FRMD6-AS2

Summary

FRMD6-AS2 (FRMD6 antisense RNA 2, HGNC:43637) is a long non-coding RNA gene on chromosome 14q22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43637
Approved symbol	FRMD6-AS2
Name	FRMD6 antisense RNA 2
Location	14q22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000258537
Ensembl biotype	lncRNA
Entrez	100874185
RNAcentral	URS000075B3AA — lncRNA, 613 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000556617, ENST00000556762, ENST00000557625, ENST00000616999, ENST00000617151, ENST00000697566, ENST00000697567, ENST00000697568, ENST00000697569, ENST00000743446, ENST00000743447, ENST00000743448, ENST00000743449, ENST00000743450, ENST00000743451

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000556617 — 3 exons

Exon	Start	End
ENSE00002471067	51454512	51454815
ENSE00002525235	51584166	51584283
ENSE00003970986	51599827	51599952

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 91.19.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2126 / max 101.0119, expressed in 39 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
143199	0.0660	20
143194	0.0495	10
143200	0.0392	16
143197	0.0196	8
143196	0.0169	5
143198	0.0094	3
143195	0.0090	3
207215	0.0029	2

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.19	gold quality
myometrium	UBERON:0001296	90.42	gold quality
body of uterus	UBERON:0009853	90.41	gold quality
uterine cervix	UBERON:0000002	80.93	gold quality
endocervix	UBERON:0000458	79.91	gold quality
left uterine tube	UBERON:0001303	79.85	gold quality
ectocervix	UBERON:0012249	79.67	gold quality
bone marrow cell	CL:0002092	75.78	silver quality
smooth muscle tissue	UBERON:0001135	73.98	gold quality
muscle tissue	UBERON:0002385	71.93	gold quality
fallopian tube	UBERON:0003889	71.74	gold quality
colonic epithelium	UBERON:0000397	71.52	gold quality
stromal cell of endometrium	CL:0002255	68.80	gold quality
endometrium	UBERON:0001295	68.22	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.02	gold quality
left ovary	UBERON:0002119	67.78	gold quality
ovary	UBERON:0000992	67.28	gold quality
urinary bladder	UBERON:0001255	66.10	gold quality
right ovary	UBERON:0002118	65.59	gold quality
vagina	UBERON:0000996	64.91	gold quality
colon	UBERON:0001155	62.95	gold quality
intestine	UBERON:0000160	61.75	gold quality
fundus of stomach	UBERON:0001160	61.60	gold quality
prostate gland	UBERON:0002367	61.53	gold quality
lower esophagus	UBERON:0013473	60.07	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.06	gold quality
tonsil	UBERON:0002372	59.88	gold quality
gall bladder	UBERON:0002110	59.26	gold quality
transverse colon	UBERON:0001157	58.51	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	57.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.28

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.