FSBP

Summary

FSBP (fibrinogen silencer binding protein, HGNC:43653) is a protein-coding gene on chromosome 8q22.1, encoding Fibrinogen silencer-binding protein (O95073). Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain.

Enables identical protein binding activity. Located in nucleoplasm.

Source: NCBI Gene 100861412 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001256141

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43653
Approved symbol	FSBP
Name	fibrinogen silencer binding protein
Location	8q22.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000265817
Ensembl biotype	protein_coding
OMIM	616306
Entrez	100861412

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 nonsense_mediated_decay

ENST00000481490, ENST00000517506

RefSeq mRNA: 1 — MANE Select: NM_001256141 NM_001256141

CCDS: CCDS59106

Canonical transcript exons

ENST00000481490 — 2 exons

Exon	Start	End
ENSE00001088877	94436495	94436944
ENSE00003754955	94427716	94432656

Expression profiles

Bgee: expression breadth ubiquitous, 173 present calls, max score 84.28.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.0792 / max 484.7332, expressed in 1030 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
93988	4.0792	1030

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pigmented layer of retina	UBERON:0001782	84.28	gold quality
colonic epithelium	UBERON:0000397	81.85	gold quality
buccal mucosa cell	CL:0002336	81.71	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.60	gold quality
ventricular zone	UBERON:0003053	77.82	gold quality
oviduct epithelium	UBERON:0004804	77.54	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.16	gold quality
ganglionic eminence	UBERON:0004023	76.40	gold quality
calcaneal tendon	UBERON:0003701	76.13	gold quality
adrenal tissue	UBERON:0018303	75.27	gold quality
cortical plate	UBERON:0005343	73.28	gold quality
stromal cell of endometrium	CL:0002255	72.16	gold quality
corpus epididymis	UBERON:0004359	71.80	gold quality
endothelial cell	CL:0000115	71.55	silver quality
caput epididymis	UBERON:0004358	68.76	silver quality
tibialis anterior	UBERON:0001385	68.49	silver quality
endometrium	UBERON:0001295	68.35	gold quality
fallopian tube	UBERON:0003889	67.74	gold quality
islet of Langerhans	UBERON:0000006	67.73	gold quality
right uterine tube	UBERON:0001302	67.66	gold quality
tibial nerve	UBERON:0001323	67.16	gold quality
cauda epididymis	UBERON:0004360	66.79	silver quality
hindlimb stylopod muscle	UBERON:0004252	65.74	gold quality
ovary	UBERON:0000992	65.66	gold quality
right ovary	UBERON:0002118	65.48	gold quality
left ovary	UBERON:0002119	65.47	gold quality
smooth muscle tissue	UBERON:0001135	65.32	gold quality
prefrontal cortex	UBERON:0000451	64.97	gold quality
urinary bladder	UBERON:0001255	64.97	gold quality
right atrium auricular region	UBERON:0006631	64.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.21

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

202 targeting FSBP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-373-5P	99.98	75.36	4753

Literature-anchored findings (GeneRIF, showing 1)

• we show here that through its PDZ domains, X11alpha interacts with a novel transcription factor, fibrinogen silencer binding protein (PMID:20531236)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	fsbp	ENSDARG00000101437
mus_musculus	Fsbp	ENSMUSG00000094595

Protein

Protein identifiers

Fibrinogen silencer-binding protein — O95073 (reviewed: O95073)

All UniProt accessions (2): O95073, J3KSW4

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.

Subunit / interactions. Interacts with APBA1 (via PDZ 1 and 2 domains).

Subcellular location. Nucleus.

Tissue specificity. Expressed in multiple tissues including brain.

Miscellaneous. Intragenic, in the second intron of RAB54B gene.

Isoforms (2)

UniProt ID	Names	Canonical?
O95073-1	1	yes
O95073-2	2

RefSeq proteins (1): NP_001243070* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR028002	Myb_DNA-bind_5	Domain
IPR042383	FSBP	Family

Pfam: PF13873

UniProt features (4 total): chain 1, cross-link 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95073-F1	70.25	0.39

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 94

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 95 (showing top): RNGTGGGC_UNKNOWN, RORA1_01, CATRRAGC_UNKNOWN, OCT1_06, chr8q22, BASAKI_YBX1_TARGETS_DN, GATA1_02, GATA4_Q3, ISRE_01, YNGTTNNNATT_UNKNOWN, FOXO4_02, GCCNNNWTAAR_UNKNOWN, ER_Q6_02, RORA2_01, FOXO3_01

GO Biological Process (0):

GO Molecular Function (2): identical protein binding (GO:0042802), protein binding (GO:0005515)

GO Cellular Component (2): nucleus (GO:0005634), nucleoplasm (GO:0005654)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein binding	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

46 interactions, top by confidence:

A	B	Type	Score
FSBP	FSBP	psi-mi:“MI:0915”(physical association)	0.620
FSBP	SUMO1	psi-mi:“MI:0915”(physical association)	0.560
FSBP	FLJ13057	psi-mi:“MI:0915”(physical association)	0.560
FSBP	PRKAA1	psi-mi:“MI:0915”(physical association)	0.560
FSBP	ATPAF2	psi-mi:“MI:0915”(physical association)	0.560
FSBP	TCEANC	psi-mi:“MI:0915”(physical association)	0.560
ANKRD36BP1	FSBP	psi-mi:“MI:0915”(physical association)	0.560
FSBP	ENKD1	psi-mi:“MI:0915”(physical association)	0.560
FSBP		psi-mi:“MI:0915”(physical association)	0.560
FSBP	CDC23	psi-mi:“MI:0915”(physical association)	0.560
FLJ13057	FSBP	psi-mi:“MI:0915”(physical association)	0.560
PRKAA1	FSBP	psi-mi:“MI:0915”(physical association)	0.560
TCEANC	FSBP	psi-mi:“MI:0915”(physical association)	0.560
ENKD1	FSBP	psi-mi:“MI:0915”(physical association)	0.560
CDC23	FSBP	psi-mi:“MI:0915”(physical association)	0.560
SUMO1	FSBP	psi-mi:“MI:0915”(physical association)	0.560
FSBP	ANKRD36BP1	psi-mi:“MI:0915”(physical association)	0.560
	FSBP	psi-mi:“MI:0915”(physical association)	0.560
ATPAF2	FSBP	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (86): RAD54B (Affinity Capture-MS), RAD54B (Two-hybrid), RAD54B (Two-hybrid), RAD54B (Two-hybrid), RAD54B (Two-hybrid), GMCL1 (Two-hybrid), MYO15B (Two-hybrid), ENKD1 (Two-hybrid), ANKRD36BP1 (Two-hybrid), ATPAF2 (Two-hybrid), TCEANC (Two-hybrid), RAD54B (Affinity Capture-Western), RAD54B (Affinity Capture-Western), MDM2 (Affinity Capture-Western), RAD54B (Reconstituted Complex)

ESM2 similar proteins: A0A1W2PQ72, A7J1T0, A7J1T2, A7MBB4, A8MZ59, D3ZXW3, M0R5D6, O36371, O43283, O43310, O73622, O95073, P03177, P10242, P21705, P46200, Q0P4H6, Q1HKZ5, Q1HVD1, Q1LVK9, Q22811, Q2NKQ1, Q3KSQ2, Q3UPF5, Q535K8, Q562B4, Q567C6, Q5R8X7, Q5ZI27, Q6DGX3, Q6INH1, Q6J1H4, Q6PEE2, Q6ZTZ1, Q71M44, Q7SXL7, Q80T85, Q8BFX3, Q8BIL2, Q8BKE5

Diamond homologs: D3ZXW3, O95073, Q8BKE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2601 predictions. Top by Δscore:

Variant	Effect	Δscore
8:94378378:TAC:T	acceptor_gain	1.0000
8:94378381:C:CC	acceptor_gain	1.0000
8:94378381:CTAAA:C	acceptor_loss	1.0000
8:94393737:TTATA:T	donor_loss	1.0000
8:94393738:TATA:T	donor_loss	1.0000
8:94393739:ATACC:A	donor_loss	1.0000
8:94393740:TA:T	donor_loss	1.0000
8:94393741:A:AG	donor_loss	1.0000
8:94393742:C:CG	donor_loss	1.0000
8:94400232:TCTTA:T	donor_loss	1.0000
8:94400233:CTTAC:C	donor_loss	1.0000
8:94400234:TTAC:T	donor_loss	1.0000
8:94400235:TACCT:T	donor_loss	1.0000
8:94400236:ACCTG:A	donor_loss	1.0000
8:94400237:C:CG	donor_loss	1.0000
8:94400460:CATT:C	acceptor_gain	1.0000
8:94400464:C:CC	acceptor_gain	1.0000
8:94404241:T:C	acceptor_gain	1.0000
8:94404241:T:TC	acceptor_gain	1.0000
8:94407437:A:AC	donor_gain	1.0000
8:94407438:C:CC	donor_gain	1.0000
8:94407438:CTTGG:C	donor_gain	1.0000
8:94407544:T:A	donor_gain	1.0000
8:94407581:T:TA	donor_gain	1.0000
8:94407582:C:A	donor_gain	1.0000
8:94411167:T:A	donor_gain	1.0000
8:94411252:A:C	donor_gain	1.0000
8:94411312:TGAA:T	acceptor_gain	1.0000
8:94411316:C:CC	acceptor_gain	1.0000
8:94432652:TTGCA:T	acceptor_gain	1.0000

AlphaMissense

1973 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:94436641:T:A	K76N	1.000
8:94436641:T:G	K76N	1.000
8:94436731:C:A	W46C	1.000
8:94436731:C:G	W46C	1.000
8:94436733:A:G	W46R	1.000
8:94436733:A:T	W46R	1.000
8:94436839:A:C	F10L	1.000
8:94436839:A:T	F10L	1.000
8:94436840:A:G	F10S	1.000
8:94436841:A:G	F10L	1.000
8:94436633:G:T	A79D	0.999
8:94436645:A:G	L75P	0.999
8:94436647:C:A	R74S	0.999
8:94436647:C:G	R74S	0.999
8:94436648:C:A	R74M	0.999
8:94436650:T:A	K73N	0.999
8:94436650:T:G	K73N	0.999
8:94436651:T:A	K73I	0.999
8:94436652:T:C	K73E	0.999
8:94436655:A:C	Y72D	0.999
8:94436657:A:G	L71P	0.999
8:94436664:G:T	R69S	0.999
8:94436666:A:G	L68P	0.999
8:94436732:C:G	W46S	0.999
8:94436743:C:A	K42N	0.999
8:94436743:C:G	K42N	0.999
8:94436744:T:A	K42M	0.999
8:94436745:T:C	K42E	0.999
8:94436745:T:G	K42Q	0.999
8:94436753:A:T	I39K	0.999

dbSNP variants (sampled 300 via entrez): RS1000210868 (8:94430080 G>A), RS1000381786 (8:94432931 A>G), RS1000773869 (8:94438943 T>A,C), RS1001115919 (8:94431504 G>A,C), RS1001218143 (8:94429323 T>C), RS1001713426 (8:94429622 A>G), RS1002055861 (8:94434517 G>A,T), RS1002150756 (8:94434905 T>C), RS1002446543 (8:94438049 GTTT>G), RS1002626191 (8:94427626 T>C), RS1002799128 (8:94438737 A>G), RS1003298377 (8:94430789 C>A,T), RS1004566968 (8:94432388 C>A,T), RS1005199829 (8:94435715 A>T), RS1005235247 (8:94432843 TACTC>T)

Disease associations

OMIM: gene MIM:616306 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
FR900359	increases phosphorylation	1
methylmercuric chloride	decreases expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
trichostatin A	decreases expression	1
beta-lapachone	decreases expression	1
methacrylaldehyde	increases oxidation, increases abundance, affects cotreatment	1
indeno(1,2,3-cd)pyrene	increases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	increases oxidation, affects cotreatment, increases abundance	1
Amphotericin B	decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
Dimethyl Sulfoxide	increases expression	1
Ozone	increases oxidation, increases abundance, affects cotreatment	1
Phenylmercuric Acetate	decreases expression	1
Dihydrotestosterone	increases expression	1
Valproic Acid	decreases expression	1
Okadaic Acid	decreases expression	1
Volatile Organic Compounds	affects cotreatment, increases oxidation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.