte	CL:0000576	61.29	gold quality
adipose tissue	UBERON:0001013	61.00	gold quality
tendon	UBERON:0000043	60.40	gold quality
prostate gland	UBERON:0002367	60.30	gold quality
cortex of kidney	UBERON:0001225	59.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• The lncRNA FOXP4-AS1 expression is up-regulated in CRC tissues and that FOXP4-AS1 overexpression is a poor prognostic factor in colorectal cancer patients. (PMID:27790757)
• FOXP4-AS1 is overexpressed in osteosarcoma (OS), and is the independent risk factor in OS prognosis. Upregulated FOXP4-AS1 promotes the proliferation, migration and cell cycle, but inhibits apoptosis of OS cells. Furthermore, FOXP4-AS1 participates in the development and progression of OS by downregulating LATS1 via binding to LSD1 and EZH2. (PMID:29859193)
• paired box 5 (PAX5) transcriptionally activated FOXP4-AS1 and FOXP4 in prostate cancer. (PMID:31209207)
• Identify potential clinical significance of long noncoding RNA forkhead box P4 antisense RNA 1 in patients with early stage pancreatic ductal adenocarcinoma. (PMID:31991068)
• Long non-coding RNA FOXP4-AS1 acts as an adverse prognostic factor and regulates proliferation and apoptosis in nasopharyngeal carcinoma. (PMID:32767327)
• lncRNA FOXP4AS1 predicts poor prognosis and accelerates the progression of mantle cell lymphoma through the miR4235p/NACC1 pathway. (PMID:33416160)
• Identification of a Prognostic Colorectal Cancer Model Including LncRNA FOXP4-AS1 and LncRNA BBOX1-AS1 Based on Bioinformatics Analysis. (PMID:33481661)
• Long Noncoding RNA FOXP4-AS1 Predicts Unfavourable Prognosis and Regulates Proliferation and Invasion in Hepatocellular Carcinoma. (PMID:33604387)
• FOXP4-AS1 is a favorable prognostic-related enhancer RNA in ovarian cancer. (PMID:33870423)
• Long non-coding RNA FOXP4-AS1 facilitates the biological functions of hepatocellular carcinoma cells via downregulating ZC3H12D by mediating H3K27me3 through recruitment of EZH2. (PMID:34545456)
• LncRNA FOXP4-AS promotes the progression of non-small cell lung cancer by regulating the miR-3184-5p/EIF5A axis. (PMID:34921595)
• The FOXP4-AS1/miR-3130-3p/SP4 feedback loop is associated with prostate cancer. (PMID:37114256)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.