FRMPD2

Summary

FRMPD2 (FERM and PDZ domain containing 2, HGNC:28572) is a protein-coding gene on chromosome 10q11.22, encoding FERM and PDZ domain-containing protein 2 (Q68DX3). Functions as a scaffold protein and likely plays a role in N-methyl-D-aspartic acid receptor (NMDAR)-mediated synaptic excitatory transmission.

This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 143162 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 207 total
• MANE Select transcript: NM_001018071

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28572
Approved symbol	FRMPD2
Name	FERM and PDZ domain containing 2
Location	10q11.22
Locus type	gene with protein product
Status	Approved
Aliases	MGC35285
Ensembl gene	ENSG00000170324
Ensembl biotype	protein_coding
OMIM	613323
Entrez	143162

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 7 retained_intron, 3 protein_coding, 3 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000305531, ENST00000374201, ENST00000463706, ENST00000468556, ENST00000474573, ENST00000477710, ENST00000486151, ENST00000491130, ENST00000492045, ENST00000494505, ENST00000505547, ENST00000635925, ENST00000636244, ENST00000637395

RefSeq mRNA: 3 — MANE Select: NM_001018071 NM_001018071, NM_001042512, NM_001318191

CCDS: CCDS31195, CCDS81460

Canonical transcript exons

ENST00000374201 — 29 exons

Exon	Start	End
ENSE00001631802	48222313	48222451
ENSE00001702910	48211954	48212109
ENSE00001726333	48223123	48223270
ENSE00001883394	48274543	48274696
ENSE00002463746	48178047	48178151
ENSE00002492231	48156562	48157370
ENSE00003469469	48168595	48168693
ENSE00003478210	48240360	48240492
ENSE00003497484	48192684	48192894
ENSE00003526705	48236482	48236553
ENSE00003529662	48174870	48174955
ENSE00003531582	48251566	48251691
ENSE00003531602	48201228	48201384
ENSE00003538842	48170994	48171208
ENSE00003551827	48184774	48184881
ENSE00003564431	48206748	48206933
ENSE00003578372	48184566	48184682
ENSE00003590296	48249021	48249178
ENSE00003592162	48175846	48175939
ENSE00003599184	48163328	48163671
ENSE00003617735	48172946	48173093
ENSE00003625550	48185553	48185645
ENSE00003635349	48239605	48239692
ENSE00003641074	48232115	48232289
ENSE00003672372	48244784	48244849
ENSE00003673441	48242161	48242352
ENSE00003678092	48180803	48181008
ENSE00003680303	48237991	48238123
ENSE00003691697	48187192	48187292

Expression profiles

Bgee: expression breadth ubiquitous, 127 present calls, max score 93.17.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.9917 / max 164.6851, expressed in 173 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
109291	0.4176	107
109294	0.2435	49
109295	0.1572	51
109293	0.0562	16
109292	0.0514	17
109288	0.0305	10
109287	0.0172	4
109290	0.0161	4
109289	0.0020	0

Top tissues by expression

141 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
superior frontal gyrus	UBERON:0002661	93.17	gold quality
quadriceps femoris	UBERON:0001377	87.31	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.29	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	86.03	gold quality
Brodmann (1909) area 9	UBERON:0013540	85.82	gold quality
right frontal lobe	UBERON:0002810	85.21	gold quality
anterior cingulate cortex	UBERON:0009835	84.47	gold quality
frontal cortex	UBERON:0001870	83.34	gold quality
right uterine tube	UBERON:0001302	83.17	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.03	gold quality
cerebral cortex	UBERON:0000956	82.15	gold quality
corpus callosum	UBERON:0002336	82.05	gold quality
prefrontal cortex	UBERON:0000451	81.29	gold quality
primary visual cortex	UBERON:0002436	79.21	gold quality
telencephalon	UBERON:0001893	78.73	gold quality
left testis	UBERON:0004533	77.73	gold quality
hypothalamus	UBERON:0001898	77.63	gold quality
temporal lobe	UBERON:0001871	77.47	gold quality
amygdala	UBERON:0001876	77.27	gold quality
testis	UBERON:0000473	77.25	gold quality
right testis	UBERON:0004534	76.88	gold quality
caudate nucleus	UBERON:0001873	76.81	gold quality
brain	UBERON:0000955	73.85	gold quality
Ammon’s horn	UBERON:0001954	73.49	gold quality
nucleus accumbens	UBERON:0001882	71.67	gold quality
substantia nigra	UBERON:0002038	68.90	gold quality
fallopian tube	UBERON:0003889	67.56	gold quality
putamen	UBERON:0001874	66.77	gold quality
right lung	UBERON:0002167	64.44	gold quality
right atrium auricular region	UBERON:0006631	62.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.71

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• These results provide novel insights into the molecular function of FRMPD2 and into the targeting mechanism of peripheral membrane proteins in polarized epithelial cells. (PMID:19706687)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	frmpd2	ENSDARG00000074119
mus_musculus	Frmpd2	ENSMUSG00000108841
rattus_norvegicus	Frmpd2	ENSRNOG00000029131
caenorhabditis_elegans		WBGENE00001492
caenorhabditis_elegans		WBGENE00021406

Paralogs (5): LNX1 (ENSG00000072201), MPDZ (ENSG00000107186), PATJ (ENSG00000132849), LNX2 (ENSG00000139517), STXBP4 (ENSG00000166263)

Protein

Protein identifiers

FERM and PDZ domain-containing protein 2 — Q68DX3 (reviewed: Q68DX3)

Alternative names: PDZ domain-containing protein 4, PDZ domain-containing protein 5C

All UniProt accessions (3): Q68DX3, A0A1B0GUQ4, A0A1B0GV40

UniProt curated annotations — full annotation on UniProt →

Function. Functions as a scaffold protein and likely plays a role in N-methyl-D-aspartic acid receptor (NMDAR)-mediated synaptic excitatory transmission. May be involved in synapse formation in cone photoreceptor cells. May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). May play a role in the regulation of NOD2-mediated NF-kappa-B activation in immune response.

Subunit / interactions. Interacts (via the second PDZ domain) with CTNND2 (via the extreme C-terminus). Interacts (via the second PDZ domain) with PKP4 (via the extreme C-terminus); the interaction directs FRMPD2 to the basolateral membranes. Interacts (via the second PDZ domain) with ARVCF (via the extreme C-terminus). Interacts (via the second PDZ domain) with NMDAR subunits GRIN2A/GLUN2A and GRIN2B/GLUN2B (via the extreme C-terminus); the interaction is direct and is likely to promote NMDAR-mediated neural signal transmission. Interacts (via the third PDZ domain) with LRIT1 (via the extreme C-terminus); the interaction leads to their colocalization in photoreceptor synapses. Interacts with NOD2; the interaction is likely to trigger NOD2-mediated NF-kappa-B activation.

Subcellular location. Cytoplasm. Basolateral cell membrane. Cell junction. Tight junction. Postsynaptic density.

Tissue specificity. Expressed in epithelial cells.

Domain organisation. The FERM and PDZ 2 domains are necessary for localization to the basolateral cell membrane. The FERM domain binds to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and is sufficient for membrane localization.

Isoforms (5)

UniProt ID	Names	Canonical?
Q68DX3-1	1	yes
Q68DX3-2	2
Q68DX3-3	3
Q68DX3-4	4
Q68DX3-5	5

RefSeq proteins (2): NP_001018081, NP_001305120 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000299	FERM_domain	Domain
IPR001478	PDZ	Domain
IPR011019	KIND_dom	Domain
IPR011993	PH-like_dom_sf	Homologous_superfamily
IPR014352	FERM/acyl-CoA-bd_prot_sf	Homologous_superfamily
IPR018979	FERM_N	Domain
IPR018980	FERM_PH-like_C	Domain
IPR019748	FERM_central	Domain
IPR019749	Band_41_domain	Domain
IPR029071	Ubiquitin-like_domsf	Homologous_superfamily
IPR035963	FERM_2	Homologous_superfamily
IPR036034	PDZ_sf	Homologous_superfamily
IPR052074	NonRcpt_TyrProt_Phosphatase	Family

Pfam: PF00373, PF00595, PF09379, PF09380

UniProt features (36 total): sequence conflict 9, splice variant 8, sequence variant 6, domain 5, region of interest 4, compositionally biased region 2, chain 1, mutagenesis site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q68DX3-F1	64.04	0.27

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (1):

Position	Phenotype
955	abolishes the basolateral membrane localization.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 58 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_DN, GOBP_APICAL_JUNCTION_ASSEMBLY, GOBP_CELL_JUNCTION_ORGANIZATION, GOBP_CELL_JUNCTION_ASSEMBLY, GOBP_CELL_CELL_JUNCTION_ASSEMBLY, GOCC_CELL_CELL_JUNCTION, GOCC_APICAL_PART_OF_CELL, GOCC_POSTSYNAPSE, GOCC_SYNAPSE, CAMPS_COLON_CANCER_COPY_NUMBER_DN, GOCC_ANCHORING_JUNCTION, GOCC_PLASMA_MEMBRANE_REGION, GOCC_BASAL_PART_OF_CELL, GOMF_PHOSPHATIDYLINOSITOL_BINDING, GOMF_1_PHOSPHATIDYLINOSITOL_BINDING

GO Biological Process (1): bicellular tight junction assembly (GO:0070830)

GO Molecular Function (2): 1-phosphatidylinositol binding (GO:0005545), protein binding (GO:0005515)

GO Cellular Component (10): cytoplasm (GO:0005737), plasma membrane (GO:0005886), bicellular tight junction (GO:0005923), postsynaptic density (GO:0014069), basolateral plasma membrane (GO:0016323), apical part of cell (GO:0045177), cytoskeleton (GO:0005856), membrane (GO:0016020), synapse (GO:0045202), anchoring junction (GO:0070161)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
cell junction	2
apical junction assembly	1
tight junction assembly	1
phospholipid binding	1
binding	1
intracellular anatomical structure	1
membrane	1
cell periphery	1
apical junction complex	1
tight junction	1
asymmetric synapse	1
postsynaptic specialization	1
basal plasma membrane	1
plasma membrane region	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

434 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
FRMPD2	PKP4	Q99569	804
FRMPD2	ARVCF	O00192	755
FRMPD2	CTNND2	Q9UQB3	699
FRMPD2	CTNND1	O60716	597
FRMPD2	PTPN20	Q4JDL3	533
FRMPD2	REM1	O75628	460
FRMPD2	ARHGAP22	Q7Z5H3	449
FRMPD2	GDF10	P55107	443
FRMPD2	AGAP6	Q5VW22	436
FRMPD2	SNTA1	Q13424	435
FRMPD2	UBTD1	Q9HAC8	434
FRMPD2	PPP1R27	Q86WC6	427
FRMPD2	KNDC1	Q76NI1	419
FRMPD2	CDH1	P12830	415
FRMPD2	FHIP2A	Q5W0V3	411

IntAct

1132 interactions, top by confidence:

A	B	Type	Score
PCGF5	CSNK2A2	psi-mi:“MI:0914”(association)	0.880
FRMPD2	NRXN3	psi-mi:“MI:0407”(direct interaction)	0.440
FRMPD2	PTEN	psi-mi:“MI:0407”(direct interaction)	0.440
GAS2L2	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
ABCA1	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
DGKI	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
TRPV3	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
MCM7	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC1A7	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
EPHA7	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
RAPGEF2	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
ARHGAP6	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
DGKZ	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
PLEKHA1	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
RAPGEF6	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
CNKSR2	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
XKR7	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
FRMPD2	FCHSD2	psi-mi:“MI:0407”(direct interaction)	0.440
RGS12	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
PBK	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
PTPRZ1	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
HTR2A	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
FRMPD2	ATP2B4	psi-mi:“MI:0407”(direct interaction)	0.440
APC	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
CTNND2	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
FRMPD2	PTPRG	psi-mi:“MI:0407”(direct interaction)	0.440
NECTIN3	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
KCNA7	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC16A3	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
FRMPD2	PPFIA1	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (19): PKN2 (Affinity Capture-MS), SARS (Affinity Capture-MS), PKN2 (Affinity Capture-MS), SARS (Affinity Capture-MS), FRMPD2 (Affinity Capture-RNA), FRMPD2 (Protein-peptide), E6 (PCA), PKN2 (Affinity Capture-MS), FRMPD2 (Affinity Capture-MS), SARS (Affinity Capture-MS), PROSC (Affinity Capture-MS), NAGK (Affinity Capture-MS), SLC25A31 (Affinity Capture-MS), LIMCH1 (Affinity Capture-MS), VPS37C (Affinity Capture-MS)

ESM2 similar proteins: A0A140LI67, B5KFD7, D4A7V9, M0R4F8, O08774, O35827, O43187, O70167, O70173, O88866, O88900, O95398, O95704, P0C5Y8, Q0P5I2, Q13322, Q14449, Q4QQS0, Q5BIW4, Q5ICW4, Q5JV73, Q5PQS0, Q5R810, Q60760, Q68DX3, Q6IFT4, Q6IRN0, Q6P4K6, Q6REY9, Q6S5L8, Q6TXD4, Q7TSI1, Q80TQ5, Q80VA5, Q8BW88, Q8CFA1, Q8IWE5, Q8R1C9, Q8R2S1, Q8VCC8

Diamond homologs: A0A140LI67, A5PKA5, A7UA95, E1JIT7, O14910, O15018, O19132, O35274, O35867, O35889, O62666, O62674, O62675, O62676, O62677, O62678, O88951, O88952, P11434, P29475, P29476, P31016, P51140, P55196, P57105, P78352, Q07436, Q0P5F3, Q12923, Q14005, Q29498, Q2KIB6, Q32LM6, Q3T0C9, Q3UHD6, Q4KL35, Q5F425, Q5RAA5, Q62108, Q64512

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 115 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
EPHB-mediated forward signaling	5	16.4×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

207 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	168
Likely benign	26
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

5101 predictions. Top by Δscore:

Variant	Effect	Δscore
10:48174865:CTCA:C	donor_loss	1.0000
10:48174866:TCA:T	donor_loss	1.0000
10:48174867:CAC:C	donor_loss	1.0000
10:48174868:ACCTG:A	donor_gain	1.0000
10:48174869:C:CG	donor_loss	1.0000
10:48174869:CCTGC:C	donor_gain	1.0000
10:48174953:CAC:C	acceptor_gain	1.0000
10:48174955:CCTGG:C	acceptor_loss	1.0000
10:48174956:C:CC	acceptor_gain	1.0000
10:48174956:CTGGG:C	acceptor_loss	1.0000
10:48174957:T:A	acceptor_loss	1.0000
10:48175844:AC:A	donor_gain	1.0000
10:48175845:CC:C	donor_gain	1.0000
10:48175863:T:TA	donor_gain	1.0000
10:48178045:A:AC	donor_gain	1.0000
10:48178046:C:CC	donor_gain	1.0000
10:48183363:C:CA	donor_gain	1.0000
10:48183372:T:TA	donor_gain	1.0000
10:48187186:CCATA:C	donor_loss	1.0000
10:48187187:CATA:C	donor_loss	1.0000
10:48187188:ATAC:A	donor_loss	1.0000
10:48187189:TA:T	donor_loss	1.0000
10:48187190:A:C	donor_loss	1.0000
10:48187191:C:CA	donor_loss	1.0000
10:48187288:AGGGG:A	acceptor_gain	1.0000
10:48187289:GGGG:G	acceptor_gain	1.0000
10:48187290:GGG:G	acceptor_gain	1.0000
10:48187291:GG:G	acceptor_gain	1.0000
10:48187291:GGCTG:G	acceptor_loss	1.0000
10:48187293:C:CC	acceptor_gain	1.0000

AlphaMissense

8547 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:48171160:A:G	F1091S	0.996
10:48171159:G:C	F1091L	0.993
10:48171159:G:T	F1091L	0.993
10:48171161:A:G	F1091L	0.993
10:48171043:T:A	D1130V	0.990
10:48171043:T:G	D1130A	0.990
10:48171163:C:T	G1090E	0.990
10:48171037:A:G	I1132T	0.989
10:48171043:T:C	D1130G	0.989
10:48171037:A:T	I1132N	0.988
10:48171044:C:G	D1130H	0.988
10:48171032:C:G	A1134P	0.987
10:48171037:A:C	I1132S	0.987
10:48249078:G:C	F84L	0.987
10:48249078:G:T	F84L	0.987
10:48249080:A:G	F84L	0.987
10:48171073:G:T	A1120D	0.986
10:48171055:A:T	I1126N	0.984
10:48171100:A:G	I1111T	0.984
10:48184586:A:G	L855S	0.984
10:48171100:A:C	I1111S	0.983
10:48178057:A:G	F962S	0.983
10:48168650:A:G	L1161P	0.981
10:48171164:C:G	G1090R	0.981
10:48171164:C:T	G1090R	0.981
10:48171156:A:C	S1092R	0.979
10:48171156:A:T	S1092R	0.979
10:48171158:T:G	S1092R	0.979
10:48175854:A:G	I994T	0.978
10:48168650:A:T	L1161H	0.976

dbSNP variants (sampled 300 via entrez): RS1000010349 (10:48189409 G>A), RS1000021197 (10:48218438 C>A,G), RS1000053387 (10:48224847 G>A,T), RS1000076901 (10:48231494 T>G), RS1000159264 (10:48248179 C>G,T), RS1000172559 (10:48250175 C>A), RS1000179280 (10:48208776 C>T), RS1000209009 (10:48207440 T>C), RS1000299296 (10:48231057 C>T), RS1000317810 (10:48247863 A>G), RS1000320814 (10:48236949 T>C), RS1000348668 (10:48255918 A>C), RS1000401651 (10:48217602 T>C,G), RS1000419806 (10:48261984 T>A), RS1000420897 (10:48223280 A>C)

Disease associations

OMIM: gene MIM:613323 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST003518_9	Daytime sleep phenotypes	4.000000e-06
GCST003997_7	Myopia	4.000000e-13
GCST006291_29	Spherical equivalent or myopia (age of diagnosis)	2.000000e-13
GCST010002_287	Refractive error	2.000000e-49

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007828	daytime rest measurement
EFO:0004847	age at onset

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
(+)-JQ1 compound	decreases expression	2
Aflatoxin B1	decreases methylation, increases methylation	2
6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	increases expression	1
OTX015	decreases expression	1
mivebresib	decreases expression	1
methyleugenol	decreases expression	1
sodium arsenite	decreases expression	1
tebuconazole	decreases expression	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
Resveratrol	decreases expression, affects cotreatment	1
Acetaminophen	increases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Calcitriol	decreases expression, affects cotreatment	1
Copper	affects cotreatment, decreases expression	1
Phthalic Acids	decreases expression	1
Rotenone	decreases expression	1
Testosterone	decreases expression, affects cotreatment	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	decreases expression	1
Okadaic Acid	decreases expression	1
Permethrin	decreases expression	1
S-Nitrosoglutathione	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.